Article
Surgery
Daniela Huber, Yannick Hurni
Summary: The study found that retroperitoneal vNOTES for SLNB in endometrial cancer is a feasible, safe, and valuable approach. The operative time was short, with minimal blood loss and a high bilateral detection rate. Although one case required conversion to conventional laparoscopy, no postoperative complications were observed.
FRONTIERS IN SURGERY
(2022)
Article
Surgery
Li Deng, Yi Liu, Yuanyan Yao, Yuan Deng, Shuai Tang, Li Sun, Yanzhou Wang
Summary: The study aims to verify the safety and effectiveness of vaginal natural orifice transluminal endoscopic surgery (vNOTES) in early endometrial cancer staging. The results showed that vNOTES had comparable lymph node detection rates and perioperative outcomes to conventional laparoscopic surgery, with lower postoperative pain and shorter hospital stay.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Obstetrics & Gynecology
Lior Lowenstein, Omer Mor, Emad Matanes, Roy Lauterbach, Sari Boulus, Zeev Weiner, Jan Baekelandt
Summary: This study assessed the feasibility and safety of the Hominis surgical system for RvNOTES hysterectomy. The positive results indicate that this new technology is a safe and effective tool for surgeons to operate vaginally.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Yanzhou Wang, Li Deng, Shuai Tang, Yuya Dou, Yuanyang Yao, Yudi Li, Yuan Deng, Yong Chen, Zhiqing Liang
Summary: The study suggests that vNOTES surgery is feasible and may lead to a reduced postoperative hospital stay, faster recovery, and better cosmetic outcomes in patients with endometrial cancer. However, further prospective research is needed to confirm its broader clinical application.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2021)
Article
Medicine, General & Internal
Zi-Jia Song, Yi-Qing Shi, Yi-Mei Jiang, Kun Liu, You Li, Chang-Gang Wang, Ren Zhao
Summary: Pure transvaginal natural orifice transluminal endoscopic surgery (vNOTES) for colorectal cancer, performed by experienced surgeons, is a feasible approach that can overcome the technical challenges of traditional NOTES procedures. In this study, a 65-year-old female patient underwent vNOTES right hemicolectomy for colon cancer with successful outcomes and no complications during the 30-day follow-up period.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Medicine, General & Internal
Maria Lieta Interdonato, Paolo Scollo, Tommaso Bignardi, Francesca Massimello, Martina Ferrara, Gianluca Donatiello, Marta Caretto, Paolo Mannella, Basilio Pecorino, Mario Giuseppe Meroni, Tommaso Simoncini
Summary: This study evaluated the feasibility, safety, and outcomes of transvaginal natural orifice transluminal endoscopic surgery (vNOTES) hysterectomy performed at three institutions in Italy. The results showed that vNOTES had shorter operation times, lower postoperative pain levels, and lower complication rates. This suggests that vNOTES is a feasible alternative to conventional surgery.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Marco Puccini, Carlo Enrico Ambrosini, Leonardo Rossi, Luigi De Napoli, Gabriele Materazzi
Summary: This paper describes the current status and potential perspectives of sentinel node mapping (SNM) in thyroid tumors. SNM has been tested in papillary thyroid cancer (PTC) and medullary thyroid cancer (MTC) since the end of the twentieth century. While effective in spotting sentinel nodes, uncertainty about the clinical significance of occult metastases in differentiated thyroid cancer and MTC micrometastases has hindered the results. The lack of well-designed randomized controlled trials makes SNM in thyroid tumors an interesting yet experimental methodology. New technology could facilitate such studies and provide solid information about the clinical significance of occult neck metastases in thyroid cancer.
FRONTIERS IN MEDICINE
(2023)
Editorial Material
Obstetrics & Gynecology
Jan F. Baekelandt, Supuni Kapurubandara
Summary: This study describes the use of a vaginal natural orifice transluminal endoscopic surgery approach to repair a uterine isthmocele. This approach is considered a novel and potentially less invasive method that combines vaginal surgery and endoscopic magnification. It should be performed in carefully selected patients.
FERTILITY AND STERILITY
(2023)
Article
Medicine, Research & Experimental
Giri Krishnan, Nynke S. van den Berg, Naoki Nishio, Georgina Juniper, Jaqueline Pei, Quan Zhou, Guolan Lu, Yu-Jin Lee, Kimberly Ramos, Andrei H. Iagaru, Fred M. Baik, Alexander D. Colevas, Brock A. Martin, Eben L. Rosenthal
Summary: The study showed that intravenous infusion of a tumor-targeted tracer could accurately identify sentinel and metastatic lymph nodes, potentially improving the practice of SLNB surgery.
