期刊
SURVEY OF OPHTHALMOLOGY
卷 57, 期 5, 页码 463-473出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.survophthal.2011.12.004
关键词
fluorescence in situ hybridization (FISH); monosomy 3; tumor; uveal melanoma
Tumor monosomy 3 confers a poor prognosis in patients with uveal melanoma. We critically review the techniques used for fluorescence in situ hybridization (FISH) detection of monosomy 3 in order to assess variability in practice patterns and to explain differences in results. Significant variability that has likely affected reported results was found in tissue sampling methods, selection of FISH probes, number of cells counted, and the cut-off point used to determine monosomy 3 status. Clinical parameters and specific techniques employed to report FISH results should be specified so as to allow meta-analysis of published studies. FISH-based detection of monosomy 3 in uveal melanoma has not been performed in a standardized manner, which limits conclusions regarding its clinical utility. FISH is a widely available, versatile technology, and when performed optimally has the potential to be a valuable tool for determining the prognosis of uveal melanoma. (Surv Ophthalmol 57:463 173, 2012. (C) 2012 Elsevier Inc. All rights reserved.)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据