Article
Medicine, General & Internal
Alison Halliday, Richard Bulbulia, Leo H. Bonati, Johanna Chester, Andrea Cradduck-Bamford, Richard Peto, Hongchao Pan
Summary: The international multicentre randomised trial ACST-2 compared the effects of CAS and CEA for asymptomatic patients with severe stenosis, showing that the long-term effects of these two procedures on fatal or disabling stroke are comparable.
Article
Neuroimaging
Ivan Lylyk, Carlos Bleise, Pedro N. Lylyk, Nicolas Perez, Javier Lundquist, Esteban Scrivano, Anibal A. Francone, Martin Charles, Tamara Zompa, Pedro Lylyk
Summary: The study aims to investigate the correlation between AMD and compromised blood flow in the eye, as well as to demonstrate the potential of OA angioplasty as a treatment for late-stage AMD. Results showed the feasibility and safety of OA angioplasty, with perceived benefits in patients with profound vision loss. Further clinical trials are needed to confirm these findings.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Clinical Neurology
Yunlu Tao, Yang Hua, Lingyun Jia, Liqun Jiao, Beibei Liu
Summary: Factors influencing residual stenosis after carotid artery stenting include closed-loop stents, irregular plaques, and plaques with calcification as independent risk factors, while a high radial expansion rate of stents acts as a protective factor. The incidence of restenosis is higher in the group with residual stenosis compared to the group without residual stenosis after 1-year follow-up.
FRONTIERS IN NEUROLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Martin Andreas Geiger, Ronald Luiz Gomes Flumignan, Marcone Lima Sobreira, Wagner Mauad Avelar, Carla Fingerhut, Sokrates Stein, Ana Terezinha Guillaumon
Summary: Advances in imaging methods have allowed for better evaluation and management of patients with atherosclerotic carotid disease. Specific plaque characteristics such as intraplaque hemorrhage, lipid rich necrotic core, plaque inflammation, thickness, and ulceration significantly increase the risk of ischemic events.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Joseph Kamtchum-Tatuene, Luca Saba, Mirjam R. Heldner, Michiel H. F. Poorthuis, Gert J. de Borst, Tatjana Rundek, Stavros K. Kakkos, Seemant Chaturvedi, Raffi Topakian, Joseph F. Polak, Glen C. Jickling
Summary: This study demonstrates that circulating IL-6 levels predict carotid plaque severity, vulnerability, and progression. A cutoff of 2.0 pg/mL for IL-6 levels could facilitate the selection of individuals that would benefit from anti-IL-6 drugs for stroke prevention.
CIRCULATION RESEARCH
(2022)
Article
Clinical Neurology
Qi Lyu, Bai Zhang, Xiaojie Tian, Yabo Huang, Pinjing Hui
Summary: This study found that plaque vulnerability is independently associated with hypertension and dyslipidemia. Hypertension was significantly associated with the presence of a ruptured fibrous cap, intraplaque hemorrhage, and a large lipid core. The incidence of having a large lipid core was also significantly increased in patients with dyslipidemia.
WORLD NEUROSURGERY
(2022)
Review
Clinical Neurology
Jean Jacques Noubiap, Joseph Kamtchum-Tatuene, John L. Fitzgerald, Prashanthan Sanders
Summary: The study found that carotid stenosis was not associated with ischemic stroke, but was linked to thromboembolism. There was more consistent evidence suggesting that carotid plaque predicts stroke or transient ischemic attack in AF patients. Including carotid plaque and carotid intima-media thickness may improve stroke prediction and prevention in AF patients.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Dat Tin Nguyen, Boldizsar Voko, Balazs Bence Nyaradi, Tamas Munkacsi, Akos Berczi, Zoltan Voko, Edit Dosa
Summary: This study evaluated the long-term outcomes of carotid endarterectomy (CEA) and carotid artery stenting (CAS) in patients who underwent both procedures on different sides. The results showed a higher risk of restenosis for CEA compared to CAS.
Article
Clinical Neurology
K. Dilba, D. H. K. van Dam-Nolen, A. C. van Dijk, M. Kassem, A. F. W. van der Steen, P. J. Koudstaal, P. J. Nederkoorn, J. Hendrikse, M. E. Kooi, J. J. Wentzel, A. van der Lugt
Summary: The study revealed an association between large atherosclerotic plaques, intraplaque hemorrhage, and lipid-rich necrotic cores with plaque ulcerations at baseline and follow-up.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Article
Medicine, General & Internal
Twan Jowan van Velzen, Jeffrey Stolp, Dianne van Dam-Nolen, Mohamed Kassem, Jeroen Hendrikse, Marianne Eline Kooi, Daniel Bos, Paul J. Nederkoorn
Summary: Inflammation inside the vessel wall plays a significant role in atherosclerosis, and an association between leukocyte count and carotid vulnerable plaque characteristics has been found in this study. This finding can contribute to a better understanding of the role of inflammation in plaque vulnerability and provide new targets for intervention.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Ruijun Liu, Jing Shao
Summary: The article reviews the reasons for the increasing number of cardiovascular and cerebrovascular disease patients in recent years, as well as the related risk factors, providing a theoretical basis for early detection and treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Neuroimaging
Ichiro Nakagawa, Masashi Kotsugi, Shohei Yokoyama, Ryosuke Maeoka, Takanori Furuta, Haku Tanaka, Yasuhiro Takeshima, Ryosuke Matsuda, Shuichi Yamada, Hiroyuki Nakase
Summary: The study aimed to evaluate whether dual-layered stents reduce embolic infarcts and change of lipid signal in patients with high lipid core plaque (LCP) undergoing carotid artery stenting (CAS). The results showed that dual-layered stents significantly reduced the ipsilateral cerebral embolism rate and NIRS-derived lipid signals after stenting, particularly in highly lipidic lesions.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Neuroimaging
Francesco Diana, Michele Romoli, Giada Toccaceli, Aymeric Rouchaud, Charbel Mounayer, Daniele Giuseppe Romano, Francesco Di Salle, Paolo Missori, Andrea Zini, Diana Aguiar de Sousa, Simone Peschillo
Summary: Emergent carotid artery stenting (eCAS) appears to be associated with better functional outcomes compared to no-stenting approach in patients with acute ischemic stroke and tandem occlusion. However, eCAS carries a higher risk of symptomatic intracerebral hemorrhage.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Review
Medicine, General & Internal
Carolina Giordano, Alberto Morello, Nicola Corcione, Salvatore Giordano, Simona Gaudino, Cesare Colosimo
Summary: Carotid artery disease is a cause of ischemic stroke and cognitive decline. Evaluating the morphology of atherosclerotic plaques is crucial for accurate diagnosis and decision-making. Noninvasive imaging methods such as ultrasound, angiography, computed tomography, and magnetic resonance angiography are commonly used.
Article
Medicine, General & Internal
Vadim V. Klimontov, Elena A. Koroleva, Rustam S. Khapaev, Anton I. Korbut, Alexander P. Lykov
Summary: This study aimed to identify risk factors and biomarkers of subclinical carotid atherosclerosis (CA) and carotid artery stenosis (CAS) in individuals with type 2 diabetes (T2D). Carotid ultrasonography and evaluation of various clinical parameters were conducted on 389 patients. The results showed that age, sex, glycemic control, complications, and comorbidities were associated with subclinical CA, while factors such as blood pressure, insulin dosage, and kidney function were associated with CAS.
JOURNAL OF CLINICAL MEDICINE
(2022)