Article
Biochemistry & Molecular Biology
Paulo H. C. Mesquita, Donald A. Lamb, Joshua S. Godwin, Shelby C. Osburn, Bradley A. Ruple, Johnathon H. Moore, Christopher G. Vann, Kevin W. Huggins, Andrew D. Fruge, Kaelin C. Young, Andreas N. Kavazis, Michael D. Roberts
Summary: The study found that 6 weeks of resistance training reduced oxidative damage and increased antioxidant enzyme activities in skeletal muscle of older adults. The responses of older adults to resistance training involve multi-level control (transcriptional, post-transcriptional, and post-translational) of the redox status of skeletal muscle.
Article
Biology
Peiman Zandi, Ewald Schnug
Summary: Environmental changes caused by anthropogenic activities have a significant impact on plants, leading to the generation of reactive oxygen species (ROS) and ultimately oxidative stress. Plants have developed defensive mechanisms, including enzymatic and non-enzymatic antioxidants, to scavenge excess ROS and maintain cellular redox homeostasis. Additionally, plant-microbe interactions have been found to improve immune systems in plants under stress. Understanding and studying these antioxidant systems and beneficial microbiome interactions in plants are important for plant survival and productivity.
Review
Biochemistry & Molecular Biology
Angelo Azzi
Summary: This article evaluates the meaning, appropriate usage, and misusage of the terms oxidative stress, oxidative eustress, and oxidative distress. It reveals that oxidative stress and oxidative damage are often incorrectly used as synonyms. The term eustress, intended to signify good stress, is also found unsuitable for indicating signaling by reactive molecules that can have variable effects. The defined oxidative distress is identified as oxidative damage rather than oxidative stress. Additionally, damaging oxidations and signaling oxidant events, both positive and negative, can coexist in different locations within a cell, tissue, or body. The measurement of oxidant events in body fluids or tissue samples can only reflect the combined effects of non-separable events, sometimes with opposite effects. Officially approved therapies to prevent or cure oxidative stress or oxidative damage are currently lacking.
Article
Medicine, Research & Experimental
B. Haridevamuthu, Tamilvelan Manjunathan, Ajay Guru, Rajendran Saravana Kumar, Rajakrishnan Rajagopal, Palaniselvam Kuppusamy, Annie Juliet, Pushparathinam Gopinath, Jesu Arockiaraj
Summary: Compounds BP and EP exhibited strong in vitro free radical scavenging ability. The maximum tolerated concentration of the compounds in zebrafish larvae was 80 μM. The antioxidant system in zebrafish larvae was dysregulated due to acrylamide exposure, and improvement was observed when acrylamide-exposed larvae were treated with compounds BP and EP. These compounds enhanced SOD and CAT activity, reduced ROS and lipid peroxidation levels, and decreased cell death in zebrafish larvae. Furthermore, BP and EP stabilized glutathione-related gene expressions, thus improving the glutathione redox cycle.
Article
Biochemistry & Molecular Biology
Jaime Catalan, Ivan Yanez-Ortiz, Asta Tvarijonaviciute, Luis Guillermo Gonzalez-Arostegui, Camila P. Rubio, Isabel Barranco, Marc Yeste, Jordi Miro
Summary: This study examined the relationship between enzymatic and non-enzymatic antioxidants in seminal plasma and horse sperm's ability to withstand freeze-thawing. The results showed that enzymatic antioxidants PON1 and SOD, as well as non-enzymatic antioxidant TEAC, were positively correlated with sperm motility and plasma membrane integrity. On the other hand, the oxidative stress index (OSI) was negatively correlated with these parameters and positively correlated with plasma membrane lipid disorder. Further investigation is needed to explore the potential use of these antioxidants and OSI in predicting sperm cryotolerance in horses.
