Article
Environmental Sciences
Erin R. Kulick, Melissa N. Eliot, Adam A. Szpiro, Brent A. Coull, Lesley F. Tinker, Charles B. Eaton, Eric A. Whitsel, Joel D. Kaufman, Gregory A. Wellenius, James D. Stewart
Summary: This study conducted a 15-year follow-up investigation in the US on 155,410 postmenopausal women without previous cerebrovascular disease, and found that long-term exposure to fine particulate matter (PM2.5), respirable particulate matter (PM10), and nitrogen dioxide (NO2) significantly increased the risk of cerebrovascular events among these women.
ENVIRONMENTAL RESEARCH
(2023)
Review
Clinical Neurology
Petra Ijas
Summary: Pregnancy is a specific risk factor for stroke in women, and although rare, it leads to high maternal mortality and persistent neurological deficits. Recent studies have shown an increasing incidence of pregnancy-associated stroke, likely due to the rising prevalence of stroke risk factors among pregnant women. To reduce pregnancy-related stroke, increased awareness and preventive measures focusing on risk factor management and symptom recognition are necessary.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Aditya Kumar, Louise McCullough
Summary: Cerebrovascular disease poses a significant burden on women in terms of morbidity, mortality, and disability, with unique risk factors and disparities in representation in clinical trials and stroke outcomes. There is a growing need for sex-specific management guidelines and health policies to address these differences and improve outcomes for women with cerebrovascular disease.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2021)
Article
Clinical Neurology
Carolin Beuker, Jeanette Koeppe, Jannik Feld, Christian Lennart Meyer, Patrik Droege, Thomas Ruhnke, Christian Guenster, Heinz Wiendl, Holger Reinecke, Jens Minnerup
Summary: A retrospective cohort study found that age is strongly associated with long-term outcomes after mechanical thrombectomy for stroke patients. Patients aged 80 and above had higher mortality, disability, and worse living conditions compared to younger patients.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Clinical Neurology
David J. Seiffge, Thomas Meinel, Jan Christoph Purrucker, Johannes Kaesmacher, Urs Fischer, Duncan Wilson, Teddy Y. Wu
Summary: This review discusses the primary therapeutic option for stroke prevention in atrial fibrillation patients, Direct Oral Anticoagulants (DOACs); it evaluates different approaches to patient selection, including time since last DOAC intake, drug-specific coagulation assays, and the use of reversal agents; precision medicine using a tailored approach seems to be a reasonable choice based on clinicoradiological information, anticoagulant activity, and the use of specific reversal agents only if necessary.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Clinical Neurology
Gian Marco De Marchis, David J. Seiffge, Sabine Schaedelin, Duncan Wilson, Valeria Caso, Monica Acciarresi, Georgios Tsivgoulis, Masatoshi Koga, Sohei Yoshimura, Kazunori Toyoda, Manuel Cappellari, Bruno Bonetti, Kosmas Macha, Bernd Kallmuenzer, Carlo W. Cereda, Philippe Lyrer, Leo H. Bonati, Maurizio Paciaroni, Stefan T. Engelter, David J. Werring
Summary: This study compared the optimal timing of starting direct oral anticoagulants (DOACs) after acute ischemic stroke (AIS) related to atrial fibrillation (AF) and found no significant difference in the risk of recurrent AIS and intracranial hemorrhage between early versus late DOAC-start groups. The sevenfold higher risk of recurrent AIS than intracranial hemorrhage suggests that an early DOAC-start might be reasonable, supporting enrollment into randomized trials comparing an early versus late DOAC-start.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Martina Locatelli, Mario Grassi, Valentina Saba, Licia Iacovello, Augusto di Castelnuovo, Giovanni de Gaetano, Marialuisa Zedde, Simona Marcheselli, Giorgio Silvestrelli, Alfonso Ciccone, Maria Luisa Delodovici, Lucia Princiotta Cariddi, Alessia Giossi, Andrea Zini, Maurizio Paciaroni, Monica Acciarresi, Cristiano Azzini, Alessandro De Vito, Massimo Gamba, Mauro Magoni, Massimo del Sette, Antonella Toriello, Carlo Gandolfo, Cinzia Finocchi, Domenico Marco Bonifati, Rossana Tassi, Giuseppe Martini, Anna Cavallini, Andrea Morotti, Sonia Bonacina, Valentina Mazzoleni, Debora Pezzini, Alberto Chiti, Rocco Salvatore Calabro, Rosa Musolino, Paolo La Spina, Francesco Grillo, Giampaolo Tomelleri, Corrado Lodigiani, Marco Ritelli, Marina Colombi, Alessandro Padovani, Alessandro Pezzini
