Article
Health Care Sciences & Services
Dong Zhang, Liangran Huang, Zheng Huang, Qi Zhou, Xin Yang, Hongqiu Gu, Zixiao Li, Ying Shi, Lanxia Gan, Haibo Wang, Xvdong Ma, Yongjun Wang, Jizong Zhao
Summary: This study investigated the epidemiological characteristics of moyamoya disease in mainland China from 2016 to 2018. The annual incidence rate was 1.14 per 100,000 inhabitants and showed an increasing trend. Children had a significantly lower incidence rate compared to adults, with the peak incidence occurring in the 45-54 age group. The geographical distribution of MMD incidence presented as a clustered regional pattern.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2022)
Article
Clinical Neurology
Yuanbing Chen, Miao Tang, Yinhua Liang, Hongwei Liu, Junyu Wang, Jun Huang
Summary: This study investigated the relationship between transdural collateral circulation and the side of relative cerebral ischemia in MMD patients. The results showed that transdural collaterals were more common in patients with infarctions and were more easily found on the side of relative cerebral ischemia. These findings have important implications for the diagnosis and treatment of MMD.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Yudai Hirano, Satoru Miyawaki, Hideaki Imai, Hiroki Hongo, Yu Teranishi, Daiichiro Ishigami, Yu Sakai, Daisuke Shimada, Motoyuki Umekawa, Masafumi Segawa, Satoshi Koizumi, Hideaki Ono, Hirofumi Nakatomi, Nobuhito Saito
Summary: This study aimed to clarify the clinical and genetic characteristics of patients with both ischemic and hemorrhagic cerebrovascular events in moyamoya disease. The majority of patients experienced an ischemic event first, and those who developed ischemia in childhood may have subsequent hemorrhage approximately 20-25 years after bypass surgery. In adults, male sex is a risk factor for a subsequent hemorrhagic event in ischemic moyamoya disease.
WORLD NEUROSURGERY
(2023)
Review
Biochemistry & Molecular Biology
Yao-Ching Fang, Ling-Fei Wei, Chaur-Jong Hu, Yong-Kwang Tu
Summary: Abnormal circulating angiogenetic factors observed in MMD patients may play a critical role in the formation of Moyamoya vessels, promoting intimal hyperplasia in vessels and excessive collateral formation. These factors drive the development of Moyamoya disease through endothelial hyperplasia, smooth muscle migration, and atypical neovascularization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Clinical Neurology
Michael S. Rallo, Omar Akel, Akhilesh Gurram, Hai Sun
Summary: Experimental animal models for MMD can be broadly categorized into three types: surgical, immunological, and genetic. While each model reflects important aspects of MMD pathogenesis, the lack of a single model recapitulating the full development, progression, and outcomes of the disease highlights the need for future work in developing a multi-etiology model.
NEUROSURGICAL FOCUS
(2021)
Article
Medicine, General & Internal
Pieter Thomas Deckers, Annick Kronenburg, Esther van den Berg, Monique M. van Schooneveld, Evert-Jan P. A. Vonken, Willem M. Otte, Bart N. M. van Berckel, Maqsood Yaqub, Catharina J. M. Klijn, Albert van der Zwan, Kees P. J. Braun
Summary: A study on patients with moyamoya vasculopathy (MMV) showed that revascularization led to significant improvements in TIA frequency, headache, CVR, and mRS, as well as an improvement in the language domain while other domains remained stable.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Behavioral Sciences
Zhiyang Ma, Dayu Chen, Sheng Wang, Yaozu Zhu, Jincao Chen
Summary: A retrospective study on Chinese patients with moyamoya disease (MMD) revealed that the age at onset (AAO) of MMD has been increasing over time, possibly due to reduced exposure to leptospiral infection.
