Article
Clinical Neurology
Mariarita Galbiati, Marco Meroni, Marina Boido, Matilde Cescon, Paola Rusmini, Valeria Crippa, Riccardo Cristofani, Margherita Piccolella, Veronica Ferrari, Barbara Tedesco, Elena Casarotto, Marta Chierichetti, Marta Cozzi, Francesco Mina, Maria Elena Cicardi, Silvia Pedretti, Nico Mitro, Anna Caretto, Patrizia Rise, Angelo Sala, Andrew P. Lieberman, Paolo Bonaldo, Maria Pennuto, Alessandro Vercelli, Angelo Poletti
Summary: Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease characterized by motor neuron degeneration, muscle weakness, and an expansion of the CAG triplet repeat in the androgen receptor (AR) gene. In this study, the use of the antiandrogen bicalutamide and the natural disaccharide trehalose showed promising results in ameliorating SBMA pathology in a mouse model. These compounds reduced ARpolyQ toxicity, prevented autophagic flux blockage, and improved muscle morphology and function, suggesting their potential for future clinical trials in SBMA patients.
Article
Endocrinology & Metabolism
Sarah El Kharraz, Vanessa Dubois, Kaisa-Mari Launonen, Laura Helminen, Jorma J. Palvimo, Claude Libert, Elien Smeets, Lisa Moris, Roy Eerlings, Dirk Vanderschueren, Christine Helsen, Frank Claessens
Summary: Research suggests that the N/C interactions in the androgen receptor (AR) are not essential for the development of male phenotype under normal physiological conditions.
Article
Multidisciplinary Sciences
David R. Garcia Castro, Joseph R. Mazuk, Erin M. Heine, Daniel Simpson, R. Seth Pinches, Caroline Lozzi, Kathryn Hoffman, Phillip Morrin, Dylan Mathis, Maria V. Lebedev, Elyse Nissley, Kang Hoo Han, Tyler Farmer, Diane E. Merry, Qiang Tong, Maria Pennuto, Heather L. Montie
Summary: Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by polyglutamine expansion. Targeting metabolic anomalies, such as activating SIRT3 and replenishing NAD(+), can restore motor function and correct impaired metabolic pathways in SBMA mice.
Article
Biochemistry & Molecular Biology
Yongjun Quan, Xiaodong Zhang, William Butler, Zhen Du, Mingdong Wang, Yuexin Liu, Hao Ping
Summary: The dysregulation of androgen receptor signaling is crucial in prostate cancer progression, and targeting N-cadherin may overcome resistance to hormone therapy. N-cadherin collaborates with c-Jun and NDRG1 to promote CRPC progression through EMT, providing insights into potential therapeutic strategies for advanced prostate cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Neurosciences
Ji-Eun Kim, Duk-Shin Lee, Tae-Hyun Kim, Hana Park, Min-Ju Kim, Tae-Cheon Kang
Summary: In this study, we found that the DARPP-32-PP1-AMPAR signaling pathway may play an important role in the latency of seizure onset. Pyridoxal-5'-phosphate phosphatase/chronophin (PLPP/CIN) transiently dephosphorylated DARPP-32 and increased the seizure onset latency, while casein kinase 2 (CK2) phosphorylated DARPP-32 and exacerbated the intensity, duration, and progression of seizures.
Review
Biochemistry & Molecular Biology
Emma J. Montgomery, Enming Xing, Moray J. Campbell, Pui-Kai Li, James S. Blachly, Allan Tsung, Christopher C. Coss
Summary: Hepatocellular carcinoma (HCC) is a common type of liver cancer and a leading cause of cancer-related death worldwide. The androgen receptor (AR) has been found to play an important role in HCC, although current AR-targeted therapies have not shown efficacy in HCC. However, by building upon research in prostate cancer (PCa), potential AR-targeted therapeutic approaches for HCC could be developed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Ja Yeon Park, Woo Yong Park, Gahee Song, Se Jin Jung, Beomsu Kim, Minji Choi, Sang Hee Kim, Jinbong Park, Hyun Jeong Kwak, Kwang Seok Ahn, Jun Hee Lee, Jae-Young Um
Summary: This study aimed to investigate the therapeutic effects of Panax ginseng water extract (PGWE) on benign prostatic hyperplasia (BPH) and its potential in treating side effects related to finasteride (Fi), an FDA-approved drug for BPH. The results showed that PGWE alleviated BPH symptoms and downregulated androgen-related factors. PGWE also induced prostatic cell apoptosis and improved sperm count in BPH rats. Furthermore, PGWE protected against Fi-induced sperm loss without compromising the therapeutic effects of Fi on BPH. These findings suggest that PGWE could be an alternative therapeutic agent for BPH.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dhirodatta Senapati, Vikas Sharma, Santosh Kumar Rath, Uddipak Rai, Naresh Panigrahi
Summary: The article discusses the role of the androgen receptor in prostate cancer and the mechanisms of resistance. It highlights the plasticity of AR-DNA binding and emphasizes the importance of developing alternative strategies to antagonize AR activity.
