Review
Endocrinology & Metabolism
Aliki Economides, Konstantinos Giannakou, Ioannis Mamais, Panayiotis A. Economides, Panagiotis Papageorgis
Summary: The study found that higher BMI is significantly associated with ETE, multifocality, and tumor size. Further research with a larger number of participants is needed to elucidate the association of increased BMI with advanced TNM stage and LN metastasis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Surgery
Anna C. Beck, Anand Rajan, Shannon Landers, Sarah Kelley, Andrew M. Bellizzi, Geeta Lal, Sonia L. Sugg, James R. Howe, Carlos H. Chan, Ronald J. Weigel
Summary: The study showed that the tall cell variant of papillary thyroid carcinoma has increased expression of cancer stem cell markers compared to classic papillary thyroid carcinoma. A gene signature similar to the tall cell variant identified a subtype of classic papillary thyroid carcinoma with worse recurrence-free survival.
Article
Clinical Neurology
Renhui Chen, Faya Liang, Minhong Wang, Ping Han, Peiliang Lin, Long Zhang, Xiaoming Huang
Summary: Objective: This study aimed to explore the relationship between obstructive sleep apnea (OSA) and aggressive features of papillary thyroid carcinoma (PTC). The study found that moderate-to-severe OSA was associated with increased odds of larger tumor size, capsular invasion, multifocality, cervical lymph node metastasis, and BRAF mutation, indicating that OSA may contribute to cancer progression in PTC patients.
Article
Endocrinology & Metabolism
Jin Seok Lee, Jun Sung Lee, Hyeok Jun Yun, Seok Mo Kim, Hojin Chang, Yong Sang Lee, Hang-Seok Chang, Cheong Soo Park
Summary: In this retrospective study, the medical records of 11,570 patients with papillary thyroid carcinomas (PTCs) smaller than or equal to 1 cm who underwent thyroidectomy were reviewed. The study revealed that aggressive subtypes of small PTC tumors exhibited more extrathyroidal extension and neck node metastasis. Surgeons should consider the aggressive subtypes as important factors when deciding the range of surgery in PTCs smaller than 1 cm.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Daqi Zhang, Mingyu Yang, Xin Zhang, Cheng Wang, Kunlin Li, Hongbo Wang, Hao Chi, Chengqiu Sui, Gianlorenzo Dionigi, Hui Sun
Summary: This study presents a rare case series of synchronous occurrence of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) in the same thyroid gland. The synchronous MTC/PTC were classified into 4 subtypes and the clinical and pathological aspects as well as the results were presented.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Tiantian Wang, Jinyuan Shi, Luchuan Li, Xiaoming Zhou, Hui Zhang, Xiaofang Zhang, Yong Wang, Lian Liu, Lei Sheng
Summary: This study used single-cell RNA sequencing to analyze the tumor microenvironment in PTC and found significant inter-tumor heterogeneity in bilateral PTC. They also identified biomarkers and pathways associated with prognosis and disease progression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Meihua Jin, Dong Eun Song, Jonghwa Ahn, Eyun Song, Yu-Mi Lee, Tae-Yon Sung, Tae Yong Kim, Won Bae Kim, Young Kee Shong, Min Ji Jeon, Won Gu Kim
Summary: Aggressive variants of papillary thyroid carcinoma (PTC) are associated with unfavorable clinical outcomes. Targeted next-generation sequencing in 36 tissue samples from patients with aggressive variants of PTC revealed a higher prevalence of BRAF mutation and lower prevalence of RAS mutation. The prevalence of mutations in the TERT promoter, TP53, and genes encoding three functional groups ranged between that of PTCs and poorly differentiated/anaplastic carcinoma.
