Article
Oncology
Sharon Elad, Noam Yarom, Yehuda Zadik, Michal Kuten-Shorrer, Stephen T. Sonis
Summary: Oral mucositis is a common and highly symptomatic complication of cancer therapy, affecting patients' quality of life and treatment tolerance. Research on managing oral mucositis is ongoing, with reports of oral mucosal toxicities in other therapies as well.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Review
Oncology
Clifton P. Thornton, Mengchi Li, Chakra Budhathoki, Chao Hsing Yeh, Kathy Ruble
Summary: Anti-inflammatory mouthwashes are a potentially effective means to prevent or reduce mucositis associated with cancer therapy, reducing the incidence of symptomatic mucositis and dose-limiting mucositis. Limited adverse effects and high adherence indicate the safety and feasibility of using these mouthwashes. They should be considered for supportive care in individuals at risk for mucositis and further evaluated for efficacy across various chemotherapy agents, adverse effects, and impacts on symptoms, pain, and quality of life.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Douglas Magno Guimaraes, Tamara Melo Nunes Ota, Diego Assuncao Calixto Da Silva, Fabio De Lucas Da Silva Almeida, Tatiana Dias Schalch, Alessandro Melo Deana, Jose Miguel Alves Junior, Kristianne Porta Santos Fernandes
Summary: This study compared the efficacy of LLLT and LEDT for prevention and treatment of oral mucositis, finding that LEDT has similar effects to LLLT in reducing symptoms of oral mucositis. Therefore, LEDT could be considered as an alternative option for preventing and treating oral mucositis.
SUPPORTIVE CARE IN CANCER
(2021)
Review
Biochemistry & Molecular Biology
Dasa Hafner, Petra Hrast, Tanja Tomazevic, Janez Jazbec, Marko Kavcic
Summary: Oral mucositis (OM) is a common side effect of chemotherapy, particularly in children. Photobiomodulation (PMB) with low-level laser therapy (LLLT) has shown promising results in relieving pain and promoting healing. This review analyzed 15 clinical trials and identified inconsistencies in laser parameters and a lack of standardized protocols for pediatric patients.
Review
Microbiology
Ziyang Min, Lei Yang, Yu Hu, Ruijie Huang
Summary: With the advancement of metagenomic high-throughput sequencing technology, it has been found that oral mucosal diseases are closely related to shifts or dysbiosis in oral microbiota. Dysbiosis can damage the defense mechanisms of oral mucosal epithelium and accelerate the pathological process. This review aims to retrospectively summarize the etiologies, specific alterations in oral flora, pathogenic changes, and microbiota therapy in order to provide a new perspective on managing oral mucosal lesions and improving patients' quality of life.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Elodie Courtois, Wafa Bouleftour, Jean-Baptiste Guy, Safa Louati, Rene-Jean Bensadoun, Claire Rodriguez-Lafrasse, Nicolas Magne
Summary: This review discusses the mechanisms of photobiomodulation (PBM) in the prevention and treatment of oral mucositis, focusing on its effects on tumor and healthy cells. There is controversy regarding the carcinogenic effect of PBM, with studies reporting that it may enhance malignant cell proliferation, suggesting a lack of protective effect. More prospective studies are needed to assess the impact of PBM on cancer cells for improving its use in oral mucositis prevention and treatment.
