Article
Biochemistry & Molecular Biology
Angelo Di Vincenzo, Marnie Granzotto, Andrea Graziani, Marika Crescenzi, Mirto Foletto, Luca Prevedello, Federico Capone, Roberto Vettor, Marco Rossato
Summary: Obesity is a systemic disease associated with significant complications, including chronic low-grade systematic inflammation. This study focused on evaluating the plasma levels of soluble P2X7R (sP2X7R) in obese patients before and after bariatric surgery, and its relation to inflammatory markers. The results showed that weight loss via surgery significantly reduced both sP2X7R levels and inflammatory marker levels in obese patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Rexiati Ruze, Tiantong Liu, Xi Zou, Jianlu Song, Yuan Chen, Ruiyuan Xu, Xinpeng Yin, Qiang Xu
Summary: The prevalence of obesity and diabetes mellitus (DM) is increasing globally due to shared genetic and environmental factors. Obesity amplifies the impact of genetic susceptibility and environmental factors on DM by interfering with metabolic balance and causing insulin resistance. The dysregulation of immunometabolism through low-grade systemic inflammation leads to the loss of functional beta-cells and elevated blood glucose. Treatment approaches for obesity and type 2 DM have interconnected effects, and surgical procedures like bariatric surgery are more effective. More research is needed to improve the efficacy and safety of available and new treatments.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Arianna Bonizzi, Marta Sevieri, Leopoldo Sitia, Andrea Rizzi, Lorenzo Conti, Fabio Corsi, Carlo Morasso, Serena Mazzucchelli
Summary: The study revealed that despite the improvements in weight, glycemic control, and lipid profile of type 2 diabetes mellitus patients after bariatric surgery, Raman spectroscopy indicated that their metabolic profiles were not fully restored post-surgery.
APPLIED SCIENCES-BASEL
(2021)
Article
Endocrinology & Metabolism
Guanhua Lu, Huanhuan Gao, Zhiyong Dong, Shuwen Jiang, Ruixiang Hu, Cunchuan Wang
Summary: This study investigated the differences in miRNA expression in obese patients with and without T2DM, as well as before and after bariatric surgery in obese T2DM patients. The study found 16 up-regulated and 32 down-regulated miRNAs in T2DM patients compared to non-T2DM patients. Improvement in metabolic metrics after bariatric surgery was correlated with changes in miRNA expression. Seven intersecting miRNAs with opposite changes were identified, and their target genes were enriched in pathways associated with T2DM. These miRNAs and their target genes may be potential targets for regulating T2DM.
DIABETES & METABOLISM JOURNAL
(2023)
Article
Endocrinology & Metabolism
Gladys Wojciechowska, Lukasz Szczerbinski, Marek Kretowski, Magdalena Niemira, Hady Razak Hady, Adam Kretowski
Summary: This study suggests that four serum miRNAs may serve as predictive biomarkers for type 2 diabetes remission 12 months after sleeve gastrectomy. Further validation studies are needed to confirm the findings.
Review
Endocrinology & Metabolism
Paolo Gentileschi, Emanuela Bianciardi, Domenico Benavoli, Michela Campanelli
Summary: Bariatric surgery has been shown to promote remission or significant improvement of Type II Diabetes Mellitus and related comorbidities in obese patients. Different gastrointestinal procedures may have varying effects and mechanisms of action on glucose metabolism. Metabolic surgery integrates knowledge and multidisciplinary expertise to provide a combination of conservative and surgical treatments for Type II diabetes.
