Article
Nanoscience & Nanotechnology
Hytham Elbohy, Hiroo Suzuki, Takeshi Nishikawa, Thiri Htun, Kosei Tsutsumi, Chiyu Nakano, Aung Ko Ko Kyaw, Yasuhiko Hayashi
Summary: This study investigates the impact of benzophenone (BP) on the performance and stability of inverted perovskite solar cells. The results show that BP significantly enhances the power conversion efficiency and improves the stability of the cells stored under ambient air.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Medicine, Research & Experimental
Onur Cil, Peter M. Haggie, Joseph-Anthony Tapia Tan, Amber A. Rivera, Alan S. Verkman
Summary: Functional evidence suggests complementary and region-specific roles of PAT1 and DRA in intestinal fluid absorption, with PAT1 as the predominant anion exchanger in mouse ileum. The compound PAT1(inh)-B01 is considered a novel tool for studying intestinal ion and fluid transport and potentially a drug candidate for small intestinal hyposecretory disorders.
Article
Cell Biology
Jack F. V. Hunt, Meng Li, Ryan Risgaard, Gene E. Ananiev, Scott Wildman, Fan Zhang, Tim S. Bugni, Xinyu Zhao, Anita Bhattacharyya
Summary: This study demonstrates the use of FXS patient iPSC-derived cell lines to screen for small molecule activators of the FMR1 gene, providing a new strategy for the discovery of treatments for FXS and other related diseases.
Article
Immunology
Nandadeva Lokugamage, Imran H. Chowdhury, Ronald J. Biediger, Robert Market, Sayadeth Khounlo, Navin D. Warier, Shen-An Hwang, Jeffrey K. Actor, Darren G. Woodside, Upendra Marathi, Peter Vanderslice, Nisha Jain Garg
Summary: 7HP349 is a small molecule activator that enhances the efficacy of DNA subunit vaccines in a model of Chagas disease. It improves control of acute parasite burden, reduces inflammatory infiltrate, improves tissue integrity, and controls tissue fibrosis in the heart and skeletal muscle. Additionally, 7HP349 increases splenic frequencies of CD8(+)T effector cells and enhances production of IFN-gamma and cytolytic molecules by CD4(+) and CD8(+) effector and central memory subsets in response to challenge infection.
Article
Chemistry, Applied
Suha Lee, Hee Su Kim, Hea Jung Park, Ning Yang, Bogyu Lim, Do-Hoon Hwang
Summary: This study synthesized and characterized two small-molecule donors, BDT-IDTT-ORH and BDT-C8IDTT-ORH, based on highly fused indacenodithiophene (IDTT). The different side chains of these molecules led to different crystallinities in the film state. These two synthesized molecules showed absorption in the long wavelength range and demonstrated potential as small-molecule donors in donor:Y6 blend for SM-OSCs. The BDT-C8IDTT-ORH:Y6 blend exhibited the highest power conversion efficiency (PCE) of 6.33% due to its tighter molecular packing compared to the BDT-IDTT-ORH blend.
Article
Oncology
Dan You, Stephen Hillerman, Gregory Locke, Charu Chaudhry, Caitlyn Stromko, Anwar Murtaza, Yi Fan, Jennifer Koenitzer, Yali Chen, Stephanie Briceno, Rajarshi Bhadra, Elizabeth Duperret, Johnni Gullo-Brown, Chan Gao, Dandan Zhao, John Feder, Joshua Curtin, Andrew P. Degnan, Godwin Kumi, Mark Wittman, Benjamin M. Johnson, Karen E. Parrish, Giridharan Gokulrangan, John Morrison, Michael Quigley, John T. Hunt, Luisa Salter-Cid, Emma Lees, Miguel A. Sanjuan, Jinqi Liu
Summary: This study identified a novel, potent, and selective HPK1 small molecule kinase inhibitor called Compound K (CompK), which significantly improved human T-cell immune responses in the tumor microenvironment and showed significant synergy with anti-PD-1 therapy. Animal model studies demonstrated improved immune responses and antitumor efficacy with CompK in combination with anti-PD-1, suggesting its potential as a novel pharmacological agent for cancer treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Microbiology
Mohamed Belal Hamed, Ewa Burchacka, Liselotte Angus, Arnaud Marchand, Jozefien De Geyter, Maria S. Loos, Jozef Anne, Hugo Klaassen, Patrick Chaltin, Spyridoula Karamanou, Anastassios Economou
Summary: The study identified 14 secretion inhibitors with potential antibacterial activity through high-throughput screening, some of which demonstrated bactericidal effects against both Gram-negative and Gram-positive bacteria. These results provide evidence for the development of potential antibiotics starting compounds.