Summary: The study found age-dependent differences in the effects of susceptibility factors on the risk of intracerebral haemorrhage, with untreated hypertension having a higher impact in younger age groups and untreated hypercholesterolaemia having a higher impact in older age groups. Untreated diabetes and excessive alcohol intake were only detected to have an effect in the older age group.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Clinical Neurology
Amit Kumar, Ganesh Chauhan, Shriram Sharma, Surekha Dabla, P. N. Sylaja, Neera Chaudhary, Salil Gupta, Chandra Sekhar Agrawal, Kuljeet Singh Anand, Achal Kumar Srivastava, Deepti Vibha, Ram Sagar, Ritesh Raj, Ankita Maheshwari, Subbiah Vivekanandhan, Bhavna Kaul, Samudrala Raghavan, Sankar Prasad Gorthi, Dheeraj Mohania, Samander Kaushik, Rohtas Kanwar Yadav, Anjali Hazarika, Pankaj Sharma, Kameshwar Prasad
Summary: The GWAS study in an Indian population identified novel loci for stroke and replicated previously known loci. The study showed that modifiable risk factors such as hypertension, smoking, and alcohol consumption have the highest effect on stroke.
Article
Clinical Neurology
Kristina Norman, Marie Eriksson, Mia von Euler
Summary: This study investigates sex differences and longitudinal changes in ischemic stroke in the younger population. The results show that men have a higher incidence than women, and certain risk factors such as atrial fibrillation, diabetes, and smoking are more common in men. The incidence of ischemic stroke stabilizes and then decreases over time, but fluctuations are substantial due to its rarity in the younger population.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Jun Zhang, Johnathan Abou-Fadel, Mellisa Renteria, Ofek Belkin, Bixia Chen, Yuan Zhu, Philipp Dammann, Daniele Rigamonti
Summary: This paper reviews the possible coexistence of PIK3CA and CCM mutations/phenotypes in CCM lesions and attempts to conceptualise their relationships and differences. The study suggests that the activation of the PIK3CA pathway may be a possible universal regulator of vascular morphogenesis, but conflicting data exist among different groups and studies.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Dermatology
Charlotte Naslund-Koch, Signe Vedel-Krogh, Stig Egil Bojesen, Lone Skov
Summary: Women with hospital-diagnosed psoriasis have a higher prevalence of traditional and non-traditional cardiovascular risk factors, and increased risk of heart failure and ischemic cerebrovascular disease, even after adjusting for these cardiovascular risk factors.
ACTA DERMATO-VENEREOLOGICA
(2022)
Article
Emergency Medicine
Hannah M. Higgins, Lucia Chen, Brandy C. Ravare, Kerri A. Jeppson, Heather T. Bina, Paco S. Herson, Andrew A. Monte, Sharon N. Poisson, Layne Dylla
Summary: This study found that there was no difference in the frequency of patient presentation with classic stroke symptoms based on biological sex alone, nor a significant difference in the distribution of infarcts between males and females. However, an infarct involving the anterior circulation was associated with a classic presentation.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Medicine, General & Internal
Ohood Kh. Almutairi, Yasser Abdulmoez
Summary: This case report presents a rare case of Moyamoya disease in an adult female, diagnosed through high-resolution vessel wall MRI. The case highlights the importance of considering Moyamoya disease in patients presenting with sudden neurological symptoms.
