Article
Oncology
Ke Chen, Yu Pan, Chao-jie Huang, Qi-long Chen, Ren-chao Zhang, Miao-zun Zhang, Guan-yu Wang, Xian-fa Wang, Yi-ping Mou, Jia-fei Yan
Summary: Comparing laparoscopic pancreatic resection with open surgery for pancreatic ductal adenocarcinoma, it was found that laparoscopic procedures have advantages in terms of surgical and oncological outcomes. However, both approaches showed similar postoperative outcomes and long-term survival among patients.
Article
Oncology
Kosuke Mima, Hiromitsu Hayashi, Shigeki Nakagawa, Takashi Matsumoto, Shotaro Kinoshita, Kazuki Matsumura, Fumimasa Kitamura, Norio Uemura, Yosuke Nakao, Rumi Itoyama, Takayoshi Kaida, Katsunori Imai, Yo-ichi Yamashita, Hideo Baba
Summary: This retrospective study analyzed data from 142 patients undergoing resection for pancreatic cancer and found that higher scores on the CFS were associated with worse cancer-specific survival (CSS) and overall survival (OS), suggesting that preoperative measurement of frailty may improve risk assessment among patients with pancreatic cancer.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jan Bednarsch, Zoltan Czigany, Isabella Lurje, Christian Trautwein, Tom Luedde, Pavel Strnad, Nadine Therese Gaisa, Alexandra Barabasch, Philipp Bruners, Tom Ulmer, Sven Arke Lang, Ulf Peter Neumann, Georg Lurje
Summary: In a European cohort of patients undergoing surgical resection for HCC, Child-Pugh Score, operative time, and intraoperatively administered fresh frozen plasma were identified as independent prognostic markers of major surgical complications. Intraoperative administration of FFP was found to be an important independent predictor of perioperative morbidity in these patients.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Surgery
Breanna C. Perlmutter, Julie Ali, Turgut Bora Cengiz, Sayf Al-Deen Said, Andrew Tang, Toms Augustin, Daniel Joyce, Robert Simon, R. Matthew Walsh
Summary: This study aimed to evaluate the correlation between validated measures of physical status in a prehabilitation program and an established frailty score, and to analyze the changes in these measures and postoperative outcomes. The results showed a negative correlation between the physical status measures and the frailty score. One of the physical measures decreased after the prehabilitation program, while the others remained unchanged. Differences in the measures were unchanged when stratified by frailty scores. There were no significant differences in hospital duration, complications, and 90-day readmission rates between frailty groups. The study concluded that using one of the physical measures is sufficient to estimate patients' preoperative physical status, and a longer or more comprehensive prehabilitation program or expedited operation may improve patient outcomes.
Review
Orthopedics
Feng Wanjiang, Zhang Xiaobo, Wu Xin, Meng Ye, Huang Lihua, Wang Jianlong
Summary: This study analyzed the accuracy of POSSUM and P-POSSUM scores in predicting postoperative morbidity and mortality in elderly hip fracture surgery. The results showed that POSSUM can predict the morbidity of elderly hip fractures, while P-POSSUM is more accurate in predicting mortality compared to POSSUM, but the predictive value for mortality is influenced by sample size and fracture type.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Multidisciplinary Sciences
Fiona R. Kolbinger, Julia Lambrecht, Stefan Leger, Till Ittermann, Stefanie Speidel, Jurgen Weitz, Ralf-Thorsten Hoffmann, Marius Distler, Jens-Peter Kuehn
Summary: This article introduces a preoperatively available image-based risk scoring method for predicting clinically relevant postoperative pancreatic fistula (CR-POPF) after pancreatic head resection. The score, considering factors such as pancreatic gland texture, pancreatic duct diameter, and pathology, correlates with fistula-related outcomes and predicts the risk of pancreatic remnant volume.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Kyle Crocker, Joshua Johnson, Wolfgang Pfeifer, Carlos Castro, Ralf Bundschuh
Summary: A physical model is developed to predict the probability of DNA origami nano-hinges containing gold nanoparticles being open at different temperatures based on partition function analysis. The model accurately matches experimental data and reveals important microscopic interactions influencing macroscopic behavior. This insight could inform future designs incorporating nanoparticles into dynamic DNA origami structures.
Article
Biochemical Research Methods
Benjamin R. Weeder, Mary A. Wood, Ellysia Li, Abhinav Nellore, Reid F. Thompson
Summary: The study introduces a new open-source tool called pepsickle for proteasomal cleavage prediction, which has better performance and computational speed compared to current models, can predict sites based on protein profiles, and improves immune-responsive epitopes enrichment by post hoc filtering of predicted patient neoepitopes.
