Article
Orthopedics
Leilei Zhang, Juntao Zhang, Dawei Liang, Haonan Ling, Ying Zhang, Youwen Liu, Xiantao Chen
Summary: The study compared the clinical efficacy and safety of autologous iliac bone graft and bioceramics bone graft in the treatment of early and middle stage femoral head necrosis. The results showed that the bioceramics bone group had better outcomes in terms of operation time, intra-operative blood loss, haemoglobin, and haematocrit values compared to the autologous iliac bone group.
INTERNATIONAL ORTHOPAEDICS
(2021)
Article
Endocrinology & Metabolism
Yiwei Chen, Yu Miao, Kexin Liu, Bin Zhu, Feng Xue, Junhui Yin, Jian Zou, Guangyi Li, Changqing Zhang, Yong Feng
Summary: This study investigated the differences in bone microarchitecture, bone remodeling activity, and histomorphological characteristics between glucocorticoid-associated osteonecrosis of femoral head (GONFH) and alcohol-associated osteonecrosis of femoral head (AONFH). The results showed that GONFH exhibited a less sclerotic bone microarchitecture and a more active bone metabolic status in both the reactive interface and normal region. These differences might contribute to the development of disease-modifying strategies and treatments for osteonecrosis of femoral head.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Sumit Murab, Teresa Hawk, Alexander Snyder, Sydney Herold, Meghana Totapally, Patrick W. Whitlock
Summary: Avascular necrosis (AVN) of the femoral head commonly leads to symptomatic osteoarthritis of the hip. While hip replacement is a viable option for older patients, it poses significant challenges for pediatric, adolescent, and young adult patients. Early detection is vital, but current diagnostic techniques are not sensitive enough. Various surgical techniques exist to prevent disease progression, but their effectiveness is limited, and more research is needed in tissue engineering for a potential long-term solution.
BIOENGINEERING-BASEL
(2021)
Article
Orthopedics
Hyon Pak, Song Gun Ri, Myong Guk Jang, Sung Jae Kim
Summary: Endoscopic examination was conducted to observe necrotic findings of the femoral head during decompression procedures for osteonecrosis. The efficacy of bone marrow injection was 93.88%, and the efficacy of vascularized bone graft was 94.44%, based on the endoscopic findings. Additional treatments based on endoscopic findings can improve the treatment efficacy of osteonecrosis of the femoral head.
INTERNATIONAL ORTHOPAEDICS
(2021)
Article
Chemistry, Multidisciplinary
Yuxuan Zhao, Songhang Li, Maogeng Feng, Mei Zhang, Zhiqiang Liu, Yangxue Yao, Tianxu Zhang, Yueying Jiang, Yunfeng Lin, Xiaoxiao Cai
Summary: Osteonecrosis of the femoral head (ONFH) is a common refractory orthopedic disease that causes severe pain and poor quality of life. Puerarin (Pue), a natural isoflavone glycoside, shows potential in treating ONFH by promoting osteogenesis and inhibiting apoptosis of bone mesenchymal stem cells (BMSCs). However, the limitations of Pue, such as low solubility, fast degradation, and inadequate bioavailability, hinder its clinical application. In this study, tetrahedral framework nucleic acids (tFNAs) are used as carriers for Pue, resulting in a tFNA/Pue complex (TPC) that exhibits enhanced stability, biocompatibility, and tissue utilization. In vitro and in vivo models are established to investigate the effects of TPC on osteogenesis and apoptosis of BMSCs under glucocorticoid-induced conditions. The findings demonstrate that TPC can restore osteogenesis dysfunction and attenuate BMSC apoptosis through hedgehog and Akt/Bcl-2 pathways, offering a promising treatment for GC-induced ONFH.
Article
Pharmacology & Pharmacy
Ilenia Mastrolia, Andrea Giorgini, Alba Murgia, Pietro Loschi, Tiziana Petrachi, Valeria Rasini, Massimo Pinelli, Valentina Pinto, Francesca Lolli, Chiara Chiavelli, Giulia Grisendi, Maria Cristina Baschieri, Giorgio De Santis, Fabio Catani, Massimo Dominici, Elena Veronesi
Summary: In this study, a rabbit model was established to mimic human osteonecrosis of the femoral head (ONFH) and evaluate the autologous MSC-based treatment. Results showed that implantation of autologous BM-MSCs could restore the damaged tissue in rabbit femurs. Furthermore, the study found that osteonecrosis did not affect the behavior of MSCs.