BRAIN AND BEHAVIOR
(2023)
Article
Clinical Neurology
Junsheng Li, Peicong Ge, Qian Zhang, Fa Lin, Rong Wang, Yan Zhang, Dong Zhang, Wen Wang, Jizong Zhao
Summary: Growing evidence suggests that hyperhomocysteinemia is a risk factor for cerebral infarction. This study found that HHcy is significantly associated with postoperative ischemia in patients with moyamoya disease, making it a potential therapeutic target.
NEUROSURGICAL REVIEW
(2021)
Review
Endocrinology & Metabolism
Guibo Zhang, Erheng Liu, Xueyi Tan, Chengyuan Liu, Shuaifeng Yang
Summary: This article summarizes the coexistence of thyroid diseases and moyamoya disease, discusses the potential mechanisms, treatment methods, and the possible relationship between the two.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Masakazu Kobayashi, Yosuke Akamatsu, Kohei Chida, Shun Uchida, Shunrou Fujiwara, Kenji Yoshida, Takahiro Koji, Yoshitaka Kubo, Kuniaki Ogasawara
Summary: The study found that periventricular anastomosis tends to regress after indirect revascularization surgery alone for adult patients with misery perfusion due to ischemic MMD. The formation of collateral vessels from the lenticulostriate artery significantly decreases after surgery, but the formation of collateral vessels from the thalamic artery or anterior choroidal artery seldom changes.
NEUROSURGICAL REVIEW
(2022)
Review
Medicine, General & Internal
Isabella Canavero, Ignazio Gaspare Vetrano, Marialuisa Zedde, Rosario Pascarella, Laura Gatti, Francesco Acerbi, Sara Nava, Paolo Ferroli, Eugenio Agostino Parati, Anna Bersano
Summary: Moyamoya angiopathy is a cerebrovascular condition characterized by progressive steno-occlusion of certain arteries in the brain, leading to the development of fragile collateral vessels. The underlying pathophysiology is not fully understood, leading to uncertainties in patient management. Treatment options include pharmacological and surgical interventions, with surgical revascularization showing promising outcomes in symptomatic cases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Fangbao Li, Chuanfeng Li, Yunwei Sun, Yue Bao, Wenbo Jiang, Zuoyan Song, Yongyi Wang, Mingxing Liu, Weimin Wang, Tong Li, Luo Li
Summary: This study investigated the association between postoperative cerebral ischemia and nutritional blood parameters in patients with moyamoya disease (MMD). It found that surgical side, admission score, white blood cell count, and total cholesterol were independent risk factors for postoperative cerebral ischemic complications.
FRONTIERS IN NUTRITION
(2022)
Article
Clinical Neurology
Toshiaki Hayashi, Tomomi Kimiwada, Hiroshi Karibe, Reizo Shirane, Tatsuya Sasaki, Hirohito Metoki, Teiji Tominaga
Summary: In pediatric moyamoya disease, young age at diagnosis and a high MRA score may be associated with rapid disease progression and preoperative infarction. It is recommended that surgery be performed within 2 months of diagnosis for patients under 4 years of age with a high MRA score (>5) and cerebral infarction. Further study is needed to define the optimal timing of surgery.
Article
Clinical Neurology
Xiang Zou, Yujun Liao, Conglin Jiang, Yifan Yuan, Fan Zhao, Ding Ding, Liang Chen, Bin Xu, Ying Mao
Summary: By studying the correlation between cerebral blood flow and cognitive decline, as well as plasma AD biomarkers, it was found that reduced blood flow is associated with cognitive decline and AD pathology burden.
ALZHEIMERS & DEMENTIA
(2023)
Review
Clinical Neurology
R. Mertens, M. Graupera, H. Gerhardt, A. Bersano, E. Tournier-Lasserve, M. A. Mensah, S. Mundlos, P. Vajkoczy
Summary: Moyamoya disease is a rare cerebrovascular disease characterized by progressive bilateral occlusion of the intracranial internal cerebral arteries. Clinical presentation varies depending on age and population, with hemorrhage and ischemic infarcts leading to severe neurological dysfunction or death. Surgical revascularization is currently the only established treatment for MMD.
TRANSLATIONAL STROKE RESEARCH
(2022)