Article
Environmental Sciences
Kyoung-Bin Ryu, Gun-Hee Jo, Young-Chun Gil, Donggu Jeon, Na-Rae Choi, Seung-Hyun Jung, Seonmi Jo, Hye Suck An, Hae-Youn Lee, Seong-il Eyun, Sung-Jin Cho
Summary: The eye of a cephalopod, such as the common long-arm octopus, is an example of convergent evolution and shares similarities with vertebrate eyes. This study focuses on the genetic and developmental analysis of crystallin genes in the eye of Octopus minor to understand the convergent evolution of lens-containing eyes.
FRONTIERS IN MARINE SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Paul Dowling, Stephen Gargan, Dieter Swandulla, Kay Ohlendieck
Summary: The loss of skeletal muscle mass and strength is the main cause of frailty syndrome, which is closely associated with sarcopenia in the elderly. Mass spectrometry-based proteomic surveys have improved our understanding of the molecular and cellular changes during muscle atrophy and age-related fiber-type shifting. Proteomic analysis suggests that contractile proteins can be used as markers of fiber-type transitions during aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Matthew H. Doran, William Lehman
Summary: Actin, a highly conserved protein, plays diverse roles in cellular processes by interacting with actin-binding proteins. The ATP-dependent cycle of myosin attachment and detachment drives muscle contraction and cellular transport. The variations in actin function are influenced by myosin isoforms and other actin-binding proteins.
Article
Fisheries
Ramiro Braga, Silvina Van der Molen, Julian Pontones, Nicolas Ortiz
Summary: The study on the early development stages of Octopus tehuelchus under different temperatures revealed that embryonic duration was shorter at 16 degrees C compared to 13 degrees C, but the survival time of juveniles was longer. Temperature also affected juvenile performance, with differences in size and weight but similar chromatophore patterns at both temperatures.
Article
Biochemistry & Molecular Biology
Galina V. V. Kopylova, Anastasia M. M. Kochurova, Daria S. S. Yampolskaya, Victoria V. V. Nefedova, Andrey K. K. Tsaturyan, Natalia A. A. Koubassova, Sergey Y. Y. Kleymenov, Dmitrii I. I. Levitsky, Sergey Y. Y. Bershitsky, Alexander M. M. Matyushenko, Daniil V. V. Shchepkin
Summary: The TPM1 gene expresses two isoforms of tropomyosin (Tpm) in the myocardium, alpha (aTpm; Tpm 1.1) and kappa (?Tpm; Tpm 1.2), with ?Tpm being the result of alternative splicing. In this study, the structural features and regulatory function of ?Tpm in the atrial and ventricular myocardium were investigated using an in vitro motility assay. The formation of a?Tpm heterodimer was found to be thermodynamically favorable, indicating that ?Tpm most likely exists as a?Tpm heterodimer in the myocardium.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ecology
Adi Khen, Lillian R. McCormick, Christine A. Steinke, Greg W. Rouse, Phil J. Zerofski
Summary: The North Pacific bigeye octopus, Octopus californicus, is a cold-water, deep-sea octopod with limited knowledge regarding its biology. This study presents the first-known observation and documentation of the brooding, development, and hatching process of fertilized eggs for this species in an aquarium setting. The findings contribute to our understanding of this species and support theories of prolonged embryonic development at lower temperatures.
ECOLOGY AND EVOLUTION
(2022)
Article
Biochemistry & Molecular Biology
Kinga Duszyc, Guillermo A. Gomez, Anne K. Lagendijk, Mei-Kwan Yau, Bageshri Naimish Nanavati, Briony L. Gliddon, Thomas E. Hall, Suzie Verma, Benjamin M. Hogan, Stuart M. Pitson, David P. Fairlie, Robert G. Parton, Alpha S. Yap
Summary: Extrusion is the primary response to apoptosis in epithelial cells, involving E-cadherin and RhoA signaling pathways. Mechanical tension-sensitive mechanotransduction activates RhoA specifically in neighboring cells of apoptotic cells, with S1P also playing a crucial role in the process.
