Article
Surgery
Laleh Zarrinkoob, Anders Wahlin, Khalid Ambarki, Anders Eklund, Jan Malm
Summary: This study utilized 4D PC-MRI to quantify and map the distribution of blood flow in cerebral arteries before and after carotid endarterectomy. It was found that total cerebral blood flow increased after the surgery and the distribution of blood flow became more balanced postoperatively. Patients with collateral recruitment showed laterality in the middle cerebral artery before but not after the surgery, indicating hemodynamic disturbances in this territory. This noninvasive method provides valuable insights into the pathophysiology of cerebral hemodynamics in patients with carotid stenosis.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Surgery
Yoel Solomon, Rens R. B. Varkevisser, Nicholas J. Swerdlow, Chun Li, Patric Liang, Jeffrey J. Siracuse, Gert J. de Borst, Marc L. Schermerhorn
Summary: This study investigated the perioperative outcomes based on preprocedural symptom status of TFCAS, finding that patients with recent stroke had a significantly higher rate of in-hospital stroke/death compared to other patients, while asymptomatic patients had the lowest risk. The results support further symptom stratification by the degree of presenting neurologic injury in preoperative risk assessment.
JOURNAL OF VASCULAR SURGERY
(2021)
Review
Genetics & Heredity
Navneet Kumar, Chandi C. Mandal
Summary: Cholesterol accumulation in cancer cells is associated with tumor development, while cholesterol-lowering drugs have been found to play a role in the prevention and treatment of various cancers. Dysregulation of Akt in cancer is common and targeting Akt is considered an effective approach for cancer therapy. Cholesterol-lowering drugs affect Akt expression and activation in cancer cells, showing anticancer activity in different types of cancers.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Anton A. Raskurazhev, Polina Kuznetsova, Alla A. Shabalina, Marine M. Tanashyan
Summary: This study described the miRNA and hemostasis profile of patients with moderate and advanced stages of carotid atherosclerosis and identified potential correlations with hemostatic activation. The down-regulation of miR-126-5p was found to be a promising biomarker for advanced carotid atherosclerosis. The study also revealed potential interplay between miRNAs and hemostatic activation in the setting of carotid atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Takuro Abe, Kensuke Shimazaki, Tetsu Moriyama, Akira Murohashi, Yuji Iwanami, Akihito Sasaki, Katsumi Saito, Kentaro Jujo
Summary: Deferring percutaneous coronary intervention (PCI) for functionally insignificant stenosis with a fractional flow reserve (FFR) > 0.80 is associated with favorable long-term outcomes. This study examined the optimal management of low-density lipoprotein cholesterol (LDL-C) in patients with intermediate coronary stenosis and deferred PCI based on FFR values. The results showed that uncontrolled LDL-C levels were associated with higher major adverse cardiovascular and cerebrovascular events (MACCE) rates in patients with FFR values of 0.81-0.85, highlighting the importance of strict LDL-C-lowering therapy for this high-risk population.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Alison Halliday, Richard Bulbulia, Leo H. Bonati, Johanna Chester, Andrea Cradduck-Bamford, Richard Peto, Hongchao Pan
Summary: The international multicentre randomised trial ACST-2 compared the effects of CAS and CEA for asymptomatic patients with severe stenosis, showing that the long-term effects of these two procedures on fatal or disabling stroke are comparable.
Article
Surgery
Yoel Solomon, Christina L. Marcaccio, Vinamr Rastogi, Jinny J. Lu, Mahmoud B. Malas, Grace J. Wang, Peter A. Schneider, Gert J. de Borst, Marc L. Schermerhorn
Summary: This study aimed to evaluate the impact of timing of intervention and stroke severity on postoperative outcomes for carotid endarterectomy (CEA) in stroke patients. Severe disability patients (mRS score 5) had a high risk from CEA at any time point, while mild disability patients (mRS score 0-1) may benefit from CEA within 3-14 days. In contrast to current guidelines, patients with moderate disability (mRS score 2) may benefit from delaying CEA to 15-90 days, and those with moderate disability (mRS score 3-4) might benefit from CEA within 3-90 days. These data should be considered in the context of the clinical situation to determine the net benefit of delayed CEA.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Endocrinology & Metabolism
Stephan Kaczmarz, Jens Goettler, Jan Petr, Mikkel Bo Hansen, Kim Mouridsen, Claus Zimmer, Fahmeed Hyder, Christine Preibisch
Summary: Improved understanding of complex hemodynamic impairments in asymptomatic internal carotid artery stenosis is crucial for better stroke risk assessment. MRI-based perfusion and oxygenation parameters offer deeper perspectives on microvascular impairments, with most pronounced changes detected within individual watershed areas.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Medicine, General & Internal
Piotr Kaszczewski, Michal Elwertowski, Jerzy Leszczynski, Tomasz Ostrowski, Zbigniew Galazka
Summary: This study aimed to estimate cerebral blood flow in Doppler ultrasonography and compare the flow volume in asymptomatic and symptomatic patients with carotid artery stenosis. The results showed that the percentage of patients with flow compensation increased with the severity of stenosis in symptomatic patients. Patients with flow compensation had a lower risk of ischemic symptoms.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Peripheral Vascular Disease
Valentina Nardi, John Benson, Melanie C. Bois, Luca Saba, Anthony S. Larson, Ilke Ozcan, Ali Ahmad, David W. Morse, Fredric B. Meyer, Waleed Brinjikji, Giuseppe Lanzino, Lilach O. Lerman, Luis E. Savastano, Amir Lerman
Summary: This study found that intraplaque hemorrhage (IPH) as a marker of plaque vulnerability is more prominent in patients with mild carotid artery stenosis compared to those with moderate and severe stenosis, and a lower degree of stenosis is associated with a higher extent of IPH. This suggests that IPH may play an important role in the mechanism of stroke in patients with nonobstructive carotid stenosis.
