Article
Multidisciplinary Sciences
Ting-Ann Wang, Tzy-Haw Wu, Shin-Liang Pan, Hsiu-Hsi Chen, Sherry Yueh-Hsia Chiu
Summary: The study evaluated the long-term effects of aspirin and nicametate treatment on cerebrovascular death in ischemic stroke patients. The findings showed that patients treated with nicametate had a higher risk of stroke recurrence, but a significantly reduced risk of cerebrovascular death compared to the aspirin group.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Jakub Kornacki, Pawel Gutaj, Anastasia Kalantarova, Rafal Sibiak, Maurycy Jankowski, Ewa Wender-Ozegowska
Summary: The endothelium, crucial in various physiological functions, undergoes changes during pregnancy that are associated with gestational complications. Research is needed to elucidate mechanisms, find specific clinical markers, and incorporate them into predictive models for improved prognostic value. Further studies are required to fine-tune clinical markers and explore therapeutic techniques for preventing or reversing endothelial damage.
Article
Multidisciplinary Sciences
Nicholas Omid Daneshvari, Michelle Christina Johansen
Summary: The study found a significant association between ischemic stroke infarct volume and stroke subtypes, with each 5mL increase in infarct volume leading to a change in the risk of different stroke types. Multiple infarcts may be associated with cardioembolic strokes, while a single large-volume infarct may be related to large-artery atherosclerosis.
Review
Biochemistry & Molecular Biology
Daniela Jaime Garcia, Audrey Chagnot, Joanna M. Wardlaw, Axel Montagne
Summary: Small vessel disease (SVD) is a prevalent disorder of the brain's microvessels and is a common cause of dementia and strokes. Recent evidence suggests that endothelial dysfunction and a compromised blood-brain barrier play a key role in the development and progression of SVD. Understanding the molecular mechanisms underlying endothelial dysfunction in SVD could lead to better diagnostic tools and potential therapeutic interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Takahiko Kiyooka, Vahagn Ohanyan, Liya Yin, Yuh Fen Pung, Yeong-Renn Chen, Chwen-Lih Chen, Patrick T. Kang, James P. Hardwick, June Yun, Danielle Janota, Joanna Peng, Christopher Kolz, Giacinta Guarini, Glenn Wilson, Inna Shokolenko, Donte A. Stevens, William M. Chilian
Summary: Endothelial dysfunction in diabetes is mainly attributed to impaired mitochondrial function, not just the result of oxidative stress. Restoring mitochondrial function can reverse endothelial dysfunction, indicating the critical role of mitochondrial function in endothelium-dependent vasodilation.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Daniele Santi, Giorgia Spaggiari, Carla Greco, Clara Lazzaretti, Elia Paradiso, Livio Casarini, Francesco Poti, Giulia Brigante, Manuela Simoni
Summary: Endothelial dysfunction is an early indicator of atherosclerosis and cardiovascular diseases, while also playing a crucial role in human fertility and reproduction. Evaluating markers of endothelial health is essential for clinical practice and research, shedding light on the connection between endothelial and reproductive health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ronodeep Mitra, Alina Nersesyan, Kaleigh Pentland, M. Mark Melin, Robert M. Levy, Eno E. Ebong
Summary: The endothelial glycocalyx (GCX), a protective covering for endothelial cells, plays an important role in maintaining endothelial function. This study investigated the effect of diosmin on GCX integrity and endothelial function in a mouse model. The results showed that diosmin treatment improved GCX coverage, reduced inflammation, and restored vascular tone. These findings suggest that diosmin may be a potential therapy for endothelial dysfunction.
Review
Biochemistry & Molecular Biology
Natasha Ting Lee, Lin Kooi Ong, Prajwal Gyawali, Che Mohd Nasril Che Mohd Nassir, Muzaimi Mustapha, Harshal H. Nandurkar, Maithili Sashindranath
Summary: Cerebral endothelium plays a crucial role in regulating various physiological functions to maintain the health of the central nervous system. Cardiovascular risk factors contribute to cerebral endothelial dysfunction, leading to impaired vasodilation, aggravated inflammatory responses, increased oxidative stress, and vascular proliferation.
Review
Psychiatry
Aline J. Waclawovsky, Edineia de Brito, Lee Smith, Davy Vancampfort, Antonio M. da Silva, Felipe B. Schuch
Summary: Individuals diagnosed with depression show impaired endothelial dysfunction compared to controls, with HDL cholesterol levels and differences in FMD assessment modalities moderating the difference. The study suggests that clinical depression may lead to greater dysfunction in endothelial function.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Medicine, General & Internal
Ke-Wu Wang, Yang-Miao Xu, Chao -Bin Lou, Jing Huang, Chao Feng
Summary: The main determinants for depression after lacunar and non-lacunar stroke were found to be different in this study. Lesion location was critical only for depression after non-lacunar stroke.
