Article
Radiology, Nuclear Medicine & Medical Imaging
Song Liu, Ruowei Tang, Weiwei Xie, Shengting Chai, Qingqing Zhang, Yu Luo, Yu Guo, Chao Chai, Lixiang Huang, Meizhu Zheng, Jinxia Zhu, Binge Chang, Qi Yang, Song Jin, Zhaoyang Fan, Shuang Xia
Summary: The characteristics of plaque in the middle cerebral artery (MCA) and hemodynamics may help predict the occurrence of ischemic stroke and neurological impairment. Intraplaque hemorrhage (IPH) and anterograde score (AnS) are independent predictors for stroke occurrence. Tmax > 6.0-s volume, IPH, hypertension, and AnS are associated with neurological impairment in patients.
EUROPEAN RADIOLOGY
(2021)
Article
Clinical Neurology
Huihui Liu, Jing Jing, Anxin Wang, Qin Xu, Xia Meng, Hao Li, Zixiao Li, Yongjun Wang
Summary: This study compared the risk of stroke recurrence and the responses to dual antiplatelets with ticagrelor-aspirin versus clopidogrel-aspirin between patients with posterior circulation infarct (PCI) and those with anterior circulation infarct (ACI). The study found that the risk of stroke recurrence was similar between PCI and ACI patients, and ticagrelor-aspirin was superior to clopidogrel-aspirin in reducing the risk of stroke in both PCI and ACI patients within 90 days.
Article
Pharmacology & Pharmacy
Shijia Yu, Jing An, Ran Sun, Juan Feng, Mingjun Yu
Summary: Transient ischemic attack (TIA) poses a significant risk of cerebrovascular diseases, and long non-coding RNAs (lncRNAs) play critical roles in its development. KCNQ1OT1 has been identified as an independent predictor for subsequent ischemic stroke and may be involved in the regulation of early inflammatory response during TIA recurrence.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Clinical Neurology
Sherief Ghozy, Salah Eddine Oussama Kacimi, Mohammed Elfil, Mohamed Gomaa Sobeeh, Abdullah Reda, Kevin M. Kallmes, Alejandro A. Rabinstein, David R. Holmes, Waleed Brinjikji, Ramanathan Kadirvel, David F. Kallmes
Summary: TIAs can enhance brain tolerance to ischemic events, potentially leading to improved functional outcomes in patients suffering from subsequent ischemic strokes.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Rongrong Liu, Siwei Luo, Yu-Sheng Zhang, Chi Kwan Tsang
Summary: Transient ischemic attack (TIA) induces ischemic tolerance by upregulating bioactive metabolites in the plasma, which can protect against cerebral ischemic damage and improve neurological functions through the positive role of circulating neutrophils.
Article
Biochemical Research Methods
Leonidas Mavroudakis, Susan L. Stevens, Kyle D. Duncan, Mary P. Stenzel-Poore, Julia Laskin, Ingela Lanekoff
Summary: Ischemic stroke is a major cause of death and disability worldwide, and prophylactic treatment with CpG oligodeoxynucleotides has been shown to provide neuroprotection by reducing ischemic damage. The molecular mechanisms of CpG preconditioning involve limiting cell membrane breakdown and overall ischemic damage through an initialized inflammatory response.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu Lan, Jin Shang, Yue Ma, Yanhua Zhen, Yuxue Dang, Dongqing Ren, Ting Liu, Ronghui Ju, Ning Guo, Ximing Wang, Yang Hou
Summary: This study evaluates the incremental predictive value of pericarotid fat density (PFD) on head and neck computed tomography angiography (CTA) for obstructive coronary artery disease (CAD) compared to a clinical risk model (Framingham risk score), carotid artery stenosis, and plaque type in acute ischemic stroke (AIS) or transient ischemic attack (TIA) patients without a known history of CAD. The results show that CTA-derived PFD measurements offer additional predictive value for obstructive CAD beyond the clinical risk model and stenosis, improving risk stratification for TIA or stroke patients without a history of CAD.