Review
Materials Science, Multidisciplinary
Bin Kan, Yuanyuan Kan, Lijian Zuo, Xueliang Shi, Ke Gao
Summary: Recent breakthroughs have been made in solution-processed organic solar cells combining small-molecule donor and nonfullerene acceptor, with certified efficiency over 15%. By modifying materials and optimizing morphology, researchers have achieved impressive progress in this area. Small-molecule materials with easily tuned properties will be a key focus for future developments.
Article
Chemistry, Multidisciplinary
Nailiang Qiu, Chunyan Liu, Haijiao Lang, Jingyang Xu, Rui Su, Jie Jiang, Jiaqi Tian, Jisen Li
Summary: A new small-molecule donor, BTEHR-FT, has been designed and synthesized for the fabrication of all-small-molecule organic solar cells (ASM-OSCs). It exhibits excellent solubility and thermal stability. By introducing fluorine atoms, it achieves a low-lying highest occupied molecular orbital energy level. After thermal annealing treatment, the solar cell shows a significant enhancement in power conversion efficiency.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Cell Biology
Julien Roy Ishibashi, Riya Keshri, Tommy Henry Taslim, Daniel Kennedy Brewer, Tung Ching Chan, Scott Lyons, Anika Marie McManamen, Ashley Chen, Debra Del Castillo, Hannele Ruohola-Baker
Summary: This study utilized a genetically tractable model for stem cell survival in Drosophila gonads to identify small molecule drug candidates that may sensitize cancer stem cells to apoptosis, uncovering the NF-kappa B pathway as essential in GSC quiescence and viability. The study highlights the potential of the Drosophila stem cell niche as a model system for targeted drug discovery.
Article
Chemistry, Multidisciplinary
Haojiang Shen, Yi Ren, Jianfeng Li, Yixuan Xu, Chenyang Han, Wentao Zou, Huajun Xu, Yanna Sun, Yuanyuan Kan, Ke Gao
Summary: All-small-molecule organic solar cells (ASM OSCs) are promising for commercial application due to their well-defined chemical structures and convenient purifying process. However, the similarity of molecule structures between small molecule donors and acceptors makes it difficult to regulate their blend morphology, which limits efficiency. This study demonstrates that altering pi-bridge units can improve film morphology and enhance device performance, providing insights for molecule design and structure-property correlation.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Chorlada Paiboonrungruang, Zhaohui Xiong, David Lamson, Yahui Li, Brittany Bowman, Julius Chembo, Caizhi Huang, Jianying Li, Eric W. Livingston, Jon E. Frank, Vivian Chen, Yong Li, Bernard Weissman, Hong Yuan, Kevin P. Williams, M. Ben Major, Xiaoxin Chen
Summary: This study identified and validated pyrimethamine as an NRF2 inhibitor that can effectively suppress NRF2 overexpression in esophageal squamous cell carcinoma (ESCC) and showed promising results in a genetically modified mouse model.
Article
Nanoscience & Nanotechnology
Qian Wang, Shuyi Lei, Mei Luo, Jiahao Liang, Deng Zhou, Lianjie Zhang, Junwu Chen
Summary: In this study, three small molecular donors with different numbers of siloxane-terminated side chain were synthesized for all-small-molecule organic solar cells. The addition of two symmetric siloxane-terminated side chains to the central unit resulted in elevated melting and crystalline temperatures, lowered surface energy, and pure face-on orientation when blended with the acceptor Y6. The S35-2Si:Y6 blend showed superior performance with a power conversion efficiency of 13.50%, suggesting the potential of siloxane-terminated side chains in regulating the crystalline ability of small molecular donors for high efficiency ASM-OSCs.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Physical
Liangang Xiao, Cong Yan, Zhengdong Li, Wenkai Zhong, Wanyi Tan, Yidong Liu, Feng Liu, Xiaobin Peng, Yonggang Min
Summary: Advancements in small-molecule non-fullerene acceptors have increased the power conversion efficiencies of organic solar cells. By improving crystallization properties and emphasizing the importance of morphology control during fabrication, highly efficient all-small molecule solar cells have been successfully developed.
ACS APPLIED ENERGY MATERIALS
(2021)
Article
Cell Biology
Kalina R. Atanasova, Saptarshi Chakraborty, Ranjala Ratnayake, Kshitij D. Khare, Hendrik Luesch, Tanmay P. Lele
Summary: Irregular nuclear shapes are a common feature of human cancers and alterations to chromatin regulators may be responsible for these irregularities. By screening an epigenetic small molecule library, researchers identified compounds that can revert abnormal nuclear shapes induced by gene knockdown in noncancerous breast epithelial cells. This approach may have potential in screening new cancer therapies targeting chromatin structure.