ACTA DIABETOLOGICA
(2021)
Article
Surgery
Xinqiang Zhu, Gang Zhou, Xingwei Gu, Xuetong Jiang, Hailong Huang, Sainan You, Gong Zhang
Summary: This study aimed to compare the clinical outcomes of bariatric surgery and medical treatment for obese adolescents with type 2 diabetes. The results showed that bariatric surgery was more effective than medical treatment in controlling weight loss and type 2 diabetes, with LRYGB surgery having better effects on weight loss and glycemic control.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Endocrinology & Metabolism
David Lopez-Perez, Anais Redruello-Romero, Jesus Garcia-Rubio, Carlos Arana, Luis A. Garcia-Escudero, Francisco Tamayo, Javier Salmeron, Julio Galvez, Josefa Leon, Angel Carazo
Summary: The paradigm of mast cells in type 2 diabetes is changing. Research has found that mast cells, once considered harmful inflammatory cells, play important roles in adipose tissue homeostasis. A study measuring the surface expression of four proteins on mast cells in the adipose tissue of obese patients with different stages of diabetes found that type 2 diabetes affects mast cells more severely in omental adipose tissue than in subcutaneous adipose tissue.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Surgery
Mohammad Kermansaravi, Rohollah Valizadeh, Amirhossein Davarpanah Jazi, Shahab Shahabi Shahmiri, Jose Antonio Lopez Martinez, Ali Mousavimaleki, Foolad Eghbali, Amirhossein Aliakbar, Hamed Atarodi, Ebrahim Aghajani, Panagiotis Lainas
Summary: This study systematically reviewed and conducted a meta-analysis to evaluate the efficacy of metabolic/bariatric surgeries in patients with type 1 diabetes mellitus. The results showed that these surgeries had significant effects on insulin and glycemic control.
Review
Medicine, General & Internal
Hairul Islam Mohamed Ibrahim
Summary: The prevalence of obesity is increasing in developed countries, causing public health concerns. Understanding the molecular basis of obesity and related diseases is crucial for their management. The mechanisms underlying the interactions between environment, lifestyle, and genetics play a key role in developing effective strategies. Epigenetic changes have been found to be crucial in the etiology of obesity. Although the use of epigenetic treatments has been discussed in cancer, challenges remain for type 2 diabetes mellitus.
MEDICINA-LITHUANIA
(2022)
Article
Surgery
Anahita Jalilvand, Alecia Blaszczak, David Bradley, Joey Liu, Valerie Wright, Bradley Needleman, Willa Hsueh, Sabrena Noria
Summary: The study found that lower visceral AT-Treg abundance in bariatric surgery patients was associated with increased baseline medication requirements for type 2 diabetes, hypertension, and hyperlipidemia, suggesting a correlation between reduced AT-Tregs and higher obesity-related comorbidity severity.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Endocrinology & Metabolism
D. Moriconi, M. L. Manca, M. Anselmino, E. Rebelos, R. Bellini, S. Taddei, E. Ferrannini, M. Nannipieri
Summary: This study assessed the impact of bariatric surgery on remission and relapse of type 2 diabetes mellitus (T2DM) and analyzed predictive factors. The results showed that bariatric surgery significantly improved BMI, fasting glucose, and haemoglobin A1c (HbA1c). The remission rates at 1 and 10 years post-surgery were 74% and 53% respectively. T2DM duration, baseline HbA1c, and ensuing insulin therapy were identified as the strongest predictors of remission. Short T2DM duration and good glycemic control before surgery were essential for long-lasting remission, while weight loss did not impact the long-term relapse of T2DM.