Review
Biochemistry & Molecular Biology
Daniel J. Ritchie, Christopher R. Friesen
Summary: Human-induced climate change is leading to rapid effects on ectothermic organisms' vulnerability to temperature changes. The role of oxidative stress in these processes is crucial, with acute and acclimation temperature treatments yielding different responses in vertebrate ectotherms. Phylogeny and adaptation play important roles in shaping oxidative stress responses, highlighting the need for further research on the physiological effects of temperature alterations in adaptable populations.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2022)
Review
Neurosciences
Sina Shadfar, Sonam Parakh, Md Shafi Jamali, Julie D. Atkin
Summary: Redox homeostasis refers to the balance between the production and elimination of reactive oxygen and nitrogen species, and it is crucial for cellular activities. Oxidative stress, caused by an imbalance between pro-oxidants and antioxidants, disrupts cellular functions, including DNA integrity maintenance. DNA damage and deficiencies in DNA repair are commonly observed in aging-related neurodegenerative diseases, such as Alzheimer's, Parkinson's, ALS, and Huntington's. This review discusses the emerging connections between redox dysregulation and DNA damage in these disorders, and highlights the importance of understanding these associations for developing therapeutic strategies.
TRANSLATIONAL NEURODEGENERATION
(2023)
Article
Plant Sciences
Mohd Saleem, Qazi Fariduddin, Christian Danve M. Castroverde
Summary: Reactive oxygen species (ROS) play important roles in regulating various processes in plants, but over-accumulation can lead to oxidative stress, emphasizing the importance of maintaining redox homeostasis. Salicylic acid (SA) serves as a chief regulator in controlling ROS and antioxidant defense system signaling, yet the underlying mechanisms require further exploration.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Fisheries
Xiaozhou Qi, Yilin Zhang, Gaoxue Wang, Fei Ling
Summary: Redox potential in the gut is an important indicator for the environment and health of the host. This study used zebrafish and common carp models to investigate the influence of gut redox potential on host susceptibility to pathogen infections. The results showed that gut redox potential increased significantly after host infection with pathogenic bacteria, and the level of reactive oxygen species (ROS) was positively correlated with gut redox potential. Reduction of gut redox potential with antioxidants improved host resistance to pathogen infections, and the combination of antioxidants and low concentrations of antibiotics achieved a similar therapeutic effect to high concentrations of antibiotics. This study highlights the importance of altered redox potential in host resistance to infection and suggests new perspectives for the treatment of pathogen infections.
Article
Plant Sciences
Ashim Kumar Das, Touhidur Rahman Anik, Md. Mezanur Rahman, Sanjida Sultana Keya, Md. Robyul Islam, Md. Abiar Rahman, Sharmin Sultana, Protik Kumar Ghosh, Sabia Khan, Tofayel Ahamed, Totan Kumar Ghosh, Lam Son-Phan Tran, Mohammad Golam Mostofa
Summary: Soil salinity is a major environmental concern that significantly reduces plant growth and production worldwide. This study has shown that the priming of soybean plants with exogenous ethanol can enhance their growth performance and alleviate the negative effects of salinity by enhancing antioxidant mechanisms and maintaining osmotic adjustment. Furthermore, ethanol treatment can promote the uptake and partitioning of K+ and Mg2+ in salt-stressed plants, ultimately increasing soybean production in salt-affected areas.
Review
Biochemistry & Molecular Biology
Elle E. M. Scheijen, Sven Hendrix, David M. Wilson
Summary: Oxidative stress plays a crucial role in spinal cord injury (SCI), causing damage to proteins, nucleic acids, lipids, cytoskeleton, and organelles. Oxidative DNA damage is likely a major contributor to the pathogenesis of SCI, although the evidence supporting this hypothesis is limited. Improved analysis methods are needed to uncover the role of DNA damage and repair in SCI.
Article
Biochemistry & Molecular Biology
Marisa L. Henry, Deborah Velez-Irizarry, Joe D. Pagan, Lorraine Sordillo, Jeff Gandy, Stephanie J. Valberg
Summary: The study found that oral coenzyme Q10 and N-acetyl-cysteine supplementation significantly increased muscle glutathione concentrations in horses after intense exercise, while also positively impacting mitochondrial proteins.
