Article
Chemistry, Medicinal
Y. U. A. N. K. A. I. SI, Z. H. I. G. U. I. WU, L. I. GU, H. U. A. L, P. E. I. GE, W. E. N. X. I. A. N. YIN, M. E. I. J. U. A. N. CHEN
Summary: The relationship between BKCa and vascular lesions in T2DM was investigated by observing vascular reactivity and BKCa current changes in VSMCs. The results showed that BKCa current amplitude in diabetic rats was higher than in the control group, and the opening probability of BKCa was significantly increased. This study suggests that BKCa may be a new target for diabetic vascular disease.
Review
Pharmacology & Pharmacy
Xiao-Yu Liu, Ling-Ling Qian, Ru-Xing Wang
Summary: This review summarizes the role of hydrogen sulfide (H2S) in the regulation of vascular tone, specifically through its interaction with different vascular potassium channels. Studies have shown that H2S plays a key role in the pathophysiology of vascular diseases and physiological vascular homeostasis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ruo-bing Guo, Yin-feng Dong, Zhi Yin, Zhen-yu Cai, Jin Yang, Juan Ji, Yu-qin Sun, Xin-xin Huang, Teng-fei Xue, Hong Cheng, Xi-qiao Zhou, Xiu-lan Sun
Summary: The study demonstrates that iptakalim can significantly promote recovery of cerebral blood flow after cerebral ischemia and reperfusion, inhibit pericytes contraction, improve cerebral microcirculation, and reduce the number of obstructed capillaries. Furthermore, iptakalim treatment promotes K-ATP channel opening, leading to decreased calcium influx and ET-1 release.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Physiology
William F. Jackson
Summary: Resistance arteries and arterioles in the peripheral microcirculation play crucial roles in controlling blood pressure, blood flow distribution, and vascular resistance, with myogenic tone being a hallmark feature. However, our understanding of the signaling pathways underlying this key microvascular property remains incomplete, with emphasis on the roles of G-protein-coupled receptors, ion channels, and various kinases in the activity of vascular smooth muscle cells.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fuyao Xiao, Xiaojie Zhang, Pinfei Ni, Haibo Yu, Qiming Gao, Mengyao Li, Peiyun Huo, Ziwei Wei, Sihan Wang, Yi Zhang, Rui Zhao, Aixue Li, Zhirui Li, Yuejia Li, Haixiao Cheng, Libo Du, Suping Ren, Qun Yu, Yang Liu, Yuming Zhao
Summary: The study suggests that Kv4.2 may promote neurogenesis through multiple signal pathways after stroke, enhancing neural stem cell proliferation, inducing differentiation, and increasing neurotrophic factors and intracellular calcium concentration to restore post-stroke neurological function. Kv4.2 could be a potential drug target for ischemic stroke intervention.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Cardiac & Cardiovascular Systems
Vahagn Ohanyan, Sean M. Raph, Marc M. Dwenger, Xuemei Hu, Thomas Pucci, Gregory Mack, Joseph B. Moore, William M. Chilian, Aruni Bhatnagar, Matthew A. Nystoriak
Summary: The Kv beta proteins play a crucial role in regulating vascular tone and blood flow in the heart. Kv beta 2 promotes oxygen sensitivity, while Kv beta 1.1 inhibits oxygen-dependent vasodilation.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Cheng Liu, Tianwang Guan, Yanxian Lai, Yan Shen
Summary: This study found that certain KATP gene polymorphisms are associated with hypertension, dyslipidemia, and ischemic stroke.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Article
Environmental Sciences
Maria Ines Fonseca, Margarida Lorigo, Elisa Cairrao
Summary: This study investigated the effects of BPA on the vasculature during pregnancy using human umbilical arteries. The results showed that exposure to BPA may interfere with vasorelaxant response by modulating sGC and activating BKCa channels, leading to disruption of the NO/sGC/cGMP/PKG pathway. Additionally, the study found that BPA can modulate the reactivity of human umbilical arteries, increasing the activity of L-type Ca2+ channels, which is a common vascular response in hypertensive disorders of pregnancy.
