Article
Multidisciplinary Sciences
Shanliang Zheng, Dong Zhao, Guixue Hou, Song Zhao, Wenxin Zhang, Xingwen Wang, Li Li, Liang Lin, Tie-Shan Tang, Ying Hu
Summary: The study demonstrates the interaction between TMCO1 and iASPP in colon cancer, affecting tumor growth and cell apoptosis by modulating Ca2+ homeostasis. Intervention in the iASPP-TMCO1 axis can effectively inhibit tumor progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Medicine, Research & Experimental
Priyanka Saklani, Heena Khan, Saurabh Gupta, Amarjot Kaur, Thakur Gurjeet Singh
Summary: Neuropeptides play a crucial neuroprotective role in ischemic injury, providing powerful protection by modulating various signaling pathways.
Article
Clinical Neurology
Xia Liu, Qinlian Ye, Zhengzheng Huang, Xiuping Li, Liping Zhang, Xuan Liu, Yun-Cheng Wu, Ulf Brockmeier, Dirk M. Hermann, Ya-Chao Wang, Lijie Ren
Summary: In this study, a switch from UPS to autophagy due to changes in BAG3 expression was observed in cerebral ischemia. BAG3 overexpression activated autophagy and inhibited apoptosis, leading to improved neurological function and reduced ischemic injury.
Article
Plant Sciences
Pei Zhang, Suxin You, Xinyue Ding, Pengwei Luan, Jiazhen Xu, Qianfei Cui, Feiyun Wang, Ruixiang Li, Yuying Zhu, Jiange Zhang
Summary: Musk is a widely used traditional Chinese medicine with resuscitation, activating blood, and disperse swelling effects. This study aimed to investigate the effect and mechanism of muscone in improving ischemic stroke, and verified its efficacy in ischemia-reperfused rats, as well as investigated its mechanism using PC12 and THP-1 cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Xiuli Cheng, Jin Hu, Xiaofeng Liu, Jonnea Japhet Tibenda, Xiaobo Wang, Qipeng Zhao
Summary: Traditional Chinese medicine plays a significant role in treating ischemic cardiovascular and cerebrovascular diseases by inhibiting apoptosis. More research is needed on the pharmacodynamic ingredients of TCM.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Haixia Du, Yu He, Jiaqi Zhu, Huifen Zhou, Chongyu Shao, Jiehong Yang, Haitong Wan
Summary: This study found that Danhong injection (DHI) can alleviate cerebral ischemia-reperfusion injury in hyperlipidemia rats. This may be achieved by restoring the mitochondrial respiratory chain and changing the balance of mitochondrial fusion and fission proteins to inhibit mitochondria-dependent apoptosis and improve mitochondrial function.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Wei Li, Xueqi Yang, Mao Ding, Wenjuan Shi, Yuyou Huang, Qi An, Zhifeng Qi, Yongmei Zhao
Summary: This study investigates whether intracellular zinc accumulation aggravates ischemia/reperfusion (I/R) injury through inflammatory response and inflammation-mediated neuronal apoptosis. Results show that cerebral ischemia triggers inflammation, leading to zinc accumulation and neuronal inflammation. Chelation of zinc reverses neuronal inflammation and apoptosis. Excessive zinc activation of inflammation contributes to brain injury, specifically through inflammation-induced neuronal apoptosis, providing an important mechanism for cerebral I/R injury.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Oncology
Chun-Yu Lin, Kaustuv Basu, Aino Ruusala, Inna Kozlova, Yan-Shuang Li, Spyridon S. Skandalis, Carl-Henrik Heldin, Paraskevi Heldin
Summary: The tumor suppressor p53 interacts with the inhibitor of the apoptosis-stimulating protein of p53 (iASPP) to suppress tumor cell growth and chemotherapy resistance. iASPP physically interacts with the hyaluronan receptor CD44, specifically the standard isoform CD44s. Formation of iASPP-CD44s complexes is promoted by hyaluronan stimulation. The cellular level of p53 affects the amount of iASPP-CD44 complexes, and CD44 alters the sub-cellular localization of iASPP-p53 complexes.
