期刊
SUPRAMOLECULAR CHEMISTRY
卷 23, 期 6, 页码 480-485出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10610278.2010.550290
关键词
host; cavitand; water-soluble; octa-acid; supramolecular chemistry
资金
- National Institutes of Health [GM074031]
- Louisiana Board of Regents
An improved synthesis of a water-soluble deep-cavity cavitand (octa-acid, 1) is presented. Previously (Gibb, C.L.D.; Gibb, B.C. J. Am. Chem. Soc. 2004, 126, 11408-11409), we documented access to host 1 in eight (non-linear) steps starting from resorcinol; a synthesis that required four steps involving chromatographic purification. Here, we reveal a modified synthesis of host 1. Consisting of seven (non-linear) steps, this new synthesis involves only one chromatographic step, and avoids a minor impurity observed in the original approach. This improved synthesis is therefore useful for the laboratories that are investigating the properties of these types of host.
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