Review
Psychology, Multidisciplinary
Paloma E. Fava-Felix, Silvia R. C. Bonome-Vanzelli, Fabiana S. Ribeiro, Flavia H. Santos
Summary: This review investigates the cognitive, functional, and behavioral effects of computerized rehabilitation in stroke patients and considers cognitive reserve proxies. The findings suggest that combining computerized cognitive training with education as a cognitive reserve proxy can improve cognitive abilities in patients.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Carlo Domenico Maida, Mario Daidone, Gaetano Pacinella, Rosario Luca Norrito, Antonio Pinto, Antonino Tuttolomondo
Summary: Diabetes and atherosclerosis are two complementary diseases that interact through multiple molecular mechanisms, increasing the risk of cardio- and cerebrovascular events. Chronic hyperglycemia and advanced glycosylation end-products contribute to accelerated atherosclerosis by damaging the endothelium and impairing cellular function. Diabetic patients are more susceptible to cerebrovascular complications, especially in younger individuals and those with hypertension and other vascular disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Galit Levi Dunietz, Wei Hao, Kerby Shedden, Claudia Holzman, Ronald D. Chervin, Lynda D. Lisabeth, Marjorie C. Treadwell, Louise M. O'Brien
Summary: Habitual snoring during pregnancy is associated with hypertensive disorders of pregnancy. This study compared patterns of blood pressure during pregnancy in three groups of women and found that those with pregnancy-onset habitual snoring and chronic habitual snoring had significantly higher blood pressure compared to nonhabitual snoring controls.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Article
Clinical Neurology
Xiaqing Jiang, Lewis B. Morgenstern, Christine T. Cigolle, Lu Wang, Edward S. Claflin, Lynda D. Lisabeth
Summary: Mexican Americans have worse stroke outcomes compared to non-Hispanic White people. Multiple chronic conditions have implications for poststroke functional outcome, and Mexican Americans have a higher burden of multiple chronic conditions. However, multiple chronic conditions only partially explain the ethnic difference in poststroke functional outcome.
Article
Education & Educational Research
Devin L. Brown, Joan E. Cowdery
Summary: This study examined the knowledge, attitudes, and willingness to participate in COVID-19 vaccine trials and accept a COVID-19 vaccine among college students. The results showed that general clinical trial knowledge and positive attitudes were associated with greater likelihood of participating in COVID-19 trials and accepting the vaccine. Therefore, educational interventions should focus on improving clinical trial knowledge and fostering positive attitudes.
JOURNAL OF AMERICAN COLLEGE HEALTH
(2023)
Article
Psychiatry
Liming Dong, Linda S. Williams, Emily Briceno, Lewis B. Morgenstern, Lynda D. Lisabeth
Summary: This study examined the assumptions and invariance of using the PHQ-8 for repeated measurement of depression in stroke patients during the first year post-stroke. The findings suggest that the PHQ-8 may be a reasonable tool for repeated measurement of depression in stroke patients, but further research on its longitudinal psychometric properties is needed.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2022)
Review
Clinical Neurology
Michelle H. Leppert, James F. Burke, Lynda D. Lisabethx, Tracy E. Madsen, Dawn O. Kleindorfer, Stefan Sillau, Lee H. Schwamme, Stacie L. Daugher, Cathy J. Bradley, Michael Ho, Sharon N. Poisson
Summary: This article aims to reconcile and synthesize existing evidence of sex differences in young adults with ischemic strokes. The results indicate that women have a higher risk of ischemic strokes than men among young adults under the age of 35, while the sex difference is not significant among young adults aged 35-45.
