Article
Radiology, Nuclear Medicine & Medical Imaging
David Morland, Pascaline Jallerat, Hedia Brixi, Guillaume Cadiot, Dimitri Papathanassiou, Sophie Deguelte
Summary: This study evaluated the performance of F-18-FDOPA PET/CT in predicting the surgical peritoneal cancer index for patients with small intestine NET. The results indicated that F-18-FDOPA PET/CT showed good performance in predicting the surgical peritoneal cancer index, which could help optimize surgical procedures and patient selection.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Oncology
Tobias Hofving, Erik Elias, Anna Rehammar, Linda Inge, Gulay Altiparmak, Marta Persson, Erik Kristiansson, Martin E. Johansson, Ola Nilsson, Yvonne Arvidsson
Summary: Patients with small intestinal neuroendocrine tumors (SINETs) often have lymph node and liver metastases at diagnosis, with hemizygous loss of chromosome 18q and the SMAD4 gene being the most common genetic event. Reduced SMAD4 protein expression in primary tumors is associated with a higher likelihood of metastatic disease. Functional consequences of reduced SMAD4 protein levels may play a role in the clonal selection of these genetic aberrations in SINETs.
Article
Endocrinology & Metabolism
Maria J. Klomp, Julie Refardt, Peter M. van Koetsveld, Claudia Campana, Simone U. Dalm, Fadime Dogan, Marie-Louise F. van Velthuysen, Richard A. Feelders, Wouter W. de Herder, Johannes Hofland, Leo J. Hofland
Summary: This study found that DNA methylation and histone modifications are associated with SST2 expression in SI-NETs. DNA methylation levels and H3K27me3 levels were lower in SI-NETs compared to normal tissue, and there was a negative correlation between SST2 mRNA expression level and DNA methylation. However, the role of histone modifications in SI-NETs remains unclear.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Clare Vesely, Yien Ning Sophia Wong, Alexa Childs, Ayse U. Akarca, Pawan Dhami, Heli Vaikkinen, Lucia Conde, Javier Herrero, Olagunju Ogunbiyi, Amir Gander, Tu Vinh Luong, Chrissie Thirlwell, Martyn Caplin, Christos Toumpanakis, Karl Peggs, Sergio A. Quezada, Teresa Marafiot, Tim Meyer
Summary: This study investigated the immune checkpoint landscape and immune cell infiltration in small intestinal neuroendocrine tumors (siNETs). The results showed that siNETs have low tumor mutational burden and a combination therapy approach is needed to enhance the immune response.
CLINICAL CANCER RESEARCH
(2022)
Article
Medicine, General & Internal
Christine Koch, Cornelia Bambey, Natalie Filmann, Marc Stanke, Oliver Waidmann, Gabriele Husmann, Joerg Bojunga
Summary: This study analyzed data from 145 patients with small intestine neuroendocrine tumors and found that multimodal therapy did not significantly improve survival for stage IV patients compared to treatment with somatostatin analogues alone (SSA). Resection of the primary tumor significantly improved survival.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Amram Kupietzky, Roi Dover, Haggi Mazeh
Summary: Small intestinal neuroendocrine tumors (NETs) are a common type of epithelial tumors with neuroendocrine differentiation. They have been increasing in prevalence worldwide and often present with synchronous metastases due to delayed diagnosis. Primary tumor resection is the only curative option for small intestinal NETs. This review article discusses various surgical aspects for excising these tumors.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Mervi Aavikko, Eevi Kaasinen, Noora Andersson, Nalle Pentinmikko, Paivi Sulo, Iikki Donner, Paivi Pihlajamaa, Anna Kuosmanen, Simona Bramante, Riku Katainen, Lauri J. Sipila, Samantha Martin, Johanna Arola, Olli Carpen, Ilkka Heiskanen, Jukka-Pekka Mecklin, Jussi Taipale, Ari Ristimaki, Kaisa Lehti, Erika Gucciardo, Pekka Katajisto, Camilla Schalin-Jantti, Pia Vahteristo, Lauri A. Aaltonen
Summary: This study identified a novel genetic susceptibility associated with intestinal tumors in a family, with a heterozygous deletion at the cystic fibrosis locus perfectly segregating with the predisposition. Multiple molecular methods were used to understand the mechanism, revealing the tumorigenic effects of aberrant WNT activation in the human intestine.
