Article
Agriculture, Dairy & Animal Science
Qingqing Deng, Yirui Shao, Qiye Wang, Jianzhong Li, Yali Li, Xueqin Ding, Pengfei Huang, Jia Yin, Huansheng Yang, Yulong Yin
Summary: The study found that the 250 mEq/kg dietary electrolyte balance (dEB) diet with citric acid (CA) improved piglet intestinal morphology and digestive enzyme activities, enhancing intestinal digestion and absorption function. Similar improvements were also observed in piglets fed the 100 mEq/kg dEB diet without CA.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Marcus Fulde, Kira van Vorst, Kaiyi Zhang, Alexander J. Westermann, Tobias Busche, Yong Chiun Huei, Katharina Welitschanski, Isabell Froh, Dennis Paegelow, Johanna Plendl, Christiane Pfarrer, Jorn Kalinowski, Jorg Vogel, Peter Valentin-Weigand, Michael Hensel, Karsten Tedin, Urska Repnik, Mathias W. Hornef
Summary: The study suggests that SPI2 T3SS effector molecules contribute to the apical to basolateral transmigration of Salmonella-containing vacuoles during the early stage of infection in the intestinal epithelium. Contrary to expectations, infection with SPI2 T3SS mutants results in significantly enlarged intraepithelial Salmonella-containing vacuoles with altered cellular positioning.
Article
Chemistry, Physical
Zhixiong Deng, Bing Yuan, Kai Yang
Summary: This study used molecular dynamics simulations to uncover the key role of interfacial cardiolipin in regulating the functional dimerization of the membrane protein VsSemi-SWEET. The research identified four binding sites for cardiolipins and observed two types of dimerization modes during the assembly process. The findings provide valuable information on the relationship between lipid binding and functional dimerization, contributing to a better understanding of the molecular mechanism of sugar transporter biological function.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Immunology
Yan-hua Wang
Summary: Bacterial translocation can lead to multiple organ dysfunction syndrome, and ensuring the integrity of the intestinal mucosal barrier is crucial for prevention. Early diagnosis, intervention, or prevention of bacterial translocation may be a new avenue in the treatment of various diseases. Elimination of the primary disease, maintaining blood and oxygen supply to the intestine, and selective digestive decontamination are key in treatment.
MICROBIAL PATHOGENESIS
(2021)
Article
Biochemistry & Molecular Biology
Markus M. Rinschen, Jennifer L. Harder, Madalina E. Carter-Timofte, Luis Zanon Rodriguez, Carmen Mirabelli, Fatih Demir, Naziia Kurmasheva, Suresh K. Ramakrishnan, Madlen Kunke, Yifan Tan, Anja Billing, Eileen Dahlke, Alexey A. Larionov, Wibke Bechtel-Walz, Ute Aukschun, Marlen Grabbe, Rikke Nielsen, Erik I. Christensen, Matthias Kretzler, Tobias B. Huber, Christiane E. Wobus, David Olagnier, Gary Siuzdak, Florian Grahammer, Franziska Theilig
Summary: This study reveals that lipid kinase VPS34 plays important roles in controlling metabolism, endocytosis, autophagy, and antiviral responses in proximal tubule cells in the kidney. The deficiency of VPS34 leads to alterations in the metabolome, membrane recycling, and fuel utilization, as well as an antiviral response. The findings provide insights into the function of VPS34 in kidney cells and its potential implications in diseases such as cancer and metabolic disorders.
Article
Multidisciplinary Sciences
Ratjika Wongwanakul, Sasitorn Aueviriyavit, Tomomi Furihata, Pattarapond Gonil, Warayuth Sajomsang, Rawiwan Maniratanachote, Suree Jianmongkol
Summary: The potential use of a quaternized chitosan (MW 600 kDa) with 65% of 3-chloro-2-hydroxypropyltrimethylammonium (600-HPTChC(65)) as an absorptive enhancer was investigated in Caco-2 monolayers. The results showed that 600-HPTChC(65) could enhance drug absorption through tight junction opening and decreased P-gp function. Its interaction with the absorptive barrier mainly resulted in disrupting ZO-1 and occludin organization as well as changing in P-gp conformation.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Volodymyr Radchuk, Zeinu M. Belew, Andre Guendel, Simon Mayer, Alexander Hilo, Goetz Hensel, Rajiv Sharma, Kerstin Neumann, Stefan Ortleb, Steffen Wagner, Aleksandra Muszynska, Christoph Crocoll, Deyang Xu, Iris Hoffie, Jochen Kumlehn, Joerg Fuchs, Fritz F. Peleke, Jedrzej J. Szymanski, Hardy Rolletschek, Hussam H. Nour-Eldin, Ljudmilla Borisjuk
Summary: This study focuses on the functionality of the SWEET family of barley and reveals the crucial role of HvSWEET11b in the distribution of sugars and cytokinins during grain development. Knocking down HvSWEET11b leads to impaired grain development, disrupted sugar and cytokinin distribution, and changes in grain size, starch content, and protein content. The findings highlight the important regulatory role of HvSWEET11b in barley grain filling.
