Article
Oncology
Doke J. M. Buurman, Caroline M. Speksnijder, Marlies E. Granzier, Veronique C. M. L. Timmer, Frank J. P. Hoebers, Peter Kessler
Summary: This study aimed to gain insight into the number of redundantly extracted teeth prior to radiotherapy and the factors associated with this. The results showed that tumor location and nodal stage were the most important factors associated with the number of teeth extracted.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Thyago Morais Vicente da Silva, Thayanara Silva Melo, Romulo Cesar de Alencar, Jose Ricardo Dias Pereira, Jair Carneiro Leao, Igor Henrique Morais Silva, Luiz Alcino Gueiros
Summary: Photobiomodulation therapy (PBMT) has a significant positive impact on promoting surgical alveolar mucosal lining in patients who have undergone head and neck radiation therapy, leading to faster healing and reduced postoperative pain.
SUPPORTIVE CARE IN CANCER
(2021)
Review
Oncology
Ana Gabriela Costa Normando, Maria Eduarda Perez-de-Oliveira, Eliete Neves Silva Guerra, Marcio Ajudarte Lopes, Andre Caroli Rocha, Thais Bianca Brandao, Ana Carolina Prado-Ribeiro, Luiz Alcino Monteiro Gueiros, Joel B. Epstein, Cesar Augusto Migliorati, Alan Roger Santos-Silva
Summary: This systematic review found that tooth extraction prior to head and neck radiotherapy can reduce the risk of osteoradionecrosis. The meta-analysis showed a significant association between post-RT tooth extraction and increased risk of ORN.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Oncology
Carlo Lajolo, Cosimo Rupe, Gioele Gioco, Giuseppe Troiano, Romeo Patini, Massimo Petruzzi, Francesco Micciche', Michele Giuliani
Summary: This systematic review found that post-RT teeth extractions are a major risk factor for ORN development, especially in the mandible, with a decreasing trend in recent years. Further research on other potential risk factors could enhance this evidence.
Article
Otorhinolaryngology
Pei-Hsun Liao, Che Lin, Jing-Yang Huang, Hsin-Mei Lin, Tsu-Jen Kuo
Summary: This study aimed to determine the risk of osteoradionecrosis (ORN) in patients who undergo tooth extraction during radiotherapy (RT). The study found that there was no significant association between tooth extraction during RT and the risk of ORN in patients with head and neck cancer.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Oncology
Erin Watson, Zahra Dorna Mojdami, Afisu Oladega, Andrew Hope, Michael Glogauer
Summary: This study utilized expert consensus to develop tooth-specific dental treatment pathways for head and neck cancer patients prior to radiation therapy. Dental oncologists from a single nation engaged in a Modified Delphi process to establish guidelines for tooth extraction and other dental treatments to prevent osteoradionecrosis.
Article
Dentistry, Oral Surgery & Medicine
Yin-Ju Shih, Jing-Yang Huang, Yu-Cheng Lai, Hsin-Mei Lin, Tsu-Jen Kuo
Summary: This study examined the effect of a waiting period between tooth extraction and head and neck radiotherapy on osteoradionecrosis risk. The results showed no significant difference in risk between tooth extraction within 2 weeks before radiotherapy and other time periods. Factors such as radiation dose, chemotherapy, tumor excision, post-radiotherapy tooth extraction, mandibulectomy, hyperlipidemia, and oral cavity as tumor subsite were significantly associated with osteoradionecrosis risk.
Article
Dentistry, Oral Surgery & Medicine
Rhys Ward, Ria Kanani, Shihab A. Romeed
Summary: This study retrospectively reviewed the records of 154 head and neck cancer patients undergoing radiotherapy and found that only 1.3% of patients developed osteoradionecrosis (ORN) after a minimum of 20 months of follow-up, with no apparent correlation between the timing of dental extractions and the occurrence of ORN.
BRITISH DENTAL JOURNAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Samanta Oliveira, Renata S. Vellei, Daniele Heguedusch, Carina Domaneschi, Claudio Costa, Camila de Barros Gallo
Summary: Tooth extraction after head and neck radiotherapy carries a higher risk of osteoradionecrosis of the jaw. Complete mucosal repair is observed within 30 days post-surgery, but significant bone formation is only seen 12 months after the tooth extractions.
