Article
Pediatrics
Cynthia R. Rovnaghi, Joseph Rigdon, Jean-Michel Roue, Monica O. Ruiz, Victor G. Carrion, Kanwaljeet J. S. Anand
Summary: This study aimed to identify children at risk for altered HPA-axis function due to early life stress by examining longitudinal trajectories of hair cortisol concentrations. The results revealed different classes of children with distinct HCC profiles, suggesting varying impacts of ELS on HPA-axis function.
FRONTIERS IN PEDIATRICS
(2021)
Review
Endocrinology & Metabolism
Jody A. Rusch, Brian T. Layden, Lara R. Dugas
Summary: Cognitive function in humans relies on the complex interplay between multiple body systems, including the HPA axis. The gut microbiota, which outnumbers human cells and has a greater genetic potential, plays a crucial role through the MGB axis, a bidirectional communication pathway. Stress can affect the MGB axis through the HPA axis and other pathways, and animal research has contributed to a paradigm shift in understanding the influence of microbiota on human health and disease. Preclinical and human trials are currently investigating the applicability of these findings in humans.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Skand Shekhar, Raven McGlotten, Sunyoung Auh, Kristina Rother, Lynnette K. Nieman
Summary: The study revealed that abnormal thyroid function, likely mediated by subnormal nocturnal TSH levels, is prevalent in patients with Cushing syndrome. This abnormality can be reversed after cure.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Selina Schaer, Ines Muerner-Lavanchy, Stefanie J. Schmidt, Julian Koenig, Michael Kaess
Summary: This series of meta-analyses aimed to quantify the effect of child maltreatment on various measures of HPA axis activity. The results showed evidence for blunted cortisol stress reactivity in individuals exposed to child maltreatment. However, no overall differences were found in other measures of HPA axis activity. The study also discussed moderators, methodological shortcomings, and potential directions for future research.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Hongyuan Zhu, Luming Wu, Tingwei Su, Lei Jiang, Weiwei Zhou, Yiran Jiang, Cui Zhang, Xu Zhong, Weiqing Wang
Summary: This study investigated the association between radiological characteristics of benign adrenocortical tumors and the hypothalamus-pituitary-adrenal (HPA) axis in 494 patients. It was found that patients with mild autonomous cortisol secretion (MACS) had larger tumor diameter, thinner contralateral adrenal gland, and lower plasma ACTH and serum DHEAS levels compared to those with non-functional adrenocortical tumors (NFAT). ACTH was shown to mediate the effects of MACS on DHEAS and contralateral adrenal gland.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Sergi Olvera-Maneu, Anais Carbajal, Jaume Gardela, Manel Lopez-Bejar
Summary: Monitoring the endocrine status of horses through hair samples can provide valuable information on their welfare and reproductive health. This study found that cortisol, testosterone, and dehydroepiandrosterone sulphate levels in horse hair were significantly influenced by season, with varying hormone ratios between seasons. Seasonality should be considered when analyzing sexual and stress hormones in stallion hair to avoid misinterpretations.
Article
Endocrinology & Metabolism
Jacinda C. Li, Molly A. Hall, Idan Shalev, Hannah M. C. Schreier, Tomas Gonzalez Zarzar, Isabel Marcovici, Frank W. Putnam, Jennie G. Noll
Summary: This study suggests a mechanistic association between HPA axis attenuation and obesity, with the attenuated cortisol growth rate mediating the effects of childhood sexual abuse on accelerated BMI accumulation and elevated adulthood obesity rates.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Psychiatry
Jose Antonio Monreal, Neus Salvat-Pujol, Alexandre Gonzalez-Rodriguez, Mikel Urretavizcaya, Jose Manuel Crespo, Roser Nadal, Aida de Arriba-Arnau, Clara Massaneda, Diego Palao, Jose Manuel Menchon, Javier Labad, Virginia Soria
Summary: The aim of this study was to examine whether there are sex-based differences in the relationship between personality traits and hypothalamic-pituitary-adrenal (HPA) axis measures. The study found that female sex was associated with an increased cortisol awakening response and a more flattened diurnal cortisol slope. However, a negative significant interaction between harm avoidance and female sex was found. Regarding the cortisol suppression ratio, perseverance was associated with increased cortisol suppression after dexamethasone; sex did not affect this association.