HUMAN MOLECULAR GENETICS
(2021)
Article
Oncology
Anela Blazevic, Anand M. Iyer, Marie-Louise F. van Velthuysen, Johannes Hofland, Gaston J. H. Franssen, Richard A. Feelders, Marina Zajec, Theo M. Luider, Wouter W. de Herder, Leo J. Hofland
Summary: Mesenteric metastases in small intestinal neuroendocrine tumors (SI-NETs) are associated with mesenteric fibrosis (MF). Proteomics-based analysis found differential protein abundance primarily in the stromal compartment of mesenteric metastases of SI-NET patients with MF. The differentially abundant proteins included collagen and proteoglycans associated with profibrotic extracellular matrix dysregulation and signaling pathways. COL12A1 and C9 were confirmed to have significantly higher expression in MF mesenteric metastases. This study provides insights into new signaling pathways involved in MF development.
ENDOCRINE-RELATED CANCER
(2023)
Review
Endocrinology & Metabolism
James Y. Lim, Rodney F. Pommier
Summary: Small bowel neuroendocrine tumors are rare, with challenges in early detection, but genetic predisposition plays a significant role in familial cases. Screening for familial small bowel neuroendocrine tumors can lead to earlier diagnosis and improved patient outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Anna Bryan Stensbol, Jesper Krogh, Pernille Holmager, Marianne Klose, Peter Oturai, Andreas Kjaer, Carsten Palnaes Hansen, Birgitte Federspiel, Seppo W. Langer, Ulrich Knigge, Mikkel Andreassen
Summary: The incidence of siNET and pNETs has increased over the past decade. There has been an increase in incidentally discovered pNET cases, and 44% of incidentally discovered siNET patients had disseminated disease.
Article
Endocrinology & Metabolism
Anela Blazevic, Anand M. Iyer, Marie-Louise F. Van Velthuysen, Johannes Hofland, Lindsey Oudijk, Wouter W. de Herder, Leo J. Hofland, Richard A. Feelders
Summary: Small-intestinal neuroendocrine tumors (SI-NETs) have a higher prevalence and worse prognosis in male patients. This study found that mesenteric metastasis and fibrosis were more common in men than women. The risk of mesenteric metastasis in women increased around menopause. The expression of estrogen receptor alpha and androgen receptor was observed in primary tumors and mesenteric metastases.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Stine Karlsen Oversoe, Boe Sandahl Sorensen, Elizaveta Mitkina Tabaksblat, Henning Gronbaek, Jens Kelsen
Summary: The study found that cfDNA levels are higher in NET patients compared to healthy controls but are not associated with prognosis, and are not affected by PRRT. In contrast to other malignancies, cfDNA levels do not correlate with the disease course in low-grade NET.
NEUROENDOCRINOLOGY
(2022)
Review
Oncology
Darren R. Carpizo, Chris R. Harris
Summary: Ileal neuroendocrine tumors have been difficult to study due to their genetic uniqueness, with a lack of recurrently mutated genes. Recent advancements, including the discovery of IGF2 and CDK4 as genetic drivers, may lead to new treatment options for patients.
Article
Genetics & Heredity
Jianxian Chen, Yiliang Meng, Xiaojuan Huang, Xuegan Liao, Xiaochun Tang, Yuanchao Xu, Jie Li
Summary: This study aimed to find effective diagnostic biomarkers for patients with primary and metastatic small intestinal neuroendocrine tumors (SI-NETs) that could be applied for clinical diagnosis. Through differential gene expression analysis, a set of genes and long non-coding RNAs related to SI-NETs were obtained. Enrichment analysis revealed that these genes were mainly involved in cancer-related biological processes and pathways. A global regulatory network involving dysregulated genes was constructed and key genes were identified. These key genes were upregulated in patients with primary SI-NETs and had strong diagnostic power in both the training and test sets according to ROC analysis.
FRONTIERS IN GENETICS
(2023)
Article
Oncology
Anela Blazevic, Martijn P. A. Starmans, Tessa Brabander, Roy S. Dwarkasing, Renza A. H. van Gils, Johannes Hofland, Gaston J. H. Franssen, Richard A. Feelders, Wiro J. Niessen, Stefan Klein, Wouter W. de Herder
Summary: By combining CT scans with clinical criteria and radiomics, it is possible to identify the risk of intestinal complications in patients with small intestinal neuroendocrine tumors. Both clinicians and radiomics models showed similar performance in predicting complications, but with poor inter-observer agreement among clinicians.