Article
Obstetrics & Gynecology
Z. Lu, K. Hua, Y. Chen, C. Hu
Summary: This study describes the standard practice of presacral exposure during vNOTES for sacrocolpopexy in women with uterine prolapse, including key techniques such as identifying nerves, removing tissue, incising fascia, attaching mesh, and completing peritonealisation.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Oncology
Giorgio Bogani, Andrea Papadia, Alessandro Buda, Jvan Casarin, Violante Di Donato, Maria Luisa Gasparri, Francesco Plotti, Ciro Pinelli, Maria Chiara Paderno, Salvatore Lopez, Anna Myriam Perrone, Fabio Barra, Rocco Guerrisi, Claudia Brusadelli, Antonella Cromi, Debora Ferrari, Valentina Chiapp, Mauro Signorelli, Umberto Leone Roberti Maggiore, Antonino Ditto, Innocenza Palaia, Simone Ferrero, Pierandrea De Iaco, Roberto Angioli, Pierluigi Benedetti Panici, Fabio Ghezzi, Fabio Landoni, Michael D. Mueller, Francesco Raspagliesi
Summary: This study evaluated the outcomes of high-risk EC patients undergoing SNM, with or without back-up lymphadenectomy, and found that the type of nodal assessment did not impact survival outcomes. Back-up lymphadenectomy may help remove positive nodes, but its therapeutic value remains controversial.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Automation & Control Systems
Zhenxuan Hu, Jinhua Li, Shuxin Wang
Summary: This article introduces a novel robotic instrument that can assist in Natural Orifice Transluminal Endoscopic Surgery (NOTES). The instrument has a diameter of 6.5 mm and 7 degrees of freedom (DOF). It utilizes helical springs with high torsional rigidity for three continuum elastic joints, and patterned concentric tubes to change the stiffness of the force transmission structure. Analytical solutions for inverse kinematics are obtained based on the arrangement of coupled joints. A disk-elastomer model is established to simplify the derivation of kinematics, and the relationship between cable slack and joint parameters is derived. Experimental results verify the trajectory tracking accuracy, bending accuracy, and variable stiffness ability of the proposed instrument.
IEEE-ASME TRANSACTIONS ON MECHATRONICS
(2023)
Article
Medicine, General & Internal
Myeong-Seon Kim, Joseph J. Noh, Tae-Joong Kim
Summary: The study evaluated the feasibility and safety of hysterectomy and adnexal procedures by vaginal natural orifice transluminal endoscopic surgery (vNOTES). Although there were three complications, vNOTES offers advantages to patients and surgeons, with surgical techniques continuing to be developed in this field. The learning curve analysis showed that port-installation time and total operation time appeared to reach proficiency level by the 10th case.
FRONTIERS IN MEDICINE
(2021)
Editorial Material
Obstetrics & Gynecology
Dan Feng, Li He
Summary: Incision of the posterior vaginal fornix during vNOTES did not have any negative effects on cervical dilation and vaginal extension in nine patients.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Oncology
Nicolo Bizzarri, Andrea Rosati, Giovanni Scambia, Francesco Fanfani
Summary: Occult endometrial cancer after supracervical hysterectomy is rare, and restaging should be considered for optimal management. A case report described a patient with metastatic parametrium after laparoscopic surgery, highlighting the feasibility of SLN mapping with cervical injection even without the uterine corpus.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
R. Sparks, S. Power, E. Kearns, A. Clarke, H. M. Mohan, A. Brannigan, J. Mulsow, C. Shields, R. A. Cahill
Summary: Precise localization of colonic neoplasia is crucial for laparoscopic oncological resection. The practice of preoperative endoscopic peritumoral tattooing is widely recommended but seldom scrutinized. A retrospective review was conducted on consecutive patients with preoperative lesional tattoo who underwent laparoscopic colonic resection, and the results emphasized the importance of tattoos in ensuring precision cancer surgery.
ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND
(2023)
Article
Medicine, General & Internal
Niall James McInerney, Mohammad Faraz Khan, Laiose Coady, Jeffrey Dalli, Maurice Stokes, Suzzane Donnelly, Helen Heneghan, Ronan Cahill
Summary: This study evaluates the usefulness of a rapidly implemented on-site simulation program for medical students during the COVID-19 pandemic. The results show that students who received simulation training performed better in history taking and test ordering. Most students found the simulation beneficial and advocated for more.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Correction
Medicine, General & Internal
Niall James McInerney, Mohammad Faraz Khan, Laoise Coady, Jeffrey Dalli, Maurice Stokes, Suzzane Donnelly, Helen Heneghan, Ronan Cahill
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Letter
Gastroenterology & Hepatology
Mohammad F. Khan, Kearns Emma, Ellen O'Brien, David Galvin, Tom Walsh, Ronan A. Cahill
COLORECTAL DISEASE
(2023)
Letter
Gastroenterology & Hepatology
Mohammad Faraz Khan, Emma Kearns, Ronan A. Cahill (ambrose)
COLORECTAL DISEASE
(2023)
Article
Oncology
Michael E. Kelly, Niall J. O'Sullivan, Jarlath C. Bolger, Francesco Polignano, Haney Youssef, Andrew Renehan, Lee Malcomson, Sue Alves, Tom Cecil, Jurgen Mulsow, Brendan Moran, Faheez Mohamed
Summary: This study reviewed data from the UK and Ireland Colorectal Peritoneal Metastases Registry to assess the influence of age on the efficacy of cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) for colorectal peritoneal metastases. The results indicated that age did not appear to impact morbidity or long-term survival following CRS and HIPEC. Good survival outcomes were observed when complete cytoreduction was achieved.