IMAGING SCIENCE IN DENTISTRY
(2021)
Article
Dentistry, Oral Surgery & Medicine
J. P. Kovarik, I. Voborna, S. Barclay, M. S. Iqbal, M. Cunnell, C. Kelly, N. Willis, M. Kennedy, J. Kovarik
Summary: Osteoradionecrosis (ORN) is a significant complication of radiotherapy (RT) in head and neck cancer (HNC). This study aimed to identify the risk factors for the development of ORN in HNC. A comprehensive analysis of 935 HNC patients revealed that smoking, primary site in the oropharynx, bone surgery before adjuvant RT, concurrent chemotherapy, xerostomia, dental extraction pre-RT, time <20 days between dental extraction and start of RT, and receiving >55Gy RT dose were significant risk factors for the development of ORN.
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2022)
Article
Oncology
Michael T. Brennan, Nathaniel S. Treister, Thomas P. Sollecito, Brian L. Schmidt, Lauren L. Patton, Alexander Lin, Linda S. Elting, James S. Hodges, Rajesh Lalla
Summary: This study aimed to investigate tooth failure in head and neck cancer patients after radiation therapy (RT). The results demonstrated that tooth failure occurred within 2 years after RT, and factors such as baseline tooth count, reduction in salivary flow rate, and noncompliance with oral hygiene were associated with a higher risk of tooth failure.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Review
Dentistry, Oral Surgery & Medicine
Daniel Jan Toneatti, Ronny Roger Graf, John-Patrik Burkhard, Benoit Schaller
Summary: This systematic review assessed dental implant survival and osteoradionecrosis incidence in irradiated head and neck cancer patients. Results showed lower implant survival in irradiated patients compared to non-irradiated patients, and osteoradionecrosis as a rare but serious complication. Radiation therapy and grafting status were key factors influencing implant survival.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Oncology
Atsushi Musha, Hirofumi Shimada, Nobuteru Kubo, Hidemasa Kawamura, Naoko Okano, Hiro Sato, Takuya Kaminuma, Kohei Okada, Mai Anakura, Akiko Adachi, Katsuyuki Shirai, Jun-ichi Saitoh, Satoshi Yokoo, Kazuaki Chikamatsu, Tatsuya Ohno
Summary: This retrospective study analyzed the occurrence of osteoradionecrosis (ORN) of the mandible in patients with head and neck tumors treated with carbon ion radiotherapy (C-ion RT). The findings indicate that doses of 30 Gy to the mandible and teeth had the most significant effects on causing ORN, with cut-off values identified. This study provides important insights for establishing clinical strategies for patients receiving C-ion RT near the mandible.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Meera Samani, Shahryar Beheshti, Hilary Cheng, Chris Sproat, Jerry Kwok, Vinod Patel
Summary: Compliance with the prophylactic antifibrotic regimen pentoxifylline can significantly reduce the incidence of osteoradionecrosis (ORN) caused by dental extractions in post-radiotherapy patients. Prophylactic use of pentoxifylline could be considered for dental extractions in patients with head and neck cancer who have undergone radiation therapy.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2022)
Article
Otorhinolaryngology
Junhyung Lee, Katrina Hueniken, Karl Cuddy, Jiajie Pu, Amr El Maghrabi, Andrew Hope, Ali Hosni, Michael Glogauer, Erin Watson
Summary: This retrospective cohort study aims to determine the association between the timing of pre-radiation therapy (RT) dental extractions and the development of osteoradionecrosis (ORN) in patients with head and neck cancer. The findings suggest that dental extractions within 7 days prior to the start of RT increase the risk of ORN. However, the occurrence of ORN after pre-RT extractions is relatively rare. Therefore, patients with head and neck cancer undergoing RT should not delay treatment for extractions when it might compromise oncologic control.
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2023)
Article
Otorhinolaryngology
C. Vandersteen, L. Castillo, C. Roger, C. Savoldelli, N. Guevara
Summary: In this study, TMM was used to evaluate obstructive eustachian tube dysfunction in patients with chronic rhinosinusitis. The results showed a significant percentage of patients with pathologic tubomanometric results, highlighting the potential of TMM as an additional tool in the clinical assessment of chronic rhinosinusitis patients.