Article
Plant Sciences
Pavel Kerchev, Frank Van Breusegem
Summary: Reactive oxygen species (ROS), once considered harmful metabolic byproducts, are now seen as integral to cellular programs, activating signaling pathways that regulate plant growth, development, and defense. Adverse environmental conditions can lead to excessive ROS levels, causing oxidative stress and negative impacts on cellular components. Research efforts have focused on enhancing antioxidant mechanisms to improve oxidative stress resilience in both model and crop species.
Review
Biochemistry & Molecular Biology
Evangelos N. Symeonidis, Evangelini Evgeni, Vasileios Palapelas, Dimitra Koumasi, Nikolaos Pyrgidis, Ioannis Sokolakis, Georgios Hatzichristodoulou, Chara Tsiampali, Ioannis Mykoniatis, Athanasios Zachariou, Nikolaos Sofikitis, Ares Kaltsas, Fotios Dimitriadis
Summary: Male infertility is a common medical condition affecting approximately 15% of couples globally, with an estimated 190 million people struggling with it. Urologists face a wide range of male infertility conditions, from typical cases to more complex ones, with oxidative stress being a critical component entailing an imbalance between ROS and antioxidants. The antioxidant paradox poses one of the biggest challenges in andrology, with the emergence of new tools like the MiOXSYS (R) assay offering a quantification of OS and potential solutions for maintaining redox balance.
Article
Environmental Sciences
Jodie Buytaert, Marcel Eens, Hamada Abd Elgawad, Lieven Bervoets, Gerrit Beemster, Thimo Groffen
Summary: Over the past 7 decades, PFAS has been widely used in various products, leading to widespread contamination. However, little is known about its effects on avian wildlife. This study investigated the association between PFAS concentrations and oxidative status in great tits near a fluorochemical manufacturing facility. The results showed a clear link between PFAS and the antioxidant status of the birds, with higher antioxidant capacity and peroxidase activity near the plant site.
ENVIRONMENTAL POLLUTION
(2023)
Review
Veterinary Sciences
Michael J. A. Wilkinson, Colin Selman, Lynn McLaughlin, Linda Horan, Lindsay Hamilton, Colin Gilbert, Caroline Chadwick, J. Norman Flynn
LABORATORY ANIMALS
(2020)
Article
Biology
Neal J. Dawson, Caroline Millet, Colin Selman, Neil B. Metcalfe
JOURNAL OF EXPERIMENTAL BIOLOGY
(2020)
Article
Ecology
Thomas Bodey, Ian R. Cleasby, Jon Blount, Graham McElwaine, Freydis Vigfusdottir, Stuart Bearhop
JOURNAL OF ANIMAL ECOLOGY
(2020)
Article
Geriatrics & Gerontology
Stephen E. Wilkie, Lorna Mulvey, William A. Sands, Diana E. Marcu, Roderick N. Carter, Nicholas M. Morton, Christopher Hine, James R. Mitchell, Colin Selman
Editorial Material
Geriatrics & Gerontology
Arnold Y. Seo, John R. Speakman, Colin Selman
EXPERIMENTAL GERONTOLOGY
(2020)
Article
Biology
Paul J. Jacobs, M. K. Oosthuizen, C. Mitchell, J. D. Blount, N. C. Bennett
Summary: Modeling of anthropogenic induced climate change predicts more frequent and severe heatwaves in the future, leading to potential mass die-off of various organisms. Studies on Namaqua rock mice show that oxidative stress induced by severe heat stress can have negative effects on animal health, while the availability of water plays a crucial role in preventing oxidative stress.
JOURNAL OF THERMAL BIOLOGY
(2021)
Article
Environmental Sciences
Simon F. Allen, Francesca Ellis, Christopher Mitchell, Xianyu Wang, Neeltje J. Boogert, Chun-Yin Lin, Joseph Clokey, Kevin Thomas, Jonathan D. Blount
Summary: This study investigated the accumulation of plastic-derived contaminants phthalates in European herring gull eggs and their associations with lipid peroxidation and dietary antioxidants. Positive associations were found between MDA and DCHP, as well as negative associations with alpha-tocopherol, indicating potential oxidative stress in gulls. Further research on the consequences of phthalate exposure for offspring development is warranted.