Article
Medicine, General & Internal
Piotr Kaszczewski, Michal Elwertowski, Jerzy Leszczynski, Tomasz Ostrowski, Joanna Kaszczewska, Tomasz Brzezinski, Daniel Jarosz, Siavash Swieczkowski-Feiz, Zbigniew Galazka
Summary: This study aimed to assess cerebral blood flow in patients with internal carotid artery stenosis and focused on the circulation pathways and flow volume in extracranial arteries. The results showed that patients could compensate for the reduced blood flow through volumetric flow compensation, and this compensatory ability decreased with age.
Article
Endocrinology & Metabolism
Marianne Benn, Frida Emanuelsson, Anne Tybjaerg-Hansen, Borge G. Nordestgaard
Summary: The study found a causal relationship between high plasma glucose levels and increased risk of ischemic stroke. Glucose-lowering drugs such as glucagon-like peptide-1 receptor agonists and thiazolidinediones were shown to reduce the risk of stroke. These results may help guide clinicians in treating individuals at high risk for ischemic stroke.
Article
Surgery
Veena Mehta, Mathew Wooster
Summary: Intravascular lithotripsy is an effective adjunct for enabling stent expansion in heavily calcified lesions, providing a treatment option for high-risk carotid lesions that are not suitable candidates for endovascular treatment.
JOURNAL OF ENDOVASCULAR THERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Ciaran N. Kohli-Lynch, Brandon K. Bellows, Yiyi Zhang, Bonnie Spring, Dhruv S. Kazi, Mark J. Pletcher, Eric Vittinghoff, Norrina B. Allen, Andrew E. Moran
Summary: The study revealed that around 27% of ASCVD-free young adults in the United States have LDL-C levels >_130 mg/dL, and 9% have LDL-C >_160 mg/dL. Using statins or lifestyle interventions for lipid-lowering can prevent ASCVD events and increase QALYs compared to standard care.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lena Schmitzer, Nico Sollmann, Jan Kufer, Michael Kallmayer, Hans-Henning Eckstein, Claus Zimmer, Christine Preibisch, Stephan Kaczmarz, Jens Goettler
Summary: This study aimed to investigate whether revascularization treatment can reverse the spatial displacement of individual WSAs (iWSAs) and impaired hemodynamics. The results from sixteen patients with high-grade carotid artery stenosis and seventeen healthy controls showed that after revascularization, patients exhibited a significant spatial shift of iWSAs and significantly reduced perfusion delay ipsilateral to the stenosis.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Editorial Material
Medicine, General & Internal
Larry B. Goldstein
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Editorial Material
Clinical Neurology
Else Charlotte Sandset, Larry B. Goldstein
Review
Clinical Neurology
Narayanaswamy Venketasubramanian, Craig Anderson, Hakan Ay, Selma Aybek, Waleed Brinjikji, Gabriel R. de Freitas, Oscar H. Del Brutto, Klaus Fassbender, Miki Fujimura, Larry B. Goldstein, Roman L. Haberl, Graeme J. Hankey, Wolf-Dieter Heiss, Isabel Lestro Henriques, Carlos S. Kase, Jong S. Kim, Masatoshi Koga, Yoshihiro Kokubo, Satoshi Kuroda, Kiwon Lee, Tsong-Hai Lee, David S. Liebeskind, Gregory Y. H. Lip, Stephen Meairs, Roman Medvedev, Man Mohan Mehndiratta, Jay P. Mohr, Masao Nagayama, Leonardo Pantoni, Panagiotis Papanagiotou, Guillermo Parrilla, Daniele Pastori, Sarah T. Pendlebury, Luther Creed Pettigrew, Pushpendra N. Renjen, Tatjana Rundek, Ulf Schminke, Yukito Shinohara, Wai Kwong Tang, Kazunori Toyoda, Katja E. Wartenberg, Mohammad Wasay, Michael G. Hennerici
Summary: The COVID-19 pandemic has posed challenges for stroke management, with clinicians facing various etiologies for stroke compounded by unique complications associated with the virus. Strict infection control measures and continuous medical care are essential throughout the patient care journey.
