Review
Orthopedics
Rongli Zhang, Yahui Zhang, Liyuan Hou, Chengyong Yan
Summary: This study compares the clinical outcomes of vacuum-assisted closure (VAC) versus conventional dressing on necrotizing fasciitis. The results showed that patients treated with VAC had a significantly lower mortality rate compared to conventional dressing. There were no significant differences in the number of debridements, total length of hospital stay, and complication rate between the two groups.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Review
Health Care Sciences & Services
Mihaela Pertea, Madalina-Cristina Fotea, Stefana Luca, Dan Cristian Moraru, Alexandru Filip, Doinita Olinici-Temelie, Sorinel Lunca, Adrian Claudiu Carp, Oxana-Madalina Grosu, Alexandru Amarandei, Bogdan Veliceasa
Summary: Necrotizing fasciitis is a severe pathology with rapid progression and high mortality risk. This case report presents a rare case of periocular necrotizing fasciitis, in which the patient's condition showed cyclical evolution but with favorable survival outcomes and significant disabilities as sequelae. A systematic review revealed the uniqueness of this case compared to previous literature.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Engineering, Biomedical
Ning Tang, Youbin Zheng, Daxiang Cui, Hossam Haick
Summary: Smart wound dressings integrated with multifunctional materials, wearable sensors, and drug delivery systems can monitor wounds and provide timely diagnosis and treatment, but there are still challenges to be addressed in their development and application.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Yongping Liang, Jiahui He, Baolin Guo
Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.
Review
Polymer Science
Pavel Yudaev, Yaroslav Mezhuev, Evgeniy Chistyakov
Summary: This review examines the use of dressings containing nanoparticles for wound repair and evaluates their antimicrobial effects and healing actions. The analysis of 31 sources published between 2021 and 2022 demonstrates a trend towards the development of modern antibacterial wound-healing nanomaterials.
Article
Multidisciplinary Sciences
Hadhami Rouiss, Hajer Bettaieb, Nesrine Souayeh, Hichem El Aifi, Raja Jouini, Imen Helal, Hedhili Oueslati, Chaouki Mbarki
Summary: Necrotizing fasciitis is a dangerous and rapidly spreading infection, especially in the breast area. Surgical debridement and mastectomy are the main methods of treatment, with dermal autograft used for cosmetic improvement.
Article
Engineering, Environmental
Lirong Wang, Mengyun Zhou, Tailin Xu, Xueji Zhang
Summary: The multifunctional hydrogel wound dressing promotes wound healing by providing antibacterial, hemostatic, and adhesive properties, while also enabling real-time monitoring of wound status. The personalized wound management model accurately analyzes and evaluates wound healing and infection status using the colorimetric signal of the hydrogel dressing, achieving high accuracy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Surgery
Rui He, Xiangyan Li, Kun Xie, Bing Wen, Xin Qi
Summary: In this retrospective study, we analyzed the clinical data of 36 patients with FG and evaluated the effects of NPWT. Perianal and external genital infections were the most common types of FG, with Escherichia coli, Enterococcus, and Staphylococcus haemolyticus being the most common pathogens. Patients treated with NPWT had shorter hospital stays, fewer operations, and faster wound healing compared to those treated with conventional dressings. Therefore, clinicians should consider the possibility of FG in patients with diabetes and NPWT can be an effective adjuvant therapy for managing FG wounds.
FRONTIERS IN SURGERY
(2023)
Review
Pharmacology & Pharmacy
Yuqing Liang, Yongping Liang, Hualei Zhang, Baolin Guo
Summary: Bacterial infection and resistance pose a significant threat to human health, especially in wound healing. This review focuses on antibacterial wound dressings and discusses various biomaterials and antibacterial agents used in their fabrication. It also explores challenges and future perspectives in this field.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Polymer Science
Chang Huang, Xizi Xu, Junhao Fu, Deng-Guang Yu, Yanbo Liu
Summary: Bleeding control is crucial in healthcare, which has led to advancements in wound dressing research and development. Electrospun polyacrylonitrile nanofibers offer excellent properties for wound dressings, showing great potential in manufacturing.
Review
Health Care Sciences & Services
Massimiliano Creta, Antonello Sica, Luigi Napolitano, Giuseppe Celentano, Roberto La Rocca, Marco Capece, Armando Calogero, Gianluigi Califano, Luigi Vanni, Francesco Mangiapia, Davide Arcaniolo, Lorenzo Spirito, Ferdinando Fusco, Marco De Sio, Ciro Imbimbo, Vincenzo Mirone, Caterina Sagnelli, Nicola Longo
Summary: Patients with hematological malignancies are at higher risk of Fournier's gangrene (FG) due to immunosuppression, and surgical treatment, vacuum-assisted closure, and hyperbaric oxygen therapy can contribute to recovery in these patients.