DIABETES & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Eun Ran Kim, Ji Ho Yun, Hyo-Jin Kim, Hyeon Young Park, Yoonseok Heo, Young Suk Park, Do Joong Park, Soo Kyung Koo
Summary: This study investigated the differences in serum hormone and inflammatory cytokine levels before and after surgery in Korean patients with obesity. The results showed that weight loss after surgery led to improvements in clinical parameters and reductions in inflammatory cytokines and hormones. These findings help us understand the mechanism of how bariatric surgery improves glucose metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Ana Maria Dascalu, Anca Pantea Stoian, Alina Popa Cherecheanu, Dragos Serban, Daniel Ovidiu Costea, Mihail Silviu Tudosie, Daniela Stana, Denisa Tanasescu, Alexandru Dan Sabau, Gabriel Andrei Gangura, Andreea Cristina Costea, Vanessa Andrada Nicolae, Catalin Gabriel Smarandache
Summary: Most obese type 2 diabetes patients undergoing bariatric surgery showed stable diabetic retinopathy outcomes postoperatively, with a smaller percentage experiencing new onset or progression. Preoperative preparation and regular ophthalmologic follow-up are essential to minimize the risk of worsening diabetic retinopathy. Further randomized trials are needed to better understand organ-specific risk factors and provide personalized counseling for these patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Editorial Material
Endocrinology & Metabolism
Samuel Klein, Randy J. Seeley
Summary: Many individuals with obesity and type 2 diabetes experience diabetes remission after Roux-en-Y gastric bypass surgery, but there is disagreement regarding the underlying mechanisms. We present our perspective on conflicting datasets suggesting that the remission could be attributed solely to weight loss or weight loss-independent factors.
Editorial Material
Endocrinology & Metabolism
Rafael Ferraz-Bannitz, Sangeeta Kashyap, Mary Elizabeth Patti
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Matthew C. Riddle, William T. Cefalu, Philip H. Evans, Hertzel C. Gerstein, Michael A. Nauck, William K. Oh, Amy E. Rothberg, Carel W. le Roux, Francesco Rubino, Philip Schauer, Roy Taylor, Douglas Twenefour
Summary: Improvement of glucose levels in people with diabetes can occur spontaneously or after medical interventions. Newer forms of treatment may lead to more sustained improvement. However, the terminology and objective measures for defining this process are not established, and the long-term risks and benefits are not well understood. An international expert group proposed the term "remission" and HbA1c < 6.5% as the usual diagnostic criterion. They also suggested active observation and further research on predictors and outcomes of remission.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Neda Rasouli, Irwin G. Brodsky, Ranee Chatterjee, Sun H. Kim, Richard E. Pratley, Myrlene A. Staten, Anastassios G. Pittas
Summary: Supplementation with vitamin D-3 for 24 months did not improve beta-cell function in people with prediabetes, but showed benefits in those with very low baseline vitamin D levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Editorial Material
Surgery
Paulina Salminen, Gerhard Prager, Phil R. Schauer
Article
Endocrinology & Metabolism
Kenneth Cusi, Scott Isaacs, Diana Barb, Rita Basu, Sonia Caprio, W. Timothy Garvey, Sangeeta Kashyap, Jeffrey I. Mechanick, Marialena Mouzaki, Karl Nadolsky, Mary E. Rinella, Miriam B. Vos, Zobair Younossi
Summary: This article provides evidence-based recommendations for the diagnosis and management of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) for endocrinologists, primary care clinicians, and other stakeholders. The guideline includes 34 evidence-based clinical practice recommendations and contains relevant citations.
ENDOCRINE PRACTICE
(2022)
Article
Clinical Neurology
Pornprapa Chindamporn, Lu Wang, James Bena, Alexander Zajichek, Alex Milinovic, Roop Kaw, Sangeeta R. Kashyap, Derrick Cetin, Ali Aminian, Nancy Kempke, Nancy Foldvary-Schaefer, Loutfi S. Aboussouan, Reena Mehra
Summary: By analyzing a clinical cohort, this study found that patients with obesity-associated sleep hypoventilation have a higher risk of adverse outcomes after bariatric surgery.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Article
Endocrinology & Metabolism
Cyrus Desouza, Ranee Chatterjee, Ellen M. Vickery, Jason Nelson, Karen C. Johnson, Sangeeta R. Kashyap, Michael R. Lewis, Karen Margolis, Richard Pratley, Neda Rasouli, Patricia R. Sheehan, Anastassios G. Pittas
Summary: The study investigated the effects of vitamin D supplementation on cardiovascular outcomes in adults with prediabetes, finding that it did not reduce Major Adverse Cardiovascular Events (MACE) but did have a small favorable effect on ASCVD risk score.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2022)
Article
Medicine, Research & Experimental
Karim Kheniser, Ali Aminian, Sangeeta R. Kashyap
Summary: The assessment and management of patient-reported outcomes (PROs) is considered secondary to that of cardiometabolic outcomes. Health-related quality of life (HRQOL), a PRO, can provide information that can't be obtained from cardiometabolic assessments, such as quantifying and treating physical and mental distress, as well as evaluating treatment convenience and satisfaction.
