Article
Clinical Neurology
James D. Stefaniak, Fatemeh Geranmayeh, Matthew A. Lambon Ralph
Summary: The recovery of language abilities in aphasia patients is heterogeneous and multidimensional, with different components of language showing distinct recovery trajectories. These components rely on different neural regions, suggesting that treatment strategies should be personalized based on individual language profiles to be effective.
Article
Neurosciences
James D. Stefaniak, Reem S. W. Alyahya, Matthew A. Lambon Ralph
Summary: Aphasia recovery post-stroke may not rely on novel recruitment of right hemisphere territory, but on the utilization of under-utilized regions within the language network. Regions such as the right anterior insula, frontal operculum, and inferior frontal gyrus were more likely to be activated in individuals with PSA than controls during language tasks.
Article
Neurosciences
Kelly C. Martin, Anna Seydell-Greenwald, Peter E. Turkeltaub, Catherine E. Chambers, Margot Giannetti, Alexander W. Dromerick, Jessica L. Carpenter, Madison M. Berl, William D. Gaillard, Elissa L. Newport
Summary: This study investigates the plasticity patterns in the brain following irreparable damage to critical cognitive regions at birth. The findings suggest that after a left hemisphere perinatal stroke, the right hemisphere consistently recruits mirror-image areas of the left hemisphere and aligns better with the strongly activated left hemisphere areas in typically developed brains. This suggests that successful development of language processing in the right hemisphere after a left hemisphere perinatal stroke may rely on recruiting an arrangement similar to the typical dominant left hemisphere.
Article
Radiology, Nuclear Medicine & Medical Imaging
Olurotimi O. Komolafe, Victor A. Adetiloye, Oluwagbemiga O. Ayoola, Olufemi Adefehinti, Chidiogo Onwuka
Summary: This study found abnormal peripheral hemodynamic characteristics in the lower limbs of children with sickle cell anemia, but no evidence of occlusive peripheral artery disease.
Review
Medicine, General & Internal
Sarah Park, Ada Tang, Courtney Pollock, Brodie M. Sakakibara
Summary: This paper describes the protocol of a systematic review and meta-analysis that aims to evaluate the clinical outcomes of lower extremity-focused telerehabilitation interventions for stroke patients.
Review
Engineering, Biomedical
Jamille A. Feitosa, Corina A. Fernandes, Raphael F. Casseb, Gabriela Castellano
Summary: Virtual reality (VR) rehabilitation has been shown to improve motor and cognitive abilities in different populations. This study systematically reviewed the effects of VR intervention on cortical reorganization and functional improvement. The results demonstrated changes in brain activation and reorganization patterns in stroke patients, older adults, and patients with other neurological conditions, which were associated with functional improvement after VR intervention.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Clinical Neurology
Hyun Haeng Lee, Min Kyun Sohn, Deog Young Kim, Yong-Il Shin, Gyung-Jae Oh, Yang-Soo Lee, Min Cheol Joo, So Young Lee, Min-Keun Song, Junhee Han, Jeonghoon Ahn, Young-Hoon Lee, Won Hyuk Chang, Soo Mi Choi, Seon Kui Lee, Jongmin Lee, Yun-Hee Kim
Summary: The study results demonstrate that the proportional recovery model for the lower extremity is invalid.
Article
Neurosciences
Grigori Yourganov, Brielle C. Stark, Julius Fridriksson, Leonardo Bonilha, Christopher Rorden
Summary: Using a large sample of 116 participants who had experienced stroke, this study systematically examined the relationship between brain damage and functional connectivity within the intact hemisphere. The findings suggest evidence of contralateral cortical network reorganization in response to brain damage, particularly in well-connected regions where connectivity increases with the degree of damage.
BRAIN CONNECTIVITY
(2021)
Article
Critical Care Medicine
Joshua J. Van Wyngaarden, Brian Noehren, Paul E. Matuszewski, Kristin R. Archer
Summary: The study found that the STarT-Lower Extremity Screening Tool (STarT-LE) can help identify patients at risk for long-term pain and disability in lower extremity fracture patients, and may be used to guide the postoperative management of these patients.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2021)
Article
Surgery
Nicole Ilonzo, Jonathan Lee, Crystal James, John Phair, Windsor Ting, Peter Faries, Ageliki Vouyouka
Summary: This study found that women are more likely to experience loss of independence after lower extremity revascularization, along with unplanned readmission and longer length of stay. Endovascular revascularization is associated with decreased likelihood of loss of independence.
AMERICAN JOURNAL OF SURGERY
(2022)
Article
Medicine, General & Internal
Andrew S. Tseng, Marlene Girardo, Christine Firth, Shubhang Bhatt, David Liedl, Paul Wennberg, Win-Kuang Shen, Leslie T. Cooper, Fadi E. Shamoun
Summary: The study examines the relationship between peripheral arterial disease (PAD) and incident atrial fibrillation (AF), finding that PAD patients are at increased risk for developing AF, ischemic stroke, and all-cause mortality. Patients with abnormal ankle-brachial index (ABI), especially those with severe PAD and cardiac structural abnormalities, may benefit from routine monitoring for AF and management of cardiovascular risk factors.