Article
Orthopedics
Junming Wan, Yanqing Hu, Jiachun Li, Yuqing Zeng, Haiyong Ren
Summary: This study compared the early-middle outcomes of four different bone grafts for the treatment of early stage osteonecrosis of the femoral head (ONFH). The beta-TCP bioceramics graft showed satisfactory results and had the advantages of shorter operation time and lesser blood loss compared to other bone grafts.
INTERNATIONAL ORTHOPAEDICS
(2022)
Review
Orthopedics
Liyou Hu, Xiaolei Deng, Bo Wei, Jian Wang, Decai Hou
Summary: A total of 18 RCTs were included in the meta-analysis, comparing various surgical treatments for ONFH. Bone grafting procedures such as ABG, VBG, FFG, ABG + BMAC, and BMG + VBG showed significant results in preventing ONFH progression compared with core decompression. Among them, ABG + BMAC was identified as the most effective treatment option.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Review
Engineering, Biomedical
Hongyu Quan, Chencan Ren, Yuwei He, Fuyou Wang, Shiwu Dong, Hong Jiang
Summary: Osteonecrosis of the femoral head (ONFH) is a progressive pathological process caused by multiple etiologies, with no complete cure at present. Biomaterials have gained extensive attention in the treatment of early ONFH, aiming to sustain normal morphology and function, and slow disease progression.
ACTA BIOMATERIALIA
(2023)
Review
Cell Biology
Jiaqian Wang, Peirong Xu, Liang Zhou
Summary: This study aims to compare the effects of core decompression (CD) and bone grafting (BG) on osteonecrosis of the femoral head (ONFH) and to evaluate the efficacy of CD based on cell therapy. PubMed, Embase, and the Cochrane Library were searched for relevant studies between 2012 and 2022. The findings suggest that CD combined with cell therapy shows promising results, with BMAC and BMMC in specific doses likely to achieve better outcomes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Orthopedics
Donghai Li, Shuo Sun, Zhouyuan Yang, Yue Luo, Pengde Kang
Summary: This study compared the clinical outcomes of autogenous and artificial bone grafting (DBM/CaS) in the treatment of osteonecrosis of the femoral head. The results showed that percutaneous femoral neck-head fenestration combined with artificial bone grafting had comparable clinical outcomes to autologous bone grafting in preventing femoral head collapse and rescuing total hip arthroplasty.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Orthopedics
Yongheng Ye, Yue Peng, Peiheng He, Qinqin Zhang, Dongliang Xu
Summary: This study identified 13 differentially abundant miRNAs in the urine of patients with idiopathic osteonecrosis of femoral head (ONFH), indicating their diagnostic and prognostic value as biomarkers for ONFH. The noninvasive nature of urinary miRNAs testing makes it potentially useful for the diagnosis and monitoring of ONFH progression.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Article
Cell Biology
Jiahe Liu, Chenzhi Li, Fan Yang, Minde Li, Baolin Wu, Haojie Chen, Shaopeng Li, Xiuzhi Zhang, Jiahui Yang, Yan Xia, Mingjian Wu, Yancheng Li, Baoyi Liu, Dewei Zhao
Summary: This study aimed to establish a new mouse model of osteonecrosis using angiotensin II combined with asparaginase and dexamethasone, and to study the effects of this drug combination on femoral head osteonecrosis in mice. The results showed that this drug combination can significantly promote necrosis of the femoral head and disrupt the local blood supply.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Computer Science, Interdisciplinary Applications
Peixu Wang, Xingyu Liu, Jia Xu, Tengqi Li, Wei Sun, Zirong Li, Fuqiang Gao, Lijun Shi, Zhizhuo Li, Xinjie Wu, Xin Xu, Xiaoyu Fan, Chengxin Li, Yiling Zhang, Yicheng An
Summary: A fully automatic deep learning model was developed in this study to detect early-stage ONFH lesions on MRI, showing promising diagnostic performance. The model's AUC was 0.97 with high sensitivity and specificity, and it exhibited good correlation with the ground truth definition. More extensive multicenter studies are needed to further validate and refine the model.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Dina Saginova, Elyarbek Tashmetov, Yevgeniy Kamyshanskiy, Berik Tuleubayev, Denis Rimashevskiy
Summary: This research aimed to assess the effect of bone allograft combined with platelet-rich plasma (PRP), recombinant human bone morphogenetic protein-2 (rhBMP-2), and zoledronic acid (Zol) on bone formation. The study found that the combination of PRP with bone allograft promoted new bone formation and neovascularization. Additionally, the use of rhBMP-2 induced higher bone formation but also excessive osteoclast activity. The local co-administration of Zol inhibited allograft resorption and new bone formation.