Article
Medicine, General & Internal
S. Dhanani, L. Hornby, A. van Beinum, N. B. Scales, M. Hogue, A. Baker, S. Beed, J. G. Boyd, J. A. Chandler, M. Chasse, F. D'Aragon, C. Dezfulian, C. J. Doig, F. Duska, J. O. Friedrich, D. Gardiner, T. Gofton, D. Harvey, C. Herry, G. Isac, A. H. Kramer, D. J. Kutsogiannis, D. M. Maslove, M. Meade, S. Mehta, L. Munshi, L. Norton, G. Pagliarello, T. Ramsay, K. Rusinova, D. Scales, M. Schmidt, A. Seely, J. Shahin, M. Slessarev, D. So, H. Talbot, W. N. K. A. van Mook, P. Waldauf, M. Weiss, J. T. Wind, S. D. Shemie
Summary: This study investigated the timing of resumption of cardiac activity in patients after planned withdrawal of life-sustaining measures. It found that 14% of patients experienced transient resumption of cardiac activity after pulselessness, with only 1% of resumptions being identified at the bedside. These events occurred within 4 minutes 20 seconds after a period of pulselessness.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Robert Qaqish, Yui Watanabe, Konrad Hoetzenecker, Jon Yeung, Manyin Chen, Andrew Pierre, Kazuhiro Yasufuku, Laura Donahoe, Marc de Perrot, Tom Waddell, Shaf Keshavjee, Marcelo Cypel
Summary: Short- and long-term outcomes are similar between recipients of lungs from donation after neurologic determination of death and donation after circulatory determination of death. Different intervals between withdrawal of life-sustaining therapies and cardiac arrest did not impact recipient outcomes, and the maximum acceptable duration of this interval remains to be established.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Clinical Neurology
Marcelo Matiello, Ashby C. Turner, Juan Estrada, Cynthia M. Whitney, Barrett T. Kitch, Patrick T. Lee, Uma Girkar, Rafael Palacios, Pooja Singla, Lee Schwamm
Summary: The study showed that conducting TN consultations for patients with severe neurologic damage and allowing expert supervision for DNC examination is feasible. Having a teleneurologist as part of the ICU assessment team helped differentiate severe neurologic deficits from DNC and was associated with an increase in organ donation.
Article
Surgery
Silvia Sanchez-Camara, Mari C. Asensio-Lopez, Mario Royo-Villanova, Fernando Soler, Ruben Jara-Rubio, Jose Francisco Garrido-Penalver, Eduardo Pinar, Alvaro Hernandez-Vicente, Jose Antonio Hurtado, Antonio Lax, Domingo A. Pascual-Figal
Summary: This study aims to determine the critical warm ischemia time based on in vivo biochemical changes. The findings suggest that there is a significant compromise in cellular function and viability 10 minutes after circulatory arrest, which is important for incorporating DCD into heart transplant programs.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Gastroenterology & Hepatology
Chia-En Hsieh, Ya-Lan Hsu, Yao-Li Chen, Hsin-Rou Liang, Kuo-Hua Lin, Wen-Yuan Chen, Hsiu-Man Wu, Sin-Bao Hunang, Yu-Ju Hung
Summary: This retrospective study analyzed 90 cases of deceased donor liver transplantation conducted in a single center from 2006 to 2019. The use of ECMO in donations after cardiac death or brain death showed significant differences in some indicators compared to donations after brain death, but there was no significant difference in survival rates.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Deane E. Smith, Zachary N. Kon, Julius A. Carillo, Stacey Chen, Claudia G. Gidea, Greta L. Piper, Alex Reyentovich, Robert A. Montgomery, Aubrey C. Galloway, Nader Moazami
Summary: The feasibility of a donation after circulatory death (DCD) heart transplantation protocol using cardiopulmonary bypass (CPB) for normothermic regional reperfusion (NRP) was evaluated in this pilot study. The study showed excellent outcomes of DCD heart transplantation, indicating the potential for wider adoption of the DCD protocol and increased availability of donor hearts in the United States.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Oncology
Yuling Yang, Xinnan Xu, Ming Liu, Yanfeng Zhao, Yongmei Yu, Xiaogang Liu, Chang Chen, Gening Jiang, Wenxin He
Summary: Voluntary contribution has been the sole source of donor lungs in China since 2015. A retrospective study of 205 patients awaiting lung transplantation (LTx) revealed that interstitial lung disease (ILD) and chronic obstructive pulmonary disease (COPD) were the most common diseases. ILD patients had a higher mortality rate than COPD patients while awaiting LTx. Shorter waiting time and higher mean pulmonary artery pressure (mPAP) were independent risk factors for waitlist mortality. LTx is more urgently needed in patients with ILD and pulmonary hypertension.
