Article
Otorhinolaryngology
A. Morris, J. N. Higgins, P. R. Axon
Summary: The case report describes a rare complication of otological surgery where injury to a highly dominant venous sinus led to venous outflow obstruction and life-threatening intracranial hypertension. The successful emergency management included surgical reconstruction of the sigmoid sinus, endovascular thrombolysis, catheter balloon angioplasty, and endovascular stenting. This complication following otological surgery and its management has not been reported previously.
JOURNAL OF LARYNGOLOGY AND OTOLOGY
(2021)
Review
Medicine, General & Internal
Philipp Buecke, Victoria Hellstern, Alexandru Cimpoca, Jose E. Cohen, Thomas Horvath, Oliver Ganslandt, Hansjoerg Baezner, Hans Henkes
Summary: This systematic review examines the use of endovascular treatment (EVT) for cerebral venous sinus/vein thromboses (SVT), focusing on patient selection, treatment strategies, and the impact of the COVID-19 pandemic. The study found that EVT was feasible and safe in a highly selected patient cohort, but did not lead to increased favorable functional outcomes according to randomized controlled trial (RCT) data. However, observational data showed frequent good functional outcomes despite an anticipated poor prognosis. Further research is needed to identify high-risk patients, determine optimal methods and devices, and establish best timing for treatment initiation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, Research & Experimental
Peije Russell, Christoph Eugen Hagemeyer, Lars Esser, Nicolas Hans Voelcker
Summary: Acute thrombosis and thromboembolisms are major global diseases, placing a huge burden on health and economic systems. Theranostic nanoparticle systems have the potential to improve patient outcomes, enabling personalized and precision medicine.
Article
Radiology, Nuclear Medicine & Medical Imaging
Umut Oguslu, Sadik Ahmet Uyanik, Halime Cevik Cenkeri, Eray Atli, Birnur Yilmaz, Burcak Gumus
Summary: Transhepatic pharmacomechanical thrombectomy is a safe and effective treatment for symptomatic acute portomesenteric venous thrombosis, with successful prevention of bowel infarction.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Article
Multidisciplinary Sciences
Kefelegn Dejene Tadesse, Meron Gebru, Atnafu Mekonnen Tekleab
Summary: This study aimed to explore the treatment outcome of patients with PVT at the Cardiac Center of Ethiopia and found that most patients responded well to medical therapy.
Review
Biochemistry & Molecular Biology
Deepti Diwan, Zeba Usmani, Minaxi Sharma, James W. Nelson, Vijay Kumar Thakur, Graham Christie, Gustavo Molina, Vijai Kumar Gupta
Summary: Enzyme therapies are gaining attention as thrombolytic drugs due to their high affinity, specificity, catalytic activity, and stability. Microbial-derived thrombolytic and fibrinolytic enzymes show promise in preventing and treating vascular occlusion with advantageous cost-benefit ratio and large-scale production, addressing major thrombotic complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Aoife Hehir, Ruth Gilmore, Sarah Power, Thomas Monaghan, Emer R. McGrath
Summary: CVST is a rare condition with inherited and acquired risk factors. Early diagnosis and treatment are crucial to prevent complications such as seizures and visual disturbance. This case highlights the potential severity of untreated CVST and the importance of a thorough history and examination in recognizing the condition.
Article
Cardiac & Cardiovascular Systems
Mehmet Ozkan, Sabahattin Gunduz, Ahmet Guner, Macit Kalcik, Mustafa Ozan Gursoy, Begum Uygur, Hasan Kaya, Alev Kilicgedik, Emrah Bayam, Semih Kalkan, Mehmet Ali Astarcioglu, Suleyman Karakoyun, Mahmut Yesin, Duygu Inan, Ali Fedakar, Sabit Sarikaya, Mehmet Aksut, Burak Onan, Cevdet Ugur Kocogullari
Summary: This study aimed to evaluate the outcomes of thrombolytic therapy (TT) and surgery as the first-line treatment strategy in patients with obstructive prosthetic valve thrombosis (PVT). The results showed that low-dose and slow/ultraslow infusion of tissue plasminogen activator (t-PA) were associated with low complications and mortality and high success rates.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Clinical Neurology
Oguz Oren, Cemile Haki, Halil Kaya, Melih Yuksel
Summary: This study aimed to investigate whether the baseline neutrophil/lymphocyte ratio (NLR) predicts symptomatic intracranial hemorrhage (SICH) due to intravenous thrombolytic therapy. However, the results showed that NLR did not provide strong specificity and sensitivity for predicting SICH, and a precise cut-off value could not be found to predict hemorrhagic transformation.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Joerg B. Schulz, Peter Berlit, Hans-Christoph Diener, Christian Gerloff, Andreas Greinacher, Christine Klein, Gabor C. Petzold, Marco Piccininni, Sven Poli, Rainer Roehrig, Helmuth Steinmetz, Thomas Thiele, Tobias Kurth
Summary: The study found a higher incidence of cerebral sinus and venous thrombosis (CVT) after ChAdOx1 vaccination in Germany, especially among females. Among the 45 CVT patients, 26 were highly probable cases of vaccine-induced immune thrombotic thrombocytopenia (VITT).