ENDOCRINE-RELATED CANCER
(2021)
Article
Oncology
Achyut Ram Vyakaranam, Joakim Crona, Olov Norlen, Per Hellman, Anders Sundin
Article
Oncology
Achyut Ram Vyakaranam, Joakim Crona, Olov Norlen, Dan Granberg, Ulrike Garske-Roman, Mattias Sandstrom, Katarzyna Fross-Baron, Espen Thiis-Evensen, Per Hellman, Anders Sundin
Article
Endocrinology & Metabolism
Samuel Backman, Duska Bajic, Joakim Crona, Per Hellman, Britt Skogseid, Peter Stalberg
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Johan Botling, Angela Lamarca, Duska Bajic, Olov Norlen, Vincent Lonngren, Josefine Kjaer, Barbro Eriksson, Staffan Welin, Per Hellman, Guido Rindi, Britt Skogseid, Joakim Crona
NEUROENDOCRINOLOGY
(2020)
Article
Surgery
J. Eriksson, O. Norlen, M. Ogren, H. Garmo, C. Ihre-Lundgren, P. Hellman
Summary: The average annual incidence of small intestinal neuroendocrine tumors is 5.33 per 100,000 individuals, with an average annual prevalence of 581 per 100,000. Most patients with small intestinal neuroendocrine tumors ultimately die from other causes, and 48% of patients also have at least one other malignancy. Multiple primary tumors are common, suggesting that they may arise before metastatic disease, and there is a high rate of associated colorectal carcinoma.
SCANDINAVIAN JOURNAL OF SURGERY
(2021)
Article
Surgery
Fredrik Sellgren, Anna Koman, Erik Nordenstrom, Per Hellman, Joakim Hennings, Andreas Muth
WORLD JOURNAL OF SURGERY
(2020)
Article
Biochemistry & Molecular Biology
Karin Saljo, Anders Thornell, Chunsheng Jin, Peter Stalberg, Olov Norlen, Susann Teneberg
Summary: The glycosphingolipid patterns of the human parathyroid and thyroid glands were very similar, with the major acid glycosphingolipids being sulfatide and gangliosides. Complex glycosphingolipids with terminal blood group determinants were found in both tissues. The glycosylation of human thyroid and parathyroid glands is more complex than previously appreciated, providing a platform for further studies of alterations in cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Surgery
Matilda Anneback, Edward McHale Sjodin, Per Hellman, Peter Stalberg, Olov Norlen
Summary: This retrospective cohort study investigated the potential benefit of preoperative active vitamin D supplementation on hypocalcaemia and its symptoms after thyroidectomy. The study found that preoperative alfacalcidol treatment was associated with reduced biochemical hypocalcaemia and duration of hospital stay.
Article
Endocrinology & Metabolism
Katarina Edfeldt, Per Hellman, Dan Granberg, Pernilla Lagergren, Espen Thiis-Evensen, Anders Sundin, Camilla Andersson
Summary: This study aimed to assess the impact of PRRT on patient's HRQoL. The results showed that HRQoL improved in aspects of global quality of life, functioning, and symptom relief during PRRT. Older and overweight patients may have worse HRQoL during PRRT.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Meeting Abstract
Endocrinology & Metabolism
A. R. Vyakaranam, J. Crona, E. Thiis-Evensen, P. Hellman, O. Norlen, D. Granberg, U. Garske-Roman, K. Fross-Baron, M. Sandstrom, A. Sundin
NEUROENDOCRINOLOGY
(2020)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
A. Vyakaranam, J. Crona, E. Thiis-Evensen, P. Hellman, O. Norlen, D. Granberg, U. Garske-Roman, K. Fross-Baron, M. Sandstrom, A. Sundin
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2019)
Meeting Abstract
Oncology
J. Botling, A. Lamarca, D. Bajic, O. Norlen, V. Lonngren, J. Kjaer, B. Eriksson, S. Welin, P. Hellman, G. Rindi, B. Skogseid, J. Crona
ANNALS OF ONCOLOGY
(2019)
Meeting Abstract
Biochemical Research Methods
Mahabuba Jahan, Isabella Silins, Per Hellman, Anders Sundin, Morris Brown, Mark Gurnell, Franklin Aigbirhio, Patrik Nordeman, Gunnar Antoni
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2019)
Meeting Abstract
Endocrinology & Metabolism
A. Sundin, A. R. Vyakaranam, J. Crona, P. Hellman
NEUROENDOCRINOLOGY
(2019)
Meeting Abstract
Endocrinology & Metabolism
J. Botling, A. Lamarca, D. Bajic, O. Norlen, V Lonngren, B. Eriksson, S. Welin, P. Hellman, G. Rindi, B. Skogseid, J. Crona
NEUROENDOCRINOLOGY
(2019)