Article
Biochemistry & Molecular Biology
Galina Kopylova, Valentina Y. Berg, Anastasia M. Kochurova, Alexander M. Matyushenko, Sergey Y. Bershitsky, Daniil Shchepkin
Summary: The study found that mutations in tropomyosin have different effects on actin-myosin interaction in the atria and ventricles, which may contribute to the differences in pathological changes in the atrial and ventricular myocardium.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Marine & Freshwater Biology
Renato U. Montero-Ruiz, Roxana De Silva-Davila, Carlos Alberto Amezcua-Gomez, Alejandra Valdez-Cibrian, Eva R. Kozak
Summary: This study reports the early life stage identification and morphological characteristics of Octopushubbsorum Berry 1953. The females of this species were captured in Tenacatita Bay, Jalisco, Mexico and observed for their spawning behavior in the laboratory. The results indicate that the embryonic development of this species lasts for 18-22 days at an average temperature of 28.3°C, resulting in paralarvae with a mantle length of 1.55mm.
Review
Multidisciplinary Sciences
Andrei I. Ivanov, Susana Lechuga, Armando Marino-Melendez, Nayden G. Naydenov
Summary: The integrity and functions of epithelial barriers depend on the formation of adherens junctions and tight junctions, which are associated with the cortical cytoskeleton composed of actin filaments and nonmuscle myosin II motors. Different actin and myosin isoforms play distinct roles in the assembly, stability, and remodeling of junctions. This review focuses on the roles of actin and myosin in controlling the integrity and barrier properties of various epithelia.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Medicine, Research & Experimental
Allison B. Mason, Melissa L. Lynn, Anthony P. Baldo, Andrea E. Deranek, Jil C. Tardiff, Steven D. Schwartz
Summary: This study utilized computational modeling to predict and simulate the effects of mutations on cardiac thin filament proteins. Experimental validation was used to identify pathogenic signatures and reclassify variants, providing unique structural and dynamic information for classification of both new and conflicting variants.
Article
Cell Biology
Qing Tang, Luther W. Pollard, Kaitlin E. Homa, David R. Kovar, Kathleen M. Trybus
Summary: It was proposed that S. pombe tropomyosin Cdc8 (Tpm) segregates into two populations based on the presence or absence of amino-terminal acetylation, which determines its binding to formin-mediated F-actin networks. However, there was no supporting biochemistry. In vitro experiments using recombinant S. pombe proteins showed that acetyl-Tpm tightly binds to actin, while unacetylated Tpm binds weakly. Contrary to the differential recruitment model, Tpm did not show preferential binding to filaments assembled by the FH1-FH2 domains of two S. pombe formins.
Article
Oncology
Xing Xu, Yao Wang, Nicole S. Bryce, Katrina Tang, Nicola S. Meagher, Eun Young Kang, Linda E. Kelemen, Martin Kobel, Susan J. Ramus, Michael Friedlander, Caroline E. Ford, Edna C. Hardeman, Peter W. Gunning
Summary: The study found that Tpm3.1 is overexpressed in almost all epithelial ovarian cancer tissues and showed promising efficacy in treatment, especially in combination with vinorelbine. This combined targeting strategy of Tpm3.1/actin and microtubules can promote post-mitotic G1 arrest, leading to increased cell death.
BRITISH JOURNAL OF CANCER
(2021)
Article
Cell Biology
Komaki Ninomiya, Kai Ohta, Kazunari Yamashita, Kensaku Mizuno, Kazumasa Ohashi
Summary: PLEKHG4B plays a crucial role in epithelial cell-cell junction formation by regulating actin remodeling and modulating the activities of Cdc42 and RhoA. Knockdown of PLEKHG4B leads to open junctions and aberrant myosin activity.
JOURNAL OF CELL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Andrea E. Deranek, Anthony P. Baldo, Melissa L. Lynn, Steven D. Schwartz, Jil C. Tardiff
Summary: The application of electron microscopy techniques has greatly improved the structural analysis of large protein complexes, such as the cardiac thin filament (cTF). However, these studies have provided limited information on highly flexible regions, like the extended cardiac troponin T (cTnT) linker. In this study, a computational cTF model was used in combination with time-resolved fluorescence resonance energy transfer measurements to map the positioning and motion of the cTnT linker. The findings provide important insights into the structural dynamics of the cTnT linker in myofilament activation and disease.
