Article
Clinical Neurology
Ying Chen, Yan Dong, Zai-Li Zhang, Jie Han, Feng-Shou Chen, Xiang-Yi Tong, Hong Ma
Summary: This study demonstrates that Fra-1 plays a promoting role in apoptosis and inflammation in spinal cord ischemia/reperfusion injury. It is found that S100A8 is an upstream regulator of Fra-1 and the interaction between Fra-1 and S100A8 forms a feedback loop in the signaling pathways activated by this injury.
Article
Cardiac & Cardiovascular Systems
Josephina Haunschild, Zara Khachatryan, Konstantin von Aspern, Johanna Herajaervi, Susann Ossmann, Joerg Naumann, Michael A. Borger, Christian D. Etz
Summary: The study evaluates the effects of distal aortic perfusion (DaP) on regional spinal cord blood flow during descending aortic cross-clamping and iatrogenic elevation of cerebrospinal fluid pressure. DaP leads to hyperperfusion of the distal spinal cord but does not provide adequate flow to upper and middle spinal cord segments, and is unable to counteract an experimental cerebrospinal fluid pressure elevation, resulting in decreased blood flow to certain spinal cord segments.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Health Care Sciences & Services
Nicole M. Vecin, David R. Gater
Summary: This manuscript reviews the risk of pressure injuries caused by spinal cord injury and discusses the multidisciplinary approach required to prevent and treat these injuries in the vulnerable population.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Guohui Yang, Pengfei Yao, Shengli Ma, Chi Zhang
Summary: In rats with spinal cord ischemic injury, levels of bradykinin and B2 receptors were decreased. Bradykinin treatment significantly improved motor function, reduced inflammatory mediators, and activated B2 receptors, suggesting a potential mechanism for improving hind limb recovery.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Immunology
Jingyi Mi, Yang Yang, Hao Yao, Zhirong Huan, Ce Xu, Zhiheng Ren, Wenfu Li, Ying Tang, Rao Fu, Xin Ge
Summary: The study showed that silencing HSPA8 can alleviate spinal cord damage caused by SCII by inhibiting astrocyte activation and NF-κB, NLRP3 inflammasome activation, leading to reduced neuroinflammation and protection of neurons.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Cardiac & Cardiovascular Systems
Josephina Haunschild, Konstantin Von Aspern, Martin Misfeld, Piroze Davierwala, Michael A. Borger, Christian D. Etz
Summary: Spinal cord injury is a major complication of aortic aneurysm repair surgeries, despite the existence of various neuroprotective adjuncts. No strategy currently guarantees definitive preservation of spinal cord integrity during and after aortic aneurysm repair surgeries.
JOURNAL OF CARDIOVASCULAR SURGERY
(2021)
Review
Health Care Sciences & Services
Adriana D. Valbuena Valecillos, David R. Gater, Gemayaret Alvarez
Summary: Spinal cord injury (SCI) is a severe event with multiple comorbidities. It is often accompanied by traumatic brain injury (TBI), which has its own set of complications. Understanding the etiology and epidemiology of these dual diagnoses and employing appropriate assessment and management strategies can help optimize functional recovery.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
James Guest, Nilanjana Datta, George Jimsheleishvili, David R. Gater
Summary: The spinal cord serves as a communication conduit between the brain and the body, responsible for transmitting information and controlling various functions. Following a spinal cord injury, various complications can arise, including paralysis, pain, and autonomic dysfunction.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Immunology
Hui Li, Pengfei Wang, Lin Tang, Jingjing Sun, Yanling Zhang, Wei Luo, Cong Luo, Zhaolan Hu, Lin Yang
Summary: Recent studies have shown that microglia and monocyte-derived macrophages (MDMs) exhibit different polarized statuses and functions following spinal cord ischemia/reperfusion injury (SCIRI). Depletion of infiltrating MDMs can significantly preserve neurological functions and attenuate neuronal damage caused by SCIRI, suggesting a potential novel approach for SCIRI treatment.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Neurosciences
Libang Yuan, Jin Xu, Fuen Qin, Xiaobo Yi, Zuling Zhong, Xiaoping Gu, Gu Gong
Summary: This study found that spinal cord ischemia-reperfusion injury (SCII), often caused by spinal surgery, can lead to severe neurological deficits. The ubiquitin-specific protease 18 (USP18) plays a significant role in neurological diseases. It was demonstrated that upregulation of USP18 improves motor function, inhibits inflammation and cell apoptosis after SCII in rats and protects PC12 cells from OGD/R-induced damage by modulating inflammatory responses and apoptosis.
