Article
Ophthalmology
Yangfan Yang, Xinyi Zhang, Zidong Chen, Yifan Wei, Qiaona Ye, Yanmei Fan, Neil Nathwani, Gus Gazzard, Minbin Yu
Summary: This study aimed to report the baseline characteristics and diurnal fluctuation of intraocular pressure (IOP) in a Chinese cohort of patients with glaucoma and ocular hypertension. The results showed that younger age, male gender, and thicker central corneal thickness were correlated with higher IOP in patients with primary open-angle glaucoma, while only thicker central corneal thickness was related to higher IOP in patients with ocular hypertension. Peak IOP occurred mostly in the early morning or late afternoon, and trough IOP occurred mostly in the early afternoon.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Thibaut Gaboriau, Remi Dubois, Boris Foucque, Florence Malet, Cedric Schweitzer
Summary: The purpose of this study was to compare the 24-hour intraocular pressure (IOP) related fluctuations monitoring between two groups of visual field progression rates in patients with open angle glaucoma (OAG). The results showed that patients with higher visual field progression rates had significantly higher amplitudes and absolute areas under the 24-hour monitoring curve. Therefore, this monitoring method can help adjust the treatment strategy for glaucoma earlier.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Anna-Sophie Mursch-Edlmayr, Matthias Bolz, Clemens Strohmaier
Summary: Glaucomatous optic neuropathies have long been considered diseases caused by high intraocular pressure, but recent research has shown that vascular factors also play an important role in glaucoma. Advances in the study of ocular vasculature, ciliary circulation, retinal circulation, etc., may bring new breakthroughs in the treatment of glaucoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Denis Gubin, Vladimir Neroev, Tatyana Malishevskaya, Germaine Cornelissen, Sergei Y. Astakhov, Sergey Kolomeichuk, Natalya Yuzhakova, Yana Kabitskaya, Dietmar Weinert
Summary: The study investigated the effects of long-term oral melatonin administration on circadian rhythms, retinal cell function, sleep, and mood in patients with stable or advanced glaucoma. Melatonin improved Tb circadian rhythm stability, alignment with IOP, decreased IOP, improved RGCs function, and had greater effects on sleep and mood in advanced glaucoma. MTNR1B gene polymorphism affected melatonin and Tb phases in individuals with advanced glaucoma, indicating a potential for personalized treatment strategies.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Ophthalmology
Peizeng Yang, Chaokui Wang, Guannan Su, Su Pan, Yang Qin, Jun Zhang, Qingfeng Cao, Zhenyu Zhong, Chunjiang Zhou, Yao Wang, Aize Kijlstra
Summary: This study examined the prevalence, risk factors, and treatment outcomes of OHT/glaucoma in Chinese patients with VKH. Risk factors included poorer visual acuity, longer intervals between uveitis attacks and referral, more recurrent episodes, and posterior synechiae. Medical treatment and surgical interventions were effective in achieving normalized intraocular pressure in affected eyes.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Multidisciplinary Sciences
Youssef Mohamed, Christopher L. Passaglia
Summary: Intraocular pressure (IOP) is influenced by trabecular outflow pathways. Eye cannulation is the standard method for measuring outflow resistance but is invasive. A new technology using a smart portable micropump allows for autonomous measurement of outflow facility in conscious rats. The micropump can adjust flow rate to maintain IOP at a target level. The device offers a unique tool for long-term monitoring of ocular health.
Article
Ophthalmology
Wungrak Choi, Hyoung Won Bae, Hye Jung Shin, Eun Woo Kim, Chan Yun Kim, Min Kim, Gong Je Seong
Summary: This study developed two nomograms to predict a safety zone for intravitreal DEX implantation. These can be used to identify individuals who may be safely prescribed steroid treatments and for whom extra caution should be exercised.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jiayang Zhang, Ruoyu Sun, Tingting Jiang, Guangrui Yang, Lihong Chen
Summary: Blood pressure follows a circadian rhythm, with disruptions potentially leading to worsened cardiovascular and renal outcomes. This review summarizes current understanding of the circadian blood pressure regulation and provides a therapeutic overview of its relationship to cardiovascular and renal health and disease.
