Review
Immunology
Jazmin Garcia-Machorro, Gema Lizbeth Ramirez-Salinas, Marlet Martinez-Archundia, Jose Correa-Basurto
Summary: This review discusses the importance of bioinformatic and immunoinformatic tools in guiding vaccine design. In silico strategies allow for the identification of potential vaccine epitopes and accelerate the vaccine development process.
Article
Biochemistry & Molecular Biology
Guihua Zhang, Lejiabao Han, Yuying Zhao, Qua Li, Shifeng Wang, Huoying Shi
Summary: This study developed a multi-epitope vaccine for Mycoplasma synoviae and demonstrated its immune responses and protective efficacy in chickens. The vaccine effectively stimulated antibody production and induced a robust cellular immune response. Vaccinated chickens exhibited reduced air sac lesion scores and tracheal mucosal thickness, as well as lower M. synoviae loads in throat swabs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biology
Manaswini Jagadeb, Kali Prasad Pattanaik, Surya Narayan Rath, Avinash Sonawane
Summary: The study identified potential peptide-based vaccine targets against tuberculosis using an immune-informatics approach. By analyzing the Mtb proteome, two potential vaccine candidates were selected, showing the ability to induce protective immune responses. The peptides exhibited strong binding affinity and antigenic properties, suggesting their potential as vaccine candidates against TB.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Microbiology
Maritriny Ruaro-Moreno, Gloria Paulina Monterrubio-Lopez, Abraham Reyes-Gastellou, Juan Arturo Castelan-Vega, Alicia Jimenez-Alberto, Gerardo Aparicio-Ozores, Karen Delgadillo-Gutierrez, Jorge Alberto Gonzalez-Y-Merchand, Rosa Maria Ribas-Aparicio
Summary: This study analyzed highly antigenic proteins and identified potential epitopes for a new tuberculosis vaccine. The vaccine construct showed stability and potential effectiveness, but further experimental studies are needed to confirm its protective effect.
Article
Biochemistry & Molecular Biology
Sari S. Sabban
Summary: This paper discusses a potential permanent treatment for allergies by computationally designing ten proteins to display a human IgE motif, which could serve as a pan anti-allergy vaccine. The designed proteins showed successful folding and displayed the IgE epitope in its native three-dimensional structure. The work utilized in silico methods for protein design and did not involve experimental verifications.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Review
Medicine, General & Internal
Aisyah Fitriannisa Prawiningrum, Rafika Indah Paramita, Sonar Soni Panigoro
Summary: Vaccines targeting tumor antigens can train the immune system to recognize tumor cells, and immunoinformatics methods can assist in designing epitope-based peptide vaccines with improved antigenicity and safety. Common protocols for designing these vaccines include tumor antigen identification, protein structure analysis, T cell epitope prediction, epitope characterization, and evaluation of protein-epitope interactions.
Article
Biochemistry & Molecular Biology
Yogeshwar Devarakonda, M. V. N. Janaradhan Reddy, R. S. Neethu, Aneesh Chandran, Kirtimaan Syal
Summary: This study developed a multi-epitope subunit vaccine using advanced immunoinformatics tools against Streptococcus pneumonia, the causative agent of sepsis, meningitis, and pneumonia. B-cell and T-cell epitopes were predicted and the vaccine design was validated and optimized using bioinformatic tools. The proposed vaccine designs have the potential to activate both humoral and cellular immune responses, making them a candidate for a S.pneumoniae vaccine, but further experimental validation is required to ensure immunogenicity and safety.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Immunology
Ramil R. Mintaev, Dina Glazkova, Olga Orlova, Elena Bogoslovskaya, German A. Shipulin
Summary: Scientists have developed an epitope-based universal vaccine rMVA-k1-k2 that provides effective protection against various strains of influenza virus. Double immunization with this vaccine has shown a 67% or greater efficiency in protecting mice against multiple subtypes of influenza A. The level of protection is comparable to other successful universal vaccines in clinical trials.
Article
Biochemistry & Molecular Biology
Nadia Moqbel Hassan Alzubaydi, Zainab Oun Ali, Sura Al-Asadi, Rusul Al-kahachi
Summary: In this study, a multi-epitope vaccine (MEV) targeting all strains of C. abortus was designed using bioinformatics and immunoinformatics approaches. Highly antigenic and non-allergic proteins were identified and incorporated into the MEV construct. Despite being in silico findings, further wet lab investigations are crucial to validate the safety and efficacy of the vaccine.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Immunology
Ali Forouharmehr
Summary: This study selected 10 antigenic proteins and isolated B cell, MHCI, and MHCII epitopes from them to engineer a poly-epitope vaccine with a molecular adjuvant. The designed vaccine, with 730 amino acids in length and a molecular weight of 77.67 kDa, showed promising features and binding energy for future application.
MICROBIAL PATHOGENESIS
(2021)
Article
Immunology
Luis F. Soto, Ana C. Romani, Gabriel Jimenez-Avalos, Yshoner Silva, Carla M. Ordinola-Ramirez, Rainer M. Lopez Lapa, David Requena
Summary: This study computationally screened the whole proteome of Clostridium perfringens and identified highly immunogenic proteins, domains, and epitopes. They found potential recombinant vaccine candidates, a potential sub-unit vaccine, and designed a multi-epitope protein. These findings are important for the development of safe and effective vaccines against C. perfringens infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kosmas A. Galanis, Katerina C. Nastou, Nikos C. Papandreou, Georgios N. Petichakis, Diomidis G. Pigis, Vassiliki A. Iconomidou
Summary: Research on predicting linear B-cell epitopes has been of increasing interest since the first method was developed in 1981. Accurate prediction of B-cell epitopes can enhance the efficiency and affordability of vaccine design, which is crucial in the current COVID-19 era. This study reviews the performance and methodology of commonly used linear B-cell epitope predictors, and proposes a consensus classifier to improve prediction accuracy and accelerate vaccine design.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Muhammad Waqas, Shahkaar Aziz, Pietro Lio, Yumna Khan, Amjad Ali, Aqib Iqbal, Faizullah Khan, Fahad Nasser Almajhdi
Summary: This study used immunoinformatics approach to design a chimeric antigen by targeting membrane-bound, enveloped, and extracellular proteins of monkeypox virus (MPXV). Multiple epitopes were selected and merged to construct a multi-epitope vaccine, which showed potential in eliciting cellular and humoral immune responses against MPXV infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Amir Samimi Hashjin, Souroush Sardari, Mosayeb Rostamian, Khadijeh Ahmadi, Hamid Madanchi, Vahid Khalaj
Summary: This study used reverse vaccinology to design a multi-epitope vaccine candidate based on the S and M proteins of SARS-CoV-2 virus. Through prediction and immunogenicity simulation, the constructed vaccine candidate was found to induce cellular and humoral immune responses and create an excellent immune memory response. Additionally, the construct was found to interact with immune receptors and neutralizing antibodies with high affinity.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Alireza Jalalvand, Fatemeh Fotouhi, Golnaz Bahramali, Bijan Bambai, Behrokh Farahmand
Summary: This study aimed to design a multi-epitope vaccine against influenza viruses by utilizing immunoinformatics methods. Through analysis and selection of epitopes, the best recombinant vaccine candidate was produced. Further validation and research will be conducted to evaluate its effectiveness.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)