期刊
STROKE
卷 42, 期 1, 页码 214-216出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/STROKEAHA.110.594010
关键词
stroke; single-nucleotide polymorphism; genetic association studies
资金
- Swedish Research Council [K2008-65X-14605-06-03, K2007-61X-20378-01-3, K2010-61X-20378-04-3]
- Swedish state [ALFBGB-11206]
- Swedish Heart and Lung Foundation [20070404]
- Yngve Land Foundation for Neurological Research
- Crafoord Foundation, Region Skane
- Freemasons Lodge of Instruction EOS in Lund
- Lund University
- Department of Neurology Lund
- Swedish Stroke Association
- Tore Nilsson Foundation
- Emelle Foundation
Background and Purpose-In a genome-wide association study and subsequent case-control studies, the single-nucleotide polymorphism rs12425791 on chromosome 12p13 was reported to be associated with ischemic stroke, but this could not be validated in a recent well-powered study. We therefore investigated whether an association between ischemic stroke and rs12425791 could be detected in 3 different case-control studies from the southwest of Sweden. Methods-We examined 3606 patients with ischemic stroke and 2528 controls from 3 independent case-controls studies. Results-No significant association between ischemic stroke and the single-nucleotide polymorphism rs12425791 was detected in any of the 3 case-control samples or in the samples combined. The odds ratio for ischemic stroke for the minor allele in the combined sample was 1.02 (95% CI, 0.93 to 1.13). Conclusions-The single-nucleotide polymorphism rs12425791 does not confer a substantial risk for ischemic stroke in our population. Our results support a recent large study including other European populations. (Stroke. 2011;42:214-216.)
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