ARCHIVES OF WOMENS MENTAL HEALTH
(2022)
Review
Immunology
Juan P. Sanabria-Mazo, Ariadna Colomer-Carbonell, Meritxell Carmona-Cervello, Albert Feliu-Soler, Xavier Borras, Mar Grasa, Montserrat Esteve, Michael Maes, Silvia Edo, Antoni Sanz, Juan V. Luciano
Summary: This systematic review identified preliminary evidence of increased levels of certain immune-inflammatory and HPA axis biomarkers in individuals with NSLBP, but also noted inconsistent results for some biomarkers. Additionally, insufficient evidence was found for IL-6, TNF-alpha, and CRP levels in NSLBP when compared exclusively with healthy controls. The dysregulated functioning of cortisol in NSLBP patients further adds complexity to the understanding of the immune-inflammatory and HPA axis biomarkers in this population.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Psychology, Multidisciplinary
Qian Liu, Jianhui Wu, Liang Zhang, Xiaofang Sun, Qing Guan, Zhuxi Yao
Summary: This study found that, for the same level of stress, the subjective perceived level of control in young adults can influence the activation of the hypothalamic-pituitary-adrenal axis.
FRONTIERS IN PSYCHOLOGY
(2021)
Review
Endocrinology & Metabolism
Yehan Bian, Heidi Hahn, Anja Uhmann
Summary: Hedgehog signaling plays essential roles in embryonic development, adult homeostasis, and tumorigenesis. Despite its close connection with pituitary embryonic development, the engagement of Hedgehog signaling in the pituitary gland has been underestimated. Dysfunction of this signaling pathway during pituitary development leads to gland malformation. Recent research also suggests a regulatory role of Hedgehog signaling in the adult pituitary, affecting homeostasis, hormone production, and possibly formation of neoplasms. Targeting this pathway with therapeutic strategies shows promise in treating pituitary diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Ali S. Alzahrani, Noha Mukhtar, Abeer Aljomaiah, Hadeel Aljamei, Abdulmohsen Bakhsh, Nada Alsudani, Tarek Elsayed, Nahlah Alrashidi, Roqayh Fadel, Eman Alqahtani, Hussein Raef, Muhammad Imran Butt, Othman Sulaiman
Summary: This study aimed to investigate the adrenocortical response to COVID-19 infection. The results revealed that patients with more severe disease had lower cortisol and ACTH levels, indicating a direct link between COVID-19 infection and impaired glucocorticoid response.
ENDOCRINE PRACTICE
(2021)
Article
Endocrinology & Metabolism
J. Di Francesco, G. F. Mastromonaco, S. L. Checkley, J. Blake, J. E. Rowell, S. Kutz
Summary: The study found that cortisol in muskox qiviut can be used as a measure of HPA axis activity, with differences across body regions, changes over time, and discrepancies between shed and unshed qiviut emphasizing the importance of consistent design and methodology in sample collection and analysis.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Melanie Spindler, Marco Palombo, Christiane Thiel, Hui M. Zhang
Summary: As part of the HPA axis, the hypothalamus plays a crucial role in metabolic and endocrine homeostasis. However, there is a lack of research on the aging human hypothalamus. This study examined the detailed hypothalamic microstructure in middle adulthood and found regional differences in the anterior-superior subunit, which is a critical area for HPA axis regulation. Waist circumference and hair cortisol levels were also associated with hypothalamic alterations, indicating the importance of endocrine and stress management in age.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Ramadevi Subramani, Adriana Estrada, Madeline Dixon, Maria Parada, Sheryl Rodriguez, Diego A. Pedroza, Matthew D. Ramirez, Alexa Clift, Lilia Garcia, Rajkumar Lakshmanaswamy
Summary: Early pregnancy reduces the lifetime risk of breast cancer by persistently altering the hypothalamic-pituitary hormonal axis, although the exact physiological mechanisms involved are not clear.
Article
Biochemistry & Molecular Biology
Idan Yelin, Olga Snitser, Gal Novich, Rachel Katz, Ofir Tal, Miriam Parizade, Gabriel Chodick, Gideon Koren, Varda Shalev, Roy Kishony
Review
Pharmacology & Pharmacy
Gideon Koren, Rana Cohen
DRUG METABOLISM REVIEWS
(2019)
Article
Psychology, Biological
Can Nakkas, Maria Bosch, Roberto LaMarca, Thomas Wyss, Hubert Annen, Serge Brand
Summary: The study compared the relationship between heart rate variability and psychological assessment, identified a psychological measure related to parasympathetic health, and validated the convergent validity of self-reported emotion regulation, supporting the Polyvagal Theory and NIM.