Article
Fisheries
G. Pazos, J. Fernandez, F. Linares, J. Sanchez, J. J. Otero, J. Iglesias, P. Domingues
AQUACULTURE RESEARCH
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Letizia Zullo, Ambra Buschiazzo, Michela Massollo, Mattia Riondato, Alessia Democrito, Cecilia Marini, Fabio Benfenati, Gianmario Sambuceti
JOURNAL OF NUCLEAR MEDICINE
(2018)
Article
Behavioral Sciences
Letizia Zullo, Hadas Eichenstein, Federica Maiole, Binyamin Hochner
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
(2019)
Article
Biology
Nir Nesher, Federica Maiole, Tal Shomrat, Benyamin Hochner, Letizia Zullo
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2019)
Article
Physiology
Federica Maiole, Sarah Giachero, Sara Maria Fossati, Anna Rocchi, Letizia Zullo
FRONTIERS IN PHYSIOLOGY
(2019)
Article
Robotics
Patricia A. Xu, A. K. Mishra, H. Bai, C. A. Aubin, L. Zullo, R. F. Shepherd
Article
Multidisciplinary Sciences
Federica Maiole, Giulia Tedeschi, Simona Candiani, Luca Maragliano, Fabio Benfenati, Letizia Zullo
SCIENTIFIC REPORTS
(2019)
Article
Developmental Biology
Jessica W. Chen, Xubo Niu, Matthew J. King, Marie-Therese Noedl, Clifford J. Tabin, Jenna L. Galloway
Article
Fisheries
Diana B. Reis, Anastasia Shcherbakova, Rodrigo Riera, Virgina M. Martin, Pedro Domingues, Jose P. Andrade, Pablo Jimenez-Prada, Covandonga Rodriguez, Antonio Sykes, Eduardo Almansa
Summary: The research on the impact of different prey on the lipid requirements and growth of Octopus vulgaris paralarvae found that using Grapsus as prey had the best effect on the growth and survival of paralarvae, while there was little difference in the effects of different stages of Artemia.
AQUACULTURE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Tamar Gutnick, Letizia Zullo, Binyamin Hochner, Michael J. Kuba
Review
Cell Biology
Letizia Zullo, Matteo Bozzo, Alon Daya, Alessio Di Clemente, Francesco Paolo Mancini, Aram Megighian, Nir Nesher, Eric Rottinger, Tal Shomrat, Stefano Tiozzo, Alberto Zullo, Simona Candiani
Review
Anatomy & Morphology
Stephanie L. Tsai, Marie-Therese Nodl, Jenna L. Galloway
Summary: Tendons play a crucial role in transmitting forces from muscle to bone, but can commonly be injured and heal poorly with inferior function. Advancing tendon regenerative medicine requires expanding our understanding of tendon development, healing, and regeneration, and applying new research findings to design more effective treatment strategies.
DEVELOPMENTAL DYNAMICS
(2021)
Article
Biology
Alessio Di Clemente, Federica Maiole, Irene Bornia, Letizia Zullo
Summary: This study investigated the organization and function of elastic fibers in octopus arm muscles, finding that longitudinal muscles may be involved in energy storage and damping, while transverse muscles may contribute to posture maintenance and resistance to deformation. The different roles of these muscles are likely influenced by their elastic fiber configurations.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Biology
Letizia Zullo, Alessio Di Clemente, Federica Maiole
Summary: Octopus arms exhibit different roles in arm movements, with longitudinal muscles being used for precise actions and transverse muscles for intense and sustained actions. The structure and morphology of the arm muscles also contribute to their functional specialization. The octopus arm can be seen as a reservoir of possibilities for different types of motion.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Review
Biology
Tamar Flash, Letizia Zullo
Summary: Muscular hydrostats are organs without skeletal support composed entirely of incompressible muscles, and they are of great interest in comparative biomechanics. Octopus arms, known for their flexibility and complex behaviors, provide insights into motor control strategies. This review discusses experimental studies on octopus arm biomechanics and neural motor control, as well as the significance of impedance in motor behavior and the need for updated models in soft robotics.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2023)