Article
Gastroenterology & Hepatology
Adel Hammoutene, Marion Tanguy, Melanie Calmels, Riccardo Pravisani, Miguel Albuquerque, Christophe Casteleyn, Lotfi Slimani, Jeremy Sadoine, Chantal M. Boulanger, Valerie Paradis, Helene Gilgenkrantz, Pierre-Emmanuel Rautou
Summary: Patients with non-alcoholic fatty liver disease (NAFLD) have impaired liver regeneration due to a defect in autophagy of liver endothelial cells. This study aimed to determine the role of endothelial autophagy in liver regeneration following liver resection in NAFLD.
LIVER INTERNATIONAL
(2023)
Review
Biotechnology & Applied Microbiology
Yi Wu, Ning Li, Xinyu Shu, Wang Li, Xiaoyu Zhang, Dongyuan Lu, Mian Long
Summary: The liver is a complex organ with vital functions and regenerative capacity after tissue injury. Mechanical cues play a significant role in liver regeneration, including changes in hemodynamics and mechanical forces within the liver. Understanding the mechanotransductive pathways and mechanocrine responses can contribute to a comprehensive understanding of liver regeneration. Proper adjustment of mechanical loading may serve as an effective therapy for liver injury and diseases.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Cell Biology
Yuan-E Lian, Yan-Nan Bai, Jian-Lin Lai, Ai-Min Huang
Summary: The study found that aberrant autophagy in fibrotic liver leads to impaired liver regeneration. Enhancement of autophagy improves hepatocyte proliferative capacity and restricts cellular hypertrophy and binuclearity ratio.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Saisai Wei, Qiang Zheng, Yu Pan, Yunwan Xu, Jiacheng Tang, Xiujun Cai
Summary: The study revealed that liver regeneration leads to reprogramming of gene expression profiles, while core clock genes' rhythm remains stable. Performing partial hepatectomy in the evening may result in retarded liver regeneration due to the accumulation of DEC1.
Article
Cell Biology
Lais A. de Paula Simino, Marina Figueiredo Fontana, Thais de Fante, Carolina Panzarin, Leticia Martins Ignacio-Souza, Marciane Milanski, Marcio Alberto Torsoni, Mina Desai, Michael G. Ross, Adriana Souza Torsoni
Summary: Obesity during pregnancy increases the risk of non-alcoholic fatty liver disease in offspring. However, the offspring of obese dams are able to overcome epigenetic changes and regenerate liver tissue after partial hepatectomy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Runbin Sun, Haokai Zhao, Shuzhen Huang, Ran Zhang, Zhenyao Lu, Sijia Li, Guangji Wang, Jiye Aa, Yuan Xie
Summary: The study investigated the dynamic metabolic changes during liver regeneration in mice using a metabolomic approach and regression analysis with different machine learning methods. The random forest method showed the best performance in predicting liver index, with several amino acid metabolic pathways and glucose metabolism pathway being the most influenced during liver regeneration.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Genis Camprecios, Aina Anton, Anna Oncins, Carla Montironi, Maria Ruart, Rosa Montanes, Hector Garcia-Caldero, Joan Carles Garcia-Pagan, Virginia Hernandez-Gea
Summary: Liver sinusoidal endothelial cells (LSEC) are key elements in regulating the liver response to injury and regeneration. Endothelial autophagy plays a crucial role in protecting cells from injury-induced oxidative stress and fibrosis. However, this study found that endothelial autophagy is not essential for liver regeneration after partial hepatectomy (PHx).
LIVER INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Hong Liu, Anqi Zhou, Zhiwen Fan, Xi Zhu, Xiulian Miao
Summary: This study investigated the role of ubiquitin-specific peptidase 47 (USP47) in liver regeneration. The results showed that USP47 expression was up-regulated in hepatocytes isolated from mice subjected to partial hepatectomy or exposed to HGF treatment. E2F1 was identified as the primary regulator of USP47 transcription. USP47 was found to play an essential role in liver regeneration, as its inhibition impaired liver regeneration in mice and its over-expression enhanced hepatocyte proliferation in vitro and promoted liver regeneration in mice. A positive correlation between USP47 expression and hepatocyte proliferation was also observed in patients with acute liver failure.
