Article
Surgery
Hannah Kapur, Rebecca Warburton, Jin-Si Pao, Carol Dingee, Leo Chen, Elaine McKevitt
Summary: Contralateral prophylactic mastectomy (CPM) is not recommended for average-risk women with breast cancer due to lack of evidence for survival benefit, yet recent studies demonstrate increasing CPM rates. Patients receiving CPMs tend to have higher reconstruction rates and be younger in age.
AMERICAN JOURNAL OF SURGERY
(2021)
Article
Oncology
Jennifer Q. Zhang, Carlos Henrique Dos Anjos, Varadan Sevilimedu, Angelena Crown, Kimberly A. Amoroso, Melissa L. Pilewskie, Mark E. Robson, Mary L. Gemignani
Summary: This study identified a high rate of contralateral prophylactic mastectomy (CPM) among breast cancer patients with ATM, CHEK2, and PALB2 gene alterations, including variants of uncertain significance (VUS). Premenopausal status and pathogenic alterations were associated with an increased use of CPM.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Alison S. Baskin, Ton Wang, Brooke C. Bredbeck, Brandy R. Sinco, Nicholas L. Berlin, Lesly A. Dossett
Summary: For women with small, unilateral breast cancer, most are suitable candidates for breast conserving surgery (BCS) but a significant portion opt for mastectomy, with a rising percentage choosing contralateral prophylactic mastectomy (CPM). Factors such as patient characteristics, tumor attributes, and facility features may influence the decision-making regarding CPM.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Oncology
Akshara Singareeka Raghavendra, Hala F. Alameddine, Clark R. Andersen, Jesse C. Selber, Abenaa M. Brewster, Carlos H. Barcenas, Abigail S. Caudle, Banu K. Arun, Debu Tripathy, Nuhad K. Ibrahim
Summary: Partners, physicians, and the media significantly influence women with unilateral breast cancer's decision to undergo CPM surgery, with physicians having a greater influence and partners and the media having a lower influence compared to self-determination. Educational aids and programs are needed to help women make informed decisions regarding CPM efficacy.
Article
Oncology
Vasily Giannakeas, David W. Lim, Steven A. Narod
Summary: Women with unilateral breast cancer have an annual risk of contralateral breast cancer similar to 0.4% per year, which persists over the 25-year follow-up period. The 25-year cumulative risk of contralateral invasive breast cancer was 9.9%, with variations based on age of diagnosis, time since diagnosis, race, and ER status of the first cancer.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Kunlong Li, Bin Wang, Zejian Yang, Ren Yu, Heyan Chen, Yijun Li, Jianjun He, Can Zhou
Summary: Contralateral prophylactic mastectomy (CPM) is associated with a decreased risk of breast cancer-specific death in male breast cancer patients. A nomogram model can provide a precise and personalized prediction of the cumulative risk in these patients after CPM, outperforming the AJCC criteria-based tumor staging.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jie Sun, Futao Chu, Jiani Pan, Yaxin Zhang, Lu Yao, Jiuan Chen, Li Hu, Juan Zhang, Ye Xu, Xiaojia Wang, Wenming Cao, Yuntao Xie
Summary: The purpose of this study is to develop a risk prediction model for contralateral breast cancer(CBC) in patients with BRCA1/2 variants. The study found that age, family history, variant location, and endocrine therapy are associated with the risk of CBC. The model provides a useful tool for BRCA1/2 carriers to select risk-reducing strategies based on individual CBC risk.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Narendra Nath Basu, James Hodson, Shaunak Chatterjee, Ashu Gandhi, Julie Wisely, James Harvey, Lyndsey Highton, John Murphy, Nicola Barnes, Richard Johnson, Lester Barr, Cliona C. Kirwan, Sacha Howell, Andrew D. Baildam, Anthony Howell, D. Gareth Evans
Summary: The study found that the contralateral risk-reducing mastectomy (CRRM) rates doubled after Angelina Jolie's announcement of undergoing a risk-reducing mastectomy, particularly among younger women and high-risk patients. Clinicians need to be mindful of how media news can impact the delivery of services related to cancer. Communicating objective risk assessment is crucial when counseling women on the benefits of risk-reducing surgery.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Baosheng Zhao, Mo Yi, Hong Lyu, Xiaoman Zhang, Yujie Liu, Xinhong Song
