Article
Medicine, General & Internal
Summary: A trial conducted in low-income and middle-income countries did not demonstrate benefits of 2% alcoholic chlorhexidine skin preparation compared with povidone-iodine, or triclosan-coated sutures compared with non-coated sutures, in preventing surgical site infections in cleancontaminated or contaminated or dirty surgical wounds. Both interventions are more costly than alternatives, and these results do not endorse routine use.
Review
Nursing
Li Li, Yu Wang, Shouyan Wang
Summary: This study conducted a systematic review and meta-analysis to evaluate the efficacy of chlorhexidine and povidone-iodine in preventing postoperative surgical site infections (SSI) and relevant bacterial data. The results indicated that chlorhexidine was more effective than povidone-iodine in preventing SSI, and the two disinfectants had different effects on bacterial colonization depending on the type of incision.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2022)
Article
Dermatology
Panfeng Wang, Dandan Wang, Lingqiao Zhang
Summary: This study conducted a systematic evaluation to assess the efficacy of chlorhexidine and povidone-iodine as primary components in preventing surgical site infection (SSI). The meta-analysis results indicated that chlorhexidine was more effective than povidone-iodine in reducing the incidence of surgical site wound infections, superficial SSIs, and deep SSIs.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Dermatology
Dunyao Bai, Fan Zhou, Liuting Wu
Summary: Surgical site infections (SSIs) have a significant impact on patient health and healthcare costs. This meta-analysis examines the effectiveness of antiseptics, chlorhexidine and povidone-iodine, in reducing SSIs and concludes that chlorhexidine is more effective than povidone-iodine.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Public, Environmental & Occupational Health
Dorothea Doerfel, Matthias Maiwald, Georg Daeschlein, Gerald Mueller, Robert Hudek, Ojan Assadian, Gunter Kampf, Thomas Kohlmann, Julian Camill Harnoss, Axel Kramer
Summary: This study compared the effects of two antiseptics on skin microbiota, demonstrating that one antiseptic was more effective in removing anaerobic bacteria.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2021)
Article
Medicine, General & Internal
Gerard P. Slobogean, Sheila Sprague, Jeffrey L. Wells, Lehana Thabane, C. Daniel Mullins, Anthony D. Harris, Amber Wood Msn, Roman M. Natoli, Todd O. McKinley, William Obremskey, Phillip M. Mitchell, Jennifer E. Hagen, Marissa Pazik, Stephen J. Warner, Joshua L. Gary, Herman Johal, Jodi L. Gallant, Kyle J. Jeray, Stephanie L. Tanner, Justin Fowler, Sarah N. Pierrie, Robert O'Toole, Andrea L. Howe, Michael J. Prayson, Jennifer Jerele, Christina L. Boulton, Jason Lowe, Niloofar Dehghan, Michael D. McKee, Saam Morshed, Meir T. Marmor, Ernesto Guerra-Farfan, Yaiza Garcia-Sanchez, Francesc Marcano-Fernandez, Laia Martinez-Carreres, Nathan N. O'Hara, Shannon Dodds, David Pogorzelski, Sofia Bzovsky, Diane Heels-Ansdell, Olivia Paige Szasz, Gregory J. Della Rocca, Robert D. Zura, Lucas S. Marchand, Joan N. Hebden, Joseph T. Patterson, Christopher Lee, Lyndsay M. O'Hara, Debra Marvel, Jana E. Palmer, I. Leah Gitajn, Jean-Claude G. D'alleyrand, Jessica C. Rivera, Franca Mossuto, Manjari Joshi, Jeff Friedrich, Gordon Guyatt, P. J. Devereaux, Mohit Bhandari
Summary: This study compared the effect of aqueous 10% povidone-iodine and aqueous 4% chlorhexidine gluconate on the risk of surgical site infection in patients with open fractures requiring surgery. The results showed no significant difference between the two groups. Either aqueous 10% povidone-iodine or aqueous 4% chlorhexidine gluconate can be selected for skin antisepsis in patients with open fractures based on availability, contraindications, or cost.
Article
Reproductive Biology
Juan E. Romano, Renato G. Zanoni, Beatrice Mislei, Diego Bucci, Domenico Mion, Gaetano Mari
Summary: The study estimated the number of colonies forming units (CFU) in penile mucosa and semen and compared the effect of two antiseptic solutions used to reduce bacterial counts in those areas. The results showed that flushing the preputial cavity with 0.05% chlorhexidine digluconate or 1% povidone-iodine solution reduced the CFU counts in penile mucosa and semen.
