期刊
CURRENT OPINION IN VIROLOGY
卷 13, 期 -, 页码 101-108出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2015.06.002
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资金
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH/NIAID) [R01 AI110703-01]
- NIH/NIAID Centers for Excellence in Influenza Research and Surveillance (CEIRS) [HHSN272201400008C]
Animal models are used to simulate, under experimental conditions, the complex interactions among host, virus, and environment that affect the person-to-person spread of influenza viruses. The three species that have been most frequently employed, both past and present, as influenza virus transmission models ferrets, mice, and guinea pigs have each provided unique insights into the factors governing the efficiency with which these viruses pass from an infected host to a susceptible one. This review will highlight a few of these noteworthy discoveries, with a particular focus on the historical contexts in which each model was developed and the advantages and disadvantages of each species with regard to the study of influenza virus transmission among mammals.
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