ENVIRONMENTAL RESEARCH
(2023)
Review
Physiology
Eric A. Pereira da Silva, Miguel Martin-Aragon Baudel, Manuel F. Navedo, Madeline Nieves-Cintron
Summary: Ion channels, such as VGCC, TRP, K-V, and BK channels, regulate vascular smooth muscle excitability by influencing membrane potential and intracellular calcium concentration. These channels are regulated by various signaling molecules, including protein kinases and phosphatases, and form macromolecular complexes to target and compartmentalize signaling events.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Environmental Sciences
Joana Feiteiro, Sandra M. Rocha, Melissa Mariana, Claudio J. Maia, Elisa Cairrao
Summary: TBBPA, a widely used flame retardant, has been found to have vascular effects on rat aortas, resulting in vasorelaxation. The mechanism of action involves the inactivation of L-Type VGCC, activation of potassium channels, and mRNA expression modulation of certain ion channels and proteins related to vascular contractility.
Article
Clinical Neurology
Xinmao Wu, Wendan Tao, Yanan Wang, Qian Wu, Chen Ye, Xindi Song, Xiaonan Guo, Junfeng Liu
Summary: The level of serum EphrinA1 is associated with the risk of parenchymal hematoma (PH) after ischemic stroke, with higher levels indicating a higher risk. Further studies are needed to confirm these findings and explore the potential role of EphrinA1 in PH.
CEREBROVASCULAR DISEASES
(2023)
Article
Geriatrics & Gerontology
Ki Jung Kim, Juan Ramiro Diaz, Jessica L. Presa, P. Robinson Muller, Michael W. Brands, Mohammad B. Khan, David C. Hess, Ferdinand Althammer, Javier E. Stern, Jessica A. Filosa
Summary: Chronic hypoperfusion alters the functional integrity of the neurovascular unit in the brain, particularly affecting the parenchymal arterioles. This uncoupling of vessel-to-neuron communication may be an early event in cognitive decline.
Article
Pharmacology & Pharmacy
Juliana Maria Navia-Pelaez, Melissa Tainan Silva Dias, Laura Alejandra Ariza Orellano, Gianne Paul Campos, Jacqueline Alvarez-Leite, Paula Peixoto Campos, Luciano Santos Aggum Capettini
Summary: Amitriptyline has a dual effect on vascular tone by altering calcium influx in smooth muscle cells and decreasing nitric oxide production in endothelial cells. The drug impairs vascular function through TLR4 blockade and reduction in NO availability, while also potentially inhibiting nNOS activity in non-neuronal cells.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Shuxian Huang, Tingting Chen, Qian Suo, Rubing Shi, Haroon Khan, Yuanyuan Ma, Yaohui Tang, Guo-Yuan Yang, Zhijun Zhang
Summary: The activation of BK channels in microglia promotes microglial phagocytosis and benefits neurological recovery after ischemic stroke, suggesting BK channels as a potential therapeutic target for acute stage of ischemic stroke therapy.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Gonzalo Ferreira, Axel Santander, Romina Cardozo, Luisina Chavarria, Lucia Dominguez, Nicolas Mujica, Milagros Benitez, Santiago Sastre, Luis Sobrevia, Garth L. Nicolson
Summary: Inwardly rectifying potassium (Kir) channels are important for maintaining membrane potential and potassium homeostasis. These channels have various subtypes and can be regulated by molecules found in nutrients, such as phosphoinositols, polyamines, and Mg2+. Changes in Kir channels can affect metabolism and the ability to absorb nutrients and electrolytes. The study of nutrigenomics of ion channels is crucial for understanding how diet and nutrients can impact ion channel function, expression, and lead to pathological conditions that affect diet and electrolyte intake.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)