Review
Medicine, General & Internal
Michal Krzysztofik, Dorota Zygadlo, Paulina Trybek, Jakub Jarosz, Adam Zajac, Nicholas Rolnick, Michal Wilk
Summary: Resistance training may be harmful to patients with or at risk of glaucoma, thus combining it with blood flow restriction may be a solution. While BFR holds potential for improving fitness, there is limited research on its safety regarding ocular health.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Cynthia L. Pervan-Steel, Uttio Roy Chowdhury, Hemchand K. Sookdeo, Ralph A. Casale, Peter I. Dosa, Thurein M. Htoo, Michael P. Fautsch, Barbara M. Wirostko
Summary: The study characterized the ocular hypotensive and pharmacological properties of QLS-101, a novel ATP-sensitive potassium channel opening prodrug. Results showed that QLS-101 lowered intraocular pressure (IOP) in mice, with a sustained effect when administered topically. The conversion of QLS-101 to levcromakalim, its active form, was also confirmed.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Medicine, General & Internal
Yumi Shigemoto, Yuka Hasebe, Kazuyoshi Kitamura, Yoshiko Fukuda, Masako Sakamoto, Mio Matsubara, Shinya Minaguchi, Kenji Kashiwagi
Summary: The study aimed to determine the number of tests required to adequately assess diurnal changes in intraocular pressure (IOP) using a self-measuring rebound tonometer among glaucoma patients. Twenty-four patients with primary open-angle glaucoma who successfully measured IOP at least three times per day during the correct time periods for four days were included in the analysis. The results showed that the diurnal IOP rhythm measured by patients was inconsistent, and multiple days of measurements may be necessary to accurately assess diurnal IOP rhythm.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Silvia Mendez-Martinez, Teresa Martinez-Rincon, Manuel Subias, Luis E. Pablo, David Garcia-Herranz, Julian Garcia Feijoo, Irene Bravo-Osuna, Rocio Herrero-Vanrell, Elena Garcia-Martin, Maria J. Rodrigo
Summary: The study demonstrates that chronic ocular hypertension can accelerate the development of slowly progressive myopia in Long-Evans rat eyes, accompanied by an initial increase in eye structure and function that later reverses.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Binze Han, Maomao Song, Liping Li, Xinghuai Sun, Yuan Lei
Summary: Despite various therapeutic methods for ocular hypertension and glaucoma, lowering intraocular pressure remains the most effective way to slow disease progression and prevent blindness. Only a couple of ocular hypotensive drugs act on the conventional outflow system, which is the main pathway for aqueous humor outflow and the major lesion site causing ocular hypertension.
Review
Pharmacology & Pharmacy
Phatsawee Jansook, Hay Marn Hnin, Thorsteinn Loftsson, Einar Stefansson
Summary: This article discusses the use of carbonic anhydrase inhibitors to lower intraocular pressure in patients with glaucoma, and explores the enhancement of drug solubility and permeability using cyclodextrin complexes. It also examines the development of drugs targeting specific CA isoenzymes in ocular tissues and the potential of pharmaceutical nanotechnology platforms.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Yousef Alqurashi, Mohamed Elsherif, Rosalia Moreddu, Magdalena Cieslak, Hemeth Dhaliwal, Khamis Essa, Haider Butt
Summary: Glaucoma is a leading cause of irreversible blindness, and intraocular pressure (IOP) is the most important biomarker for its diagnosis and monitoring. Current IOP monitoring techniques are invasive and inconvenient, while laser-processed contact lenses offer a potential solution for continuous and non-invasive monitoring of IOP variations.
APPLIED SCIENCES-BASEL
(2022)
Article
Ophthalmology
Carlo Bruttini, Carlotta Pallone, Alice Verticchio Vercellin, Giovanni Acerbi, Santina Baschetti, Pietro Bruttini, Ivano Riva, Luciano Quaranta
Summary: The study investigated the pre-operative conjunctival flora in cataract surgery patients with major risk factors for post-operative infection. Results showed a low positivity rate of swabs, with Staphylococcus aureus and Staphylococcus epidermidis being the most isolated microorganisms. Gram-negative bacteria, including Pseudomonas aeruginosa, were also present in a small percentage of cases.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Luciano Quaranta, Francesca Rovida, Ivano Riva, Carlo Bruttini, Ilaria Brambilla, Fausto Baldanti, Giovanni De Angelis, Gian Luigi Marseglia
Summary: This article reports the identification of SARS-CoV-2 RNA in ocular specimen of a pediatric patient without signs of ocular involvement. However, it is still unclear whether this could be considered an important route for the spread of SARS-CoV-2.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Ivano Riva, Eleonora Micheletti, Riccardo Fausto, Carlo Bruttini, Giovanni De Angelis, Roberto Ceccuzzi, Luciano Quaranta
Summary: A case of neurotrophic keratopathy in a patient with primary congenital glaucoma was effectively treated with human recombinant Nerve Growth Factor eye drops, leading to complete resolution of corneal integrity and improvement in visual acuity.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Roberto dell'Omo, Mariaelena Filippelli, Gianni Virgili, Francesco Bandello, Giuseppe Querques, Paolo Lanzetta, Teresio Avitabile, Francesco Viola, Michele Reibaldi, Francesco Semeraro, Luciano Quaranta, Stanislao Rizzo, Edoardo Midena, Giuseppe Campagna, Ciro Costagliola
Summary: The number of eye surgical procedures in Italy significantly decreased during the lockdown due to the COVID-19 epidemic, with only 70% of recommended surgeries being performed. Elective surgeries decreased by 96.2%, urgent surgeries by 49.7%, and intravitreal injections by 48.5% during the lockdown period.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Rosanna Guagliano, Donatella Barilla, Chiara Bertone, Silvia Montescani, Alice C. Verticchio Vercellin, Cristina Arpa, Carmine Tinelli, Giovanni De Angelis, Luciano Quaranta
Summary: This study found significant differences in optic nerve morphology, central macular thickness, and OCT scan quality between amblyopic patients and normal individuals, but no significant impact on retinal nerve fibers layers and ganglion cell complex was observed in monolateral amblyopia.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Pharmacology & Pharmacy
Andreas Katsanos, Ivano Riva, Banu Bozkurt, Gabor Hollo, Luciano Quaranta, Francesco Oddone, Murat Irkec, Gordon N. Dutton, Anastasios G. Konstas
Summary: Topical prostaglandin analogues (PGAs) have become the first line and first choice therapeutic options in the management of glaucoma and ocular hypertension (OHT) in the past 25 years. Despite extensive research on their short-term efficacy and safety, the long-term safety and tolerability of PGAs still need further investigation. New opportunities and future challenges are presented by recently launched novel PGAs or those still in development.
