Review
Cell Biology
Kitti Thiankhaw, Nipon Chattipakorn, Siripron C. Chattipakorn
Summary: MCAO and cerebral I/R injury can lead to microvascular injury, blood-brain barrier dysfunction, inflammation, oxidative stress, and neuronal death, resulting in brain infarction. HBOT has shown positive effects on neurological outcomes after these injuries, but conflicting data exists on its impact on functional recovery. Studies have been conducted to evaluate the potential benefits of HBOT, both in vivo and clinically, in the context of stroke outcomes.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Clinical Neurology
Wenbin Zhu, Catherine M. M. Davis, Elyse M. M. Allen, Sarah L. L. Feller, Thierno M. M. Bah, Robert E. E. Shangraw, Ruikang K. K. Wang, Nabil J. J. Alkayed
Summary: In this study, the researchers found that poor outcome after stroke in patients with type 2 diabetes (DM2) is linked to impaired microvascular tissue reperfusion. Furthermore, they discovered differences in microvascular reperfusion response between male and female DM2 mice after transient middle cerebral artery occlusion (MCAO). These findings suggest that DM2 impairs capillary perfusion and exacerbates ischemic brain injury in male but not female mice with DM2.
Article
Biochemistry & Molecular Biology
Chun-Wei Wu, Jia-Jin Chen, Chou-Ching K. Lin, Chien-An Chen, Chun-Ie Wu, Ing-Shiou Hwang, Tsung-Hsun Hsieh, Bor-Shing Lin, Chih-Wei Peng
Summary: This study investigated the changes in brain tissue optical properties using frequency-domain near-infrared spectroscopy (FD-NIRS) and established the relationship between cerebral hemodynamics and infarct variation in a middle cerebral artery occlusion (MCAO) model. The results suggest that FD-NIRS parameters may be associated with the severity of the infarction and subsequent pathologies in MCAO.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Fabio Pilato, Giovanni Pellegrino, Rosalinda Calandrelli, Aldobrando Broccolini, Giacomo Della Marca, Giovanni Frisullo, Roberta Morosetti, Paolo Profice, Valerio Brunetti, Fioravante Capone, Gabriella D'Apolito, Vincenzo Quinci, Alessio Albanese, Annunziato Mangiola, Enrico Marchese, Angelo Pompucci, Vincenzo Di Lazzaro
Summary: This study analyzed baseline characteristics and factors linked to therapeutic choice and determinants of prognosis in patients with mMCA undergoing DHC or BMT. The study found that DHC reduces mortality during admission, but may result in long-term disability.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Review
Neurosciences
Lang Zeng, Shengqi Hu, Lingcheng Zeng, Rudong Chen, Hua Li, Jiasheng Yu, Hongkuan Yang
Summary: Ischemic stroke is a common type of stroke that has a significant impact on human well-being and quality of life. To better understand the pathophysiology of ischemic stroke and develop new treatment strategies, controllable and consistent animal models are urgently needed. The middle cerebral artery occlusion (MCAO) model is currently the most widely used model for studying ischemic stroke. This review discusses different methods for constructing the MCAO model and compares their advantages and disadvantages, aiming to provide better approaches for studying ischemic stroke.