Article
Food Science & Technology
Qinhui Liu, Qin Tang, Xinchun Liu, Min Tian, Xiandan Jing, Zongyun Feng, Xuping Yang
Summary: Studies have demonstrated the positive effect of highland barley ss-glucan (HBBG) on various liver diseases, including acute liver injury and liver regeneration. In this study, the researchers investigated the beneficial impact of HBBG on liver regeneration following partial hepatectomy (PH) using mouse models. They found that HBBG promoted hepatocyte proliferation and liver regeneration after PH by activating the STAT3-CyclinD1 signaling pathway. Furthermore, the intervention of HBBG decreased hepatocyte apoptosis in a liver injury model induced by CCl4.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Anatomy & Morphology
Ayaka Ohashi, Nanami Saito, Rena Kashimoto, Saya Furukawa, Sakiya Yamamoto, Akira Satoh
Summary: Axolotls have remarkable organ-level regeneration capability, and their liver regeneration mechanism is unique compared to other vertebrates.
DEVELOPMENTAL DYNAMICS
(2021)
Article
Oncology
Susu Wei, Zhichao Li, Qiangqiang Shi, Xiaoyu Luan, Xinying Yuan, Yaxin Li, Chuanlong Guo, Xianggen Wu, Chunying Shi, Guohu Di
Summary: This study investigated the therapeutic effect of CBD-VEGF on liver regeneration using a mouse model of partial hepatectomy. The results demonstrated that CBD-VEGF promoted sinusoidal regeneration and remodeling in the remnant liver tissue, enhanced hepatocyte proliferation, and attenuated liver injury, suggesting its potential as a therapeutic strategy for liver regeneration.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Genetics & Heredity
Jian Zhao, Shi-Zhe Yu, Qiang Cai, Duo Ma, Long Jiang, Ling-Peng Yang, Zhi-Yong Yu
Summary: Key genes involved in cell cycle, DNA replication, and p53 signaling pathway were identified in the early stage of liver regeneration in mice after partial hepatectomy (PH). Ube2c was found to play a crucial role in regulating hepatocyte proliferation by modulating genes such as Ccna2, Cdkn1a, Chek1, and Mcm5.
FRONTIERS IN GENETICS
(2021)
Article
Cell Biology
Mengjuan Wei, Xinnan Gu, Han Li, Zhiyong Zheng, Zhimiao Qiu, Yuchen Sheng, Bin Lu, Zhengtao Wang, Lili Ji
Summary: This study investigates the role of EGR1 and CGA in liver repair and regeneration after APAP-induced hepatotoxicity. The results show that EGR1 deficiency aggravates liver injury and delays regeneration, while CGA promotes liver regeneration and repair by inducing EGR1 transcriptional activation.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Biochemical Research Methods
Jing Wu, He Liu, Haiquan Wang, Yuqi Wang, Qi Cheng, Ruochen Zhao, Hongliang Gao, Lei Fang, Feng Zhu, Bin Xue
Summary: In this study, we used iTRAQ-based proteomic analysis to study the key regulatory factors in the termination phase of liver regeneration (LR). The findings provide a foundation for further research on the molecular mechanism and biomarkers of the termination phase of LR, and can guide the perioperative management of patients after hepatectomy.
JOURNAL OF PROTEOMICS
(2022)
Review
Biochemistry & Molecular Biology
Maxime De Rudder, Alexandra Dili, Peter Staerkel, Isabelle A. Leclercq
Summary: Liver sinusoidal endothelial cells (LSEC) play unique roles in liver sinusoids and liver regeneration, but there are still many unanswered questions about their specific functions and interactions with other liver cells during different phases. Understanding the complex relationship between LSEC and liver regeneration is crucial for developing strategies to prevent small for size syndrome after extended hepatectomy or small liver transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)