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Multidisciplinary Sciences
Yuki Ohta, Masayuki Fujii, Sirirat Takahashi, Ai Takano, Kosaku Nanki, Mami Matano, Hikaru Hanyu, Megumu Saito, Mariko Shimokawa, Shingo Nishikori, Yoshiko Hatano, Ryota Ishii, Kazuaki Sawada, Akihito Machinaga, Wataru Ikeda, Takeshi Imamura, Toshiro Sato
Summary: This study develops an experimental platform for tracking cancer stem cells in colorectal cancer and identifies dormant LGR5(+) cancer stem cells. Transcriptome analysis reveals an upregulation of cell-adhesion molecule COL17A1 in dormant cancer stem cells, and chemotherapy disrupts this dormancy through FAK-YAP activation. Inhibition of YAP signaling prevents chemoresistant cells from exiting dormancy and delays tumor regrowth.
Article
Multidisciplinary Sciences
Navid Mohammad Mirzaei, Wenrui Hao, Leili Shahriyari
Summary: The complex network of cell and molecule interactions in the tumor microenvironment creates a diverse ecosystem. The proximity of cells and molecules to their activators and inhibitors is crucial for tumor progression. Using a combination of partial differential equations and linear elasticity, we investigate the impact of spatial interactions on the tumor microenvironment. Our findings reveal interesting patterns of cell and cytokine distribution influenced by macrophages. We also observe the recruitment and suppression of cytotoxic T cells at macrophage sites. Additionally, anti-tumor macrophages reorganize patterns in favor of a more spatially restricted cancer and necrotic core. Sensitivity analysis suggests that macrophages play a key role in controlling cancer cell population and spatial arrangement in the tumor microenvironment.
Article
Oncology
Shengbo Han, Decai Wang, Yan Huang, Zhu Zeng, Peng Xu, Hewei Xiong, Zunxiang Ke, Ya Zhang, Yuhang Hu, Fan Wang, Jie Wang, Yong Zhao, Wenfeng Zhuo, Gang Zhao
Summary: Research has shown that the emergence of Schwann cells around premalignant lesions of colon cancer may be an early indicator promoting tumorigenesis. This study explored the communication between colon cancer cells and Schwann cells, and identified NGF and exosomal miR-21-5p as potential therapeutic targets for colon cancer treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Veterinary Sciences
Francesca La Cava, Alberto Fringuello Mingo, Sonia Colombo Serra, Aldo Di Vito, Claudia Cabella, Paolo Oliva, Alessia Cordaro, Chiara Brioschi, Enzo Terreno, Luigi Miragoli
Summary: Breast cancer is the most common cancer among women worldwide, and CE-MRI is recommended as supplemental screening for high-risk women. This study developed a refined method to orthotopically induce breast cancer in mice and used CE-MRI to characterize the evolution of the tumoral lesion.
LABORATORY ANIMALS
(2021)
Article
Anatomy & Morphology
Kentaro Miyake, Qinghong Han, Takashi Murakami, Tasuku Kiyuna, Kei Kawaguchi, Kentaro Igarashi, Thinzar M. Lwin, Masuyo Miyake, Jun Yamamoto, Michael Bouvet, Itaru Endo, Robert M. Hoffman
Summary: The efficacy of recombinant methioninase (rMETase) on a mouse model of colorectal cancer liver metastasis was investigated in this study. The results showed that rMETase significantly inhibited the increase of liver metastasis. Therefore, rMETase may have future potential as a therapy for colorectal cancer liver metastasis.
Article
Pharmacology & Pharmacy
Zhuo Liu, Dongxin Wang, Qian Cao, Jiannan Li
Summary: This study developed a three-layered functionalized composite material for controlling the progression and inhibiting distant metastasis of colorectal cancer. The composite material can release Chinese traditional drug 20(S)-ginsenoside Rg3 and chemotherapeutic agent 5-fluorouracil, which significantly inhibits tumor cell viability. It also inhibits tumor progression and distant metastasis to the liver by increasing caspase 3 expression and inhibiting the expressions of Bcl-2, Ki-67, and VEGF. This method is safe and effective.