Article
Pharmacology & Pharmacy
Lina Zhao, Huanming Li, Qian Gao, Jin Xu, Yongjie Zhu, Meili Zhai, Peijun Zhang, Na Shen, Yanbo Di, Jinhui Wang, Tie Chen, Meina Huang, Jinglai Sun, Chong Liu
Summary: Berberine exerts neuroprotective effects against ischemic stroke by inhibiting neuronal apoptosis induced by CIRI through downregulating the CNPY2 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Qian Xu, Guohui Ma, Dandan Li, Fanghui Bai, Jintao Fang, Gui Zhang, Yuxin Xing, Jiawei Zhou, Yugang Guo, Yunchao Kan
Summary: This study elucidated the involvement of C2dat2 in regulating autophagy and apoptosis induced by CIRI, by inhibiting miR-30d-5p through a ceRNA mechanism, affecting the DDIT4/mTOR pathway. This contributes to a better understanding of the mechanisms of CIRI.
Article
Plant Sciences
Yue Yang, Huan Gao, Wenwu Liu, Xin Liu, Xiaowen Jiang, Xiang Li, Qiong Wu, Zihua Xu, Qingchun Zhao
Summary: The study demonstrates that Arctium lappa L. roots protect against cerebral ischemia by inhibiting apoptosis and AMPK/mTOR-mediated autophagy in in vitro and in vivo, providing a theoretical basis for the development of CQAs in Arctium lappa L. roots as neuroprotective drugs for the prevention and treatment of ischemic stroke.
Article
Cell Biology
Jin Yang, Xiaobai Liu, Yubo Zhao, Weiwei Dong, Yixue Xue, Xuelei Ruan, Ping Wang, Libo Liu, E. Tiange, Jian Song, Zheng Cui, Yunhui Liu
Summary: This study investigates the regulatory roles of RBPs, lncRNAs, and snoRNAs in ischemic injury. Dcp2, lncRNA-RNCR3, Dkc1, Snora62, and Foxh1 were selected as research candidates. It was found that their expression levels were upregulated in oxygen glucose deprivation-treated cells and ischemic tissues. Silencing these genes inhibited cell apoptosis and Dcp2 was found to promote RNCR3 expression.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mudan Huang, Chongjun Xiao, Liying Zhang, Lili Li, Jing Luo, Lilin Chen, Xiquan Hu, Haiqing Zheng
Summary: Physical exercise benefits the recovery of post-ischemic stroke, with miRNAs playing a potential role in the neuroprotective effects. Analysis of differentially expressed miRNAs revealed their involvement in regulating central nervous system processes and stroke-related pathways, highlighting their potential as therapeutic targets for cerebral ischemia.
NEUROCHEMICAL RESEARCH
(2021)
Article
Anatomy & Morphology
Rafael Zimak Figueiredo, Mucio Luiz de Assis Cirino, Lucas Barhosa Porsani, Fermino Sanches Lizarte Neto, Paulo Cezar Novais, Maria Julia Nunes, Janaina Regina Lellis, Jairo Pinheiro da Silva, Maria de Fatima Galli Sorita Tazima, Marina de Toledo Durand, Valeria Paula Sassoli Fazan, Benedicto Oscar Colli, Daniela Pretti da Cunha Tirapelli, Luis Fernando Tirapelli
Summary: Stroke is a major cause of death and disability worldwide. Physical exercise is considered an important approach for preventing non-communicable chronic diseases. miRNAs and other biomarkers respond to physical exercise and are associated with various epigenetic mechanisms. Studying the molecular mechanisms of physical exercise can improve the understanding of stimuli and optimal dosages, leading to better control of treatment and recovery processes for various diseases.
INTERNATIONAL JOURNAL OF MORPHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rui Zhang, De-Yun Chen, Xing-Wei Luo, Yuan Yang, Xiao-Chao Zhang, Ren-Hua Yang, Peng Chen, Zhi-Qiang Shen, Bo He
Summary: MicroRNAs (miRNAs) play an essential role in the occurrence and development of ischemic stroke. This study investigated the effect of 20(R)-ginsenosideRg3 (20(R)-Rg3) on cerebral ischemia-reperfusion injury (CIRI) and its potential neuroprotective molecular mechanism. The results showed that 20(R)-Rg3 alleviated neurobehavioral dysfunction in rats and modulated multiple signaling pathways related to differentially expressed miRNAs.