MAYO CLINIC PROCEEDINGS
(2021)
Article
Medicine, General & Internal
Jasmine J. Cash, Mark G. Bowden, Andrea D. Boan, Lisa M. McTeague, John H. Kindred
Summary: The purpose of this study was to explore the relationship between resting motor threshold (rMT) and active motor threshold (aMT). The study found that as muscle activation increased, the motor thresholds decreased. There were differences in motor thresholds between stroke survivors and healthy controls, highlighting the importance of understanding these thresholds in stroke rehabilitation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Psychology, Biological
Alexis B. Slutsky-Ganesh, Manish Anand, Jed A. Diekfuss, Gregory D. Myer, Dustin R. Grooms
Summary: Bilateral sensorimotor coordination is crucial for everyday activities, and this study investigated the neural correlates of lower extremity coordination using a novel method that combined motion analysis and fMRI. The results showed that the inability to maintain interlimb coordination was associated with increased activity in attention- and sensory-related brain regions.
Article
Clinical Neurology
Jie Shen, Xudong Gu, Jianming Fu, Yunhai Yao, Yan Li, Ming Zeng, Zhixiang Liu, Cao Lu
Summary: This study aims to explore the effects of VR-based rehabilitation on upper extremity motor function and associated brain activation in stroke patients. Through functional magnetic resonance imaging (fMRI), electroencephalography (EEG), and clinical evaluation, the study will provide high-quality evidence for the relationship between upper extremity motor function and brain activation in stroke, as well as the neuroplasticity and motor function recovery after VR in stroke patients.
FRONTIERS IN NEUROLOGY
(2023)
Article
Rehabilitation
Shashwati Geed, Christianne J. Lane, Monica A. Nelsen, Steven L. Wolf, Carolee J. Winstein, Alexander W. Dromerick
Summary: The study found that in stroke rehabilitation trials, using a Rasch-rescaled UEFM can improve the accuracy of effect size, reduce the required sample size, decrease costs, shorten duration, and decrease the number of subjects exposed to experimental risks compared to using the simple summation of ordinal UEFM items.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Rehabilitation
Hajar Almoajil, Tim Theologis, Helen Dawes, Jo Pierce, Andrew Meaney, Aziz Baklouti, Lara Poverini, Sally Hopewell, Francine Toye
Summary: This study aims to explore the factors affecting expectations and perceptions of surgical outcomes for lower limb orthopaedic surgery in children with CP, their parents or carers, and healthcare professionals. The results identified 10 factors including facilitators, barriers, motivational and demotivational factors, and categorized them into two themes: environmental and personal factors. Interdisciplinary collaboration, communication and information resources, holistic care, and shared goal setting were reported as environmental facilitators, while lack of time and resources and divergent expectations were reported as barriers. Personal motivators include family encouragement, patient's self-determination, and previous experiences, while fear of a new environment is reported as a personal demotivator.
DISABILITY AND REHABILITATION
(2023)
Article
Clinical Neurology
Hajar Almoajil, Sally Hopewell, Helen Dawes, Francine Toye, Tim Theologis
Summary: A core outcome set for lower limb orthopaedic surgery in children with cerebral palsy was developed through two rounds of Delphi survey and a consensus meeting, which included domains such as pain and fatigue, lower limb structure, motor function, mobility, gait-related outcomes, physical activity, independence, and quality of life.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Review
Rehabilitation
Cecilie Thrue, Lars G. Hvid, Mads Gamborg, Helen Dawes, Ulrik Dalgas, Martin Langeskov-Christensen
Summary: This study systematically reviewed the psychometric properties of the VO2max test in PD, VO2max levels in pwPD compared to HCs, and reported VO2max associations in PD. The results showed that VO2max was comparable between pwPD and HC as well as between different PD-medication states, and only age, sex, and fatigue were associated with VO2max. However, there was limited evidence on the psychometric properties of the VO2max test.
DISABILITY AND REHABILITATION
(2023)
Review
Rehabilitation
Jackie Parsonage-Harrison, Mary Birken, David Harley, Helen Dawes, Mona Eklund
Summary: This paper aims to review the academic literature and systematically describe and analyze occupation-based interventions for improving the mental health and wellbeing of adolescents and young people. The study identifies various interventions and research methods, but highlights the need for more consistency in core outcome measurements.
BRITISH JOURNAL OF OCCUPATIONAL THERAPY
(2023)
Editorial Material
Rehabilitation
Derick T. Wade
Summary: This article mainly introduces how the author, as the editor of Clinical Rehabilitation, supported and encouraged the publication of articles with evidence-based, conceptual and scientific basis on rehabilitation to answer the definition and features of rehabilitation. The author believes that the essential feature characterizing rehabilitation is its holistic, person-centered approach, and its focus on social integration.