Article
Multidisciplinary Sciences
Koshi Ota, Koji Oba, Keisuke Fukui, Yuri Ito, Emi Hamada, Naomi Mori, Masahiro Oka, Kanna Ota, Yuriko Shibata, Akira Takasu
Summary: The study found that disinfecting puncture sites with povidone-iodine instead of alcohol/chlorhexidine and collecting blood from the femoral artery were associated with higher rates of contaminated blood cultures.
SCIENTIFIC REPORTS
(2021)
Article
Surgery
Ryo Maemoto, Hiroshi Noda, Kosuke Ichida, Yasuyuki Miyakura, Nao Kakizawa, Erika Machida, Hidetoshi Aizawa, Takaharu Kato, Masahiro Iseki, Taro Fukui, Yuta Muto, Shota Fukai, Shingo Tsujinaka, Yuuri Hatsuzawa, Fumiaki Watanabe, Masakazu Nagamori, Jun Takahashi, Yasuaki Kimura, Shimpei Maeda, Noriya Takayama, Ryotaro Sakio, Rei Takahashi, Tsutomu Takenami, Natsumi Matsuzawa, Makiko Mieno, Toshiki Rikiyama
Summary: This trial evaluated the superiority of intraoperative wound irrigation with povidone-iodine compared with saline for reducing surgical site infection. The results showed that the irrigation with povidone-iodine did not significantly reduce the incidence of incisional SSI, suggesting a need for reconsideration of the current recommendation.
Review
Surgery
Ryckie G. Wade, Nicholas E. Burr, Gordon McCauley, Grainne Bourke, Orestis Efthimiou
Summary: The study suggests that alcoholic formulations of 4%-5% CHG are safer and twice as effective as PVI (alcoholic or aqueous solutions) in preventing infection after clean surgery in adults.
Article
Public, Environmental & Occupational Health
S. J. Monstrey, D. Lepelletier, A. Simon, G. Touati, S. Vogt, F. Favalli
Summary: This study investigated the impact of different application techniques on the antiseptic activity of alcoholic povidone-iodine solution. The results showed significant antiseptic activity with all modes of application, and greater efficacy was achieved with back-and-forth friction method compared to concentric circle method. These findings suggest that application technique may influence antiseptic activity, and comparable application techniques should be considered when comparing the efficacy of different antiseptic substances.
JOURNAL OF HOSPITAL INFECTION
(2022)
Review
Ophthalmology
Jen-Yu Liu, Hsiao-Sang Chu, Yi-Hsuan Wei, Chia-Yi Cheng, Mei-Chi Tsui, Jo-Hsuan Wu, Wei-Lun Huang, Hsin-Yu Liu, Yu-Chih Hou, I-Jong Wang, Fung-Rong Hu, Wei-Li Chen
Summary: Preoperative skin antiseptic preparation is crucial for preventing surgical infection, but improper use can cause serious ocular damage. Common antiseptics include chlorhexidine, iodine/iodophors, and alcohol-based disinfectants. Proper selection of antiseptics is important, especially in ocular surgeries.
Review
Surgery
Alexis M. Ruffolo, Ashwath J. Sampath, Stephen Colbert, Nicholas Golda
Summary: This study summarized the appropriate perioperative considerations to decrease SSI in superficial cutaneous procedures, including antiseptic use, antibiotic prophylaxis, decolonization, and clean versus sterile technique. The review highlighted the importance of decolonization of carriers ofStaphylococcus aureusand the use of Chlorhexidine in clean or outpatient superficial cutaneous procedures.
FACIAL PLASTIC SURGERY & AESTHETIC MEDICINE
(2021)
Review
Public, Environmental & Occupational Health
T. Masuyama, H. Yasuda, M. Sanui, A. K. Lefor
Summary: This study found through network meta-analysis that antiseptic agents containing 1% CHG-alcohol were more strongly associated with reduced risk for CRBSI compared with agents containing 0.5% CHG-alcohol or 10% PVI-aqueous.
JOURNAL OF HOSPITAL INFECTION
(2021)
Review
Infectious Diseases
Hasti Jalalzadeh, Hannah Groenen, Dennis R. Buis, Yasmine E. M. Dreissen, Jon H. M. Goosen, Frank F. A. Ijpma, Maarten J. van der Laan, Roald R. Schaad, Patrique Segers, Wil C. van der Zwet, Mitchel Griekspoor, Wouter J. Harmsen, Niels Wolfhagen, Marja A. Boermeester
Summary: This study compared the efficacy of different skin preparation solutions for preventing SSIs in adult patients. Results showed that 2.0-2.5% chlorhexidine in alcohol and 1.5% olanexidine were most effective in preventing SSIs. No specific concentration of chlorhexidine in alcohol was recommended for clean surgery.
