期刊
STROKE
卷 39, 期 6, 页码 1869-1874出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/STROKEAHA.107.506022
关键词
neuroglobin; neuroprotection; oxidative stress; stroke
资金
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS037074, P50NS010828, R01NS033335, R01NS049476, P01NS010828, R01NS048422] Funding Source: NIH RePORTER
- NINDS NIH HHS [P01 NS010828, R01 NS033335, R01 NS048422, R01 NS049476-03, R01 NS049476, R01 NS033335-14A1, P01 NS010828-330037, P50 NS010828, P50-NS10828, R01-NS37074, R01-NS049476, R01 NS037074] Funding Source: Medline
Background and Purpose-Emerging data suggest that neuroglobin (Ngb) may protect against hypoxic/ ischemic neuronal insults. However, the underlying mechanisms in vivo and implications for long-term outcomes are still not well understood Methods-Using our newly created Ngb overexpressing transgenic (Ngb-Tg) mice, we measured brain infarction on day 1 and day 14 after transient focal cerebral ischemia and performed neurobehavioral assessments in sensorimotor deficits on days 1, 3, 7, and 14. To test the hypothesis that Ngb may play a role in reducing oxidative stress after stroke, intracellular malondialdehyde levels were measured and compared in Ngb-Tg and wild-type mice. Results-Increased Ngb mRNA and protein levels were identified in Ngb-Tg brains. Malondialdehyde levels in ischemic hemispheres of Ngb-Tg were significantly reduced compared with wild-type controls at 8 hours and 22 hours after transient focal cerebral ischemia. Compared with wild-type controls, brain infarction volumes 1 day and 14 days after transient focal cerebral ischemia were significantly reduced in Ngb-Tg mice. However, there were no significant improvements in sensorimotor deficits for up to 14 days after stroke in Ngb-Tg mice compared with wild-type controls. Conclusions-Ngb reduces tissue infarction and markers of oxidative stress after stroke. Tissue protection by overexpressing Ngb can be sustained for up to 2 weeks.
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