CLINICAL REHABILITATION
(2023)
Review
Rehabilitation
Derick T. Wade
Summary: The concept of rehabilitation potential is used to select patients for rehabilitation and limit access to services. However, it lacks a clear definition and evidence supporting its validity. The solution is to offer a comprehensive rehabilitation assessment and formulation to all individuals who have not recently been evaluated by an expert multi-professional rehabilitation team to determine their rehabilitation potential.
CLINICAL REHABILITATION
(2023)
Review
Rehabilitation
Avril Dillon, Jackie Casey, Helen Gaskell, Avril Drummond, Nele Demeyere, Helen Dawes
Summary: This study aimed to review and analyze the relationship between fatigue and cognitive impairment in ABI patients. The findings showed that sustained attention had stronger associations with fatigue, while weak associations were found with information processing, attention, memory, and executive function.
DISABILITY AND REHABILITATION
(2023)
Editorial Material
Ethics
Derick Wade
JOURNAL OF MEDICAL ETHICS
(2023)
Article
Neurosciences
Piergiorgio Salvan, Madalena Fonseca, Anderson M. Winkler, Antoine Beauchamp, Jason P. Lerch, Heidi Johansen-Berg
Summary: In this study, the authors investigated the role of different serotonin receptors in regulating brain-wide activity and human behavior. They found that activation of specific serotonin neurons in mice modulated the amplitude and functional connectivity of different serotonin receptor networks. In humans, resting-state functional MRI also showed similar effects of serotonin receptors on impulsivity and negative biases. These findings suggest that heterogeneous distributions of serotonin receptor types in the brain may underlie behaviorally distinct modes of serotonin regulation.
NATURE NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Owen Gustafson, Elizabeth King, Michael Schlussel, Matthew Rowland, Helen Dawes, Mark A. Williams
Summary: Survivors of critical illness often experience long-term physical impairment and decreased quality of life. The MSK-ICU study aims to determine and characterize the musculoskeletal health state of ICU survivors 6 months after admission to inform rehabilitation interventions. The study will collect data on MSK health state, quality of life, employment, anxiety, and depression through telephone follow-up and physical assessments.
Article
Rehabilitation
Derick T. Wade
Summary: This article discusses the necessity of developing a general theory to explain how healthcare rehabilitation changes outcomes and evaluate its validity. The theory emphasizes the catalytic effects of rehabilitation in facilitating and guiding adaptation to illness-related changes, providing principles for diagnosis, formulation, and intervention in rehabilitation.
CLINICAL REHABILITATION
(2023)
Article
Health Care Sciences & Services
Helene Eisenhut, Johnny Collett, Farzaneh Clin Exercise Rehabil Res Grp, Farzaneh Yazdani
Summary: Volunteering has the potential to enhance physical, mental, and social well-being for people with neurological conditions. Facilitating accessible therapeutic volunteering and involving individuals with neurological conditions is crucial for its effectiveness.
HEALTH EXPECTATIONS
(2023)
Article
Rehabilitation
Amanda Figueiredo Santos de Almeida, Talita Dias da Silva, Ibis Ariana Pena de Moraes, Lilian Del Ciello de Menezes, Eduardo Dati Dias, Luciano Vieira de Araujo, Carlos Bandeira de Mello Monteiro, Helen Dawes, Amanda Orasmo Simcsik, Camila Aparecida de Oliveira Alberissi, Victoria Yanara Hernandes da Silva, Marisa Afonso Andrade Brunherotti, Maria Georgina Marques Tonello
Summary: The study aimed to evaluate the feasibility, enjoyment, and potential effect of telerehabilitation using a serious game named 'MoveHero' for people with autism spectrum disorder (ASD). The results showed that all participants safely participated with 100% adherence to sessions, 60% enjoyed the task, and there was a significant improvement in performance, particularly for the non-ASD group. These findings support the use of serious games to motivate physical activity in people with ASD and call for further research to investigate its efficacy.
DISABILITY AND REHABILITATION-ASSISTIVE TECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Nicola Clague-Baker, Sarah Tyson, Karen Leslie, Helen Dawes, Michelle Bull, Natalie Hilliard
Summary: This study aimed to evaluate the feasibility and acceptability of a home-based testing protocol to measure physiological responses in individuals with Myalgic Encephalomyelitis (ME) during everyday activities. The study found that measuring physiological parameters during everyday activities was feasible for individuals with different severities of ME, and activities must be adapted according to the severity to avoid symptom exacerbation.
FATIGUE-BIOMEDICINE HEALTH AND BEHAVIOR
(2023)
Article
Nutrition & Dietetics
Sophie Lawrie, Shelly Coe, Maedeh Mansoubi, Jessica Welch, Jamil Razzaque, Michele T. Hu, Helen Dawes
Summary: This research aimed to investigate the association between three dietary indices and nonmotor symptoms in Parkinson's disease patients. The results showed that the Healthy Diet Indicator (HDI) was related to fatigue and depression symptoms, but further research with a larger sample is needed to verify these findings.
JOURNAL OF THE AMERICAN NUTRITION ASSOCIATION
(2023)