Article
Clinical Neurology
Guangyao Wang, Jing Jing, Anxin Wang, Xiaoli Zhang, Xingquan Zhao, Zixiao Li, Chunjuan Wang, Hao Li, Liping Liu, Yongjun Wang, Yilong Wang
Summary: The study suggests that non-high-density lipoprotein cholesterol may be a qualified predictor for recurrent ischemic stroke and all-cause death within 1 year in patients with acute ischemic stroke, but not predictive for intracranial hemorrhage.
Review
Neurosciences
Ying Huang, Zhenzhen Wang, Zhi-Xin Huang, Zhenguo Liu
Summary: This review summarizes a range of important biomarkers, including glutamate, S100B, glial fibrillary acidic protein, receptor for advanced glycation end-products, intercellular adhesion molecule-1, von willebrand factor, matrix metalloproteinase-9, interleukin-6, tumor necrosis factor-a, activated protein C, copeptin, neuron-specific enolase, tau protein, gamma-aminobutyric acid, blood glucose, endothelial progenitor cells, and circulating CD34-positive cells, which may potentially indicate the disease burden and/or predict clinical outcomes of ischemic stroke. The relationship between specific biomarkers, disease burden, and outcomes is examined, along with potential underlying mechanisms. The clinical significance and implications of these biomarkers are also discussed.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Clinical Neurology
Jiejie Li, Yuesong Pan, Jie Xu, Shiyu Li, Mengxing Wang, Kehua Quan, Xia Meng, Hao Li, Jinxi Lin, Yilong Wang, Xingquan Zhao, Liping Liu, Yongjun Wang
Summary: Residual inflammatory risk only may predict recurrent stroke and poor functional outcome in patients with acute ischemic stroke or transient ischemic attack, especially in those with large-artery atherosclerosis.
Article
Neurosciences
Yueqi Zhang, Guangjian Zhang, Xuecong Chen
Summary: The aim of this study is to investigate the correlation between serum calcium levels and clinical severity or functional outcome at discharge in Chinese patients with acute ischemic stroke. The analysis of 339 patients revealed a positive correlation between serum calcium levels and stroke severity, as well as infarct size. Multivariate analysis showed that higher serum calcium levels were associated with a higher risk of unfavorable outcome. This study suggests that calcium may serve as a prognostic biomarker for stroke in Chinese patients.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Medicine, General & Internal
Yu-Xuan Li, Juan Hou, Wen-Ya Liu
Summary: This study aimed to explore the relationship between sarcopenia defined by temporal muscle thickness and physical function and prognosis of patients with acute ischemic stroke (AIS). The results showed that sarcopenia was associated with stroke risk, stroke severity, functional ability, swallow ability, venous thromboembolism risk, activities of daily living, and survival outcome.
Review
Immunology
Junqiu Jia, Lixuan Yang, Yan Chen, Lili Zheng, Yanting Chen, Yun Xu, Meijuan Zhang
Summary: Microglia play diverse roles in the pathogenesis of ischemic stroke, with their phagocytic properties being a subject of debate. Understanding the precise mechanisms of microglial phagocytosis after stroke may help in developing regulatory molecules that promote inflammation resolution without harming functional cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Bengt Zoller, MirNabi Pirouzifard, Magnus P. Lindgren, Jan Sundquist, Kristina Sundquist
Summary: This study found that a family history of short sibling survival after IS is associated with mortality after IS for younger male subjects.