Article
Clinical Neurology
Wenbo Zhao, Fang Jiang, Sijie Li, Guiyou Liu, Chuanjie Wu, Yuang Wang, Changhong Ren, Jing Zhang, Fei Gu, Quanzhong Zhang, Xinjing Gao, Zongen Gao, Haiqing Song, Qingfeng Ma, Yuchuan Ding, Xunming Ji
Summary: Daily remote ischemic conditioning for seven consecutive days was safe and tolerated in patients with intracerebral hemorrhage, potentially improving hematoma resolution rate and reducing relative perihematomal edema. However, further investigations are needed to evaluate the effects on absolute hematoma and perihematomal edema volume, as well as functional outcomes in this patient population.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Clinical Neurology
Hanhai Zeng, Xiongjie Fu, Jing Cai, Chenjun Sun, Mengyan Yu, Yucong Peng, Jianfeng Zhuang, Jingyin Chen, Huaijun Chen, Qian Yu, Chaoran Xu, Hang Zhou, Yang Cao, Libin Hu, Jianru Li, Shenglong Cao, Chi Gu, Feng Yan, Gao Chen
Summary: Neuroinflammation in patients with subarachnoid hemorrhage (SAH) is closely associated with poor prognosis, and neutrophil extracellular traps (NETs) play a key role in promoting inflammation. Inhibiting NET formation can attenuate the damage caused by neuroinflammation after SAH.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Genetics & Heredity
Fangfang Zhao, Haiping Zhao, Junfen Fan, Rongliang Wang, Ziping Han, Zhen Tao, Yangmin Zheng, Feng Yan, Yuyou Huang, Lei Yu, Xu Zhang, Lianfeng Zhang, Yumin Luo, Yuanwu Ma
Summary: The study showed that knockout of miR-29a in rats aggravated neurological damage in experimental stroke rat models by promoting M1 microglial polarization and increasing glutamate release. MiR-29a-5p levels decreased in the blood and brain tissue of rat MCAO models, as well as in the peripheral blood of acute stroke patients. Additionally, miR-29a knockout enhanced infarct volume and showed M1 polarization of microglia in the MCAO rat brain.
FRONTIERS IN GENETICS
(2021)
Article
Neurosciences
Haiyan Li, Sijie Li, Changhong Ren, Chen Gao, Ning Li, Chunxiu Wang, Lin Wang, Wenbo Zhao, Xunming Ji, Kunlin Jin
Summary: This study found that hypoxic postconditioning (HPC) helps promote neurogenesis after ischemic stroke, increasing the proliferation and migration of neural stem cells. HPC also regulates the metabolism of neural stem cells, including reducing fatty acid oxidation and increasing glycolysis.
EXPERIMENTAL NEUROLOGY
(2022)
Correction
Clinical Neurology
Xiongjie Fu, Hanhai Zeng, Jikuang Zhao, Guoyang Zhou, Hang Zhou, Jianfeng Zhuang, Chaoran Xu, Jianru Li, Yucong Peng, Yang Cao, Yin Li, Huaijun Chen, Lin Wang, Feng Yan, Gao Chen
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Integrative & Complementary Medicine
Sijie Li, Yong Yang, Wei Zhang, Haiyan Li, Wantong Yu, Chen Gao, Jiali Xu, Wenbo Zhao, Changhong Ren
Summary: The study investigates the active compounds and mechanisms of Danggui Shaoyao San (DSS) for treating ischemic stroke (IS) through network pharmacology, molecular docking, and animal experiments. The results demonstrate that DSS acts on multiple targets and pathways to treat IS, providing new insights into the mechanisms of DSS against IS.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Clinical Neurology
Jiali Xu, Qian Zhang, Gary B. Rajah, Wenbo Zhao, Fang Wu, Yuchuan Ding, Bowei Zhang, Wenting Guo, Qi Yang, Xiurong Xing, Sijie Li, Xunming Ji
Summary: This study aimed to prove the safety and efficacy of remote ischemic conditioning (RIC) on Moyamoya disease (MMD). The results showed that RIC can improve cerebral blood flow and slow down the progression of stenotic-occlusive lesions in MMD patients, making it a potential safe and effective adjunctive therapy for MMD.
FRONTIERS IN NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Liping Wang, Sijie Li, Sara Saymuah Stone, Na Liu, Kerui Gong, Changhong Ren, Kai Sun, Chunyang Zhang, Guo Shao
Summary: The long non-coding RNA MALAT1 is highly abundant in the nervous system and may play important roles in neuronal cell hypoxic/ischemic injury by interacting with proteins or RNAs.
