Article
Oncology
Rahim Ullah, Qing Yin, Aidan H. Snell, Lixin Wan
Summary: The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway that plays a critical role in cell proliferation and survival. Genetic alterations in this pathway are highly prevalent in human cancers and can lead to uncontrolled cell growth and tumor formation. The crosstalk between the RAF-MEK-ERK axis and other signaling pathways further enhances its proliferative potential in human cancers.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Oncology
Aayoung Hong, Marco Piva, Sixue Liu, Willy Hugo, Shirley H. Lomeli, Vincent Zoete, Christopher E. Randolph, Zhentao Yang, Yan Wang, Jordan J. Lee, Skylar J. Lo, Lu Sun, Agustin Vega-Crespo, Alejandro J. Garcia, David B. Shackelford, Steven M. Dubinett, Philip O. Scumpia, Stephanie D. Byrum, Alan J. Tackett, Timothy R. Donahue, Olivier Michielin, Sheri L. Holmen, Antoni Ribas, Gatien Moriceau, Roger S. Lo
Summary: Combining type II RAF inhibitor with MEK inhibitor effectively prevents and overcomes acquired resistance in cancers with specific mutations, while also expanding memory and activated CD8(+) T cells. This combination therapy shows potential in broad cancer indications and may be further enhanced by exploring mechanisms of MAPK protein interactions and preserving tumor-infiltrating T cells.
Article
Oncology
Da Wang, Fei Xiong, Guanhua Wu, Wenzheng Liu, Bing Wang, Yongjun Chen
Summary: The study found that in cholangiocarcinoma, miR-155-5p targets the 3' UTR of SOX1, activating the RAF/MEK/ERK pathway and promoting cancer progression.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Sara J. Hamis, Yury Kapelyukh, Aileen McLaren, Colin J. Henderson, C. Roland Wolf, Mark A. J. Chaplain
Summary: The study developed a mechanistic mathematical model to describe the synergistic action of dabrafenib and trametinib on ERK activity in BRAFV600E-mutant melanoma cells, elucidating the molecular mechanism underlying vertical inhibition of the BRAF-MEK-ERK cascade.
BRITISH JOURNAL OF CANCER
(2021)
Article
Virology
Chengyuan Wu, Guangyan Zhu, Fang Qiu, Fuli Ren, Binbin Lin, Dingyu Zhang, Qingyu Yang, Chaolin Huang
Summary: EV71 is a serious threat to human health and there is currently no effective drug for its treatment. PLX8394, a RAF inhibitor, has been found to have high antiviral activity against EV71 in vitro and also exhibits broad-spectrum antiviral activity against enteroviruses. In a mouse model, PLX8394 provided significant protection against EV71 infection by reducing viral load and relieving inflammation through inhibiting the RAF/MEK/ERK signaling pathway.
Review
Biochemistry & Molecular Biology
Yanlin Song, Zhenfei Bi, Yu Liu, Furong Qin, Yuquan Wei, Xiawei Wei
Summary: Molecular target inhibitors have been approved for tumor treatment and mainly target cell proliferation and metabolism. The RAS-RAF-MEK-ERK pathway plays essential roles in cell functions and abnormal activation of this pathway leads to tumor development. In this review, the development and potential combinations of inhibitors targeting this pathway are discussed.
Article
Fisheries
Linlin Zhang, Lu Chen, Meng Qi, Fuchang Yu, Xiaotong Ni, Haozheng Hong, Haotian Xu, Shiwen Xu
Summary: Glyphosate exposure induces autophagy in hepatic L8824 cells by activating nitric oxide (NO), regulating energy metabolism, and activating the RAS/RAF/MEK/ERK signaling pathway. This study provides insight into the mechanism of glyphosate toxicity and its effects on cellular processes.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dongliu Luo, Yiming Lu, Jintao Zhang, Xixi Wang, Yixuan Wang, Shiping Li, Shu Li
Summary: This study demonstrated that AC exposure inhibits NETs release and promotes neutrophil apoptosis, impairing the normal function of the immune system.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Cell Biology
Jie Zhou, Daoyuan Tu, Rui Peng, Yuhong Tang, Qiangwei Deng, Bingbing Su, Shunyi Wang, Hao Tang, Shengjie Jin, Guoqing Jiang, Qian Wang, Xin Jin, Chi Zhang, Jun Cao, Dousheng Bai
Summary: Through tissue microarray and immunohistochemistry staining, it was found that RNF173 expression is significantly lower in hepatocellular carcinoma (HCC) patients and is closely related to their survival and recurrence rates. Experimental results showed that RNF173 inhibits the invasion and metastasis of HCC through degradation of GRB2, thereby suppressing the RAF/MEK/ERK signaling pathway. Therefore, RNF173 may serve as a novel prognostic molecular and potential therapeutic target for HCC.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Ying Zhang, Qian Lu, Nan Li, Ming Xu, Tatsuo Miyamoto, Jing Liu
Summary: Sulforaphane (SFN), a natural compound derived from broccoli, has been found to significantly inhibit migration and invasion of breast cancer cells by affecting cytoskeleton formation. SFN can also directly bind to RAF family proteins and inhibit phosphorylation of the signaling pathway. These findings suggest that SFN has the potential to be used as a therapeutic drug to inhibit breast cancer cell metastasis.