Article
Cardiac & Cardiovascular Systems
Shiyu Li, Anxin Wang, Yijun Zhang, Xue Tian, Xia Meng, Yilong Wang, Hao Li, Yongjun Wang
Summary: This study found that elevated serum creatine kinase (CK) levels in patients with acute ischemic stroke or transient ischemic attack are associated with higher risks of recurrent stroke, death, and disability. CK may act as a useful predictor for recurrent stroke and poor functional outcomes in these patients. The relationship between elevated CK and disability or death is modified by sex.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Clinical Neurology
Hyungwoo Lee, Il Hyung Lee, JoonNyung Heo, Minyoul Baik, Hyungjong Park, Hye Sun Lee, Hyo Suk Nam, Young Dae Kim
Summary: Sarcopenia is associated with functional outcomes in patients with acute ischemic stroke, leading to unfavorable functional outcomes.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Eleonora Rollo, Valerio Brunetti, Irene Scala, Antonio Callea, Jessica Marotta, Catello Vollono, Giovanni Frisullo, Aldobrando Broccolini, Paolo Calabresi, Giacomo Della Marca
Summary: The occurrence of delirium in patients with acute stroke negatively impacts their prognosis. Patients who develop delirium after stroke have worse functional outcomes and shorter survival.
JOURNAL OF NEUROLOGY
(2022)
Review
Neurosciences
Xiaojia Tang, Li Jiang, Yuhan Luo, Hongyang Fan, Lilong Song, Peipei Liu, Yingzhu Chen
Summary: Ischaemic stroke often leads to leukoaraiosis in patients, affecting cognitive function, mood, and gait. Although studies suggest that leukoaraiosis has a negative impact on the prognosis of stroke, there are differing opinions among experts.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gianluca Brugnara, Adrian Engel, Jessica Jesser, Peter Arthur Ringleb, Jan Purrucker, Markus A. Moehlenbruch, Martin Bendszus, Ulf Neuberger
Summary: In this study, the influence of small vessel disease and cortical atrophy on clinical outcome after acute ischemic stroke was assessed using native cranial computed tomography (NCCT). The results showed that pre-existing brain deterioration was significantly correlated with clinical outcome. Both age-related white matter changes (ARWMC) and cortical atrophy were independent predictors of clinical outcome after endovascular treatment (EVT).
EUROPEAN RADIOLOGY
(2023)
Review
Clinical Neurology
Hai-jie Liang, Qing-yi Zhang, Yi-tong Hu, Guo-qing Liu, Rong Qi
Summary: Hypertriglyceridemia, characterized by abnormally high levels of plasma triglycerides, may increase the risk of ischemic stroke by promoting atherosclerosis and thrombosis, while also potentially providing some protective effects for stroke patients through unclear mechanisms.
Article
Neurosciences
Wenting Guo, Jiali Xu, Linqing Ma, Jin Ma, Sijie Li, Changhong Ren, Longfei Wu, Chuanjie Wu, Chuanhui Li, Jian Chen, Jiangang Duan, Qingfeng Ma, Haiqing Song, Wenbo Zhao, Xunming Ji
Summary: This study aimed to investigate the impact of different administration routes of a low dose of tirofiban on AIS patients with successful recanalization post EVT. The results showed that a low dose of tirofiban was safe for AIS patients who achieved successful recanalization with EVT, but only IA + IV tirofiban improved clinical outcomes.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Hailong Yu, Xin Chen, Xin Guo, Danni Chen, Li Jiang, Yajie Qi, Jun Shao, Luhang Tao, Jing Hang, Guangyu Lu, Yingzhu Chen, Yuping Li
Summary: This study aimed to investigate the role of serum xanthine oxidase (XO) levels in the pathogenesis of acute ischemic stroke (AIS). The results showed that the serum level of XO was significantly higher in AIS patients compared to healthy controls and was an independent risk factor for AIS. Serum XO level also had predictive value for stroke progression and prognosis in AIS patients.
Article
Cardiac & Cardiovascular Systems
Raed A. Joundi, Jie-Lena Sun, Ying Xian, Brooke Alhanti, Raul G. Nogueira, Deepak L. Bhatt, Gregg C. Fonarow, Jeffrey Saver, Lee H. Schwamm, Eric E. Smith
Summary: This study investigated the relationship between time to endovascular therapy (EVT) and treatment outcomes in patients with basilar artery occlusion (BAO). The results showed that early treatment after symptom onset was associated with improved outcomes. Therefore, rapid implementation of EVT is crucial for patients with BAO.