FRONTIERS OF MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Shivank Madan, Omar Saeed, Stephen J. Forest, Daniel J. Goldstein, Ulrich P. Jorde, Snehal R. Patel
Summary: This study provides a preliminary analysis of adult donation after circulatory death heart transplantations (DCD-HTs) in the United States, showing favorable early outcomes and suggesting the potential for a substantial increase in adult heart transplant volumes with the use of DCD donors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Stefano Mastrobuoni, Manuel Johanns, Martial Vergauwen, Gwen Beaurin, Mark Rider, Pierre Gianello, Alain Poncelet, Olivier Van Caenegem
Summary: Transplantation of heart following donation after circulatory death (DCD) has been introduced into clinical practice. In a porcine model of DCD heart, we tested the effect of different temperatures on cardiac metabolism during ex vivo reperfusion. We observed a steep fall in ATP concentrations at the end of warm ischemic time, limited regeneration during reperfusion, and an increase in lactate concentration. However, the temperature did not have an effect on ATP or lactate concentration. Additionally, all cardiac allografts experienced significant weight increase due to cardiac edema, regardless of the temperature.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Henry Aceros, Shant Der Sarkissian, Melanie Borie, Roberto Vanin Pinto Ribeiro, Simon Maltais, Louis-Mathieu Stevens, Nicolas Noiseux
Summary: This study investigates the use of a HSP90 inhibitor as a cardioprotective agent in DCD hearts, showing promising results in preserving ventricular function and reducing ischemic injury. These findings suggest that HSP90i could potentially expand the use of DCD hearts and improve organ availability for transplantation.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Jordan R. H. Hoffman, William G. McMaster, Aniket S. Rali, Zakiur Rahaman, Keki Balsara, Tarek Absi, Melissa Levack, Marshall Brinkley, Jonathan Menachem, Lynn Punnoose, Suzanne Sacks, Mark Wigger, Sandip Zalawadiya, Lynne Stevenson, Kelly Schlendorf, JoAnn Lindenfeld, Ashish S. Shah
Summary: This study conducted heart transplantations using DCD allografts, extending cold ischemic time with TA-NRP and cold static storage, which improved the feasibility and success rate of heart transplantation.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Surgery
Tatsuaki Watanabe, Mitsuaki Kawashima, Mikihiro Kohno, Jonathan Yeung, James Downar, Andrew Healey, Tereza Martinu, Meghan Aversa, Laura Donahoe, Andrew Pierre, Marc de Perrot, Kazuhiro Yasufuku, Thomas K. Waddell, Shaf Keshavjee, Marcelo Cypel
Summary: This study compared lung transplantation outcomes using medical assisting in dying (MAID) donors and neurologically determined death and controlled donation after circulatory death (NDD/cDCD) donors. The results showed excellent recipient outcomes for lung transplantation using MAID donors, with similar intermediate-term outcomes compared to other types of donors. Therefore, donation after MAID should be strongly considered for lung transplantation where permitted.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Alice L. Zhou, Jessica M. Ruck, Alfred J. Casillan, Emily L. Larson, Benjamin L. Shou, Alexander K. Karius, Jinny S. Ha, Pali D. Shah, Christian A. Merlo, Errol L. Bush
Summary: Thoracoabdominal normothermic regional perfusion (TA-NRP) is a method used in the United States to recover cardiothoracic allografts from donors after circulatory death (DCD). Limited data on lung transplants using TA-NRP has prompted a national retrospective review. The study found that recipients of TA-NRP DCD transplants had a lower likelihood of prolonged ventilation and similar outcomes to direct recovery DCD transplants.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Immunology
Thibaut Benoit, Thomas Prudhomme, Aurelien Adypagavane, Bernard Malavaud, Michel Soulie, Xavier Game, Nassim Kamar, Charles Dariane, Christophe Legendre, Arnaud Mejean, Mathieu Roumiguie, Marc Olivier Timsit
Summary: This study externally validated a predictive model for estimating postoperative eGFR in living kidney donors, demonstrating good accuracy and potential for improving the selection of kidney donor candidates.
Article
Multidisciplinary Sciences
Nicolas Sauthier, Rima Bouchakri, Francois Martin Carrier, Michael Sauthier, Louis-Antoine Mullie, Heloise Cardinal, Marie-Chantal Fortin, Nadia Lahrichi, Michael Chasse
Summary: Organ donation cannot meet the demand, and a large percentage of potential donors are not identified. We developed an automated screening system based on machine learning to reduce missed eligible organ donors. The neural network model we developed showed high accuracy and stability in identifying potential organ donors.
SCIENTIFIC REPORTS
(2023)