Article
Clinical Neurology
Ramon Iglesias-Rey, Antia Custodia, Maria Luz Alonso-Alonso, Iria Lopez-Dequidt, Manuel Rodriguez-Yanez, Jose M. Pumar, Jose Castillo, Tomas Sobrino, Francisco Campos, Andres da Silva-Candal, Pablo Hervella
Summary: This study aimed to investigate the association between smoking habit and the functional outcome of patients with acute ischemic stroke undergoing reperfusion treatment. The results showed that smoking was associated with a good functional outcome, and the decrease in sTWEAK levels was also associated with a good functional outcome in smoker patients.
FRONTIERS IN NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ewa Rudnicka-Drozak, Paulina Drozak, Grzegorz Mizerski, Martyna Drozak
Summary: Endothelial progenitor cells (EPCs) play an important role in neurovascular disorders and have potential therapeutic applications. Decreased levels of EPCs are associated with worse disease outcomes. EPCs show promising safety and efficacy in the treatment of Alzheimer's disease and ischemic stroke.
Article
Physiology
Hui Liew, Matthew A. Roberts, Lawrence P. McMahon
Summary: This study examined the longitudinal effects of kidney transplantation on the glycocalyx by measuring biochemical markers and PBR. Results showed that transplantation may improve glycocalyx stability at 3 months post-transplant, indicated by reduced PBR and syndecan-1 levels.
KIDNEY & BLOOD PRESSURE RESEARCH
(2021)
Review
Medicine, General & Internal
Lisa Raia, Lara Zafrani
Summary: Vascular endothelium plays a crucial role in maintaining vascular homeostasis, but in sepsis, endothelial cells can experience activation and dysfunction. Microcirculatory disorders are associated with poor outcomes in sepsis, highlighting the importance of recognizing and assessing microcirculatory changes for therapeutic interventions and predicting prognosis.
FRONTIERS IN MEDICINE
(2022)
Letter
Medicine, General & Internal
Juan P. Frias, Laura Fernandez Lando, Katelyn Brown
Summary: In the SURPASS-2 trial, treatment with Tirzepatide showed better glycemic control and greater weight loss compared to Semaglutide in patients with type 2 diabetes. Additionally, there were no significant differences in mean systolic blood pressure among the enrolled patients in different treatment groups.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Ruben R. De With, Vicente Artola Arita, Bao-Oanh Nguyen, Dominik Linz, Hugo Ten Cate, Henri Spronk, Ulrich Schotten, Anton Jan van Zonneveld, Omer Erkuner, M. Agustina Bayon, Anders S. Schmidt, Justin G. L. M. Luermans, Harry J. G. M. Crijns, Isabelle C. Van Gelder, Michiel Rienstra
Summary: In patients with paroxysmal atrial fibrillation, women tend to have higher levels of inflammatory biomarkers, while men tend to have higher levels of biomarkers related to vascular remodelling. This suggests that the pathophysiological mechanisms in men and women with AF may differ.
Article
Hematology
Marina Panova-Noeva, Bianca Wagner, Markus Nagler, Thomas Koeck, Vincent Ten Cate, Lisa Eggebrecht, Jurgen H. Prochaska, Imke Meyer, Christoph Gerdes, Henri M. Spronk, Karl J. Lackner, Hugo Ten Cate, Kirsten Leineweber, Stefan Heitmeier, Stavros Konstantinides, Philipp S. Wild
Summary: This study found significant differences in platelet function between different phenotypes of VTE, with distinct platelet reactivity and platelet-dependent thrombin generation between pulmonary embolism-related phenotypes and isolated deep vein thrombosis.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Sophie C. Dolleman, Stijn M. Agten, Henri M. H. Spronk, Tilman M. Hackeng, Mettine H. A. Bos, Henri H. Versteeg, Anton Jan van Zonneveld, Hetty C. de Boer
Summary: This study investigated the potential effects of different DOACs on vascular integrity. The results showed that the anti-FXa DOAC rivaroxaban preserved endothelial barrier function, while the anti-thrombin DOAC dabigatran failed to protect endothelial integrity over time. However, the loss of barrier function caused by dabigatran could be prevented by a mimicking peptide that blocks thrombin's exosite-I.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Cardiac & Cardiovascular Systems
Steven P. Grover, Taylor Coughlin, Salma M. Fleifil, Jens J. N. Posma, Henri H. M. Spronk, Stefan Heitmeier, A. Phillip Owens, Nigel Mackman
Summary: Contrary to the hypothesis, the combination of aspirin and rivaroxaban did not show a greater reduction of atherosclerosis in Ldlr(-/-) mice compared to using each agent alone. However, all treatment groups (aspirin, rivaroxaban, and combination) reduced macrophage content and apoptosis in the lesions compared to control group. The expression of a small number of proteins in the aorta and plasma was altered in mice treated with aspirin and/or rivaroxaban.
Review
Medicine, General & Internal
Sierk Dauwerse, Hugo ten Cate, Henri M. H. Spronk, Magdolna Nagy
Summary: Hemostasis is a finely tuned process with dysregulation potentially leading to bleeding or thrombotic complications. COVID-19 patients often have a hypercoagulable state and require hospitalization, with ROTEM being considered a promising tool to predict outcomes in these patients.