NEUROSCIENCE LETTERS
(2023)
Review
Cell Biology
Feng-Shou Chen, Xiang-Yi Tong, Bo Fang, Dan Wang, Xiao-Qian Li, Zai-Li Zhang
Summary: This review summarizes the relationship between miRNAs and spinal cord ischemia/reperfusion injury, as well as potential therapeutic strategies, which is of great significance for the research of spinal cord ischemia/reperfusion injury.
NEURAL REGENERATION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Yuki Ikeno, Christian V. Ghincea, Gavriel F. Roda, Linling Cheng, Muhammad Aftab, Xianzhong Meng, Michael J. Weyant, Joseph C. Cleveland, David A. Fullerton, Brett Reece
Summary: This study investigated the role of the mitochondrial adenosine triphosphate-sensitive potassium channel in pharmacologically induced tolerance to spinal cord injury. Both direct and nitric oxide-dependent indirect activation of the channel were found to contribute to the induction of ischemic metabolic tolerance.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Multidisciplinary Sciences
Fengshou Chen, Jie Han, Xiaoqian Li, Zaili Zhang, Dan Wang
Summary: Overexpression of miR-9 improves neurological outcomes after spinal cord ischemia-reperfusion injury and may inhibit blood-spinal cord barrier disruption, neuroinflammation, and apoptosis through MAP2K3- or Notch2-mediated signaling pathways.
Article
Multidisciplinary Sciences
Fengshou Chen, Jie Han, Dan Wang
Summary: Spinal cord ischemia-reperfusion injury (SCII) is a pathological process that can lead to severe complications such as paraplegia and paralysis. Aberrant miRNA expression is involved in the development of SCII, and different experimental conditions can lead to varied miRNA expression results. This study identified 19 key differently expressed miRNAs (DEmiRNAs) in SCII, with 9 upregulated and 10 downregulated DEmiRNAs. Functional and transcription factor analyses revealed that the upregulated DEmiRNAs mainly targeted the cGMP-PKG and cAMP signaling pathways, while the downregulated DEmiRNAs targeted the Chemokine and MAPK signaling pathways. Among these DEmiRNAs, miR-3568 stood out as a potential intervention target for SCII, as its inhibition preserved hind limb function by reducing apoptosis and regulating key genes such as GATA6, GATA4, and RBPJ.
Review
Health Care Sciences & Services
Gianna M. Rodriguez, David R. Gater
Summary: This article discusses the complications of neurogenic bowel in SCI patients and their treatment, including gastrointestinal anatomy and physiology, as well as the latest guidelines for assessment and medical management. For SCI patients, maintaining good health, quality of life, and supporting active lives in their homes and communities are important goals.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
Nuriye Guzin Ozdemir, Mehmet Dumlu Aydin, Coskun Yolas, Ayhan Kanat, Akin Levent, Cemal Gundogdu, Nazan Aydin
TURKISH NEUROSURGERY
(2017)
Article
Surgery
Ugur Kaya, Abdurrahim Colak, Necip Becit, Munacettin Ceviz, Hikmet Kocak
TURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2018)
Article
Surgery
Ugur Kaya, Abdurrahim Colak, Munacettin Ceviz, Necip Becit, Hikmet Kocak
TURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2018)
Article
Nutrition & Dietetics
Sevda Tanrikulu-Kucuk, Callan Basaran-Kucukgergin, Muhammed Seyithanoglu, Semra Dogru-Abbasoglu, Hikmet Kocak, Sule Beyhan-Ozda, Yildiz Oner-Iyidogan
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2019)
Letter
Cardiac & Cardiovascular Systems
