Article
Endocrinology & Metabolism
Grethe A. Ueland, Paal Methlie, Anette Heie, Ann-Elin Meling Stokland, Anne Lise Dahle, Ase B. Saevik, Kristian Lovas, Eystein S. Husebye
Summary: This study aimed to map inflammatory biomarkers in patients with autonomous cortisol secretion (ACS) and overt Cushing syndrome (CS). Serum samples from patients with ACS, CS, and healthy subjects were analyzed for 92 inflammatory biomarkers using proximity extension assay (OLINK). The results showed significant differences in levels of 49/92 inflammatory biomarkers between ACS and CS patients and healthy controls. However, there were no differences in biomarker levels between ACS and overt CS, and none of the biomarkers correlated with the degree of hypercortisolism. Postoperative samples showed no significant normalization of the biomarkers. In conclusion, there was a systemic rise in inflammatory biomarkers in patients with ACS and CS, which was not correlated to the degree of hypercortisolism and not normalized following biochemical cure.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Mara Carsote
Summary: Connshing syndrome is a distinct entity among primary hyperaldosteronisms, and it has been studied for several decades. In recent years, there have been significant advances in understanding the condition due to improvements in metabolomics and molecular genetics. Connshing syndrome overlaps with primary aldosteronism in terms of clinical presentation, but with milder hypercortisolemia.
Review
Endocrinology & Metabolism
Elisa Sconfienza, Martina Tetti, Vittorio Forestiero, Franco Veglio, Paolo Mulatero, Silvia Monticone
Summary: This study investigated the prevalence of autonomous/possible autonomous cortisol secretion (ACS), primary aldosteronism (PA), pheochromocytoma (PHEO), and Cushing syndrome (CS) in patients with adrenal incidentaloma (AI). The overall prevalence of functioning AIs was 27.5%, with ACS/possible ACS being the most frequent hormonal alteration (prevalence of 11.7%) and PA occurring in 4.4% of the patients. Asian patients had a higher prevalence of PA, while ACS/possible ACS had a lower prevalence in Asian countries. The prevalence of ACS/possible ACS was influenced by the proportion of female patients, while the prevalence of PA was positively associated with hypertension and the publication year. The prevalence of PHEO and CS were 3.8% and 3.1% respectively. Rating: 9/10.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Urology & Nephrology
Ryohei Kufukihara, Toshikazu Takeda, Kyohei Hakozaki, Yota Yasumizu, Nobuyuki Tanaka, Kazuhiro Matsumoto, Shinya Morita, Takeo Kosaka, Ryuichi Mizuno, Hiroshi Asanuma, Kazutoshi Miyashita, Isao Kurihara, Mototsugu Oya
Summary: This study investigated changes in renal function and predictors in patients with Cushing syndrome after adrenalectomy. The results showed that a low pre-operative adrenocorticotropic hormone level was an independent predictor of renal impairment after surgery.
INTERNATIONAL JOURNAL OF UROLOGY
(2022)
Review
Endocrinology & Metabolism
Iris C. M. Pelsma, Martin Fassnacht, Stylianos Tsagarakis, Massimo Terzolo, Antoine Tabarin, Anju Sahdev, John Newell-Price, Ljiljana Marina, Kerstin Lorenz, Irina Bancos, Wiebke Arlt, Olaf M. Dekkers
Summary: This systematic review and meta-analysis found that patients with adrenal incidentalomas and mild autonomous cortisol secretion (MACS) have a higher prevalence of comorbidities such as diabetes, hypertension, and dyslipidemia, as well as increased all-cause mortality. Adrenalectomy appears to improve glucometabolic control, hypertension, and dyslipidemia in patients with MACS.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Michael T. Corwin, Christopher Lan, Machelle Wilson, Thomas W. Loehfelm, Michael J. Campbell
Summary: In patients with adrenal nodules, the length and width of the nodule are the only two variables that significantly differ between nonfunctional nodules and possibly or definitely functional nodules patients. Using a threshold nodule length of 1.5 cm, there is 93.1% sensitivity for predicting possible or definite ACH.