Article
Microbiology
Yu-Kuei Lee, Chun-Chieh Lai
Summary: This report describes a rare case of concurrent periorbital NF and endophthalmitis caused by Pseudomonas aeruginosa. The patient, initially diagnosed with orbital cellulitis, developed NF involving the muscles in the eyelid, leading to scleral ulcers and endophthalmitis. Immunocompromised individuals are at higher risk of PA infection.
Article
Biophysics
Miaomiao Zhang, Shixin Xu, Chen Du, Ruoying Wang, Cuicui Han, Yongan Che, Wei Feng, Chengwei Wang, Shan Gao, Wen Zhao
Summary: In this study, a novel bilayer wound dressing made of poly(L-lactate-caprolactone) copolymer (PLCL) nanofibrous and keratin hydrogel loaded with fibroblast growth factor (FGF-2) was prepared using the low-pressure filtration-assisted method. The bilayer dressing was found to mimic the dermis and epidermis. It exhibited good porosity, maximum water absorption, and tight bond at the interface. In vitro and in vivo studies demonstrated the biocompatibility, biodegradability, and ability to promote skin healing of the bilayer dressing, making it a promising biomedical wound dressing for skin tissue engineering applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Kelly McElvain, Joshua Klister, Alessandra Ebben, Sandeep Gopalakrishnan, Mahsa Dabagh
Summary: Chronic wounds have a significant impact on individuals' health-related quality of life and healthcare systems worldwide. This study investigates the influence of mechanotransduction on the healing process in chronic wounds through the development of three-dimensional tissue models. The results demonstrate that wound dressings with lower stiffness promote force transmission within the wound tissue, with larger dressings exerting higher stresses. These findings highlight the importance of dressing characteristics in promoting healing and provide insights for the design of precision dressings.
Article
Biochemistry & Molecular Biology
Feng Xie, Liangyu Zou, Zikai Xu, Xiaolan Ou, Wenlai Guo, Yang Gao, Guanghui Gao
Summary: A new foam gel wound dressing with rapid hemostasis and antibacterial properties is reported in this study. The dressing is composed of chitooligosaccharide modified graphene oxide nanocomposites and calcium alginate foam substrate. Experimental results show that the dressing can stop bleeding quickly and accelerate wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Surgery
Angela Hill, Franklin Olumba, William Chapman
Summary: Transplantation for HCC is a complex topic, requiring considerations of multiple factors. Balancing tumor size with post-transplant outcome is still an ongoing challenge. Tumor downstaging and the use of new technologies have increased the number of HCC transplants, and these advances can also be applied to other liver tumors.
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Olanrewaju A. Eletta, Guergana G. Panayotova, Keri E. Lunsford
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Brianna Ruch, Kayla Kumm, Sandra Arias, Nitin N. Katariya, Amit K. Mathur
Summary: DCD liver transplantation is an underutilized method that can increase access to liver transplantation. With proper donor and recipient selection, matching, surgical technique, and perioperative management, these transplants can achieve similar patient and graft survival rates as DBD liver transplantation. The main limitations in the further growth of DCD liver transplantation are driven by risk aversion, and the current experience is mainly concentrated in large centers. With the advancement of regional and machine perfusion techniques, the definition of a viable DCD liver allograft may be redefined, encouraging wider usage and acceptance.
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Lauren Matevish, Madhukar S. Patel, Parsia A. Vagefi
Summary: Downstaging has been shown to be feasible within UNOS-DS criteria, with successful long-term outcomes. Interventional liver-directed therapies have been the standard, but systemic therapies are becoming more effective. Immunotherapy holds promise in downstaging, but further trials are needed to assess feasibility and safety. Individual expertise will continue to guide treatment until more data is available.
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Hassan Aziz, Paramita Nayak, David C. Mulligan
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Catherine G. Pratt, Jenna N. Whitrock, Shimul A. Shah, Zhi Ven Fong
Summary: hCCA is a biologically aggressive disease and surgical resection is the only curative treatment. Factors such as patient's physical condition, tumor involvement, residual liver volume, and assessment of metastatic disease heavily influence the feasibility of surgical resection. A multidisciplinary, holistic, and individualized approach is critical for accurately determining resectability and optimizing clinical outcomes for patients with hCCA.
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Sara-Catherine Whitney Zingg, Kristina Lemon
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Christopher J. Sonnenday
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Alban Longchamp, Tsukasa Nakamura, Korkut Uygun, James F. Markmann
SURGICAL CLINICS OF NORTH AMERICA
(2024)