Review
Oncology
Shiyu Liu, Qin Zhao, Zhuangzhuang Zheng, Zijing Liu, Lingbin Meng, Lihua Dong, Xin Jiang
Summary: Radiation-induced oral mucositis is a common complication in head and neck cancer patients undergoing radiotherapy, leading to severe discomfort and treatment interruptions. Its pathogenesis is complex, involving the release of inflammatory transmitters. Understanding and implementing preventive measures and treatments are crucial for managing this condition effectively.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemical Research Methods
Claudia C. Cotomacio, Bianca K. Yshikawa, Caio C. Calarga, Victor E. Arana-Chavez, Alyne Simoes
Summary: This study aims to compare the effects of simultaneous irradiation with the isolated application of photobiomodulation therapy (PBMT) on oral mucositis (OM). The results showed that red laser and infrared laser irradiation can effectively reduce the grade of OM, accelerate the tissue repair process, decrease the expression of inflammatory factors, and increase the concentration of collagen fibers.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Medicine, Research & Experimental
Marzieh Sahebnasagh, Vahideh Aksi, Fatemeh Eslami, Hossein Lashkardoost, Jamal Kasaian, Shiva Golmohammadzadeh, Bahareh Parkam, Reza Negarandeh, Fatemeh Saghafi, Adeleh Sahebnasagh
Summary: This study evaluated the effectiveness of zinc sulfate and polyherbal mouthwashes in preventing radiation-induced oral mucositis (OM) and reducing pain severity in head and neck cancer patients. The results showed that both zinc sulfate and polyherbal mouthwashes significantly reduced OM scores and pain severity compared to chlorhexidine or placebo mouthwashes.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Alessandro Villa, Michal Kuten-Shorrer
Summary: Targeted therapy and immunotherapy have revolutionized cancer treatment, but oral toxicities induced by these therapies remain a concern. These toxicities can manifest as mucosal lesions, salivary gland dysfunction, or orofacial neuropathies, impacting patients' quality of life and clinical outcomes. Further research is needed to better understand and manage these adverse events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Alessandro Villa, Michele Vollemans, Amanda De Moraes, Stephen Sonis
Summary: This study evaluated the concordance of three commonly used oral mucositis grading criteria, finding relatively high levels of consistency in all OM scores and severe OM scores. This indicates that these grading criteria have high accuracy in assessing oral mucositis.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Medicine, General & Internal
Carlos J. Roldan, Billy Huh, Juhee Song, Yago Nieto, Joyce Osei, Thomas Chai, Kent Nouri, Lakshmi Koyyalagunta, Eduardo Bruera
Summary: This study assessed the safety and effectiveness of methylene blue oral rinse in reducing oral mucositis pain in cancer therapy patients. The results showed that methylene blue oral rinse significantly reduced pain and improved oral functioning with minimal adverse effects.
Article
Oncology
Yuanming Xu, Natalie Wen, Stephen T. Sonis, Alessandro Villa
Summary: Immune checkpoint inhibitors have been increasingly used in cancer treatment, with oral adverse events such as xerostomia, oral mucosal disorders, and dysgeusia being more common than previously reported. These oral side effects often develop within a few months after initiating ICIT. Further studies are needed to understand the biological basis of these oral irAEs.
Article
Biochemical Research Methods
Xiaohui Zhao, Wanyi Tang, Haipeng Wang, Hao He
Summary: This study shows that a single-time scanning of tightly focused femtosecond laser can modulate the stemness and senescence of tumor cells in vitro and in vivo. The laser-induced cellular senescence and stemness demonstrate distinct transitions in vitro and in vivo. Significant senescence is induced in cells located 1.2 mm deep within the tumor tissue following transient photostimulation in the 100-200 μm shallow layer in vivo, which suppresses the growth of the entire tumor in living mice.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Oncology
Ragda Abdalla-Aslan, Yehuda Zadik, Orna Intrator, Elena Bardellini, Karis Kin Fong Cheng, Paolo Bossi, Noam Yarom, Sharon Elad
Summary: This study assessed the clinical use and patient outcome of photobiomodulation (PBM) for oral mucositis (OM) prevention and treatment among specialized practitioners. The results showed that PBM provided pain relief, but there was a wide variation in technical parameters.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