Article
Surgery
Bram D. Vermeulen, Britt van der Leeden, Jawad T. Ali, Tomas Gudbjartsson, Michael Hermansson, Donald E. Low, Douglas G. Adler, Abraham J. Botha, Xavier B. D'Journo, Atila Eroglu, Lorenzo E. Ferri, Christoph Gubler, Jan Willem Haveman, Lileswar Kaman, Richard A. Kozarek, Simon Law, Gunnar Loske, Joerg Lindenmann, Jung-Hoon Park, J. David Richardson, Paulina Salminen, Ho-Yong Song, Jon A. Soreide, Manon C. W. Spaander, Jeffrey N. Tarascio, Jon A. Tsai, Tim Vanuytsel, Camiel Rosman, Peter D. Siersema
Summary: This study found that early diagnosis (≤ 24 h) compared to late diagnosis (> 24 h) in benign esophageal perforations, particularly in IEP patients, is associated with improved clinical outcomes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Microbiology
Ve Van Le, Haeseong Lee, Shalem Raj Padakandla, In-Tae Cha, Ki-Eun Lee, Jong-Chan Chae
Summary: Bacterium P2-65(T) is a novel species of the genus Flavobacterium, with a wide range of growth conditions and close relationships with certain Flavobacterium species.
ARCHIVES OF MICROBIOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Haixia Zhang, Jalil Manafian, Gurpreet Singh, Onur Alp Ilhan, Angelina Olegovna Zekiy
Summary: By utilizing the binary Hirota polynomial scheme, the bilinear form of the generalized Kadomtsev-Petviashvili equation was constructed, leading to multiple rogue waves-type solutions and various k-solitons waves. Through analyzing the physical phenomena of these obtained soliton solutions and selecting suitable values in figures, a better understanding of interesting physical phenomena and mechanisms can be achieved.
RESULTS IN PHYSICS
(2021)
Article
Mathematics, Applied
Xuejun Zhou, Onur Alp Ilhan, Jalil Manafian, Gurpreet Singh, Nalbiy Salikhovich Tuguz
Summary: This paper investigates the generalized (2+1)-dimensional Konopelchenko-Dubrovsky-Kaup-Kupershmidt equation using the bilinear Hirota method to construct M-lump and N-soliton solutions with special activation functions. Analytical solutions and rogue waves are obtained through symbolic computation with Maple software. By applying the long wave limit method, different types of M-lump solutions and hybrid solutions between lump and solitons are derived. The dynamic structures and physical properties of these solutions are vividly illustrated through various plots, enriching the exact solutions of this equation in existing literature.
JOURNAL OF GEOMETRY AND PHYSICS
(2021)
Article
Physics, Applied
Onur Alp Ilhan, Jalil Manafian, Mehrdad Lakestani, Gurpreet Singh
Summary: This paper computed solitary wave solutions and soliton wave solutions based on ansatz methods to the perturbed NLSE in nano-fibers. New optical solitons were obtained using improved tan(theta/2)-expansion method and rational extended sinh-Gordon equation expansion method. Comparison with previous results showed the perturbed NLSE in nano-fibers is used in optical problems, and symbolic computation vividly displayed their dynamic structure and physical properties.
MODERN PHYSICS LETTERS B
(2022)
Article
Materials Science, Multidisciplinary
Lei Huang, Jalil Manafian, Gurpreet Singh, Kottakkaran Sooppy Nisar, Mahyuddin K. M. Nasution
Summary: Exact solutions for the (3 + 1)-dimensional YTSF-like equation with p = 3 and p = 5 were established using the generalized Hirota bilinear method. The solutions included M-soliton solutions, lump solutions, and three classes of interaction solutions. Additionally, N-soliton wave solutions of the equation were determined using the linear superposition principle, with the equation providing a model for studying solitons and nonlinear waves in fluid dynamics, plasma physics, and weakly dispersive media.
