Article
Surgery
Eivind Gottlieb-Vedi, Joonas H. Kauppila, Fredrik Mattsson, Jakob Hedberg, Jan Johansson, David Edholm, Pernilla Lagergren, Magnus Nilsson, Jesper Lagergren
Summary: In esophageal cancer surgery, removing more lymph nodes can improve survival, but after reaching a certain number, further lymphadenectomy may decrease survival. A population-based cohort study in Sweden and Finland found that patients who had 4-30 lymph nodes removed had higher survival rates compared to those who had only 1 lymph node removed, especially for patients with advanced T-stages (T3/T4) and those who did not receive neoadjuvant therapy, removing 21-30 lymph nodes showed the best result.
Article
Oncology
Yan Zheng, Yin Li, Xianben Liu, Haibo Sun, Sining Shen, Yufeng Ba, Zongfei Wang, Shilei Liu, Wenqun Xing
Summary: This study found that McKeown-MIE was associated with better long-term survival than McKeown-OE for resectable EC patients. It had shorter operative time, postoperative stay, and comparable mortality rates, but significantly higher 60-month survival.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Andreas Obermair, Jim Nicklin, Val Gebski, Sandra C. Hayes, Nicholas Graves, Linda Mileshkin, Ming Yin Lin, Phillip Beale, Eva Baxter, Kristy Robledo, Carlos Salomon, George B. Hanna, Monika Janda
Summary: The ENDO-3 trial aims to evaluate the value of sentinel node biopsy in the surgical management of endometrial cancer, comparing its effectiveness and potential harms with no retroperitoneal node dissection. The trial design is a phase III, open-label, two-arm, multistage, randomized non-inferiority trial with the primary endpoint being surgical recovery and disease-free survival at 4.5 years.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Review
Oncology
Anas Dabsha, Ismail A. M. H. Elkharbotly, Mohammad Yaghmour, Amr Badr, Fady Badie, Sherif Khairallah, Yomna M. Esmail, Shon Shmushkevich, Mohamed Hossny, Amr Rizk, Amgad Ishak, Jessica Wright, Abdelrahman Mohamed, Mohamed Rahouma
Summary: Minimally invasive surgery is a growing field that has replaced many open surgical techniques. Mediastinoscope-assisted esophagectomy is a promising technique that aims to decrease the surgical burden and enhance recovery.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Medicine, General & Internal
Lucian Mocan
Summary: Gastric cancer is the fifth most common cancer worldwide, with surgery being the only curative treatment. Early detection and screening combined with neoadjuvant therapy can reduce the incidence of gastric cancer, but patients are often diagnosed at an advanced stage.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Urology & Nephrology
Antoine Jeanne-Julien, Olivier Bouchot, Stephane De Vergie, Julien Branchereau, Marie-Aimee Perrouin-Verbe, Jerome Rigaud
Summary: The study aimed to evaluate the oncological results of inguinal lymph node dissection in penile cancer at our centre. The results showed that inguinal lymph node dissection is an essential part of the treatment for penile cancer, and the lymph node stage is closely associated with recurrence-free survival, specific survival, and overall survival.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Surgery
Mohamed K. Kamel, Sebron Harrison, Benjamin Lee, Jeffrey L. Port, Brendon M. Stiles, Nasser K. Altorki
Summary: This study explored the potential value of extended nodal dissection after neoadjuvant chemoradiation, using data from the National Cancer Database. The results showed that the number of dissected lymph nodes was associated with improved survival, suggesting the importance of extended nodal dissection for patients undergoing neoadjuvant treatment.
Article
Immunology
Noel E. Donlon, Maria Davern, Andrew D. Sheppard, Fiona O'Connell, Margaret R. Dunne, Conall Hayes, Eimear Mylod, Sinead Ramjit, Hugo Temperley, Michael Mac Lean, Gillian Cotter, Anshul Bhardwaj, Christine Butler, Melissa J. Conroy, Jacintha O'Sullivan, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds, Joanne Lysaght
Summary: The study analyzes the immune characteristics of EAC patients before and after surgery, and reveals a Th2-like immune phenotype post-surgery. Shifting the treatment strategy towards a Th1-like immune phenotype could promote cancer regression and prevent recurrence.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Yasuhiko Hamada, Kyosuke Tanaka, Masaki Katsurahara, Noriyuki Horiki, Yuhei Umeda, Yohei Ikenoyama, Hiroki Yukimoto, Masahiko Tameda, Junya Tsuboi, Reiko Yamada, Misaki Nakamura, Hayato Nakagawa
Summary: This study evaluated the efficacy of endoscopic submucosal dissection (ESD) for superficial esophageal cancer (SEC) in gastrectomized patients. The results showed that a history of gastrectomy did not have a significant impact on the outcomes of ESD treatment for SEC.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Julia K. Grass, Natalie Kusters, Marius Kemper, Jan Tintrup, Felix Piecha, Jakob R. Izbicki, Daniel Perez, Nathaniel Melling, Maximilian Bockhorn, Matthias Reeh
Summary: This study indicates that patients with concomitant liver cirrhosis undergoing curative esophagectomy for malignant disease have worse perioperative outcomes, including higher mortality, anastomotic leakage rate, and sepsis occurrence. Common cirrhosis scores failed to accurately predict the prognosis of these patients, while bilirubin and INR may serve as better prognostic indicators for perioperative outcomes.
Article
Oncology
Wenjun Luo, Zhaolun Cai, Fugen Li, Tingting Lu, Zhengwen Xu, Yingdong Jia, Bo Zhang
Summary: This study describes a new SMA-first approach for laparoscopic right hemicolectomy with complete mesocolic excision (CME) with central vascular ligation (CVL), using Treitz's ligament and ileocolic vascular pedicle as anatomical landmarks for early SMA identification. The procedure is safe and technically feasible, with few postoperative complications.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Surgery
Marek Olakowski, Ewa Grudzinska
Summary: Pancreatic head cancer is a highly fatal disease, but surgery has shown potential for long-term cure with a 5-year survival rate of 30% after resection and adjuvant chemotherapy. This paper presents current data on lymphadenectomy, resection margin, resectable tumors, and surgical techniques to improve pancreaticoduodenectomy.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Oncology
Robert Armbrust, Peter Ledwon, Anne Von Rusten, Constanze Schneider, Jalid Sehouli
Summary: Diagnosis and treatment of ovarian cancers have evolved over the years. This study presents a major analysis of federal cancer registry data in Germany, showing good treatment outcomes in patients with primary ovarian cancer. However, there are areas for improvement, and new quality indicators can be established to enhance treatment outcomes.
Review
Oncology
Carlo Ronsini, Maria Cristina Solazzo, Nicolo Bizzari, Domenico Ambrosio, Marco La Verde, Marco Torella, Raffaela Maria Carotenuto Md, Luigi Cobellis, Nicola Colacurci, Pasquale De Franciscis
Summary: This study focused on the significant heterogeneity in the clinical management of FST for ECC >= 2 cm. Surgery-based FST showed varying recurrence rates among different methods, while FST based on neoadjuvant chemotherapy had different complete response rates and recurrence rates.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Antonio Sommariva, Camilla Cona, Marco Tonello, Pierluigi Pilati, Carlo Riccardo Rossi
Summary: Videoscopic inguinal lymphadenectomy (VIL) is an innovative approach for melanoma lymph node (LN) metastases, showing favorable oncologic outcomes with comparable lymph node yield and locoregional recurrence rate to open techniques. Prospective studies are needed to confirm these results in a larger cohort of patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)