MOLECULAR BIOLOGY OF THE CELL
(2022)
Article
Psychology, Developmental
Samantha E. John, Sarah A. Evans, Bona Kim, Petek Ozgul, David W. Loring, Monica Parker, James J. Lah, Allan I. Levey, Felicia C. Goldstein
Summary: The study found that differences in performance on cognitive tests using mobile applications were not significant between Black and non-Hispanic white participants. Both groups found the app-based measures feasible and acceptable, with Black participants showing a stronger likelihood of future use.
AGING NEUROPSYCHOLOGY AND COGNITION
(2022)
Article
Clinical Neurology
Allan I. Levey, Deqiang Qiu, Liping Zhao, William T. Hu, Duc M. Duong, Lenora Higginbotham, Eric B. Dammer, Nicholas T. Seyfried, Thomas S. Wingo, Chadwick M. Hales, Malu Gamez Tansey, David S. Goldstein, Anees Abrol, Vince D. Calhoun, Felicia C. Goldstein, Ihab Hajjar, Anne M. Fagan, Doug Galasko, Steven D. Edland, John Hanfelt, James J. Lah, David Weinshenker
Summary: The study demonstrated that atomoxetine, a clinically approved noradrenaline reuptake inhibitor, improved multiple Alzheimer's disease biomarkers in individuals with mild cognitive impairment. Treatment with atomoxetine significantly reduced CSF levels of Tau and pTau, normalized CSF protein biomarker panels linked to synaptic function, brain metabolism, and glial immunity, and increased brain activity and metabolism in key temporal lobe circuits.
Article
Geriatrics & Gerontology
Alexis A. Bender, Rebecca L. McIntosh, Sean Sudduth, Michaela Harris, Kathy Tuckey, John C. Morgan, Joanna M. Jungerman, Abby Cox, Miranda A. Moore, Bryshia Ingram, Ellyn Pier, Theodore M. Johnson, David W. Loring, Kenneth Hepburn, Laura Medders, Allan Levey, James J. Lah, Chadwick M. Hales
Summary: GMN is an innovative care model aimed at improving access to accurate and timely diagnosis for patients with memory loss. It may help enhance the quality of life for patients and families through preventive and early care.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Neurosciences
Erik C. B. Johnson, E. Kathleen Carter, Eric B. Dammer, Duc M. Duong, Ekaterina S. Gerasimov, Yue Liu, Jiaqi Liu, Ranjita Betarbet, Lingyan Ping, Luming Yin, Geidy E. Serrano, Thomas G. Beach, Junmin Peng, Philip L. De Jager, Vahram Haroutunian, Bin Zhang, Chris Gaiteri, David A. Bennett, Marla Gearing, Thomas S. Wingo, Aliza P. Wingo, James J. Lah, Allan I. Levey, Nicholas T. Seyfried
Summary: This study analyzed the proteomes of over 1,000 brain tissues and identified new protein co-expression modules associated with Alzheimer's disease. These modules were highly conserved across cohorts and brain regions and revealed a proteopathic nature of the disease. The study also found disease-associated modules unique to the proteome, which could serve as potential therapeutic targets and biomarkers for Alzheimer's disease.
NATURE NEUROSCIENCE
(2022)
Article
Clinical Neurology
Lei Yu, Patricia A. Boyle, Aliza P. Wingo, Jingyun Yang, Tianhao Wang, Aron S. Buchman, Thomas S. Wingo, Nicholas T. Seyfried, Allan Levey, Philip L. De Jager, Julie A. Schneider, David A. Bennett
Summary: The cortical proteins implicated in Alzheimer's dementia were found to be more associated with non-AD neurodegenerative and cerebrovascular conditions rather than AD pathology. Some proteins were found to be pleiotropic and associated with both neurodegenerative and cerebrovascular pathologies.
Article
Geriatrics & Gerontology
Aron S. Buchman, Lei Yu, Hans-Ulrich Klein, Andrea R. Zammit, Shahram Oveisgharan, Francine Grodstein, Shinya Tasaki, Allan Levey, Nicholas T. Seyfried, David A. Bennett
Summary: This study identified cortical proteins that may provide motor resilience in older adults. Five proteins were associated with progressive parkinsonism, suggesting their potential as therapeutic targets for maintaining motor function despite untreatable brain pathologies.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Clinical Neurology
Thomas S. Wingo, Ekaterina S. Gerasimov, Se Min Canon, James J. Lah, Allan Levey, Aliza P. Wingo
Summary: The study found that depression manifesting after age 50 is associated with a genetic predisposition to Alzheimer's disease (AD), suggesting that genetic predisposition may be a factor contributing to the pathogenesis of mid-life depression. Further study is needed to investigate whether there is a shared genetic basis between mid-life depression and AD.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Richa Batra, Matthias Arnold, Maria A. Woerheide, Mariet Allen, Xue Wang, Colette Blach, Allan Levey, Nicholas T. Seyfried, Nilufer Ertekin-Taner, David A. Bennett, Gabi Kastenmuller, Rima F. Kaddurah-Daouk, Jan Krumsiek
Summary: This study provides a comprehensive investigation and description of AD-associated metabolic changes, laying the foundation for future mechanistic research.
