Article
Oncology
Chang Kyun Choi, Min-Ho Shin, Sang-Hee Cho, Hye-Yeon Kim, Wei Zheng, Jirong Long, Sun-Seog Kweon
Summary: This study found that the ALDH2 rs671 genotype related to alcohol consumption was associated with a reduced risk of colorectal cancer in men, especially among regular drinkers. However, the ADH1B rs1229984 genotype showed no significant association with colorectal cancer risk. The combined genotype with the highest genetically predicted alcohol consumption was associated with a higher risk for colorectal cancer.
CANCER RESEARCH AND TREATMENT
(2021)
Article
Food Science & Technology
Hua Cao, Tuoyu Zhou, Haibo Tang, Pengya Feng, Gohar Ali, Pu Liu, Xiangkai Li
Summary: The genetically modified EcN has shown effectiveness in detoxifying ethanol metabolites in liver disease models, restoring liver function, inhibiting oxidative stress, lipid peroxidation, and inflammation, as well as promoting the recovery of gut microbiota homeostasis.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Food Science & Technology
Naila Boby, Eon-Bee Lee, Muhammad Aleem Abbas, Na-Hye Park, Sam-Pin Lee, Md. Sekendar Ali, Seung-Jin Lee, Seung-Chun Park
Summary: FSC pretreatment reduces blood alcohol and acetaldehyde concentrations, modulates liver enzyme activities, increases antioxidant enzyme expression, and decreases inflammatory cytokine gene expression in the liver. Additionally, it shows no acute oral toxicity in female rats and may be beneficial for reducing alcohol-induced damage.
Article
Genetics & Heredity
Wen-Ling Liao, Fu-Chun Chan, Kai-Ping Chang, Ya-Wen Chang, Che-Hong Chen, Wen-Hui Su, Hen-Hong Chang
Summary: In East Asian population, genetic variants in ALDH isoforms are associated with NPC susceptibility and exhibit a synergistic effect with alcohol consumption, resulting in a cumulative risk effect for NPC among both drinkers and non-drinkers.
Article
Biochemistry & Molecular Biology
Che-Hong Chen, Benjamin R. Kraemer, Lucia Lee, Daria Mochly-Rosen
Summary: Human ALDH is a multigene family with 19 functional members involved in detoxification and biotransformation. Genetic mutations can lead to toxic aldehyde accumulation and human pathologies. The physiological functions and substrate specificity of many ALDH genes are still unknown.
Review
Biochemistry & Molecular Biology
Evangelia Eirini Tsermpini, Anja Plemenitas Iljes, Vita Dolzan
Summary: Alcohol use disorder (AUD) is a prevalent and disabling disorder with various comorbidities. The relationship between alcohol metabolism and oxidative stress is not fully understood. Studies have shown that oxidative stress impacts AUD through genetics, alcohol metabolism, inflammation, and neurodegeneration.
Review
Agriculture, Multidisciplinary
Estelle Fischer, Nathalie Cayot, Remy Cachon
Summary: This review explores the potential of microorganisms to reduce the beany off-flavor in vegetable proteins. It identifies the volatile compounds contributing to the off-flavor and their formation pathways, and examines the role of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in reducing the off-flavor. The presence of these enzymes in certain microorganisms is found to be linked to odor improvement. Strains with constitutive ADH or both ADH and ALDH show the best results in reducing the compounds involved in the off-flavor.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Oncology
Zili Zhai, Takeshi Yamauchi, Sarah Shangraw, Vincent Hou, Akiko Matsumoto, Mayumi Fujita
Summary: Acetaldehyde (AcAH), a carcinogenic byproduct of ethanol metabolism, has been linked to the development of malignancies in the upper gastrointestinal tract as well as cutaneous melanoma. This review examines the sources of ethanol and AcAH in the skin, their metabolic pathways, and the role of dysfunctional ethanol and AcAH metabolizing enzymes in melanoma development and progression. Data analysis also shows reduced activity of alcohol and AcAH metabolizing enzymes in melanoma tissues.