EUROPEAN ANNALS OF OTORHINOLARYNGOLOGY-HEAD AND NECK DISEASES
(2021)
Article
Otorhinolaryngology
V Parent, M. Codet, K. Aubry, P. Bordure, A. Bozorg-Grayeli, O. Deguine, C. Eyermann, V. Franco-Vidal, N. Guevara, A. Karkas, N. Klopp, M. Labrousse, J-P Lebreton, Y. Lerosey, E. Lescanne, N. Loundon, R. Marianowski, F. Merklen, K. Mezouaghi, T. Mom, S. Moreau, I Mosnier, N. Noel-Petroff, C. Parietti-Winkler, P. Piller, C. Poncet, E. Radafy, S. Roman, S. Roux-Vaillard, S. Schmerber, L. Tavernier, E. Truy, C. Vincent, B. Godey
EUROPEAN ANNALS OF OTORHINOLARYNGOLOGY-HEAD AND NECK DISEASES
(2020)
Article
Audiology & Speech-Language Pathology
Adrien Bolzer, Michel Hoen, Bettina Montaut-Verient, Charles Hoffmann, Marine Ardoint, Ariane Laplante-Levesque, Nicholas Guevara, Thierry Mom, Chadlia Karoui, Christophe Vincent, Cecile Parietti-Winkler
Summary: The Telislife questionnaire showed excellent reliability among cochlear implant users, with significant correlations found between Telislife scores, Nijmegen Cochlear Implant Questionnaire scores, and speech recognition scores. It appears to be a reliable tool for evaluating cochlear implant outcomes in clinical practice due to its short form and correlations with important measures.
JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH
(2021)
Article
Clinical Neurology
A. Gavotto, V Feuillade, S. Bresch, N. Guevara, L. Mondot, F. Almairac
Summary: In most cases, vestibular schwannomas with papilledema are associated with hydrocephalus and intracranial hypertension. However, this atypical case presented with bilateral papilledema without hydrocephalus and with normal intracranial pressure. The patient's ophthalmic signs resolved completely after tumor removal, raising questions about the mechanisms involved in visual impairment related to vestibular schwannoma.
Article
Otorhinolaryngology
G. D'Andrea, R. Giacchero, C. Roger, C. Vandersteen, N. Guevara
Summary: The study aimed to evaluate the therapeutic efficacy and acceptability of Eye Movement Desensitization and Reprocessing (EMDR) in tinnitus treatment. Results showed that after treatment, there was a significant reduction in tinnitus severity for the majority of patients, and the treatment acceptability was high. This suggests that EMDR may be an effective and acceptable alternative treatment.
EUROPEAN ANNALS OF OTORHINOLARYNGOLOGY-HEAD AND NECK DISEASES
(2022)
Article
Engineering, Biomedical
Zihao Wang, Clair Vandersteen, Thomas Demarcy, Dan Gnansia, Charles Raffaelli, Nicolas Guevara, Herve Delingette
Summary: A 3D metal artifact reduction algorithm based on generative adversarial neural network is proposed for high-resolution CT imaging of tiny implants. The method outperforms other general metal artifact reduction approaches in clinical experiments.
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
(2021)
Article
Neurosciences
Julie Fiorentino, Magali Payne, Elisa Cancian, Alexandra Plonka, Louise-emilie Dumas, David Chirio, Elisa Demonchy, Karine Risso, Florence Askenazy-Gittard, Nicolas Guevara, Laurent Castillo, Philippe Robert, Valeria Manera, Clair Vandersteen, Auriane Gros
Summary: Semantic memory impairment can occur in patients with post COVID-19 olfactory disorders, especially in younger age groups. Olfactory threshold is only significantly correlated with semantic memory scores.
