期刊
CURRENT OPINION IN VIROLOGY
卷 14, 期 -, 页码 93-100出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2015.09.004
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资金
- Medical Research Council (UK) [MR K019090]
- National Institutes of Health (USA) [P01 CA100730-11A1, R01 CA63417-15, P50 CA094056-12, LLS 6067-10]
A typical person infected with the retrovirus human T-Iymphotropic virus type 1 (HTLV-1) carries tens of thousands of clones of HTLV-1-infected T lymphocytes, each clone distinguished by a unique integration site of the provirus in the host genome. However, only 5% of infected people develop the malignant disease adult T cell leukaemia/lymphoma, usually more than 50 years after becoming infected. We review the host and viral factors that cause this aggressive disease.
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