JOURNAL OF PSYCHOPHYSIOLOGY
(2021)
Article
Environmental Sciences
Sandra Sefidan, Maria Pramstaller, Roberto La Marca, Thomas Wyss, Dena Sadeghi-Bahmani, Hubert Annen, Serge Brand
Summary: The study found that recruits with higher resilience scores were more likely to reduce perceived stress and psychological distress during military training, achieving better military performance. However, there were no differences in resilience scores, perceived stress, and psychological distress between recruits who continued training and dropouts.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Green & Sustainable Science & Technology
Sandra Sefidan, Maria Pramstaller, Roberto La Marca, Thomas Wyss, Lilian Roos, Dena Sadeghi-Bahmani, Hubert Annen, Serge Brand
Summary: This study found that the transformational leadership style in Swiss military recruits has a significant impact on their achievement motivation, organizational citizenship behavior, and perceived stress. Groups experiencing higher transformational leadership showed the highest scores for achievement motivation and OCB, and the lowest scores for perceived stress at week 11. Transformational leadership style fostered achievement motivation and OCB in Swiss military recruits, and protected them from stress both cross-sectionally and longitudinally.
Article
Psychology, Multidisciplinary
Philippe Goldammer, Hubert Annen, Christopher Lienhard, Klaus Jonas
Summary: The study examined the measurement model fit and invariance across the two largest language groups in Switzerland (German and French speakers) for general mental ability and personality tests used in the Swiss Armed Forces' cadre selection process. While partial approximate scalar invariance was found, certain test items were shown to function differently across the language groups. Future research will focus on assessing and addressing these non-invariances.
MILITARY PSYCHOLOGY
(2021)
Article
Environmental Sciences
Madlaina Niederhauser, Regula Zueger, Sandra Sefidan, Hubert Annen, Serge Brand, Dena Sadeghi-Bahmani
Summary: Resilience training has a positive effect on chronic stress and related mental health problems, but training motivation is an important factor.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Psychology, Clinical
Pei Hwa Goh, Peter Lucas Stoeckli, Dominik Schoebi, Hubert Annen
Summary: This research examines the influence of positional power and dispositional power on the perception of sexual interest in a military context. The results show that positional power induced by military rank leads to heightened sexual perceptions. Additionally, positional power is a better predictor of heightened perceived sexual interest compared to dispositional power.
ARCHIVES OF SEXUAL BEHAVIOR
(2022)
Article
Health Care Sciences & Services
Madlaina Niederhauser, Regula Zueger, Hubert Annen, Nejla Gueltekin, Zeno Stanga, Serge Brand, Dena Sadeghi-Bahmani
Summary: This study examined the associations between resilient functioning and coping strategies, stress reactivity, self-efficacy, and well-being. The results showed that resilient functioning was positively associated with task-oriented coping and well-being, and negatively associated with emotion-oriented coping and stress reactivity. Furthermore, the intervention group demonstrated significant improvement in resilient functioning from pre- to post-intervention. These findings suggest that specific interventions have the potential to enhance resilient functioning.
Article
Behavioral Sciences
Regula Zueger, Hubert Annen, Ulrike Ehlert
Summary: Prolonged or severe stress can inhibit the release of testosterone through the hypothalamic-pituitary-gonadal axis (HPG), while the response patterns to acute stress such as competition, social evaluation, or physical challenges are inconsistent. This study examined the changes in cortisol and testosterone levels during different types and durations of stress in the same individuals. The findings suggest that group stress tests and field exercises might be particularly challenging for young men and highlight the adaptive role of testosterone during acute challenges in prolonged stress.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2023)
Meeting Abstract
Psychology, Clinical
Susanne Fischer, Lea M. Bartsch, Lisa Baldelli, Tamara Moschinger, Regula Zuger, Hubert Annen, Johannes A. C. Laferton
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2021)
Article
Psychology, Applied
Philippe Goldammer, Hubert Annen, Peter Lucas Stockli, Klaus Jonas
LEADERSHIP QUARTERLY
(2020)
Article
Psychology, Applied
Andreja Wirz, Klaus G. Melchers, Martin Kleinmann, Filip Lievens, Hubert Annen, Urs Blum, Pia V. Ingold
EUROPEAN JOURNAL OF WORK AND ORGANIZATIONAL PSYCHOLOGY
(2020)
Meeting Abstract
Public, Environmental & Occupational Health
Sharon Daniel, Maya Doron, Boris Fishman, Gideon Koren, Eitan Lunenfeld, Amalia Levy
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2019)