ANNALS OF NEUROLOGY
(2021)
Article
Clinical Neurology
Adrian Scutelnic, Katarzyna Krzywicka, Joshua Mbroh, Anita van de Munckhof, Mayte Sanchez van Kammen, Diana Aguiar de Sousa, Erik Lindgren, Katarina Jood, Albrecht Guenther, Sini Hiltunen, Jukka Putaala, Andreas Tiede, Frank Maier, Rolf Kern, Thorsten Bartsch, Katharina Althaus, Alfonso Ciccone, Markus Wiedmann, Mona Skjelland, Antonio Medina, Elisa Cuadrado-Godia, Thomas Cox, Avinash Aujayeb, Nicolas Raposo, Katia Garambois, Jean-Francois Payen, Fabrice Vuillier, Guillaume Franchineau, Serge Timsit, David Bougon, Marie-Cecile Dubois, Audrey Tawa, Clement Tracol, Emmanuel De Maistre, Fabrice Bonneville, Caroline Vayne, Annerose Mengel, Dominik Michalski, Johann Pelz, Matthias Wittstock, Felix Bode, Julian Zimmermann, Judith Schouten, Alina Buture, Sean Murphy, Vincenzo Palma, Alberto Negro, Alexander Gutschalk, Simon Nagel, Silvia Schoenenberger, Giovanni Frisullo, Carla Zanferrari, Francesco Grillo, Fabrizio Giammello, Mar Morin Martin, Alvaro Cervera, Jim Burrow, Carlos Garcia Esperon, Beng Lim Alvin Chew, Timothy J. Kleinig, Cristina Soriano, Domenico S. Zimatore, Marco Petruzzellis, Ahmed Elkady, Miguel S. Miranda, Joao Fernandes, Aslog Hellstrom Vogel, Elias Johansson, Anemon Puthuppallil Philip, Shelagh B. Coutts, Simerpreet Bal, Brian Buck, Catherine Legault, Dylan Blacquiere, Hans D. Katzberg, Thalia S. Field, Vanessa Dizonno, Thomas Gattringer, Christian Jacobi, Annemie Devroye, Robin Lemmens, Espen Saxhaug Kristoffersen, Monica Bandettini di Poggio, Masoud Ghiasian, Theodoros Karapanayiotides, Sophie Chatterton, Miriam Wronski, Karl Ng, Robert Kahnis, Thomas Geeraerts, Peggy Reiner, Charlotte Cordonnier, Saskia Middeldorp, Marcel Levi, Eric C. M. van Gorp, Diederik van de Beek, Justine Brodard, Johanna A. Kremer Hovinga, Marieke J. H. A. Kruip, Turgut Tatlisumak, Jose M. Ferro, Jonathan M. Coutinho, Marcel Arnold, Sven Poli, Mirjam R. Heldner
Summary: This study evaluated adherence to VITT treatment recommendations in patients with VITT-CVT and found that adherence improved over time. Immunomodulation is crucial for reducing mortality in VITT-CVT.
ANNALS OF NEUROLOGY
(2022)
Article
Medicine, General & Internal
Paul D. Stein, Fadi Matta, Mary J. Hughes
Summary: The study found that patients with deep venous thrombosis involving the inferior vena cava had higher in-hospital mortality than those with thrombosis at other locations. Mortality rates were similar between patients with pelvic vein deep venous thrombosis and proximal lower extremity deep venous thrombosis, with thrombolytic treatment showing reduced mortality. Pulmonary embolism occurred at a considerable rate regardless of the site of deep venous thrombosis.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Hematology
Andrea Lee Cervi, Darrin Applegate, Scott M. Stevens, Scott C. Woller, Lisa M. Baumann, Kavya Punchhalapalli, Tzu-Fei Wang, Ramon Lecumberri, Kaity Greco, Yuxin Bai, Samantha Bolger, Stephanie Fontyn, Sam Schulman, Gary Foster, James Demetrios Douketis
Summary: This study aimed to determine the type and duration of antithrombotic therapy used in patients with acute lower extremity DVT who received venous stents. The results showed that anticoagulant therapy without concomitant antiplatelet therapy is the most common antithrombotic strategy in these patients, with approximately 29% receiving indefinite treatment.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Review
Biochemistry & Molecular Biology
Farwa Altaf, Shourong Wu, Vivi Kasim
Summary: Thrombosis, a major cause of deaths in the modern era, often requires treatment with classical drugs that may have unwanted side effects and high costs. Therefore, there is an urgent need to develop novel and low-cost drugs for thrombosis treatment. Fibrinolytic enzymes, as potential compounds for thrombosis therapy, have the advantage of high efficacy in eliminating thrombi.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Medicine, General & Internal
Marc E. Wolf, Beate Luz, Ludwig Niehaus, Pervinder Bhogal, Hansjoerg Baezner, Hans Henkes
Summary: The study focused on clinical manifestations and management of patients with cranial venous sinus thrombosis following exposure to the COVID-19 vaccine AstraZeneca, showing that these patients shared similarities in diagnosis and treatment processes.
JOURNAL OF CLINICAL MEDICINE
(2021)