Abdurrahim Colak, Ugur Kaya, Munacettin Ceviz, Necip Becit, Fehimcan Sevil, Hikmet Kocak
HEART SURGERY FORUM
(2018)
Article
Biochemistry & Molecular Biology
Arzu Ucar, Fatma Betul Ozgeris, Asli Cilingir Yeltekin, Veysel Parlak, Gonca Alak, Mevlut Sait Keles, Muhammed Atamanalp
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2019)
Article
Medicine, Research & Experimental
Sevda Tannkulu-Kucuk, Canan Basaran-Kucukgergin, Ibrahim Sogut, Matem Tuncdemir, Semra Dogru-Abbasoglu, Muhammed Seyithanoglu, Hikmet Kocak, Yidiz Oner-Iyidogan
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2019)
Article
Clinical Neurology
Tuba Demirci, Mehmet D. Aydin, Ozgur Caglar, Nazan Aydin, Sevilay Ozmen, Kemal A. Nalci, Ali Ahiskalioglu, Mehmet N. Kocak, Sait Keles
Article
Biology
Serhat Aras, Ihsan Oguz Tanzer, Neslihan Sayir, Mevlut Sait Keles, Fatma Betul Ozgeris
Summary: The study investigated the radioprotective effect of melatonin on rat models exposed to FF and FFF beams, showing that melatonin administration improved histopathological and biochemical parameters in the radiotherapy plus melatonin groups. There was no statistically significant difference between FF and FFF beams in terms of their effects on rat larynx and serum samples.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Biology
Serhat Aras, Mustafa Efendioglu, Aini Wulamujiang, Sidika Seyma Ozkanli, Mevlut Sait Keles, Ihsan Oguz Tanzer
Summary: The study shows that melatonin has a radioprotective effect against early brain damage caused by different dose rate beams, improving histopathological and biochemical parameters. However, there is no significant difference between low and high dose rate beams in terms of their effects on the brain. Further studies are needed to clarify the radiobiological uncertainties of different dose rates on various tissues.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Toxicology
Muhammed Atamanalp, Veysel Parlak, Fatma Betul Ozgeris, Asli Cilingir Yeltekin, Arzu Ucar, Mevlut Sait Keles, Gonca Alak
Summary: The study revealed that after exposure to pesticides, antioxidant enzyme activities increased in the N-acetyl cysteine treated group, while oxidative stress-related indicators decreased, and the kidney was found to be the most sensitive tissue.
TOXICOLOGY MECHANISMS AND METHODS
(2021)
Article
Environmental Sciences
Hasan Turkez, Serkan Yildirim, Elvan Sahin, Mehmet Enes Arslan, Bugrahan Emsen, Ozlem Ozdemir Tozlu, Gonca Alak, Arzu Ucar, Abdulgani Tatar, Ahmet Hacimuftuoglu, Mevlut Sait Keles, Fatime Geyikoglu, Muhammed Atamanalp, Fatih Saruhan, Adil Mardinoglu
Summary: There is a meaningful relationship between aluminum exposure and neurotoxic and hematotoxic damage, and boron compounds can mitigate the harmful effects of aluminum by exhibiting antioxidant, antigenotoxic, and cytoprotective effects. This study evaluates the genetic, cytological, biochemical, and pathological effects of boron compounds on aluminum-induced toxicity in different cell and animal model systems.
Article
Cardiac & Cardiovascular Systems
Abdurrahim Colak, Necip Becit, Ugur Kaya, Munacettin Ceviz, Hikmet Kocak
BRAZILIAN JOURNAL OF CARDIOVASCULAR SURGERY
(2019)
Article
Cardiac & Cardiovascular Systems
Ugur Kaya, Abdurrahim Colak, Necip Becit, Munacettin Ceviz, Hikmet Kocak
BRAZILIAN JOURNAL OF CARDIOVASCULAR SURGERY
(2018)
Article
Medicine, General & Internal
Ugur Kaya, Abdurrahim Colak, Necip Becit, Munacettin Ceviz, Hikmet Kocak
EURASIAN JOURNAL OF MEDICINE
(2018)