Editorial Material
Neuroimaging
Jeffrey L. Saver, Eva Mistry
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Letter
Neuroimaging
Chun-Hsien Lin, Jeffrey L. Saver, Meng Lee
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Clinical Neurology
Scott J. Mendelson, Shuaiqi Zhang, Roland Matsouaka, Ying Xian, Shreyansh Shah, Barbara L. Lytle, Nicole Solomon, Lee H. Schwamm, Eric E. Smith, Jeffrey L. Saver, Gregg Fonarow, Jane Holl, Shyam Prabhakaran
Summary: This study aimed to investigate the prevalence of tPA declination among patients with acute ischemic stroke (AIS) and the differences by race/ethnicity. The study found that although the overall prevalence of tPA declination is low, non-Hispanic Black patients are more likely to decline tPA, while Asian patients are less likely. Reducing rates of tPA declinations among non-Hispanic Black patients may provide an opportunity to address disparities in stroke care.
Article
Clinical Neurology
Katherine A. Fu, Jeffrey L. Saver, Susan Perlman
Summary: Recent therapeutic advances in neurology emphasize the importance of ongoing clinical trials. However, there has been a decrease in neuroscience applicants for NIH funding over the past 10 years, raising concerns about the future of clinical research in neurology. Those interested in a career in this field can identify areas of interest and seek mentorship and training to develop the necessary skills for clinical trial conduct and design.
Article
Emergency Medicine
Nichole Bosson, Jeffrey Eric Rollman, Robert A. Kloner, David M. Shavelle, Jeffrey L. Saver, James T. Niemann, Asim M. Rafique, Xiaoyan Wang, Christine Clare, Marianne Gausche-Hill
Summary: This study evaluated the correlation between COVID-19 hospitalizations and EMS responses for time-sensitive emergencies in a large EMS system in Los Angeles County. The study found a significant correlation between COVID-19 hospitalizations and the frequency of EMS responses for time-sensitive emergencies, with an increase in EMS responses corresponding to an increase in COVID-19 hospitalizations.
PREHOSPITAL EMERGENCY CARE
(2023)
Article
Clinical Neurology
Johanna M. Ospel, Wolfgang G. Kunz, Rosalie McDonough, Wim van Zwam, Floor Pinckaers, Jeffrey L. Saver, Michael D. Hill, Andrew M. Demchuk, Tudor G. Jovin, Peter Mitchell, Bruce C. Campbell, Phil White, Keith Muir, Hamza Achit, Serge Bracard, Scott Brown, Mayank Goyal
Summary: This study aimed to investigate the clinical and economic benefit of endovascular treatment (EVT) in stroke patients with mild preexisting symptoms/disability. The results showed that EVT, in addition to best medical management, was a superior treatment strategy, resulting in cost savings and improved quality of life.
Article
Cardiac & Cardiovascular Systems
Shumei Man, Nicole Solomon, Brian Mac Grory, Brooke Alhanti, Ken Uchino, Jeffrey L. Saver, Eric E. Smith, Ying Xian, Deepak L. Bhatt, Lee H. Schwamm, Muhammad Shazam Hussain, Gregg C. Fonarow
Summary: Shorter door-to-needle times are associated with better long-term functional outcomes and lower mortality among older stroke patients treated with IVT only or IVT+EVT. These findings support efforts to accelerate thrombolytic administration in all eligible patients, including those receiving EVT.
Article
Clinical Neurology
Hongfei Sang, Dongjing Xie, Yan Tian, Thanh N. Nguyen, Jeffrey L. Saver, Raul G. Nogueira, Junxiong Wu, Chen Long, Zhenxuan Tian, Zhizhou Hu, Tao Wang, Rongzong Li, Yingbing Ke, Xiurong Zhu, Daizhou Peng, Mingze Chang, Lingfei Li, Jie Ruan, Deping Wu, Wenjie Zi, Qingwu Yang, Fengli Li, Zhongming Qiu
Summary: This study investigated the efficacy and safety of IV infusion of tirofiban before endovascular thrombectomy for patients with large vessel occlusion due to intracranial atherosclerotic disease. The results showed that patients in the tirofiban group had higher rates of functional independence at 90 days without increased risk of mortality or symptomatic intracranial hemorrhage. The reduction of thrombectomy passes mediated a significant portion of the effect of tirofiban on functional independence.