Article
Medicine, General & Internal
Clair Vandersteen, Magali Payne, Louise-Emilie Dumas, Elisa Cancian, Alexandra Plonka, Gregoire D'Andrea, David Chirio, Elisa Demonchy, Karine Risso, Florence Askenazy-Gittard, Charles Savoldelli, Nicolas Guevara, Philippe Robert, Laurent Castillo, Valeria Manera, Auriane Gros
Summary: This study evaluated the efficacy of olfactory training (OT) on persistent post-viral olfactory disorders (PPVOD) after COVID-19 infection. The results showed that OT led to improvements in olfactory function and quality of life in patients with PPVOD. However, further research is needed to confirm the role of OT and explore new therapeutic strategies for the central aspects of PPVOD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Jan Margeta, Raabid Hussain, Paula Lopez Diez, Anika Morgenstern, Thomas Demarcy, Zihao Wang, Dan Gnansia, Octavio Martinez Manzanera, Clair Vandersteen, Herve Delingette, Andreas Buechner, Thomas Lenarz, Francois Patou, Nicolas Guevara
Summary: This study presents Nautilus, a web-based platform for automated cochlear analysis. It combines deep learning and Bayesian inference methods to delineate cochlear structures from clinical CT images and extract electrode locations from post-operative images. By fusing pre- and post-operative images, Nautilus can provide personalized metrics for research in cochlear implantation therapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Raabid Hussain, Attila Frater, Roger Calixto, Chadlia Karoui, Jan Margeta, Zihao Wang, Michel Hoen, Herve Delingette, Francois Patou, Charles Raffaelli, Clair Vandersteen, Nicolas Guevara
Summary: Understanding cochlear anatomy is essential for developing less invasive cochlear implantation techniques. This study analyzed over 1000 clinical temporal bone CT images to determine population statistics and correlations between cochlear dimensions and morphology. The findings indicate that cochlear morphology follows a normal distribution and that certain dimensions are more correlated with duct lengths, wrapping factor, and volume. The results also highlight the variability in scala tympani size and suggest differences in size and shape between ears of the same individual. Overall, this research provides important insights for implant development and reducing trauma during insertion.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Nicolas Guevara, Eric Truy, Michel Hoen, Ruben Hermann, Clair Vandersteen, Stephane Gallego
Summary: This study investigates the use of electrically evoked Auditory Brainstem Responses (eABRs) for measuring local channel interactions on cochlear implant (CI) electrode arrays. eABRs were recorded from 16 experienced CI patients using different stimulation configurations. Results show that increasing the stimulation level on the middle electrode leads to reduced eABR latency and amplitude, indicating local electrical interactions. Compound eABRs provide individual quantification of these interactions, which can inform audiological decisions regarding CI system mapping.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Otorhinolaryngology
A. Alshukry, G. D'Andrea, C. Vandersteen, N. Guevara
Summary: This article presents a technical note on the transcanal endoscopic approach to resection of a cholesteatoma limited to the posterior mesotympanum, providing a suitable and minimal-invasive alternative to the classic microscopic transmastoid approach.
EUROPEAN ANNALS OF OTORHINOLARYNGOLOGY-HEAD AND NECK DISEASES
(2023)
Article
Medicine, General & Internal
Manon Baranger, Valeria Manera, Chloe Serignac, Alexandre Derreumaux, Elisa Cancian, Clair Vandersteen, Auriane Gros, Nicolas Guevara
Summary: Hearing loss is correlated with cognitive performance. Our study evaluated lexical access abilities in adults with severe to profound hearing loss and after cochlear implantation. Results showed an improvement in phonemic fluency after implantation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Gregoire D'Andrea, Lun Jing, Isabelle Peyrottes, Jean-Marie Guigonis, Fanny Graslin, Sabine Lindenthal, Julie Sanglier, Isabel Gimenez, Juliette Haudebourg, Clair Vandersteen, Alexandre Bozec, Nicolas Guevara, Thierry Pourcher
Summary: In this study, the researchers evaluated the metabolomic profiles of liquid-based fine-needle aspiration cytology (FNAC) samples to identify a potential molecular diagnostic method for differentiating between malignant and benign thyroid nodules. The study found a promising metabolomic signature that can accurately differentiate papillary thyroid carcinomas (PTCs) from benign thyroid nodules. Further research with larger cohorts is needed to identify more biomarkers and establish more reliable diagnostic signatures.
Review
Medicine, Research & Experimental
Gregoire D'Andrea, Sandra Lassalle, Nicolas Guevara, Baharia Mograbi, Paul Hofman
Summary: The PD-1/PD-L1 immune checkpoint proteins are promising targets for precision oncology, but their use in ICIs treatment often leads to immune-related adverse events, including autoimmune damage. The thyroid, a common endocrine gland affected by both autoimmunity and cancer, serves as a model for studying the role of the PD-1/PD-L1 axis in thyroid diseases within the context of personalized medicine.