K. Fakiha, J. K. Coller, R. M. Logan, R. J. Gibson, J. M. Bowen
SUPPORTIVE CARE IN CANCER
(2019)
Article
Dentistry, Oral Surgery & Medicine
Valkiria D'Aiuto de Mattos, Sima Ferman, Denise Maria Araujo Magalhaes, Heliton Spindola Antunes, Simone Queiroz Chaves Lourenco
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2019)
Article
Dermatology
Molly J. Youssef, Dawn H. Siegel, Yvonne E. Chiu, Beth A. Drolet, Brian D. Hodgson
PEDIATRIC DERMATOLOGY
(2019)
Article
Oncology
J. Bowen, N. Al-Dasooqi, P. Bossi, H. Wardill, Y. van Sebille, A. Al-Azri, E. Bateman, M. E. Correa, J. Raber-Durlacher, A. Kandwal, B. Mayo, R. G. Nair, A. Stringer, K. ten Bohmer, D. Thorpe, R. V. Lalla, S. Sonis, K. Cheng, S. Elad
SUPPORTIVE CARE IN CANCER
(2019)
Review
Oncology
Yehuda Zadik, Praveen R. Arany, Eduardo Rodrigues Fregnani, Paolo Bossi, Heliton Spindola Antunes, Rene-Jean Bensadoun, Luiz Alcino Gueiros, Alessandra Majorana, Raj G. Nair, Vinisha Ranna, Wim J. E. Tissing, Anusha Vaddi, Rachel Lubart, Cesar Augusto Migliorati, Rajesh V. Lalla, Karis Kin Fong Cheng, Sharon Elad
SUPPORTIVE CARE IN CANCER
(2019)
Review
Oncology
Joanne M. Bowen, Rachel J. Gibson, Janet K. Coller, Nicole Blijlevens, Paolo Bossi, Noor Al-Dasooqi, Emma H. Bateman, Karen Chiang, Charlotte de Mooij, Bronwen Mayo, Andrea M. Stringer, Wim Tissing, Hannah R. Wardill, Ysabella Z. A. van Sebille, Vinisha Ranna, Anusha Vaddi, Dorothy M. K. Keefe, Rajesh V. Lalla, Karis Kin Fong Cheng, Sharon Elad
SUPPORTIVE CARE IN CANCER
(2019)
Review
Dentistry, Oral Surgery & Medicine
Lisia Daltro Borges Alves, Andreia Cristina de Melo, Thayana Alves Farinha, Luiz Henrique de Lima Araujo, Leandro de Souza Thiago, Fernando Luiz Dias, Heliton Spindola Antunes, Ana Lucia Amaral Eisenberg, Luiz Claudio Santos Thuler, Daniel Cohen
Summary: Secretory carcinoma mainly affects the parotid glands and presents as a slow-growing, painless mass. The main differential diagnosis is acinic cell carcinoma, and the tumor is usually treated with surgery. Although the prognosis is generally favorable, there is still a possibility of recurrence, metastasis, and death.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2021)
Article
Oncology
Sharon Elad, Karis Kin Fong Cheng, Rajesh V. Lalla, Noam Yarom, Catherine Hong, Richard M. Logan, Joanne Bowen, Rachel Gibson, Deborah P. Saunders, Yehuda Zadik, Anura Ariyawardana, Maria Elvira Correa, Vinisha Ranna, Paolo Bossi
Article
Dentistry, Oral Surgery & Medicine
Christopher E. Okunseri, Brian Hodgson, Elaye Okunseri, Raul I. Garcia, Alexis Visotcky, Aniko Szabo
COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY
(2020)
Review
Cell Biology
Elise E. Bruning, Janet K. Coller, Hannah R. Wardill, Joanne M. Bowen
Summary: TLR4 is a highly conserved protein involved in innate immunity with distinct roles in epithelial and immune cells throughout the gastrointestinal tract. While epithelial cell expression of TLR4 contributes to maintaining homeostasis, promoting immunoglobulin A production, and regulating permeability, immune cell expression is centered on maturation of dendritic cells and priming the adaptive immune system. However, further research is needed to fully understand the impact of site-specific TLR4 expression on inflammation and disease progression.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Letter
Dentistry, Oral Surgery & Medicine
Daniel Cohen Goldemberg, Andreia Cristina de Melo, Livia Cristina de Melo Pino, Heliton Spindola Antunes, Jair Carneiro Leao, Stephen Porter
Editorial Material
Oncology
Joanne Bowen, Hannah Wardill
SUPPORTIVE CARE IN CANCER
(2022)
Review
Biotechnology & Applied Microbiology
Raja Nur Firzanah Syaza Raja Sharin, Jesmine Khan, Mohamad Johari Ibahim, Mudiana Muhamad, Joanne Bowen, Wan Nor I'zzahWan Mohamad Zain
Summary: Lapatinib, a tyrosine kinase inhibitor, is effective in treating ErbB2-positive breast cancer; however, it often causes gastrointestinal toxicity, specifically diarrhea. This review article explores the mechanisms of lapatinib-induced diarrhea, focusing on the involvement of ErbB1 and its role in inflammation and intestinal permeability.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Megan Davenport, Andrew D. Welles, Matina Angelopoulou, Cesar Gonzalez, Christopher Okunseri, Lori Barbeau, Naveen K. Bansal, Rodney J. Vergotine, Brian D. Hodgson
CLINICAL COSMETIC AND INVESTIGATIONAL DENTISTRY
(2019)