Article
Oncology
Shuai Wang, Xinyan Zhang, Houfa Ning, Senyi Dong, Guangzhi Wang, Ruimei Sun
Summary: This study discovered elevated levels of B7-H3 in breast cancer, which were associated with poor prognosis. B7-H3 can promote lung metastasis in breast cancer through activation of the Raf/MEK/ERK axis.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Review
Pharmacology & Pharmacy
Yunli Huang, Yongqi Zhen, Yanmei Chen, Shaoguang Sui, Lan Zhang
Summary: This article provides a comprehensive review of the interplay between the RAS/RAF/MEK/ERK signaling pathway and autophagy, as well as their application in cancer therapy. The impact of small molecule inhibitors targeting this pathway on autophagy is discussed, and the advantages and limitations of combining these inhibitors with autophagy inhibitors are explored.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Plant Sciences
Danting Fu, Jiangfeng Zhou, Shanchun Xu, Jue Tu, Yueqin Cai, Jingyan Liu, Zhaowei Cai, Dejun Wang
Summary: TFLFs may protect against pathological cardiac hypertrophy via negative regulation of the Raf/MEK/ERK pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Oncology
Renee Barbosa, Lucila A. Acevedo, Ronen Marmorstein
Summary: The RAS-RAF-MEK-ERK pathway is crucial for cell proliferation, differentiation, and survival, with mutations in upstream proteins RAS and RAF contributing to many human cancers and nearly all cutaneous melanomas. Targeting terminal kinases in the MAPK cascade has shown promise in overcoming drug resistance and improving treatment options for patients with MAPK-aberrant cancers.
MOLECULAR CANCER RESEARCH
(2021)
Article
Oncology
Jinyoung Kim, Jun Park, Hyunju Park, Min Sun Choi, Hye Won Jang, Tae Hyuk Kim, Sun Wook Kim, Jae Hoon Chung
Summary: The study suggests using the metastatic lymph node ratio (LNR) as a quantitative evaluation tool for lymph node metastasis in patients with medullary thyroid cancer (MTC), which can potentially predict structural recurrence.
Article
Oncology
Kevin M. Sokolowski, Steven Koprowski, Selvi Kunnimalaiyaan, Mariappan Balamurugan, T. Clark Gamblin, Muthusamy Kunnimalaiyaan
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2016)
Article
Oncology
Jacob M. Wilson, Selvi Kunnimalaiyaan, Muthusamy Kunnimalaiyaan, T. Clark Gamblin
CANCER CELL INTERNATIONAL
(2015)
Article
Surgery
Steven Koprowski, Kevin Sokolowski, Selvi Kunnimalaiyaan, T. Clark Gamblin, Muthusamy Kunnimalaiyaan
JOURNAL OF SURGICAL RESEARCH
(2015)
Article
Oncology
Selvi Kunnimalaiyaan, Jose Trevino, Susan Tsai, T. Clark Gamblin, Muthusamy Kunnimalaiyaan
MOLECULAR CANCER THERAPEUTICS
(2015)
Article
Multidisciplinary Sciences
Selvi Kunnimalaiyaan, Kevin M. Sokolowski, Mariappan Balamurugan, T. Clark Gamblin, Muthusamy Kunnimalaiyaan
Article
Gastroenterology & Hepatology
Selvi Kunnimalaiyaan, T. Clark Gamblin, Muthusamy Kunnimalaiyaan
Article
Surgery
Kevin M. Sokolowski, Mariappan Balamurugan, Selvi Kunnimalaiyaan, Jacob Wilson, Thomas Clark Gamblin, Muthusamy Kunnimalaiyaan
AMERICAN JOURNAL OF SURGERY
(2016)
Article
Oncology
Selvi Kunnimalaiyaan, Victoriana K. Schwartz, Iris Alao Jackson, T. Clark Gamblin, Muthusamy Kunnimalaiyaan
Article
Oncology
Jocelyn F. Burke, Logan Schlosser, April D. Harrison, Muthusamy Kunnimalaiyaan, Herbert Chen
ANNALS OF SURGICAL ONCOLOGY
(2013)
Article
Oncology
Yvette M. Carter, Selvi Kunnimalaiyaan, Herbert Chen, T. Clark Gamblin, Muthusamy Kunnimalaiyaan
CANCER BIOLOGY & THERAPY
(2014)
Article
Surgery
Amal Alhefdhi, Jocelyn F. Burke, Aaron Redlich, Muthusamy Kunnimalaiyaan, Herbert Chen
JOURNAL OF SURGICAL RESEARCH
(2013)
Article
Surgery
J. M. Wilson, S. Kunnimalaiyaan, T. C. Gamblin, M. Kunnimalaiyaan
JOURNAL OF SURGICAL RESEARCH
(2014)
Article
Endocrinology & Metabolism
Yash Somnay, Herbert Chen, Muthusamy Kunnimalaiyaan
NEUROENDOCRINOLOGY
(2013)
Article
Multidisciplinary Sciences
Samuel Engelsgjerd, Selvi Kunnimalaiyaan, Emad Kandil, T. Clark Gamblin, Muthusamy Kunnimalaiyaan
Article
Surgery
Selvi Kunnimalaiyaan, Kevin Sokolowski, T. Clark Gamblin, Muthusamy Kunnimalaiyaan
AMERICAN JOURNAL OF SURGERY
(2017)