BRITISH JOURNAL OF CANCER
(2023)
Article
Biochemical Research Methods
Jeffrey Dalli, Abhinav Jindal, Gareth Gallagher, Jonathan P. P. Epperlein, Niall P. P. Hardy, Ra'ed Malallah, Kilian O'Donoghue, Padraig Cantillon-Murphy, Pol G. Mac Aonghusa, Ronan A. A. Cahill
Summary: This study aimed to assess the impact of camera positioning on the displayed near-infrared signal in different systems. The results showed that different systems displayed varying fluorescence performances, and factors such as lens configuration, movement, target positioning, and distance all had an impact on the fluorescence signal.
JOURNAL OF BIOMEDICAL OPTICS
(2023)
Article
Biochemistry & Molecular Biology
Cathal Caulfield, Dan Wu, Ian S. Miller, Annette T. Byrne, Pol Mac Aonghusa, Sergiy Zhuk, Lorenzo Cinelli, Elisa Bannone, Jacques Marescaux, Sylvain Gioux, Michele Diana, Taryn L. March, Alexander L. Vahrmeijer, Ronan Cahill, Donal F. O'Shea
Summary: A series of near-infrared fluorophores with mono- and bis-polyethylene glycol (PEG) substitution were synthesized for fluorescence guided intraoperative imaging, primarily for ureter identification. The bis-PEGylation improved the aqueous fluorescence quantum yields, with optimal PEG chain lengths of 2.9 to 4.6 kDa. Successful fluorescence identification of ureters was achieved in rodent and porcine models, with 3-D emission heat map imaging revealing spatial and temporal changes in intensity. These fluorophores can be spectrally distinguished from the clinically-used dye indocyanine green, suggesting their potential for intraoperative color coding of different tissues.
Article
Surgery
Niall P. P. Hardy, Pol MacAonghusa, Jeffrey Dalli, Gareth Gallagher, Jonathan P. P. Epperlein, Conor Shields, Jurgen Mulsow, Ailin C. Rogers, Ann E. E. Brannigan, John B. B. Conneely, Peter M. M. Neary, Ronan A. A. Cahill
Summary: This study focuses on the quantification and assessment of indocyanine green (ICG) through machine learning, which can distinguish tissue types and accurately characterize malignancy. By studying a series of quantitative fluorescence angiograms in a prospective patient cohort with colorectal neoplasia, the important challenges and innovative solutions for clinical validation were detailed.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Surgery
Paul A. Sutton, Martijn A. van Dam, Ronan A. Cahill, Sven Mieog, Karol Polom, Alexander L. Vahrmeijer, Joost van der Vorst
Summary: Fluorescence-guided surgery is an innovative technique that has been widely adopted in various surgical fields. It utilizes near-infrared fluorescence to provide real-time imaging and targeted imaging agents for improved surgical guidance.
Article
Surgery
Niall P. Hardy, Jonathan P. Epperlein, Jeffrey Dalli, William Robertson, Richard Liddy, John J. Aird, Niall Mulligan, Peter M. Neary, Gerard P. McEntee, John B. Conneely, Ronan A. Cahill
Summary: Artificial intelligence methods were used to accurately identify and characterize colorectal liver metastases (CRLM) based on dynamic signaling following intraoperative indocyanine green (ICG) administration. The machine learning algorithm successfully classified CRLM and benign lesions, and created 2D heatmaps based on flow parameters. The results suggest that this method can assist in reducing positive margin rates and identifying unexpected malignancies.
SURGERY OPEN SCIENCE
(2023)
Letter
Gastroenterology & Hepatology
Alice Moynihan, Mohammad Faraz Khan, Ronan A. Cahill
COLORECTAL DISEASE
(2023)
Article
Surgery
Maxime K. Collard, Ana Vaz, Hugh Irving, Mohammad Faraz Khan, Deirdre Mullis, Deirdre Brady, Kevin Nolan, Ronan Cahill
BRITISH JOURNAL OF SURGERY
(2023)
Article
Surgery
Jeffrey Dalli, Johanna J. Joosten, Abhinav Jindal, Niall P. Hardy, John Camilleri-Brennan, Predrag Andrejevic, Roel Hompes, Ronan A. Cahill
Summary: This study assesses the impact of a protocol on interpretation consistency for intra-operative colonic perfusion assessment via indocyanine green fluorescence angiography (ICGFA).
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Gastroenterology & Hepatology
A. Moynihan, N. Hardy, J. Dalli, F. Aigner, A. Arezzo, R. Hompes, J. Knol, J. Tuynman, J. Cucek, J. Rojc, M. R. Rodriguez-Luna, R. Cahill
Summary: This study aims to validate the use of artificial intelligence (AI) analysis of indocyanine green (ICG) fluorescence in the endoscopic classification of rectal polyps and tumors. By observing fluorescence patterns and developing clinical-grade software, the goal is to improve the generalizability, usability, and accuracy of the classification. The AI-based classification and guided intervention will be compared with the current standard of care to evaluate their effectiveness.
COLORECTAL DISEASE
(2023)