Article
Genetics & Heredity
Jamie N. Leckie, Matthew M. Joel, Kristina Martens, Alexandra King, Malcolm King, Lawrence W. Korngut, A. P. Jason de Koning, Gerald Pfeffer, Kerri L. Schellenberg
Summary: This study estimated a prevalence rate of 14.7 per 100,000 population of SBMA among individuals of Indigenous descent in Saskatchewan, potentially making it the highest in the world. A unique haplotype was identified and shared among 13 participants with Indigenous ancestry, while a second shared haplotype was found in 2 participants, possibly representing a second founder effect that would require further confirmation in future studies.
NEUROLOGY-GENETICS
(2021)
Article
Biology
Jacky K. Leung, Yusuke Imamura, Minoru Kato, Jun Wang, Nasrin R. Mawji, Marianne D. Sadar
Summary: The study identifies peptidyl-prolyl isomerase Pin1 targeting the intrinsically disordered N-terminal domain of the androgen receptor (AR). Combining Pin1 inhibition with ralaniten compounds that bind to the AR N-terminal domain enhances antitumor activity on castration-resistant prostate cancer in xenografts, indicating therapeutic potential.
COMMUNICATIONS BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Di Zhang, Jingjing Fan, Hui Liu, Guobin Qiu, Sheng Cui
Summary: The study reveals that testosterone enhances taurine synthesis by interacting with androgen receptor and binding to cysteine sulfinate decarboxylase (CSAD) promoter zone. Estrogen has no significant effects on liver CSAD expression or taurine synthesis in male mice, indicating gender differences in the effects of sex steroids on taurine synthesis in the liver.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Teng Guan, Ting Zhou, Xiaosha Zhang, Ying Guo, Chaoxian Yang, Justin Lin, Jiasi Vicky Zhang, Yongquan Cheng, Hassan Marzban, Yu Tian Wang, Jiming Kong
Summary: Selective removal of misfolded SOD1 delays the onset of ALS, indicating that it is a promising treatment for the disease.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Cell & Tissue Engineering
Yalan Xu, Jie Mu, Zhixia Zhou, Yu Leng, Yali Yu, Xiuyue Song, Aihua Liu, Hai Zhu, Jing Li, Dong Wang
Summary: The study isolated and cultured a novel type of castration-resistant intermediate prostate stem cells that can rapidly proliferate in 2D culture dishes and be maintained for over six months. These stem cells express markers of both basal and luminal cells, and can differentiate into prostate organoids and tissues.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Neurosciences
Neha Gogia, Luhan Ni, Victor Olmos, Fatema Haidery, Kimberly Luttik, Janghoo Lim
Summary: Spinal and Bulbar Muscular Atrophy (SBMA) is a neuromuscular disease caused by expansion of CAG trinucleotide repeats in the Androgen Receptor gene, resulting in polyglutamine tract expansion. In addition to this genetic cause, posttranslational modifications of the Androgen Receptor have also been found to play a significant role in the pathophysiology of SBMA. Therapeutic approaches targeting these modifications aim to reduce mutant AR-mediated toxicity.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Engineering, Environmental
Yibin Tong, Junqing Li, Junchen Peng, Dandan Dong, Fei He, Mingyuan Zhu, Chaofeng Huang
Summary: The Fe-N-C adsorbent shows superior desulfurization capability and recyclability, effectively removing sulfur compounds without significant deactivation. By modulating the material structure, the binding strength of adsorption sites can be optimized to enhance desulfurization efficiency.
CHEMICAL ENGINEERING JOURNAL
(2022)