CEREBROVASCULAR DISEASES
(2021)
Article
Clinical Neurology
Greg A. Jicha, Erin L. Abner, Steven E. Arnold, Maria C. Carrillo, Hiroko H. Dodge, Steven D. Edland, Keith N. Fargo, Howard H. Feldman, Larry B. Goldstein, James Hendrix, Ruth Peters, Julie M. Robillard, Lon S. Schneider, Jodi R. Titiner, Christopher J. Weber
Summary: Consensus guidance has been developed for the development and conduct of high-quality Alzheimer's disease clinical trials, covering aspects such as scientific justification, trial registration, conflict of interest disclosure, and defined trial population. This guidance aims to assist in protocol development and may also support the education of potential trial participants and the public on appropriate clinical trial participation decisions.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Else Charlotte Sandset, Larry B. Goldstein
Letter
Clinical Neurology
Zhu Cenjing, Phoebe M. Tran, Rachel P. Dreyer, Larry B. Goldstein, Judith H. Lichtman
Article
Neurosciences
Dana L. Ionel, Fred O. Odago, Andre N. Ene, Jessica D. Lee, William N. O'Connor, Larry B. Goldstein, L. Creed Pettigrew
Summary: In this case report, we describe a patient with Williams-Beuren syndrome who experienced sudden neurological deterioration following a cardiac ablative procedure. Williams-Beuren syndrome is a rare genetic disorder with distinctive clinical features. Chromosomal microdeletion leads to various neurological and cardiac complications.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2022)
Article
Clinical Neurology
Tanya N. Turan, Osama O. Zaidat, Gary S. Gronseth, Marc Chimowitz, Antonio Culebras, Anthony J. Furlan, Larry B. Goldstein, Nestor R. Gonzalez, Julius G. Latorre, Steven R. Messe, Thanh N. Nguyen, Rajbeer S. Sangha, Michael J. Schneck, Aneesh B. Singhal, Lawrence R. Wechsler, Alejandro A. Rabinstein, Mary Dolan O'Brien, Heather Silsbee, Jeffrey J. Fletcher
Summary: This study reviewed treatments for reducing the risk of recurrent stroke or death in patients with symptomatic intracranial atherosclerotic arterial stenosis (sICAS). The major recommendations include prescribing aspirin and clopidogrel for long-term prevention of stroke, recommending high-intensity statin therapy, maintaining target blood pressure levels, engaging in regular physical activity, and treating other modifiable vascular risk factors. The study also advises against certain procedures such as angioplasty and stenting for stroke prevention in moderate or severe sICAS patients.
Article
Clinical Neurology
Daniel Albjerg Rudolph, Stine Munk Hald, Luis Alberto Garcia Rodriguez, Soren Moller, Jesper Hallas, Larry B. Goldstein, David Gaist
Summary: The study demonstrates an association between long-term statin use and a lower risk of intracerebral hemorrhage.
Editorial Material
Clinical Neurology
Larry B. Goldstein
Article
Cardiac & Cardiovascular Systems
Phoebe M. Tran, Lam T. Tran, Cenjing Zhu, Tiffany Chang, Inna P. Powers, Larry B. Goldstein, Judith H. Lichtman
Summary: Poststroke antihypertensive use is comparable in rural and urban stroke survivors with a reported history of hypertension, but there is a trend for increased use among urban residents.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Clinical Neurology
Erica C. Leifheit, Yun Wang, Larry B. Goldstein, Judith H. Lichtman
Summary: Data on trends in recurrent stroke in the US are limited, but this study found an overall decrease in recurrent ischemic strokes from 2001 to 2017. However, there were geographic areas with persistently higher recurrence rates.
Article
Clinical Neurology
Phoebe M. M. Tran, Joshua L. L. Warren, Erica C. C. Leifheit, Larry B. B. Goldstein, Judith H. H. Lichtman
Summary: Long-term exposure to air pollutants is associated with increased risk of hospital readmission within 30 days after stroke, regardless of hospital performance category. The study assessed the relationship between exposure to carbon monoxide, nitrogen dioxide, ozone, particulate matter 2.5, and sulfur dioxide and 30-day all-cause hospital readmission in elderly stroke patients. Despite being below national limits, long-term exposure to air pollutants still increased the risk of readmission.
Article
Biochemistry & Molecular Biology
Deepak Kotiya, Noah Leibold, Nirmal Verma, Gregory A. Jicha, Larry B. Goldstein, Florin Despa
Summary: Amylin-A beta co-aggregation plays a significant role in Alzheimer's disease (AD), but its mechanisms are not fully understood. In this study, a new ELISA method was developed to detect amylin-A beta hetero-oligomers in brain tissue and blood. The results showed that this assay is sensitive to circulating amylin-A beta hetero-oligomers in the blood and may contribute to understanding and treating the development of AD.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Editorial Material
Clinical Neurology
Else Charlotte Sandset, Larry B. Goldstein