ALZHEIMERS & DEMENTIA
(2023)
Article
Physics, Multidisciplinary
Hanghang Chen, Zijiang Yang, Maodu Chen
Summary: The reactive collisions of nitrogen ion with hydrogen and its isotopic variations are important in astrophysics. The study investigates the N+(P-3) + HD -> NH+/ND+ + D/H reaction using quantum time-dependent wave packet calculations. The results show a preference for the ND+ product and difficulty in exciting both products to higher vibrational states. The study provides insights into the differences between the two channels and serves as a reference for further experimental studies.
Article
Spectroscopy
Wenjun Wang, Xuesong Xu, Zijiang Yang
Summary: The photoinduced charge transfer mechanisms of two Donor-pi-Donor-pi-Acceptor conjugates are analyzed based on density functional theory calculations and visualization methods. The effects of the linkage between the two donors on the excitation characteristics are studied. The results show that the efficiency of superexchange charge transfer is affected by the change of bridge in one-photon absorption process, while the advantage of superexchange charge transfer is influenced by the linkage change in two-photon absorption process.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Multidisciplinary Sciences
Guo-Wen Sun, Wei He, Hai-Long Zhu, Zi-Jiang Yang, Quan-Qi Mu, Yu-He Wang
Summary: Wireless sensor network (WSN) node fault diagnosis is crucial for ensuring reliable data collection. This study proposes a method based on power set belief rule base (PBRB), which uses power set identification framework to represent fuzzy information, employs evidential reasoning as the reasoning process, and utilizes the projection covariance matrix adaptive evolution strategy as the parameter optimization algorithm. Experimental results demonstrate that the PBRB method achieves higher accuracy and better stability compared to other commonly used fault diagnosis methods. It can effectively represent indistinguishable fault types and has the advantage of small sample training.
Article
Microscopy
Dmitry Nuzhdin, Emily G. Pendleton, Eleanor B. Munger, Luke J. Mortensen, Sophie Brasselet
Summary: Polarisation Second harmonic Generation (PSHG) is used to study molecular organisation in biological tissues, but the quality of SHG imaging is limited to about 100 micrometres due to focus loss. This study investigates how optical depth penetration affects polarisation control and uses wavefront shaping to correct for SHG signal quality at different depths. By applying adaptive optics and wavefront shaping, the study successfully recovers high-quality linear polarisation, allowing for in-depth PSHG imaging of tissues such as tendon and mouse cranial bone.
JOURNAL OF MICROSCOPY
(2023)
Article
Biology
Nazir M. Khan, Martha Elena Diaz-Hernandez, Samir Chihab, Priyanka Priyadarshani, Pallavi Bhattaram, Luke J. Mortensen, Rosa M. Guzzo, Hicham Drissi
Summary: Induced pluripotent stem cells (iPSCs) have the potential to be used in regenerative medicine. iPSCs derived from healthy chondrocytes showed enhanced chondrogenic potential compared to iPSCs derived from osteoarthritis cartilage. The molecular tracing data revealed that epigenetic and metabolic factors dysregulation observed in osteoarthritis chondrocytes persisted in iPSCs, leading to their reduced chondrogenic differentiation.
Article
Multidisciplinary Sciences
Caroline M. Watson, Eric B. Dammer, Lingyan Ping, Duc M. Duong, Erica Modeste, E. Kathleen Carter, Erik C. B. Johnson, Allan I. Levey, James J. Lah, Blaine R. Roberts, Nicholas T. Seyfried
Summary: Alzheimer's disease (AD) is the most common form of dementia, and CSF beta-amyloid, total Tau, and phosphorylated Tau (pTau) are sensitive and specific biomarkers for diagnosis. However, these biomarkers do not capture the complex changes in AD brain beyond amyloid and Tau pathologies. This study used SRM-MS with isotopically labeled standards to quantify CSF protein biomarkers, identifying proteins that could distinguish AD stages and cognitive impairment.
Article
Biochemistry & Molecular Biology
Emily G. Pendleton, Anna S. Nichenko, Jennifer Mcfaline-Figueroa, Christiana J. Raymond-Pope, Albino G. Schifino, Taylor M. Pigg, Ruth P. Barrow, Sarah M. Greising, Jarrod A. Call, Luke J. Mortensen
Summary: In this study, the researchers investigated dynamic muscle function in a TNAP knockout mouse model of severe HPP and found that it recapitulates the muscle strength impairment observed in human patients. Further exploration of the role of alkaline phosphatase in skeletal muscle could provide insight into mechanisms of muscle weakness in HPP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