EUROPEAN RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
A-Chou Su, Ling-Yan Zhang, Jing-Ge Zhang, Yu-Yan Hu, Xi-Yun Liu, Shi-Chao Li, Xiao-Hui Xian, Wen-Bin Li, Min Zhang
Summary: Several studies have shown that autophagy activation plays a role in brain ischemic tolerance induced by cerebral ischemic preconditioning. This study aimed to investigate the mechanism of autophagy activation during the process. The results suggest that the p38 MAPK-PPAR γ signaling pathway is involved in autophagy activation and neuroprotection during cerebral ischemic preconditioning.
DNA AND CELL BIOLOGY
(2022)
Article
Clinical Neurology
Wenbin Zhu, Catherine M. M. Davis, Elyse M. M. Allen, Sarah L. L. Feller, Thierno M. M. Bah, Robert E. E. Shangraw, Ruikang K. K. Wang, Nabil J. J. Alkayed
Summary: In this study, the researchers found that poor outcome after stroke in patients with type 2 diabetes (DM2) is linked to impaired microvascular tissue reperfusion. Furthermore, they discovered differences in microvascular reperfusion response between male and female DM2 mice after transient middle cerebral artery occlusion (MCAO). These findings suggest that DM2 impairs capillary perfusion and exacerbates ischemic brain injury in male but not female mice with DM2.
Article
Cell Biology
Ling-Yan Zhang, Xi-Yun Liu, A-Chou Su, Yu-Yan Hu, Jing-Ge Zhang, Xiao-Hui Xian, Wen-Bin Li, Min Zhang
Summary: This study discovered that Klotho plays an important role in cerebral ischemic tolerance induced by CIP, and it is upregulated via PPAR gamma. This finding contributes to a better understanding of the mechanisms behind cerebral ischemic tolerance and may provide new targets for the development of therapeutic strategies.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Clinical Neurology
Mathieu Kruska, Anna Kolb, Christian Fastner, Iris Mildenberger, Svetlana Hetjens, Maximilian Kittel, Kathrin Bail, Michael Behnes, Ibrahim Akin, Martin Borggrefe, Kristina Szabo, Stefan Baumann
Summary: This study analyzed the invasive coronary angiography findings of patients with acute ischemic stroke or transient ischemic attack who had elevated troponin levels and suspected myocardial infarction. The results showed that obstructive coronary artery disease was present in only 2.3% of patients with troponin elevation. Clinical features of myocardial ischemia and increased cardiovascular risk factors were predictive of obstructive CAD.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Xuanling Chen, Xuewei Qin, Jing Wang, Rong Wang, Xiangyang Guo, Lan Yao
Summary: This study evaluated the impact of perioperative regional cerebral oxygen saturation (rSO2) monitoring on the prognosis of ischemic Moyamoya disease (MMD) patients undergoing anastomosis surgery. The results showed that monitoring rSO2 during the perioperative period improved cerebral perfusion and reduced postoperative complications in MMD patients. The study suggests advocating for rSO2 monitoring in MMD patients undergoing vascular anastomosis.
FRONTIERS IN NEUROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Ibolya Rutkai, Ivan Merdzo, Sanjay Wunnava, Catherine McNulty, Partha K. Chandra, Prasad Katakam, David W. Busija
Summary: Differences in mitochondrial characteristics, including morphology, respiration, and calcium sparks activity, between male and female rats may contribute to sex differences in protective and repair mechanisms in response to transient ischemia-reperfusion.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Xiaoyi Qi, Shijia Wang, Liangxian Qiu, Xiongbiao Chen, Qianwen Huang, Kunfu Ouyang, Yanjun Chen
Summary: A two-sample Mendelian randomization (MR) study found a potential causal relationship between transient ischemic attacks (TIAs) and coronary artery disease (CAD). Further research should investigate the underlying mechanism of this association.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Neurosciences
Ya-Wei Sun, Ling-Yan Zhang, Shu-Juan Gong, Yu-Yan Hu, Jing-Ge Zhang, Xiao-Hui Xian, Wen-Bin Li, Min Zhang
Summary: The study indicates that NF-kappa B and p38 MAPK pathways are involved in the upregulation of GLT-1 during cerebral ischemic preconditioning, contributing to the neuroprotection in brain ischemia.