Article
Nanoscience & Nanotechnology
Min Lu, Xu Huang, Xiaohui Cai, Jiajia Sun, Xuemeng Liu, Lingyan Weng, Li Zhu, Qianqian Luo, Zhongping Chen
Summary: This study reports the development of hypoxia-responsive stereocomplex micelles as a reliable drug delivery system to treat breast cancer metastasis. These micelles exhibit high structural stability, improved drug loading, and sensitive response to the hypoxic tumor environment, reversing hypoxia-induced drug resistance and cell migration.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Jakub Rech, Daniel Sypniewski, Dorota Zelaszczyk, Natalia Szkaradek, Wojciech Rogoz, Anna Waszkielewicz, Henryk Marona, Ilona Bednarek
Summary: The study revealed that four novel xanthone derivatives have the potential to inhibit proliferation, motility, and induce apoptosis in colon cancer cells, with comparable activity to cisplatin and 5-fluorouracil. Further research and development of these compounds as novel drugs for colorectal cancer treatment is recommended.
Article
Biochemistry & Molecular Biology
Wojciech M. Ciszewski, Malgorzata Chmielewska-Kassassir, Lucyna A. Wozniak, Katarzyna Sobierajska
Summary: This study found a close correlation between TYMS and invasion ability in colon cancer cells, as well as its crucial role in EMT regulation. It suggests that chemotherapeutics targeting TYMS expression may enhance the effectiveness of colon cancer treatment, especially in the metastatic stage.
Article
Immunology
Mihaly Balogh, Jixiang Zhang, Caitlyn M. Gaffney, Neha Kalakuntla, Nicholas T. Nguyen, Ronnie T. Trinh, Clarissa Aguilar, Hoang Vu Pham, Bojana Milutinovic, James M. Nichols, Rajasekaran Mahalingam, Andrew J. Shepherd
Summary: This study demonstrates that colon cancer is associated with latent sensory neuron dysfunction and implicates cytokine/chemokine signaling in this process. These findings may have implications for determining risk factors and treatment responsiveness related to neuropathy in colorectal cancer.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Cell Biology
Linglong Peng, Yongfu Xiong, Rong Wang, Ling Xiang, He Zhou, Zhongxue Fu
Summary: PRDX2 is highly expressed in colon cancer stem cells (CCSCs) and its overexpression is closely correlated with stemness maintenance, tumor initiation, and invasion of CCSCs. Inhibition of PRDX2 leads to increased ROS production in CCSCs, sensitizing them to oxidative stress and chemotherapy. These findings suggest that PRDX2 could be a potential therapeutic target in CCSCs.
Article
Immunology
Jin Wang, Xingchen Liu, Junsong Ji, Jianhua Luo, Yuanyu Zhao, Xiaonan Zhou, Jianming Zheng, Meng Guo, Yanfang Liu
Summary: This study describes the construction of a novel orthotopic PDAC model through implantation of tissue slices and discusses the resistance to immunotherapy from the perspective of a PDAC microenvironment. Results show that elimination of MDSCs by NKG2D CAR can rescue impaired CAR-T cell activity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daniela Gerovska, Patricia Garcia-Gallastegi, Olatz Crende, Joana Marquez, Gorka Larrinaga, Maite Unzurrunzaga, Marcos J. Arauzo-Bravo, Iker Badiola
Summary: Cancer is closely related to aging, with tumor cells being the main driver of cancer progression, but the cells and matrix of the tumor microenvironment (TME) also play crucial roles in disease advancement. Epigenetic changes, including miRNA dysregulation, are essential for phenotypic changes in the TME during cancer progression. Specific miRNAs related to the aging process, called geromiRs, are significantly downregulated in the liver TME during colon cancer colonization, suggesting a link between aging-related miRNA dysregulation and cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Javier Perez-Duran, Aglae Luna, Andres Portilla, Pamela Martinez, Guillermo Ceballos, Miguel angel Ortiz-Flores, Juan Mario Solis-Paredes, Nayelli Najera
Summary: Breast cancer is a global public health problem, and current chemotherapy has significant adverse effects. (-)-Epicatechin (EC), a flavonoid found in plants, has been shown to have beneficial effects on skeletal muscle and the cardiovascular system without adverse effects. Recent experiments have also demonstrated that EC has an antitumor effect in a murine breast cancer model.
Article
Oncology
Long Jiao, Roman Eickhoff, Antje Egners, Sandra Jumpertz, Johanna Roth, Merve Erdem, Andreas Kroh, Hans Duimel, Carmen Lopez-Iglesias, Pilar Caro, Lara R. Heij, Maximilian Schmeding, David Meierhofer, Ulf P. Neumann, Thorsten Cramer
Summary: mTOR pathway activation is common in cancer, but mTOR inhibitors have not shown significant antiproliferative efficacy in most cancer types. Research on mTOR inhibition in hepatocytes reveals that non-malignant host cells may contribute to resistance against mTOR inhibitors.
JOURNAL OF PATHOLOGY
(2021)