MARINE POLLUTION BULLETIN
(2021)
Article
Cell Biology
Lorna Mulvey, Stephen E. Wilkie, Gillian Borland, Kate Griffiths, Amy Sinclair, Dagmara McGuinness, David G. Watson, Colin Selman
Summary: Genetic background plays a role in how organisms respond to interventions like caloric restriction, impacting parameters such as body weight, adipose tissue mass, glucose tolerance, and insulin levels. Metabolomic analysis revealed specific metabolic differences between different mouse strains under the same caloric restriction, highlighting the importance of how fat depots dynamically respond to caloric restriction in influencing lifespan.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Biology
Pablo Salmon, Caroline Millet, Colin Selman, Pat Monaghan
Summary: This study found that accelerated growth can influence telomere length in nestling zebra finches, but only when individuals show accelerated growth in response to environmental circumstances.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
H. H. Marshall, R. A. Johnstone, F. J. Thompson, H. J. Nichols, D. Wells, J. I. Hoffman, G. Kalema-Zikusoka, J. L. Sanderson, E. I. K. Vitikainen, J. D. Blount, M. A. Cant
Summary: The study demonstrates that, similar to human societies, decision-making from behind a veil of ignorance about kinship can promote fairness and reduce inequality in animal societies as well. Wild, cooperatively breeding banded mongooses allocate postnatal care in a way that reduces offspring inequality, showcasing the application of a classic idea of moral philosophy in biological systems.
NATURE COMMUNICATIONS
(2021)
Correction
Genetics & Heredity
Yavuz Kulaberoglu, Yasir Malik, Gillian Borland, Colin Selman, Nazif Alic, Jennifer M. A. Tullet
FRONTIERS IN GENETICS
(2021)
Review
Genetics & Heredity
Yavuz Kulaberoglu, Yasir Malik, Gillian Borland, Colin Selman, Nazif Alic, Jennifer M. A. Tullet
Summary: Transcription in eukaryotic cells is performed by three RNA polymerases, with Pol III playing a crucial role in transcribing various short non-coding RNAs and regulating cellular processes in response to changes in growth and stress. Dys-regulation of Pol III is associated with diseases, while its activation or inhibition can extend lifespan in model organisms, making it a potential therapeutic target for improving age-related health in humans.
FRONTIERS IN GENETICS
(2021)
Review
Biochemistry & Molecular Biology
Stephen E. Wilkie, Gillian Borland, Roderick N. Carter, Nicholas M. Morton, Colin Selman
Summary: This review discusses the important role of hydrogen sulfide in promoting longevity and improving late-life health, as well as the prospects and challenges in disease treatment utilizing this gas signaling molecule.
BIOCHEMICAL JOURNAL
(2021)
Article
Ecology
Magali Meniri, Elsa Evans, Faye J. Thompson, Harry H. Marshall, Hazel J. Nichols, Gina Lewis, Lauren Holt, Emma Davey, Christopher Mitchell, Rufus A. Johnstone, Michael A. Cant, Jonathan D. Blount
Summary: This study explores the impact of oxidative stress on the cost of reproduction and presents three mechanisms: oxidative cost, oxidative constraint, and oxidative shielding. The experiment conducted on wild female banded mongooses reveals the coexistence of two oxidative mechanisms during reproduction. The results suggest that mothers mitigate oxidative challenges by reducing damage levels, which greatly impacts long-term offspring survival.
ECOLOGY AND EVOLUTION
(2022)
Article
Ecology
Zoe E. Melvin, Hussein Dhirani, Christopher Mitchell, Tim R. B. Davenport, Jonathan D. Blount, Alexander Georgiev
Summary: This study investigates the impact of methodological confounds on urinary oxidative stress (OS) measurement and suggests that urinary OS markers provide a valuable addition to the toolkit of field ecologists and conservationists within reasonable methodological constraints. Factors like sampling time, environmental contamination, and sample storage time have limited effects on OS marker concentrations. However, individual sample variability and reversal of rank-order were observed when exposed to different freezing delays.
ECOLOGY AND EVOLUTION
(2022)