Letter
Clinical Neurology
Mersedeh Bahr-Hosseini, Nina Meissner, Paul Reidler, Jeffrey L. Saver, Steffen Tiedt
Article
Clinical Neurology
Jeffrey B. Saver, Elizabeth M. Klerman, Alastair Buchan, Patricia Calleja, Ignacio Lizasoain, Mersedeh Bahr-Hosseini, Sarah S. Lee, David Liebeskind, Philipp T. Mergenthaler, Katherine Mun, MingMing Ning, David Pelz, David M. Ray, Peter Rothwell, Pierre Seners, Anirudh Sreekrishnan, Eleanor Mina Sung, Steffen Tiedt, Alastair J. S. Webb, Teresa W. Woelfer, Gregory Albers
Summary: There is increasing evidence that circadian and diurnal rhythms have a strong influence on stroke onset, mechanism, progression, recovery, and response to therapy. To enhance our understanding, standardized definitions and coding guides for data collection are needed, as well as advanced imaging techniques and large data registries. The development of standardized data structures will aid researchers in studying the impact of circadian/diurnal biology on stroke.
Article
Clinical Neurology
Jian Miao, Hongfei Sang, Fengli Li, Jeffrey L. Saver, Bo Lei, Jinglun Li, Raul Gomes Nogueira, Bo Song, Shudong Liu, Thanh N. Nguyen, Zhenglong Jin, Hongliang Zeng, Changming Wen, Guangxiong Yuan, Weilin Kong, Weidong Luo, Shuai Liu, Dongjing Xie, Jiacheng Huang, Chang Liu, Jie Yang, Jinrong Hu, Jiaxing Song, Chengsong Yue, Linyu Li, Yan Tian, Xiao Zhang, Dan Feng, Yani Gao, Huiying Fu, Wenjie Zi, Qingwu Yang, Zhongming Qiu, Shaojun Wang
Summary: This study pooled data from two randomized clinical trials in China to assess the impact of basic imaging versus advanced imaging on clinical outcomes after endovascular thrombectomy in patients with acute ischemic stroke. The results showed no significant differences between the two imaging modalities in both the early and extended time windows.
Review
Neuroimaging
Nien-chen Liao, Mersedeh Bahr Hosseini, Jeffrey L. Saver
Summary: This study aimed to determine the correlation between the effect size of infarct growth reduction and clinically meaningful differences in clinical global disability outcomes. The results showed that each 1 mL reduction in infarct growth was associated with an increase in functional independence, providing guidance for clinical trials of neuroprotective agents.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Neuroimaging
Diego J. Ojeda, Malik Ghannam, Sebastian Sanchez, Mohammad Almajali, Prateeka Koul, Jeffrey L. Saver, Rishi Gupta, Santiago Ortega-Gutierrez, Edgar A. Samaniego
Summary: The Tigertriever device shows high success rate and short puncture to reperfusion time in patients with large vessel occlusion and underlying intracranial atherosclerotic disease, without device-related complications.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Review
Clinical Neurology
Joachim Fladt, Johanna M. Ospel, Nishita Singh, Jeffrey L. Saver, Marc Fisher, Mayank Goyal
Summary: In recent decades, with continuous technological advances and the availability of novel therapies, there has been a growing interest in shifting advanced acute care from hospitals to the prehospital setting. However, there are challenges related to conducting clinical trials, ambulance design and costs. Utilizing new technologies and customized software applications can help overcome these challenges and establish efficient, targeted care strategies in the prehospital setting.