Article
Cardiac & Cardiovascular Systems
Vicente Artola Arita, Martijn E. Van de Lande, Neda Khalilian Ekrami, Bao-Oanh Nguyen, Joost M. Van Melle, Bastiaan Geelhoed, Ruben R. De With, Vanessa Weberndorfer, Omer Erkuner, Hans Hillege, Dominik Linz, Hugo Ten Cate, Henri M. H. Spronk, Tim Koldenhof, Robert G. Tieleman, Ulrich Schotten, Harry J. G. M. Crijns, Isabelle C. Van Gelder, Michiel Rienstra
Summary: This study aimed to assess whether the 4S-AF scheme predicts AF progression in patients with self-terminating AF. The study found that the 4S-AF scheme does not predict AF progression, but the 3S-AF scheme can predict progression. Therefore, the 3S-AF scheme may be more appropriate for predicting AF progression.
Editorial Material
Cardiac & Cardiovascular Systems
Aaron Iding, Arina ten Cate-Hoek, Hugo ten Cate
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Bruna Gigante, Hugo ten Cate
Summary: Clinical trials are underway to test factor XIa inhibitors as potential alternatives to direct oral anticoagulants, with the hope of reducing bleeding events. Findings from phase II trials suggest a lower risk of bleeding, but the efficacy of these inhibitors is still uncertain.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Hematology
Katherine J. Kearney, Henri M. H. Spronk, Jonas Emsley, Nigel S. Key, Helen Philippou
Summary: It was previously believed that plasma kallikrein (PKa) only functioned to activate factor XII (FXII) in the coagulation cascade. However, recent studies have revealed a new pathway where PKa can directly activate factor IX (FIX). These studies identified the binding of FIX/FIXa with PK/PKa, the PKa-induced thrombin generation and clot formation independent of FXI, and the increased formation of FIXa:AT complexes due to PKa activity. The existence of both a canonical (FXIa-dependent) and non-canonical (PKa-dependent) pathway of FIX activation is suggested.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Article
Hematology
Aaron F. J. Iding, Bram M. M. Kremers, Alejandro Pallares Robles, Hugo ten Cate, Arina J. ten Cate-Hoek
Summary: This study evaluated an RVO-based management strategy and found that RVO was associated with recurrence, PTS, arterial events, and cancer in patients with DVT. D-dimer levels measured 1 month after stopping anticoagulant therapy provided further insight into the management strategy.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Medicine, General & Internal
Loes H. Willems, Lotte M. C. Jacobs, Laszlo A. Groh, Hugo ten Cate, Henri M. H. Spronk, Boden Wilson-Storey, Gerjon Hannink, Sander M. J. van Kuijk, Chahinda Ghossein-Doha, Magdi Nagy, Dick H. J. Thijssen, Andre S. van Petersen, Michiel C. Warle
Summary: COVID-19 affects the cardiovascular system, leading to sustained microvascular dysfunction, systemic inflammation, and coagulation activation. 18 months after infection, macrovascular dysfunction does not increase, but endothelial cell activation, inflammation, and coagulation activation still persist.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Economics
Rachel H. P. Schreurs, Arina J. ten Cate-Hoek, Hugo ten Cate, Manuela A. Joore
Summary: This study assessed the budget impact of compression therapy following deep venous thrombosis in the Netherlands and found that current therapy is suboptimal. Optimization of initial compression therapy, early consultation of an occupational therapist, and tailored duration of elastic compression stocking therapy can lead to considerable cost savings.
PHARMACOECONOMICS-OPEN
(2023)
Review
Oncology
R. A. L. Willems, N. Michiels, V. R. Lanting, S. Bouwense, B. L. J. van den Broek, M. Graus, F. A. Klok, B. Groot Koerkamp, B. de Laat, M. Roest, J. W. Wilmink, N. van Es, J. S. D. Mieog, H. ten Cate, J. de Vos-Geelen
Summary: In the past, patients with pancreatic ductal adenocarcinoma often underwent immediate surgery for tumor resection. Now, more and more patients receive chemotherapy (radiotherapy) before surgery. It is known that pancreatic cancer patients have a higher risk of developing thrombosis. However, the incidence of thrombosis in patients with pancreatic cancer during neoadjuvant chemotherapy is not well-studied. Few studies have investigated VTE incidence in this population, and it is unclear if these patients should use perioperative thromboprophylaxis. This narrative review summarizes the current evidence.
Review
Cardiac & Cardiovascular Systems
Constance C. F. M. J. Baaten, Magdolna Nagy, Wolfgang Bergmeier, Henri M. H. Spronk, Paola E. J. van der Meijden
Summary: Coronary atherosclerosis is the leading cause of heart disease in developed countries and is a chronic inflammatory process. The composition and location of atherosclerotic plaques determine the phenotype of the lesion, and plaque rupture or erosion can lead to acute clinical events. The contribution of platelets to thrombus formation differs depending on the plaque phenotype.
EUROPEAN HEART JOURNAL
(2023)