BRAIN RESEARCH BULLETIN
(2021)
Article
Clinical Neurology
James Feghali, Jennifer Kim, Abhishek Gami, Sarah Rapaport, Justin M. Caplan, Cameron G. McDougall, Judy Huang, Rafael J. Tamargo, Christopher M. Jackson
Summary: The study aimed to compare the predictive value of leukocyte ratios incorporating monocytes with the neutrophil-to-lymphocyte ratio in aSAH, finding that inflammatory indices including monocytes were more strongly associated with functional status and vasospasm outcomes in the patients.
NEUROSURGICAL REVIEW
(2021)
Article
Clinical Neurology
James Feghali, Abhishek Gami, Risheng Xu, Christopher M. Jackson, Rafael J. Tamargo, Cameron G. McDougall, Judy Huang, Justin M. Caplan
Summary: The current predictive scoring systems for unruptured aneurysms may underestimate future rupture risk, leading to overly conservative management strategies in some patients. Patients recommended for conservative therapy were more likely to experience complications and have a worse prognosis after rupture.
NEUROSURGICAL REVIEW
(2021)
Letter
Clinical Neurology
James Feghali, Sarah Rapaport, Wuyang Yang, Abhishek Gami, Jaimin Patel, Rafael J. Tamargo, Justin M. Caplan, Judy Huang
Article
Clinical Neurology
James Feghali, Shahab Aldin E. Sattari, Elizabeth Wicks, Abhishek Gami, Sarah D. Rapaport, Tej Azad, Wuyang Yang, Risheng J. Xu, Rafael Tamargo, Judy Huang
Summary: This study aims to externally validate the performance of the Nutshell tool and compare it with the conventional Subarachnoid Hemorrhage International Trialists (SAHIT) models, as well as review the ML literature on outcome prediction after aSAH and aneurysm treatment.
Article
Clinical Neurology
Albert Antar, James Feghali, Wuyang Yang, Elizabeth E. Wicks, Shahab Aldin Sattari, Sean Li, Timothy F. Witham, Henry Brem, Judy Huang
Summary: The objective of this study was to evaluate the match percentage between neurosurgical residency programs and their medical schools in the United States, and to identify program and resident characteristics associated with home program matching. The results showed that program size, research ranking, reputation ranking, and program rankings were significantly associated with home program matching.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Risheng Xu, Michael E. Xie, Jawad Khalifeh, James Feghali, Wuyang Yang, Jennifer Kim, Jason Liew, Rafael J. Tamargo, Judy Huang
Summary: The study aimed to investigate the incidence of perioperative stroke in patients with nmoyamoya disease (MMD) who presented primarily with ischemic stroke and compare it with those who presented with nonstroke symptoms. The study found that patients who underwent revascularization surgery within 90 days of their last stroke had a higher rate of perioperative stroke, higher long-term mortality rate, and lower stroke-free survival rate.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Risheng Xu, Sumil K. Nair, Joshua Materi, Divyaansh Raj, Giho Park, Ravi Medikonda, Safwan Alomari, Timothy Kim, Yuanxuan Xia, Judy Huang, Michael Lim, Chetan Bettegowda
Summary: This study examined the safety and cost-benefits of discharging patients with microvascular decompression (MVD) within 1 day of admission for severe facial pain. The results showed that discharging carefully selected patients within 1 day of admission was safe and resulted in reduced hospital admissions, complications, and total hospital costs.