Article
Multidisciplinary Sciences
Victoria Ajila, Laura Colley, Dave T. Ste-Croix, Nour Nissan, Ashkan Golshani, Elroy R. Cober, Benjamin Mimee, Bahram Samanfar, James R. Green
Summary: MicroRNAs (miRNAs) regulate gene expression through targeting messenger RNA (mRNAs) and most target predictors focus on animals but perform poorly in plants. In this study, the TarPmiR miRNA target predictor is retrained using plant-specific data from the TarDB database, leading to improved accuracy in predicting miRNA targets in plants. Surprisingly, excluding animal training data results in the most accurate plant-specific miRNA target predictor, suggesting that animal-based data may hinder miRNA target prediction in plants.
SCIENTIFIC REPORTS
(2023)
Article
Surgery
Thilo Hackert, Ulla Klaiber, Ulf Hinz, Susanne Strunk, Martin Loos, Oliver Strobel, Christoph Berchtold, Yakup Kulu, Arianeb Mehrabi, Beat P. Mueller-Stich, Martin Schneider, Markus W. Buechler
Summary: This study evaluated the outcomes of pancreatic cancer surgery with concomitant portal vein resection (PVR), focusing on the PVR type according to the International Study Group of Pancreatic Surgery (ISGPS). Surgery offers the only chance for cure in pancreatic cancer, and PVR is often performed for borderline or locally advanced tumors. The results showed that postoperative morbidity correlates with the reconstruction type, and when radical resection is achieved, thrombosis risk is outweighed by beneficial overall survival times of nearly 2 years.
Article
Oncology
Wenzel M. Hackeng, Koen M. A. Dreijerink, Wendy W. J. de Leng, Folkert H. M. Morsink, Gerlof D. Valk, Menno R. Vriens, G. Johan A. Offerhaus, Christoph Geisenberger, Lodewijk A. A. Brosens
Summary: This study developed a prediction model based on DNA methylation data that accurately predicts the origin of neuroendocrine tumors. The model demonstrated robust performance across various experimental parameters and a user-friendly online tool was established for validation and clinical use.
CLINICAL CANCER RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Christopher W. Towe, Elliot L. Servais, Maria Grau-Sepulveda, Andrzej S. Kosinski, Lisa M. Brown, Stephen M. Broderick, David W. Wormuth, Felix G. Fernandez, Benjamin D. Kozower, Daniel P. Raymond
Summary: Concomitant en bloc lung and chest wall resection (CWR) in the treatment of lung cancer invading the chest wall is associated with increased risk of adverse outcomes after surgery. Quality assessments should control for CWR in institutions performing this procedure.
ANNALS OF THORACIC SURGERY
(2022)
Article
Surgery
Yu Norimatsu, Kyoji Ito, Nobuyuki Takemura, Fuyuki Inagaki, Fuminori Mihara, Norihiro Kokudo
Summary: We investigated the risk factors for complications in elderly patients undergoing hepato-pancreato-biliary surgery using surgical risk scoring models. The E-PASS model was found to be useful in predicting complications, while the POSSUM and G8 models showed no significant correlations.
WORLD JOURNAL OF SURGERY
(2022)
Article
Gastroenterology & Hepatology
Meredith Flacs, Matthieu Faron, Olivier Mir, Fadila Mihoubi, Isabelle Sourouille, Leila Haddag-Miliani, Sarah Dumont, Philippe Terrier, Antonin Levy, Bertrand Dousset, Pascaline Boudou-Rouquette, Axel Le Cesne, Sebastien Gaujoux, Charles Honore
Summary: The retrospective study analyzed 50 patients undergoing surgery for retroperitoneal sarcoma with pancreatectomy, finding that pancreatectomy is associated with significant postoperative morbidity and mortality, with common pancreas-related complications. The study suggests avoiding pancreaticoduodenectomy whenever possible, as other procedures may lead to better long-term survival.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Orthopedics
Guangyao Yang, Guofeng Cui, Youwen Liu, Jiayi Guo, Chen Yue
Summary: This systematic review evaluated the accuracy of the POSSUM models in predicting morbidity and mortality in older patients with hip fractures. The results showed that while O-POSSUM had reasonable accuracy in predicting postoperative morbidity, both P-POSSUM and O-POSSUM substantially overestimated postoperative mortality. Further optimization of the POSSUM model is needed for this patient population.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)