Article
Clinical Neurology
Jingsi Xu, Zheyu Zhang, Bo Jin, Yu Geng, Longting Lin, Sheng Zhang
Summary: This study aimed to determine whether baseline delayed filling of the superficial middle cerebral vein (SMCV) was an independent cause of stroke prognosis in patients with acute anterior large vessel occlusion (LVO). The results showed a significant association between baseline delayed SMCV and a 3-month poor outcome, while SMCV reversal did not significantly change the stroke prognosis.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Jennifer D. Sokolowski, Sauson Soldozy, Khadijeh A. Sharifi, Pedro Norat, Kathryn N. Kearns, Lei Liu, Ashley M. Williams, Kaan Yagmurlu, Panagiotis Mastorakos, G. Wilson Miller, M. Yashar S. Kalani, Min S. Park, Ryan T. Kellogg, Petr Tvrdik
Summary: Stroke is a major burden, and despite advances in prevention and treatment, it still negatively affects patients, families, and healthcare professionals. Preclinical basic research, particularly using mouse models, can help to understand stroke pathology and discover effective interventions. This article reviews the middle cerebral artery occlusion technique and introduces various imaging approaches to enhance preclinical stroke evaluation.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Konstantinos M. Themistoklis, Themistoklis I. Papasilekas, Konstantinos S. Melanis, Konstantinos A. Boviatsis, Stefanos I. Korfias, Konstaninos Vekrellis, Damianos E. Sakas
Summary: The tifMCAO stroke model in rats is widely used and has been proven to reliably mimic human stroke. The surgical technique has been detailed with stepwise instructions and visual aids provided.
WORLD NEUROSURGERY
(2022)
Article
Biochemistry & Molecular Biology
Michael Bieber, Michael K. Schuhmann, Maximilian Bellut, David Stegner, Katrin G. Heinze, Mirko Pham, Bernhard Nieswandt, Guido Stoll
Summary: This study demonstrates that combining neuroprotective and anti-platelet interventions can enhance therapeutic effects in patients with ischemic stroke, providing new insights for the clinical treatment of hyper-acute stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Gintare Zemgulyte, Shigeru Tanaka, Izumi Hide, Norio Sakai, Katryna Pampuscenko, Vilmante Borutaite, Daiva Rastenyte
Summary: The study demonstrates that post-stroke treatment with metformin exhibits anti-inflammatory and neuroprotective effects in a model of permanent middle cerebral artery occlusion, improving neurological deficits, reducing infarct size, and preventing neuronal loss in the ischemic cortex.
Article
Immunology
Michael K. Schuhmann, Michael Bieber, Maximilian Franke, Alexander M. Kollikowski, David Stegner, Katrin G. Heinze, Bernhard Nieswandt, Mirko Pham, Guido Stoll
Summary: Progressive brain infarction can be delayed by blocking detrimental lymphocyte/platelet responses during occlusion, paving the way for ultra-early treatment strategies in hyper-acute stroke before recanalization.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Wuxian He, Hongtu Tang, Jia Li, Chenze Hou, Xiaoyan Shen, Chenrui Li, Huafeng Liu, Weichuan Yu
Summary: This study proposes an image feature-based protocol to assess the quality of the ischemic stroke induction procedure in animal experiments. The protocol utilizes specific image processing methods to improve the accuracy and reliability of the assessment.
NEUROSCIENCE BULLETIN
(2022)
Article
Neurosciences
Michael Bieber, Michael K. Schuhmann, Alexander M. Kollikowski, David Stegner, Bernhard Nieswandt, Mirko Pham, Guido Stoll
Summary: Research has shown that blocking the activatory platelet receptor can delay the progression of neocortical infarction in acute ischemic stroke caused by large vessel occlusion, as well as mitigate the local vascular recruitment of neutrophils and T-cells. This experimental data supports ongoing clinical trials of blocking platelet GPVI in acute ischemic stroke.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Nerea Chaparro-Cabanillas, Maria Arbaizar-Rovirosa, Angelica Salas-Perdomo, Mattia Gallizioli, Anna M. Planas, Carles Justicia
Summary: Stroke is a major global cause of death or chronic disability. In vivo rodent models of stroke, particularly using genetically modified mice, are crucial for gaining insights into stroke physiopathology and developing innovative therapeutic approaches.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Article
Clinical Neurology
Hai-Ji Han, Qiang Sang, Xi-Ming Wang, Yan-Feng Wu
Summary: This case report describes a patient with acute anterior multivessel occlusions and a duplicated middle cerebral artery. Using a combined approach of balloon guide catheter with stent retriever and aspiration, complete revascularization and good functional outcomes were achieved at 3 months follow-up.
FRONTIERS IN NEUROLOGY
(2023)