Summary: Currently, the choice of contralateral prophylactic mastectomy (CPM) for breast cancer patients is variable and controversial. This study aimed to conduct a meta-synthesis of qualitative studies on the decision-making experiences, real-life experiences, psychological feelings, and needs of breast cancer patients in CPM decision-making, with the aim of supporting the development of CPM practice decisions.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Siddhartha Yadav, Nicholas J. Boddicker, Jie Na, Eric C. Polley, Chunling Hu, Steven N. Hart, Rohan D. Gnanaolivu, Nicole Larson, Susan Holtegaard, Huaizhi Huang, Carolyn A. Dunn, Lauren R. Teras, Alpa V. Patel, James V. Lacey, Susan L. Neuhausen, Elena Martinez, Christopher Haiman, Fei Chen, Kathryn J. Ruddy, Janet E. Olson, Esther M. John, Allison W. Kurian, Dale P. Sandler, Katie M. O'Brien, Jack A. Taylor, Clarice R. Weinberg, Hoda Anton-Culver, Argyrios Ziogas, Gary Zirpoli, David E. Goldgar, Julie R. Palmer, Susan M. Domchek, Jeffrey N. Weitzel, Katherine L. Nathanson, Peter Kraft, Fergus J. Couch
Summary: The purpose of this study was to estimate the risk of contralateral breast cancer (CBC) among women with germline pathogenic variants (PVs) in ATM, BRCA1, BRCA2, CHEK2, and PALB2. The results showed that BRCA1, BRCA2, and CHEK2 PV carriers with breast cancer had significantly higher risks of CBC, while only PALB2 PV carriers with ER-negative breast cancer had elevated risks. However, ATM PV carriers did not have significantly increased CBC risks. The study suggests that women diagnosed with breast cancer and known to carry germline PVs in certain genes may benefit from enhanced surveillance and risk reduction strategies.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Amanda L. Nash, Diane L. Bloom, Brittany M. Chapman, Stephanie B. Wheeler, Kandace P. McGuire, Clara N. Lee, Kevin Weinfurt, Donald L. Rosenstein, Jennifer K. Plichta, Julie C. Jacobson Vann, E. Shelley Hwang
Summary: This study explored the experiences of the partners of women who undergo CPM. Most partners hoped their wives would choose a bilateral mastectomy, but the final decision was up to the women. The male partners had difficulty understanding the physical and emotional changes of mastectomy, making communication about sexuality and intimacy challenging.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Health Care Sciences & Services
Michael C. Silverstein, Clara N. Lee, Laura D. Scherer, Crystal Phommasathit, Andrea L. Merrill, Ellen Peters
Summary: Negative affect towards breast cancer may lead to the choice of CPM surgery and patients' affect towards CPM did not differ across different affect conditions. However, patients in the negative affect condition may have more positive evaluations of CPM.
MEDICAL DECISION MAKING
(2023)
Review
Surgery
Katherine B. Santosa, Jeremie D. Oliver, Adeyiza O. Momoh
Summary: Contralateral prophylactic mastectomy (CPM) rates in the United States have been on the rise, influenced by multiple factors. The authors have shed light on the current state and summarized the literature, outlining future directions for research and knowledge dissemination.
Article
Oncology
Kelly A. Metcalfe, Andrea Eisen, Aletta Poll, Alexandra Candib, David McCready, Tulin Cil, Frances Wright, Rochelle Demsky, Talia Mancuso, Ping Sun, Steven A. Narod
Summary: This study found that women use risk assessment and negative BRCA1/BRCA2 genetic test results to guide their surgical decisions. The uptake of CPM decreased for women who were initially considering CPM before genetic testing after receiving a negative BRCA1/BRCA2 genetic test result. The study also showed that the mother's breast cancer status influenced the decision to undergo CPM.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Ayat ElSherif, Daniela Cocco, Steven Bernard, Risal Djohan, Chao Tu, Stephanie A. Valente
Summary: This study compared post-operative reconstructive complications and oncologic treatment between patients who underwent unilateral versus bilateral nipple sparing mastectomy (NSM) with implant based reconstruction (IBR). The results showed that there were no significant differences in the incidence of complications and reconstructive outcomes between the two groups. These findings provide support for patient choice in breast reconstruction surgery.
AMERICAN JOURNAL OF SURGERY
(2023)
