Review
Cell Biology
Riccardo Di Fiore, Sherif Suleiman, Rosa Drago-Ferrante, Yashwanth Subbannayya, Sarah Suleiman, Mariela Vasileva-Slaveva, Angel Yordanov, Francesca Pentimalli, Antonio Giordano, Jean Calleja-Agius
Summary: The FBXW7 protein plays a role in regulating cellular growth and acts as a tumor suppressor. It is a component of the SCF complex and aids in the degradation of oncoproteins via the UPS. FBXW7 mutations are associated with cancer and could potentially serve as diagnostic and prognostic biomarkers. This review aims to provide an update on the role of FBXW7 as a potential biomarker and therapeutic target, particularly in gynecologic cancers.
Article
Medicine, General & Internal
Eun-Jung Yang, Ji-Hyeon Lee, A-Jin Lee, Nae-Ry Kim, Yong-Taek Ouh, Mi-Kyung Kim, Seung-Hyuk Shim, Sun-Joo Lee, Tae-Jin Kim, Kyeong-A So
Summary: This study investigated the prevalence and oncologic outcomes of gynecologic cancer patients with multiple primary malignant tumors (MPMT). The results showed that the prevalence of MPMT in patients was 8.6% and the average diagnostic period between primary and secondary cancer was 60 months. The most common coexisting cancer in the MPMT group was endometrial-ovarian cancer, while breast cancer was the most common non-gynecologic cancer in the coexisting cancer group. The incidence of synchronous cancer was significantly higher in the MPMT group compared to the coexisting cancer group, and early-stage ovarian cancer was more highly diagnosed in the MPMT group.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Taher Daoud, Sahil Sardana, Nir Stanietzky, Albert R. Klekers, Priya Bhosale, Ajaykumar C. Morani
Summary: Gynecologic malignancies are common cancers in women worldwide, and early detection, accurate staging, and early detection of recurrence are crucial for management and patient survival. Various imaging techniques, including ultrasound, CT, MRI, and PET-CT, play important roles in the detection, characterization, staging, and restaging of cervical, endometrial, and ovarian malignancies. Recent advances in imaging, such as functional MRI and hybrid imaging with PET/MRI, contribute to lesion specification and the overall role of imaging in gynecologic malignancies. Radiomics, a new approach, aims to enhance decision support by extracting quantitative information from radiological imaging.
Article
Oncology
L. R. Moolenaar, L. E. van Rangelrooij, M. I. E. van Poelgeest, M. van Beurden, W. J. van Driel, L. R. C. W. van Lonkhuijzen, C. H. Mom, A. Zaal
Summary: This study aimed to analyze complications and survival rates after pelvic exenteration for gynecologic malignancies and evaluate prognostic factors affecting postoperative outcomes. The study retrospectively reviewed all patients who underwent pelvic exenteration in three tertiary care centers in the Netherlands over a 20-year period. The results showed that postoperative complications were common, especially in irradiated patients. The 2-year overall survival rate was 51.1%, and positive resection margins, tumor size, and pelvic sidewall involvement were associated with poor survival outcomes. Adequate patient selection for pelvic exenteration is therefore crucial.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Matthew J. Regner, Kamila Wisniewska, Susana Garcia-Recio, Aatish Thennavan, Raul Mendez-Giraldez, Venkat S. Malladi, Gabrielle Hawkins, Joel S. Parker, Charles M. Perou, Victoria L. Bae-Jump, Hector L. Franco
Summary: Deciphering the regulatory mechanisms driving transcriptional programs in cancer cells is crucial for understanding tumor biology. The study utilized matched transcriptome and chromatin accessibility profiles at single-cell resolution to reveal complex cellular heterogeneity within ovarian and endometrial tumors. The findings demonstrate that malignant cells acquire novel regulatory elements to activate hallmark cancer pathways, and highlight the importance of intratumoral heterogeneity in cancer progression. Additionally, the study inferred the cell type-specific activity of transcription factors, indicating a reliance on oncogenic regulatory elements in cancer cells.
Review
Immunology
Yifan Xu, Jin Jiang, Yutong Wang, Wei Wang, Haokun Li, Wenyu Lai, Zhipeng Zhou, Wei Zhu, Zheng Xiang, Zhiming Wang, Zhe Zhu, Lingfeng Yu, Xiaolan Huang, Hua Zheng, Sha Wu
Summary: Gynecologic malignancies are leading causes of death among women worldwide, and adoptive T cell therapy using engineered T cells has shown promising efficacy in treating tumors. Ongoing research is driving the application of this therapy in the treatment of gynecologic malignancies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Corey M. Gill, Megan R. D'Andrea, Shannon Tomita, Jessa Suhner, Melissa Umphlett, Konstantin Zakashansky, Stephanie V. Blank, Nadejda Tsankova, Raj K. Shrivastava, Mary Fowkes, Valentin Kolev
Summary: The study reveals that an active tumor immune microenvironment is present with similar distribution in both the primary disease site and brain metastases in patients with gynecologic malignancies, with evident T cell infiltration and tumor-associated macrophages.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Review
Oncology
Jhalak Dholakia, Carly Scalise, Rebecca C. Arend
Summary: Novel treatments in immunotherapy for gynecologic oncology have not successfully advanced to clinical trials from preclinical research. Utilizing appropriate preclinical models and understanding their limitations are essential to translate findings to clinical practice and improve patient outcomes. Developing and implementing improved preclinical models will enhance research efficiency and increase the translational value of positive findings in gynecologic oncology immunotherapy.