Article
Cardiac & Cardiovascular Systems
Sonja G. Schutz, Lynda D. Lisabeth, River Gibbs, Xu Shi, Ronald D. Chervin, Madeline Kwicklis, Erin Case, Devin L. Brown
Summary: This study assessed the trends in poststroke sleep-disordered breathing (SDB) over a 10-year period and found that the prevalence and severity of poststroke SDB have increased in the past decade. These findings highlight the importance of determining whether SDB treatment improves stroke outcomes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Neurosciences
Liming Dong, Briana Mezuk, Lynda D. Lisabeth
Summary: This study examined the prevalence of serious psychological distress and depression among adults with stroke in the United States from 2004 to 2017. The results showed a decrease in prevalence over time, but the burden of mental health problems remained high. The trends varied significantly by age, but not by sex and race/ethnicity.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2022)
Letter
Cardiac & Cardiovascular Systems
Lesli E. Skolarus, Maria Cielito Robles, Maria Mansour, Rebecca L. Sudore, Evan L. Reynolds, James F. Burke, Casey L. Corches, Devin L. Brown
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Letter
Clinical Neurology
Lesli E. Skolarus, Devin L. Brown, Evan Reynolds, Ying Shi, Aiesha M. Volow, James F. Burke, Rebecca L. Sudore
Article
Clinical Neurology
Marri Horvat, Lynda D. Lisabeth, Jaewon Lim, Kevin He, Rahul Dasgupta, Erin Case, Ronald D. Chervin, Devin L. Brown
Summary: This study aimed to examine the association between ethnicity and subjective sleepiness 90 days after ischemic stroke. The results showed that Mexican American patients had higher levels of sleepiness compared to non-Hispanic white patients, and this disparity persisted even after adjusting for other factors.
Article
Cardiac & Cardiovascular Systems
Lesli E. Skolarus, Mackenzie Dinh, Kelley M. Kidwell, Chun Chieh Lin, Lorraine R. Buis, Devin L. Brown, Rockefeller Oteng, Michael Giacalone, Kimberly Warden, Deborah E. Trimble, Candace Whitfield, Zahera Farhan, Adam Flood, Dominic Borgialli, Sacha Montas, Michael Jaggi, William J. Meurer
Summary: This study aimed to address the hypertension epidemic in the US through implementing mHealth strategies in safety-net emergency departments. The results showed a decrease in systolic blood pressure over the 12-month intervention period, with no significant difference among the three mHealth components. This suggests that further study is needed to determine the efficacy of mHealth intervention components.
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2023)
Article
Clinical Neurology
Sonja G. Schutz, Lynda D. Lisabeth, Madeline Kwicklis, Erin Case, Ronald D. Chervin, Devin L. Brown
Summary: This study aimed to determine the prevalence of positive airway pressure (PAP) use after stroke. The research found that only a small proportion of stroke patients received PAP treatment in this population-based cohort study in Texas. The lack of treatment for sleep-disordered breathing (SDB) after stroke could have a negative impact on recovery and secondary stroke prevention.
Article
Clinical Neurology
Lynda D. Lisabeth, Guanghao Zhang, Ronald D. Chervin, Xu Shi, Lewis B. Morgenstern, Morgan Campbell, Susan Tower, Devin L. Brown
Summary: The aim of this study was to investigate the change in sleep-disordered breathing severity after stroke and the differences between ethnic groups. The results showed that the severity of sleep-disordered breathing remained stable for most individuals in the year following stroke, contradicting previous reports of improvement over time.
Article
Clinical Neurology
Leanna M. Delhey, Xu Shi, Lewis B. Morgenstern, Devin L. Brown, Melinda A. Smith, Erin C. Case, Mellanie V. Springer, Lynda D. Lisabeth
Summary: This study found that higher neighborhood socioeconomic status and density of recreation centers are favorably associated with poststroke outcomes, indicating that these resources may play a beneficial role in stroke recovery and rehabilitation.