WORLD NEUROSURGERY
(2022)
Letter
Clinical Neurology
Andrew M. Hersh, Jordina Rincon-Torroella, Nancy Abu-Bonsrah, Ann Liu, Alan R. Cohen, Timothy F. Witham, Judy Huang
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Risheng Xu, Sumil K. Nair, Divyaansh Raj, Joshua Materi, Raymond J. So, Sachin K. Gujar, Judy Huang, Ari M. Blitz, Michael Lim, Haris I. Sair, Chetan Bettegowda
Summary: Preoperative MRI shows moderate sensitivity and specificity in predicting neurovascular compression of the trigeminal nerve, and it should be included in the standard preoperative workup for patients with trigeminal neuralgia. However, the absence of neurovascular conflict on preoperative imaging is not sufficient to exclude patients from undergoing MVD.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Sumil K. Nair, Michael E. Xie, Kathleen Ran, Anita Kalluri, Collin Kilgore, Judy Huang, Michael Lim, Chetan Bettegowda, Risheng Xu
Summary: In most cases of trigeminal neuralgia, the trigeminal nerve is compressed by arterial vasculature. This study aimed to compare pain outcomes in patients with sole arterial versus sole venous compression.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Collin B. Kilgore, Raymond J. So, Kaitlyn Storm, Sumil K. Nair, Kathleen R. Ran, Anita L. Kalluri, Michael Lim, Judy Huang, Chetan Bettegowda, Risheng Xu
Summary: Trigeminal neuralgia is more prevalent in women, and microvascular decompression is the most effective surgical treatment for it. This study aims to investigate the relationship between sex and pain outcomes following microvascular decompression for trigeminal neuralgia.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Adham M. Khalafallah, Sachiv Chakravarti, Kyle Cicalese, Jose L. Porras, Cathleen C. Kuo, Adrian E. Jimenez, Henry Brem, Tim Witham, Judy Huang, Debraj Mukherjee
Summary: This study aimed to evaluate the knowledge of neurosurgery residents in the socioeconomic aspects of neurosurgery and assess the effectiveness of an asynchronous, longitudinal, web-based educational program tailored for them. The results showed no significant difference in resident knowledge before and after the intervention, except for a significant increase in accuracy for questions presented more frequently. Therefore, presenting content frequently can improve socioeconomic knowledge among neurosurgery trainees. This decentralized, web-based approach to resident education could be a future model for self-driven learning initiatives without disrupting existing workflows.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Clinical Neurology
Collin B. Kilgore, Sumil K. Nair, Kathleen R. Ran, Justin M. Caplan, Christopher M. Jackson, L. Fernando Gonzalez, Judy Huang, Rafael J. Tamargo, Risheng Xu
Summary: VTE is a significant concern for patients recovering from aSAH, and the optimal timing for prophylactic heparin initiation remains unclear. This retrospective study identified risk factors for VTE and found that delayed heparin introduction increased the risk of symptomatic VTE. Patients with sVTE had longer hospital stays and worse outcomes, emphasizing the importance of VTE prevention in aSAH patients.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Clinical Neurology
Anita L. Kalluri, Raymond J. So, Sumil K. Nair, Joshua Materi, Dorothy Wang, Niranjan Behera, Michael D. Kornberg, Judy Huang, Michael Lim, Chetan Bettegowda, Risheng Xu
Summary: This study compares the post-operative pain and numbness outcomes in trigeminal neuralgia (TN) patients with relapsing-remitting MS (RRMS) and progressive MS who underwent microvascular decompression (MVD). The results suggest that although the degree of pain at final follow-up may not differ, RRMS patients are at increased risk for pain recurrence following MVD for TN.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Proceedings Paper
Engineering, Biomedical
Smruti Mahapatra, Manish Balamurugan, Kathryn Chung, Venkat Kuppoor, Eli Curry, Fariba Aghabaglou, Tarana P. Kaovasia, Molly Acord, Ana Ainechi, Jeff Kim, Yohannes Tsehay, Christina Diana Ghinda, Jennifer K. Son, Aliaksei Pustavoitau, Betty Tyler, Shenandoah D. Robinson, Nicholas Theodore, Henry Brem, Judy Huang, Amir Manbachi
Summary: This study demonstrates that ultrasound technology and a specialized algorithm can accurately detect and locate cotton balls in neurosurgical procedures, to prevent potential complications postoperatively. The algorithm successfully detected cotton balls with a diameter of 5mm, suitable for surgical balls used by neurosurgeons.
MEDICAL IMAGING 2021: ULTRASONIC IMAGING AND TOMOGRAPHY
(2021)