Article
Biology
Chih-Yao Hu, Chung-Lieh Hung, Yen-Chang Huang, Po-Han Huang, Da-Yo Tseng, Yi-Hsuan Lin, Fang-Ju Sun, Fu-Jen Kao, Hung- Yeh, Yen-Yu Liu
Summary: The study found that using the HSV model analysis with APT resulted in better sensitivity and equal specificity compared to visual inspection, showing that the HSV model could help in predicting ALDH2 genetic polymorphisms.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Review
Oncology
Takeshi Yamauchi, Sarah Shangraw, Zili Zhai, Dinoop Ravindran Menon, Nisha Batta, Robert P. Dellavalle, Mayumi Fujita
Summary: Studying social-environmental risk factors associated with melanoma is crucial for improving public health initiatives and patient outreach and education methods.
Article
Food Science & Technology
Hyeonjeong Choe, Injue Yun, Yunyoung Kim, Ji-Heon Lee, Hyun-A Shin, Yong-Kyu Lee, Mi-Yeon Kim
Summary: This study aimed to investigate the effect of a mixture of herbal extracts and supplementary formula on hangovers and antioxidant enzymes in alcohol-induced liver damage. The results showed that the mixture reduced blood alcohol and acetaldehyde concentration, decreased alcohol dehydrogenase levels, and improved liver's antioxidant activity.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2022)
Article
Nutrition & Dietetics
Ahmed Ismaeel, Joseph A. Laudato, Emma Fletcher, Evlampia Papoutsi, Abigail Tice, Lara S. Hwa, Dimitrios Miserlis, Athanasios Z. Jamurtas, Jennifer Steiner, Panagiotis Koutakis
Summary: This study aimed to assess the concurrent effect of chronic heavy alcohol consumption and consumption of a high-fat diet on skeletal muscle oxidative stress and mitochondrial dysfunction. The results showed that a high-fat diet may exacerbate the negative effects of alcohol on skeletal muscle mitochondrial health and oxidative stress.
Article
Medicine, General & Internal
Ichiro Wakabayashi, Harald Sourij, Yoko Sotoda, Takashi Daimon, Klaus Groschner, Peter P. Rainer
Summary: There were no significant differences in serum levels of ALDH2- and ADH1B-related miRNAs between Austrian and Japanese middle-aged men. However, miR-150-3p and miR-4314 showed higher expression levels in Austrian men compared to Japanese men, indicating they may play a role in the ethnic difference in sensitivity to alcohol through modifying the expression of ADH1B.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Wojciech Kluzniak, Agata Szymiczek, Amelie Rodrigue, Dominika Wokolorczyk, Bogna Rusak, Klaudia Stempa, Tomasz Huzarski, Jacek Gronwald, Jan Lubinski, Neda Zamani, Shiyu Zhang, Jean-Yves Masson, Steven A. Narod, Cezary Cybulski, Mohammad R. Akbari
Summary: In the Polish population, the low-penetrance BRCA2 p.K3326* variant is associated with increased breast cancer risk only in individuals homozygous for the T allele of the ALDH2 rs10744777 variant, suggesting an interaction between these two variants.
JCO PRECISION ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yu-An Sui, Satoshi Maruyama, Natsumi Okada, Masakazu Ito, Masayoshi Muramatsu, Shusei Obata, Jun Ogawa, Shigenobu Kishino
Summary: PsADH, an alcohol dehydrogenase from Pantoea sp., was found to convert a variety of fatty alcohols into their corresponding aldehydes for alkane biosynthesis. By coupling PsADH with NpAD, a cyanobacterial aldehyde-deformylating oxygenase, and optimizing the reaction conditions, a 52% conversion of 1-tetradecanol to tridecane was achieved. This system was further used to generate alkanes ranging from C5-17, which can serve as biofuels, demonstrating the effectiveness of introducing a suitable alcohol dehydrogenase for alkane production.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2023)