Article
Medicine, General & Internal
Emre Sahin, Cemal Orhan, Fusun Erten, Fikrettin Sahin, Nurhan Sahin, Kazim Sahin
Summary: This study aimed to investigate the effects of different boron derivatives on nutrient digestibility, intestinal nutrient transporters, and lipid metabolism in rats. The results showed that supplementation of boric acid and sodium pentaborate pentahydrate improved nutrient digestibility, increased the expression levels of intestinal glucose transporters and fatty acid transport proteins, and modulated liver lipid metabolism. These findings are important for promoting intestinal health and maintaining a healthy lifestyle.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Environmental Sciences
Yaping Li, Mingjie Sun, Wei He, Hui Wang, Hong Pan, Quangang Yang, Yanhong Lou, Yuping Zhuge
Summary: Supplementation of phosphorus significantly reduced the cadmium content, translocation factor, and physiological characteristics of tall fescue under cadmium stress. It also improved the growth rates and biomass of tall fescue. Different concentrations of cadmium negatively affected all parameters except for total potassium content and catalase activity, but these negative effects were limited by phosphorus supplementation. Optimizing nutrient composition and concentrations could minimize the potential negative impacts of cadmium on plant growth.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Panagiota Kakni, Carmen Lopez-Iglesias, Roman Truckenmuller, Pamela Habibovic, Stefan Giselbrecht
Summary: Pluripotent stem cell-derived intestinal organoids with reversed epithelial polarity (apical-out) successfully recapitulate tissue-specific functions and show strong epithelial barrier formation, nutrient transport, active lipid metabolism, and expression of drug-metabolizing enzymes and transporters. This breakthrough enables high-throughput/high-content in vitro applications in the fields of nutrition, metabolism, and drug discovery.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Qiunan Zhu, Ryusuke Iwai, Takehiro Okaguchi, Yoshiyuki Shirasaka, Ikumi Tamai
Summary: In this study, the effect of apple juice on constipation was investigated. Results showed that continuous intake of apple juice improved defecation and increased the level of bile acids in feces. Further experiments suggested that apple juice relieved constipation by downregulating the expression of ASBT. Therefore, this specific mechanism of apples provides insights into the functional properties of food.
Article
Biotechnology & Applied Microbiology
Sahar Nouri Gharajalar, Siamak Kazemi-Darabadi, Hamid Valinezhad Lajimi, Amir-Ali Shahbazfar
Summary: The study showed that in rats undergoing extensive small bowel resection, treatment with a synbiotic cocktail of Lactobacillus acidophilus and pectin significantly reduced bacterial translocation and improved intestinal adaptation.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Veterinary Sciences
Po-Yun Teng, Janghan Choi, Yuguo Tompkins, Hyun Lillehoj, Woo Kim
Summary: The study found that increasing severity of Eimeria maxima infection led to a linear reduction in growth performance, jejunal villus height, and jejunal integrity in broiler chickens, while also resulting in a linear increase in the regulation of nutrient transporters and tight junction proteins. This suggests that E. maxima infection significantly impacts the intestinal function of broiler chickens.
VETERINARY RESEARCH
(2021)
Article
Multidisciplinary Sciences
C. J. Herrnreiter, X. Li, M. E. Luck, M. J. Zilliox, Mashkoor A. Choudhry
Summary: Alcohol and burn injury significantly alter the mRNA and miRNA expression profile of IECs, revealing numerous miRNA-mRNA interactions that regulate critical pathways for gut barrier function after injury.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Xiujing Sun, Shengtao Zhu, Tor Inge Tonnessen, Runkuan Yang
Summary: This study investigated the biomedical role of bile in endotoxemia, finding that bile inhibits gut bacterial translocation and promotes gut motility through an IL-6-related pathway. Additionally, bile selectively inhibits the release of IL-6 in LPS-stimulated macrophages.