METABOLIC SYNDROME AND RELATED DISORDERS
(2022)
Article
Endocrinology & Metabolism
Prabodh Sadana, Melissa Edler, Mirjavid Aghayev, Andrea Arias-Alvarado, Emilie Cohn, Serguei Ilchenko, Helen Piontkivska, Jagan A. Pillai, Sangeeta Kashyap, Takhar Kasumov
Summary: This study investigates the impact of gradual hyperglycemia during the progression of diabetes on HDL-associated protein dynamics in prediabetic and diabetic mice. The findings show that the fractional synthesis rate of HDL-associated proteins increases in prediabetic mice and decreases in diabetic mice compared to control mice. These kinetic changes provide insights into the mechanism of altered protein levels and HDL dysfunction during diabetes progression.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Endocrinology & Metabolism
Anira Iqbal, Zehra Tekin, Michael W. Kattan, Xinge Ji, Alex Milinovich, Kevin M. Pantalone, Robert S. Zimmerman, Mina K. Chung, Sangeeta Kashyap
Summary: Initiation of metformin as a first line monotherapy for T2D is not associated with a decreased risk of developing AF.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2022)
Article
Endocrinology & Metabolism
Michelle D. Lundholm, James Bena, Keren Zhou, Yumiko Tsushima, Sangeeta R. Kashyap
Summary: This study aimed to investigate the prevalence and clinical risk factors for non-alcoholic fatty liver disease (NAFLD) in type 1 diabetes (T1DM) using liver scores. The results showed that liver steatosis was common in adults with T1DM with obesity and/or metabolic syndrome, and was associated with older age, hypertension, and dyslipidemia. However, the diagnosis and treatment of NAFLD were still inadequate.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2023)
Editorial Material
Endocrinology & Metabolism
Gwendolyne Anyanate Jack, Sangeeta R. Kashyap
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Karen D. Corbin, Anastassios G. Pittas, Cyrus Desouza, Kristine K. Grdinovac, Karl-Heinz Herzig, Sangeeta R. Kashyap, Sun H. Kim, Jason Nelson, Neda Rasouli, Ellen M. Vickery, William C. Knowler, Richard E. Pratley
Summary: NAFLD is common in individuals at high risk for developing T2D and is associated with worse glycemic control. Routine screening for NAFLD using non-invasive scores may help reduce the burden of T2D and identify individuals who require further follow up to assess liver health.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2023)
Article
Clinical Neurology
Jagan A. Pillai, James Bena, Lynn Bekris, Nandan Kodur, Takhar B. Kasumov, James B. R. Leverenz, Sangeeta R. Kashyap
Summary: The relationship between biomarkers of metabolic syndrome and cognitive decline in individuals with mild cognitive impairment (MCI) and dementia stages of Alzheimer's disease (AD) was investigated. Elevated plasma triglyceride/HDL cholesterol (TG/HDL-C) ratio and plasma Apolipoprotein A1 (ApoA1) levels were associated with worse cognitive outcomes in MCI and dementia participants. However, CSF ApoA1 levels were found to relate to slower cognitive decline in MCI.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Sangeeta R. Kashyap, Cyrus Desouza, Vanita R. Aroda, Sun H. Kim, Lisa M. Neff, Shannon S. Wu, Philip Raskin, Richard Pratley
Summary: This study analyzed the association between glycemic and metabolic sub-classifications of prediabetes and cardiovascular disease (CVD) risk, finding that multiple glycemic and metabolic criteria are needed to fully recognize the elevated CVD risk profile in prediabetes.
AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