RESULTS IN PHYSICS
(2021)
Article
Multidisciplinary Sciences
Mingchen Zhang, Xing Xie, Jalil Manafian, Onur Alp Ilhan, Gurpreet Singh
Summary: The multiple Exp-function scheme is used to search for multiple soliton solutions for the fractional generalized Calogero-Bogoyavlenskii-Schiff-Bogoyavlensky-Konopelchenko equation. The Hirota bilinear technique is employed to detect the lump and interaction with two stripe soliton solutions. More than twelve sets of solutions are obtained, including combinations of polynomial and exponential functions. The existence conditions are discussed for the obtained solutions.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Infectious Diseases
Lalit Kishore Ahirwar, Esther Sheba, Saumya Jakati, Rajagopalaboopathi Jayasudha, Shalem Raj Padakandla, Bhupesh Bagga, Savitri Sharma
Summary: This study reports the clinico-microbiological features of Macrophomina phaseolina keratitis. DNA sequencing, phylogenetic analysis, and specific PCR confirmed the presence of Macrophomina phaseolina in six patients with keratitis. Although the susceptibility testing showed the organism to be susceptible to natamycin, five patients did not respond to treatment and needed keratoplasty.
Article
Multidisciplinary Sciences
Shalem Raj Padakandla, Taraprasad Das, Gumpili Sai Prashanthi, Kiran Kumar Angadi, S. Sreenivasa Reddy, G. Bhanuprakash Reddy, Sisinthy Shivaji
Summary: This study compared the gut mycobiomes of diabetic rats and diabetic rats with retinal changes with normal control rats, indicating dysbiosis at the genus level in both diabetic groups. The researchers speculated that increased pathogenic fungi may contribute to inflammatory status in both diabetic rats and rats showing retinal changes.
Article
Chemistry, Medicinal
Prateek Raj, Karthik Selvam, Koyel Roy, Shailesh Tripathi, Sharyu Kesharwani, Balasubramanian Gopal, Umesh Varshney, Sandeep Sundriyal
Summary: This study conducted the first structure-based virtual screening and discovered a series of potential compounds inhibiting Mycobacterium tuberculosis uracil-DNA glycosylase. One compound exhibited better inhibitory effect than known inhibitors. These compounds represent a diverse set of scaffolds for developing next-generation MtUng inhibitors.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Ophthalmology
Taraprasad Das, Shalem Raj Padakandla, Sisinthy Shivaji, Rajagopalaboopathi Jayasudha, Brijesh Takkar
Summary: This study compared the microbiome in the aqueous humour and gut of people with diabetes mellitus (DM) with and without diabetic retinopathy (DR). It was found that there are differences in the microbiome of the eye and gut regardless of disease or health. The intraocular microbiome showed more distinct features compared to the gut, but further confirmation is needed with larger studies.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Biology
Jini Sugatha, Amulya Priya, Prateek Raj, Ebsy Jaimon, Uma Swaminathan, Anju Jose, Thomas John Pucadyil, Sunando Datta, Felix Campelo
Summary: SNX32 interacts with SNX4 via its BAR domain and with TfR, CIMPR, and BSG through its PX domain, regulating cargo sorting and trafficking processes. Silencing of SNX32 leads to defects in intracellular trafficking and neuronal differentiation, suggesting its crucial role in maintaining neuroglial coordination.
Article
Mathematics, Applied
Junjie Li, Gurpreet Singh, Onur Alp Ilhan, Jalil Manafian, Yusif S. Gasimov
Summary: The multiple Exp-function method is utilized to find multiple soliton solutions to the generalized (3+1)-dimensional Kadomtsev-Petviashvili equation, which include various types of wave solutions. Modulation instability and semi inverse variational principle are used to discuss the stability of solutions, and the physical phenomena are analyzed in figures. These analytical solutions and rogue waves are obtained using Maple software and displayed in various charts showcasing the dynamical characteristics of the waves.
Article
Mathematics, Applied
Huiqing Wang, Md Nur Alam, Onur Alp Ilhan, Gurpreet Singh, Jalil Manafian
Summary: This paper studies and analyzes the complex Ginzburg-Landau model to obtain new solitary wave structures using the modified (G'/G)-expansion method. The solutions are explained through hyperbolic, trigonometric, and rational functions, and the graphical design highlights the dynamics of the equations. The method examined in this study is important, powerful, and significant in generating numerous solitary wave structures in various nonlinear wave models in physics and engineering.
Article
Mathematics, Applied
Jalil Manafian, Onur Alp Ilhan, Sherin Youns Mohyaldeen, Subhiya M. Zeynalli, Gurpreet Singh
Summary: This article discusses an equation describing the control of Internet traffic, analyzing it using two integration schemes to present various traveling wave solutions. The available solutions, restriction conditions, and graphical features are also showcased, highlighting the use of the model in applied sciences.
MATHEMATICAL SCIENCES
(2021)