ABDOMINAL RADIOLOGY
(2021)
Article
Endocrinology & Metabolism
Ning Ai Liu, Anat Ben-Shlomo, John D. Carmichael, Christina Wang, Ronald S. Swerdloff, Anthony P. Heaney, Garni Barkhoudarian, Daniel Kelly, Mazen Noureddin, Lin Lu, Manish Desai, Yana Stolyarov, Kevin Yuen, Adam N. Mamelak, James Mirocha, Mourad Tighiouart, Shlomo Melmed
Summary: Seliciclib may directly target pituitary corticotrophs in patients with Cushing's disease and reverse hypercortisolism. However, further research is needed regarding the liver toxicity associated with seliciclib.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Surgery
Francesco Pennestri, Carmela De Crea, Nikolaos Voloudakis, Marco Raffaelli
Summary: Severe uncontrolled Cushing's syndrome may require emergency bilateral adrenalectomy. However, laparoscopic transabdominal anterior bilateral adrenalectomy may be the most appropriate therapeutic option as these patients cannot tolerate prone and lateral positioning required during conventional surgery.
UPDATES IN SURGERY
(2023)
Review
Endocrinology & Metabolism
C. E. Lam-Chung, D. Cuevas-Ramos
Summary: Despite the challenges in screening for Cushing syndrome, the development and validation of clinical models may help in accurately predicting the presence of the disease, particularly in high-risk populations, and thereby reducing the time to diagnosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Michael P. Catalino, Dominic T. Moore, Natasha Ironside, Alexander R. Munoz, Justin Coley, Rachel Jonas, Kathryn Kearns, Le Min, Mary Lee Vance, John A. Jane Jr, Edward R. Laws Jr
Summary: This study retrospectively analyzed postoperative serum cortisol levels and recurrence rates in patients with Cushing's disease, and found that the lowest postoperative cortisol level is the most important predictor for recurrence and time-to-recurrence. Compared to the first postoperative cortisol level and cortisol halving time, a nadir < 2 μg/dL appears within the first 24 to 48 hours after surgery and has the strongest association with long-term remission.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Fang Wang, Michael P. Catalino, Wenya Linda Bi, Ian F. Dunn, Timothy R. Smith, Yunlei Guo, Dawid Hordejuk, Ursula B. Kaiser, Edward R. Laws, Le Min
Summary: Our study identified that postoperative day 1 morning serum cortisol level, female sex, and proliferative index are significantly associated with Cushing disease recurrence. These could be used as biomarkers to predict long-term remission after neurosurgery.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Heng Sun, Chunli Wu, Biao Hu, Genqing Xie
Summary: This study is the first to report a high prevalence of radiologic VFs in recently diagnosed CD patients. VFs may represent an early manifestation of CD and may be related to cortisol levels. Therefore, VF assessment should be included in the workup during CD diagnosis.