Article
Oncology
Lili Zhang, Baixue Shi, Mingyang Hu, Linxue Qian
Summary: The overexpression of HIF-1 alpha and caspase-3 is associated with carcinogenesis in papillary thyroid carcinoma (PTC). HIF-1 alpha expression is positively correlated with caspase-3 expression, suggesting their potential as therapeutic targets.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Jacques A. Greenberg, Maureen D. Moore, Jessica W. Thiesmeyer, Caitlin E. Egan, Yeon Joo Lee, Paul Christos, Rasa Zarnegar, Toni Beninato, Thomas J. Fahey, Brendan M. Finnerty
Summary: The prognosis of patients with coexisting papillary thyroid cancer (PTC) and anaplastic thyroid carcinoma (ATC) depends on the presence of aggressive clinicopathologic features and lies between that of PTC and ATC. Adjuvant radioactive iodine (RAI) and external beam radiation therapy (EBRT) may improve survival, even after complete surgical resection.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Jasna Metovic, Francesco Cabutti, Simona Osella-Abate, Giulia Orlando, Cristian Tampieri, Francesca Napoli, Francesca Maletta, Lorenzo Daniele, Marco Volante, Mauro Papotti
Summary: The study aimed to find clinical, pathological, and molecular characteristics associated with aggressive forms of papillary thyroid carcinoma (PTC). 43 aggressive PTC cases were selected based on metastasis at diagnosis, development of distant metastasis during follow-up, and/or biochemical recurrence, and matched with 43 PTC patients who remained disease-free during follow-up. Distinctive clinical and morphological features were observed in aggressive PTCs. Various pathways, including DNA damage repair, MAPK, and RAS pathways, were differentially regulated in aggressive PTC. The hedgehog pathway showed differential de-regulation in aggressive PTC. Specific molecular signatures and morphological features in aggressive PTC may be helpful in predicting aggressive behavior and developing tailored treatment options for these patients.
ENDOCRINE PATHOLOGY
(2023)
Article
Oncology
Jessica Limberg, Yeon J. J. Lee-Saxton, Caitlin E. E. Egan, AlAnoud AlAnazi, Imaani Easthausen, Dessislava Stefanova, Alexia Stamatiou, Toni Beninato, Rasa Zarnegar, Theresa Scognamiglio, Thomas J. J. Fahey III, Brendan M. M. Finnerty
Summary: This study found that perineural invasion (PNI) is associated with aggressive behavior, increased locoregional recurrence, and decreased survival in papillary thyroid cancer (PTC). Patients with PNI had higher rates of lymphovascular invasion and nodal metastasis, as well as poorer prognosis.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Timothy M. Ullmann, Jessica W. Thiesmeyer, Yeon Joo Lee, Shaham Beg, Juan Miguel Mosquera, Olivier Elemento, Thomas J. Fahey, Theresa Scognamiglio, Yariv Houvras
Summary: This study aimed to investigate the different phenotypic tumor behavior in papillary thyroid cancer (PTC) driven by different genetic drivers. The results showed that RET-driven tumors were more aggressive than tumors with BRAF(V600E) mutation or RAS mutation, with higher rates of extrathyroidal extension, multifocal disease, and distant metastases.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Jia Liu, Deqian Wu, Jinxin Zhu, Su Dong
Summary: This study found that HIV infection was associated with larger tumors, more extensive invasion, more lymph node metastasis, and more distant metastasis in patients with papillary thyroid carcinoma (PTC). These findings suggest that HIV infection may promote the development and progression of PTC, highlighting the need for more comprehensive treatment for these patients.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jinwei Hu, Isabella J. Yuan, Saied Mirshahidi, Alfred Simental, Steve C. Lee, Xiangpeng Yuan
Summary: Thyroid carcinoma is a group of phenotypically heterogeneous cancers, and recent advances in biological technologies have helped delineate the genetic, epigenetic, and non-genetic factors contributing to their heterogeneities. Understanding the mechanisms of intratumor heterogeneity and therapeutic resistance can facilitate the development of novel targeting therapies for thyroid cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Jiaojiao Ma, Yuan Wang, Xuehua Xi, Jiajia Tang, Linping Wang, Liangkai Wang, Di Wang, Xiaolong Liang, Bo Zhang
Summary: A targeted microbubble was successfully designed and prepared for the specific ultrasound imaging diagnosis of highly aggressive papillary thyroid cancer. The targeted microbubbles showed good stability, biosafety, and high targeting specificity, significantly improving the tumor signal-to-noise ratio of highly invasive PTC and facilitating accurate diagnosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
