期刊
CELL REPORTS
卷 10, 期 6, 页码 873-882出版社
CELL PRESS
DOI: 10.1016/j.celrep.2015.01.032
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类别
资金
- Medical Research Council
- Wellcome Trust
- European Research Council
- Lister prize fellowship
- MRC [G0901307, G0901899] Funding Source: UKRI
- Medical Research Council [G0901307, G0901899] Funding Source: researchfish
Spontaneous neurotransmitter release is a core element of synaptic communication in mature neurons, but despite exceptionally high levels of spontaneous vesicle cycling occurring in developing axons, little is known of its function during this period. We now show that high-level, spontaneous axonal release of the neurotransmitter glutamate can signal at long range to NMDA receptors on developing dendrites, prior to synapse formation and, indeed, axodendritic contact. Blockade of NMDA signaling during this early period of spontaneous vesicle cycling leads to a reduction in dendritic arbor complexity, indicating an important role for early spontaneous release in dendritic arbor growth.
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