Article
Biochemistry & Molecular Biology
Lina Jakubauskiene, Matas Jakubauskas, Gintare Razanskiene, Bettina Leber, Jennifer Weber, Lisa Rohrhofer, Diana Ramasauskaite, Kestutis Strupas, Philipp Stiegler, Peter Schemmer
Summary: The study demonstrates that pretreatment with relaxin, erythropoietin, or their combination can effectively reduce uterine tissue damage caused by ischemia-reperfusion injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Jennifer S. Y. Li, Harry Robertson, Katie Trinh, Arti M. Raghubar, Quan Nguyen, Nicholas Matigian, Ellis Patrick, Angus W. Thomson, Andrew J. Mallett, Natasha M. Rogers
Summary: Ischemia reperfusion injury is a common cause of acute kidney injury. Adoptively transferred tolerogenic dendritic cells can successfully limit kidney injury and provide protection against ischemia reperfusion injury.
KIDNEY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Stephanie M. Mutchler, Mahpara Hasan, Donald E. Kohan, Thomas R. Kleyman, Roderick J. Tan
Summary: Our study demonstrates that deletion of the gamma subunit of ENaC, while allowing for greater activation of eNOS, is not sufficient to prevent IRI. This suggests that the protective effects of alpha subunit deletion may be due, in part, to other mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Fayez T. Hammad, Suhail Al-Salam, Rahaf Ahmad, Javed Yasin, Awwab F. Hammad, Jasmine Abdul Rasheed, Loay Lubbad
Summary: It has been found that nerolidol has a protective effect on renal ischemia-reperfusion injury, improving renal function and reducing tissue damage.
Article
Medicine, Research & Experimental
Abolfazl Badripour, Mohamad Behzadi, Amin Hassanipour, Pasha Reza Shams Azar, Alireza Rahbar, Zhaleh Abbaslou, Elnaz Ehghaghi, Ashkan Piranviseh, Mohammad Mahdi Khavandi, Seyed Mohsen Ahmadi-Tafti, Mohammad Ashouri, Zahra Ebrahim Soltani, Ahmadreza Dehpour
Summary: This study aimed to evaluate the effects of Albendazole pretreatment on mesenteric ischemia reperfusion (MIR) injury. The findings demonstrated that Albendazole could ameliorate the inflammatory response and enhance the ischemia threshold following MIR injury.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Cardiac & Cardiovascular Systems
Magda C. Diaz-Vesga, Ursula Zuniga-Cuevas, Andres Ramirez-Reyes, Nicolas Herrera-Zelada, Ivan Palomo, Roberto Bravo-Sagua, Jaime A. Riquelme
Summary: Despite advances in treating myocardial infarction, limiting infarct size after reperfusion to prevent heart failure remains a challenge, with factors such as comorbidities and experimental models needing to be considered for effective cardioprotection studies. Studies show that current therapeutic strategies may not fully protect the aging heart from myocardial infarction, prompting the need for potential new cardioprotective strategies targeting the aging heart.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Medicine, General & Internal
Sara Akalay, Sarah A. Hosgood
Summary: Although machine perfusion is gradually being applied in clinical practice, the improvement of organ reconditioning therapies is still at the experimental stage, showing a translational gap. This review discusses the biological processes and current strategies and interventions for preventing ischemia-reperfusion injury, treating its deleterious consequences, or supporting the reparative response of the kidney, and explores prospects to improve the clinical translation of these therapies by addressing multiple aspects of ischemia-reperfusion injury to achieve robust and long-lasting protective effects on the kidney graft.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Asmaa A. Khalifa, Mennatallah A. Ali, Nahed H. Elsokkary, Samar S. Elblehi, Mahmoud M. El-Mas
Summary: This study investigated the protective effects of simultaneous exposure to a minimal dose of erythropoietin (EPO) and remote ischemic preconditioning (RIPC) against skeletal muscle ischemia and reperfusion (S-I/R) injury. The results showed that the combined application of RIPC and EPO significantly ameliorated the structural and functional abnormalities as well as mitochondrial oxidative and apoptotic damage caused by S-I/R injury.
Article
Critical Care Medicine
Chunli Liu, Dong Yuan, Robert Crawford, Rajabrata Sarkar, Bingren Hu
Summary: The study successfully alleviates severe organ injuries and functional deficits during REBOA management of lethal hemorrhage by directly cooling the colon to 10-12 degrees Celsius, reducing mortality and improving tissue protection.
Article
Cardiac & Cardiovascular Systems
Young Sook Lee, Hadi Javan, Jo-Anna Reems, Ling Li, Jessica Lusty, Christine Schaaf, Jan Pierce, John D. Phillips, Craig H. Selzman
Summary: Cell-free human amniotic fluid, a naturally derived cocktail composed of thousands of proteins involved with innate immunity and anti-inflammation, significantly reduces injury and preserves cardiac function in a model of rodent myocardial ischemia-reperfusion, suggesting its potential as a cardioprotective adjunct.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chiara Bellini, Salvatore Antonucci, Lucia Morillas-Becerril, Sara Scarpa, Regina Tavano, Fabrizio Mancin, Fabio Di Lisa, Emanuele Papini
Summary: The study demonstrated the effectiveness of utilizing two formulations of poly(lipoic acid)-based nanoparticles (NPs) in combating radical damage and ROS formation in various cell types. Results indicate that NPs could effectively protect against myocardial cell damage induced by ischemic reperfusion injury.
Review
Medicine, General & Internal
Xin-li Mao, Yue Cai, Ya-hong Chen, Yi Wang, Xiu-xiu Jiang, Li-ping Ye, Shao-wei Li
Summary: Hepatic ischemia reperfusion injury (IRI) is a major complication caused by various clinical situations, and the exact mechanisms and therapeutic targets are yet to be clarified. Activation of PPAR gamma, FAM3A, and non-coding RNAs may have a protective effect against hepatic IRI, but further research is needed.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Shijie Qiu, Xuyi Li, Jingyan Zhang, Pilong Shi, Yonggang Cao, Yongzhi Zhuang, Liquan Tong
Summary: The study prepared nano-taurine by coating taurine with neutrophil membranes, and demonstrated that nano-taurine can treat hepatic ischemia-reperfusion injury by inhibiting inflammation, oxidative stress, and ferroptosis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pathology
Juthipong Benjanuwattra, Nattayaporn Apaijai, Titikorn Chunchai, Kodchanan Singhanat, Busarin Arunsak, Kannaporn Intachai, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: In a model of myocardial ischemia/reperfusion injury, the timing of erythropoietin (EPO) administration was found to have varying effects on cardioprotection. EPO given during ischemia or reperfusion was shown to attenuate arrhythmia, improve cardiac function, reduce infarct size and apoptosis.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2022)
Article
Pharmacology & Pharmacy
Seckin Tuncer, Ahmet Akkoca, Murat Cenk Celen, Nizamettin Dalkilic
Summary: The study showed that MitoTEMPO can protect against sciatic nerve damage caused by abdominal ischemia-reperfusion (I/R) by preserving nerve conduction velocity and structural integrity, thereby preventing functional nerve damage. MitoTEMPO, which can enter mitochondria and reduce oxidative stress, prevented the contribution of fast-conducting fibers and caused a shift in nerve conduction velocity distribution, ultimately protecting against nerve damage.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)