Article
Neurosciences
Guangwen Li, Xiaoqing Ma, Haiping Zhao, Junfen Fan, Tianwei Liu, Yumin Luo, Yunliang Guo
Summary: This study reveals that long non-coding RNA H19 regulates the expression of C1QTNF6 in leukocytes by sponging miR-29b, leading to leukocyte inflammation during acute ischemic stroke. This finding provides new insights into the inflammatory mechanism of stroke.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Integrative & Complementary Medicine
Xiao Liang, Wenhui Gao, Jiali Xu, Sara Saymuah, Xiaojie Wang, Jing Wang, Wenbo Zhao, Xiurong Xing, Changyuan Wang, Fangyan Liu, Lei Feng, Sijie Li
Summary: This study aimed to explore whether triage nurse-activated emergency evaluation could reduce the door-to-needle time (DNT) in acute ischemic stroke (AIS) patients who failed to use emergency medical services (EMSs). The results showed that triage nurse-activated group had significantly reduced DNT compared to doctor-activated group, as well as shorter door-to-vein open time (DVT) and door-to-blood sample delivery time (DBT).
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Clinical Neurology
Fangfang Li, Qingfeng Ma, Lingzhi Li, Lin Zhang, Zhenhong Yang, Yuyou Huang, Ziping Han, Rongliang Wang, Zhen Tao, Yangmin Zheng, Junfen Fan, Shengpan Chen, Yumin Luo, Haiping Zhao
Summary: By measuring circulating cytokines in the plasma, we identified the alterations of cytokines in patients with super-acute ischemic stroke (AIS). Comparing to healthy controls, certain cytokines in AIS patients were significantly changed, and lymphocytes and neutrophils played a pivotal role in the inflammation of AIS.
JOURNAL OF CLINICAL NEUROSCIENCE
(2022)
Article
Neurosciences
Wenbo Zhao, Ran Liu, Wantong Yu, Longfei Wu, Chuanjie Wu, Chuanhui Li, Sijie Li, Jian Chen, Haiqing Song, Yang Hua, Qingfeng Ma, Xunming Ji
Summary: This study aimed to evaluate the pulsatility index (PI) in patients with acute ischemic stroke (AIS) who underwent endovascular thrombectomy (EVT). The results showed that higher MCA-PI was associated with worse functional outcomes at 3 months. The MCA-PI on the affected side may serve as a prognostic biomarker for extremely poor functional outcomes.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Neurosciences
Sijie Li, Wenbo Zhao, Guiyou Liu, Changhong Ren, Ran Meng, Yuan Wang, Haiqing Song, Qingfeng Ma, Yuchuan Ding, Xunming Ji
Summary: Chronic remote ischemic conditioning (RIC) appears to be well-tolerated and associated with a low annual risk of ischemic stroke and cardio-cerebrovascular events in patients with symptomatic internal carotid artery or middle cerebral artery occlusion with impaired hemodynamics.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Sijie Li, Yong Yang, Ning Li, Haiyan Li, Jiali Xu, Wenbo Zhao, Xiaojie Wang, Linqing Ma, Chen Gao, Yuchuan Ding, Xunming Ji, Changhong Ren
Summary: Neurogenesis plays a crucial role in the prognosis of stroke patients. This study demonstrated that limb remote ischemic conditioning (LRIC) could promote neurogenesis in cerebral ischemic mice, and the miR-449b/Notch1 pathway was involved in LRIC-induced neuroprotection.
Article
Medicine, General & Internal
Yue Li, Sijie Li, Kun Yang, Yong Liu, Liying Chen, Jianjun Chen, Xiaochu Wen, Tingting Ji, Kefan Chen, Liyong Wu, Xunming Ji, Jie Lu
Summary: This study explored the transformational leadership competency of medical graduates from a medical university in China and its influencing factors. The results showed that the competency of the medical graduates in transformational leadership was medium. Knowledge learning, organizational involvement, and social/community involvement were found to be associated with leadership capacity building. Furthermore, the values and emotional intelligence abilities of leaders influenced their behaviors, indicating that medical graduates should prioritize leadership training that combines knowledge learning and practical experience.
ANNALS OF MEDICINE
(2023)