EXPERT OPINION ON DRUG SAFETY
(2022)
Article
Optics
Alice Verticchio Vercellin, Alon Harris, Aditya Belamkar, Ryan Zukerman, Lucia Carichino, Marcela Szopos, Brent Siesky, Luciano Quaranta, Carlo Bruttini, Francesco Oddone, Ivano Riva, Giovanna Guidoboni
Summary: Altitude has an impact on intraocular pressure, blood pressure, and retinal hemodynamics. The study found that increasing altitude leads to an increase in blood flow and pressure in the retinal vasculature, while decreasing intraocular pressure. These findings provide insights into the underlying mechanisms of changes in ocular blood flow and pressure at different altitudes.
Review
Ophthalmology
Luciano Quaranta, Alessio Novella, Mauro Tettamanti, Luca Pasina, Robert N. N. Weinreb, Alessandro Nobili
Summary: Glaucoma is a progressive optic neuropathy characterized by retinal ganglion cell loss and visual field deterioration. While the exact cause of glaucoma is still unknown, elevated intraocular pressure has been identified as a modifiable risk factor. Treatment with eye drops to lower intraocular pressure has been proven effective in reducing the risk of disease progression. However, many patients with glaucoma struggle with adherence to medication, which is associated with poor treatment outcomes and increased healthcare costs.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Engineering, Electrical & Electronic
Tommaso Fedullo, Davide Cassanelli, Giovanni Gibertoni, Federico Tramarin, Luciano Quaranta, Ivano Riva, Lucia Tanga, Francesco Oddone, Luigi Rovati
Summary: The adoption of artificial intelligence methods in the field of instrumentation and measurements is an attractive research area, allowing for automatic measurements and improved test accuracy and diagnostic accessibility.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2022)
Proceedings Paper
Optics
Davide Cassanelli, Tommaso Fedullo, Giovanni Gibertoni, Giorgia Saporito, Manuela Ferrazza, Francesco Oddone, Ivano Riva, Luciano Quaranta, Federico Tramarin, Luigi Rovati
Summary: This paper presents a deep learning algorithm for automatically determining the Van Herick grade, with the performances of three different Convolutional Neural Networks verified on eye images of 80 patients. The networks demonstrate sufficient accuracy for Van Herick grade classification in a screening system and can offer real-time response after proper training.
OPHTHALMIC TECHNOLOGIES XXXII
(2022)
Article
Ophthalmology
Francesco Testa, Vittoria Murro, Sabrina Signorini, Leonardo Colombo, Giancarlo Iarossi, Francesco Parmeggiani, Benedetto Falsini, Anna Paola Salvetti, Raffaella Brunetti-Pierri, Giorgia Aprile, Chiara Bertone, Agnese Suppiej, Francesco Romano, Marianthi Karali, Simone Donati, Paolo Melillo, Andrea Sodi, Luciano Quaranta, Luca Rossetti, Luca Buzzonetti, Marzio Chizzolini, Stanislao Rizzo, Giovanni Staurenghi, Sandro Banfi, Claudio Azzolini, Francesca Simonelli
Summary: This study investigated the development of inherited retinal degenerations (IRD) due to mutations in the RPE65 gene in an Italian population. By collecting data on visual acuity, visual field, and imaging, the study found a correlation between genotype and phenotype, which can contribute to better management of RPE65-associated IRD patients.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