ANNALS OF MEDICINE
(2023)
Article
Endocrinology & Metabolism
Yagmur Unsal, Onur Gozmen, Idil Rana User, Hayriye Hizarcioglu, Bora Gulhan, Saniye Ekinci, Tevfik Karagoz, Z. Alev Ozon, E. Nazli Gonc
Summary: This article presents successful treatment and long-term follow-up of a rare case of neonatal McCune-Albright syndrome (MAS). The patient exhibited café-au-lait skin macules, Cushing syndrome, hyperthyroidism, and liver and cardiac dysfunction. Although spontaneous resolution of hypercortisolism has been reported, the outcome is usually unfavorable. There is currently no unified approach to the diagnosis, treatment, and follow-up of MAS, and addressing side effects and identifying treatment outcomes are vital for improving the patient's quality of life and survival.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Regin Jay Mallari, Jai Deep Thakur, Garni Barkhoudarian, Amy Eisenberg, Amanda Rodriguez, Sarah Rettinger, Pejman Cohan, Lynnette Nieman, Daniel F. Kelly
Summary: This study describes the predictive performance of preoperative biochemical and imaging data on postoperative remission and clinical characteristics in patients with presumed Cushing's disease. The use of strict biochemical thresholds can improve surgical remission rates and avoid recommending surgery to patients with equivocal biochemical data.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Urology & Nephrology
Takanobu Utsumi, Shota Iijima, Yuka Sugizaki, Takamichi Mori, Takatoshi Somoto, Seiji Kato, Ryo Oka, Takumi Endo, Naoto Kamiya, Hiroyoshi Suzuki
Summary: The major adrenal tumors with endocrine activity include primary aldosteronism, Cushing's syndrome/mild autonomous cortisol secretion, and pheochromocytoma/paraganglioma. These tumors can cause various complications such as cardiovascular damage, obesity, hypertension, impaired glucose tolerance, and cerebrocardiovascular disease. Adequate preoperative evaluation and advanced perioperative management have significantly reduced complications and improved outcomes in these patients.
INTERNATIONAL JOURNAL OF UROLOGY
(2023)
Article
Endocrinology & Metabolism
Chrisanthi Marakaki, Dimitrios T. Papadimitriou, Kleanthis Kleanthous, Anna Papadopoulou, Anastasios Papadimitriou
HORMONE RESEARCH IN PAEDIATRICS
(2015)
Article
Pediatrics
Chrisanthi Marakaki, Olga Karapanou, Alexandros Gryparis, Ze'ev Hochberg, George Chrousos, Anastasios Papadimitriou
JOURNAL OF PEDIATRICS
(2017)
Article
Behavioral Sciences
Chrisanthi Marakaki, Panagiota Pervanidou, Ioannis Papassotiriou, George Mastorakos, Ze'ev Hochberg, George Chrousos, Anastasios Papadimitriou
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2018)
Article
Endocrinology & Metabolism
C. Marakaki, D. T. Papadimitriou, A. Papadopoulou, A. Fretzayas, A. Papadimitriou
HORMONE RESEARCH IN PAEDIATRICS
(2014)
Article
Endocrinology & Metabolism
Dimitrios T. Papadimitriou, Chrisanthi Marakaki, Andreas Fretzayas, Polyxeni Nicolaidou, Anastasios Papadimitriou
JOURNAL OF DIABETES
(2013)
Review
Endocrinology & Metabolism
Anastasios Papadimitriou, Chrisanthi Marakaki, Dimitrios T. Papadimitriou
Summary: Normal growth pattern variations are associated with early puberty and delayed puberty, and insulin-like growth factor-1 (IGF-1) plays a crucial role. Early activation of the growth hormone (GH)/IGF-1 axis induces the growth pattern of early puberty, and IGF-1 is a key factor for the release of the gonadotropin-releasing hormone (GnRH) inhibition brake in prepuberty.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Pediatrics
Dimitrios T. Papadimitriou, Eleni Dermitzaki, Panagiotis Christopoulos, Maria Papagianni, Kleanthis Kleanthous, Chrysanthi Marakaki, Anastasios Papadimitriou, George Mastorakos
Summary: Research shows that taking 2000 IU of cholecalciferol daily from birth can reduce the incidence of type 1 diabetes (T1D) by 80%. Oral calcitriol has been found to convert T1D-associated autoantibodies (T1Ab) to negative within 0.6 years. A clinical trial has shown that secondary prevention of T1D with calcitriol and its analog paricalcitol can effectively prevent the development of T1D.
Article
Endocrinology & Metabolism
Chrisanthi Marakaki, Anna Papadopoulou, Olga Karapanou, Dimitrios T. Papadimitriou, Kleanthis Kleanthous, Anastasios Papadimitriou
ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS
(2015)