Review
Medicine, Research & Experimental
Tianye Li, Xinrun Wang, Shuang Qin, Bingxin Chen, Ming Yi, Jianwei Zhou
Summary: Gynecologic cancer is a major health concern for women worldwide, and patients often progress to advanced stages with high mortality rates despite available treatment options. PARPi and ICI have shown significant efficacy in treating advanced and metastatic gynecologic cancer. However, their limitations make the combination therapy of PARPi and ICI a promising approach in treating gynecologic malignancies.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Oncology
Susmita Parashar, Nausheen Akhter, Elisavet Paplomata, Islam Y. Elgendy, Deepa Upadhyaya, Marielle Scherrer-Crosbie, Tochukwu M. Okwuosa, Rupa M. Sanghani, Eva Chalas, Kathryn J. Lindley, Susan Dent
Summary: Advances in early detection and treatment of gynecologic malignancies have led to an increased number of survivors at risk of long-term cardiac complications from cancer treatment. Multimodality therapies for gynecologic malignancies can cause cancer therapy-related cardiovascular toxicity, but this potential adverse effect has been less recognized compared to female predominant cancers like breast cancer. This review provides a comprehensive overview of cancer therapeutic agents used in gynecologic malignancies, associated cardiovascular toxicities, risk factors for cardiotoxicity, cardiac imaging, and prevention strategies.
JACC: CARDIOONCOLOGY
(2023)
Review
Oncology
Carlos Martinez-Gomez, Martina Aida Angeles, Alejandra Martinez, Bernard Malavaud, Gwenael Ferron
Summary: Pelvic exenteration involves complex surgery for multiple organ resections and functional reconstruction, with different techniques available for urinary reconstruction. The choice of technique should be based on individual factors, including disease progression, patient characteristics, and surgical expertise, with varying rates of complications and adaptation requirements for each method.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Review
Oncology
Monica Avila, Michaela Onstad Grinsfelder, Melissa Pham, Shannon N. Westin
Summary: This review explores common aberrations in the PI3K pathway in gynecologic malignancies, discusses relevant therapeutic targets with a focus on successes in endometrial cancers, and highlights the importance of predictive biomarkers for therapy response. The PI3K signaling pathway is frequently altered in gynecologic malignancies, making the development of PI3K pathway modulators and identification of molecular markers for predicting response crucial for these cancer types.
CURRENT ONCOLOGY REPORTS
(2022)
Review
Multidisciplinary Sciences
Surabhi Tewari, Roberto Vargas, Ofer Reizes
Summary: The link between obesity and various types of cancer, including breast, ovarian, and endometrial cancer, is well established. Adipokines, such as leptin, play a crucial role in carcinogenesis and tumor progression. Understanding the mechanisms and implications of adipokine signaling may lead to new treatment strategies and biomarkers for obesity-related cancers.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Pathology
Lanisha D. Fuller, Andrew Dunn, Aaron R. Huber, Monika Vyas, Raul S. Gonzalez
Summary: Gynecologic malignancies, particularly serous carcinoma, can sometimes present as gastrointestinal lesions, with clues on biopsy including lack of colonic mucosal involvement/dysplasia, desmoplasia, or dirty necrosis.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Medicine, General & Internal
Christoph Wohlmuth, Iris Wohlmuth-Wieser
Summary: This study assessed the incidence and prognostic indicators of gynecologic malignancies in pediatric population, finding ovarian tumors to be the most common. Sarcomas were the predominant type of malignancies in vagina, cervix, uterus, and vulva.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Angela Hill, Franklin Olumba, William Chapman
Summary: Transplantation for HCC is a complex topic, requiring considerations of multiple factors. Balancing tumor size with post-transplant outcome is still an ongoing challenge. Tumor downstaging and the use of new technologies have increased the number of HCC transplants, and these advances can also be applied to other liver tumors.
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Olanrewaju A. Eletta, Guergana G. Panayotova, Keri E. Lunsford
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Brianna Ruch, Kayla Kumm, Sandra Arias, Nitin N. Katariya, Amit K. Mathur
Summary: DCD liver transplantation is an underutilized method that can increase access to liver transplantation. With proper donor and recipient selection, matching, surgical technique, and perioperative management, these transplants can achieve similar patient and graft survival rates as DBD liver transplantation. The main limitations in the further growth of DCD liver transplantation are driven by risk aversion, and the current experience is mainly concentrated in large centers. With the advancement of regional and machine perfusion techniques, the definition of a viable DCD liver allograft may be redefined, encouraging wider usage and acceptance.
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Lauren Matevish, Madhukar S. Patel, Parsia A. Vagefi
Summary: Downstaging has been shown to be feasible within UNOS-DS criteria, with successful long-term outcomes. Interventional liver-directed therapies have been the standard, but systemic therapies are becoming more effective. Immunotherapy holds promise in downstaging, but further trials are needed to assess feasibility and safety. Individual expertise will continue to guide treatment until more data is available.
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Hassan Aziz, Paramita Nayak, David C. Mulligan
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Catherine G. Pratt, Jenna N. Whitrock, Shimul A. Shah, Zhi Ven Fong
Summary: hCCA is a biologically aggressive disease and surgical resection is the only curative treatment. Factors such as patient's physical condition, tumor involvement, residual liver volume, and assessment of metastatic disease heavily influence the feasibility of surgical resection. A multidisciplinary, holistic, and individualized approach is critical for accurately determining resectability and optimizing clinical outcomes for patients with hCCA.
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Sara-Catherine Whitney Zingg, Kristina Lemon
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Christopher J. Sonnenday
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Alban Longchamp, Tsukasa Nakamura, Korkut Uygun, James F. Markmann
SURGICAL CLINICS OF NORTH AMERICA
(2024)
