Review
Biochemistry & Molecular Biology
Kazunori Kageyama, Yasumasa Iwasaki, Makoto Daimon
Summary: This review focuses on the molecular mechanisms of CRF regulation in the hypothalamus during stress and stress resilience, highlighting the central role of CRF in regulating the stress response. The involvement of ACTH, glucocorticoids, various regulatory factors, and different CRF receptors in stress resilience are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mizuki Tasso, Kazunori Kageyama, Yasumasa Iwasaki, Yutaka Watanuki, Kanako Niioka, Shinobu Takayasu, Makoto Daimon
Summary: This study investigated the regulatory role of GDF15 in Crf gene expression in hypothalamic cells under stressful conditions. The results demonstrated that GDF15 increased Crf promoter activity and mRNA levels through activating GFRAL protein and subsequent activation of AKT and cAMP signaling pathways.
Article
Anesthesiology
Zheng Xu, Yu Zhou, Qingchen Guo, Di Wang, Yi-Hong Gao, Wei -Nan Zhao, Hui-Mei Tang, Jun-Xia Yang, Xiaolu Yu, Hai -Lei Ding, Jun -Li Cao
Summary: PVNCRF neurons in the paraventricular nucleus of the hypothalamus play a role in isoflurane anesthesia and its modulation by acute stress. Inhibition of PVNCRF neurons can facilitate emergence from anesthesia, while activation of these neurons delays emergence.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Review
Neurosciences
Anita E. Autry
Summary: The article reviews the role of BDNF signaling in the cortex, hippocampus, and hypothalamus in relation to depression, emphasizing the consistency between hypothalamic dysfunction and depressive symptoms and suggesting areas for further research.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Krisztina Csabafi, Katalin Eszter Ibos, Eva Bodnar, Kata Filkor, Julia Szakacs, Zsolt Bagosi
Summary: Intracerebroventricular administration of KP-13 induces anxiety-like behavior and activates the HPA axis in rats. The study found that KP-13 alters the AVP and CRF signaling, which may be responsible for its effect on the HPA axis and anxiety-like behavior.
Article
Endocrinology & Metabolism
Kanako Takahashi, Takeru Shima, Mariko Soya, Jang Soo Yook, Hikaru Koizumi, Subrina Jesmin, Tsuyoshi Saito, Masahiro Okamoto, Hideaki Soya
Summary: Exercise at an intensity above the lactate threshold leads to an increase in plasma adrenocorticotropic hormone (ACTH), indicating a stress response. This study investigated the involvement of arginine vasopressin (AVP) and corticotropin-releasing hormone (CRH) in regulating exercise-induced ACTH response. Using a rat model, the researchers administered AVP and CRH receptor antagonists and observed a suppression of ACTH levels after exercise. Immunohistochemical evaluation confirmed the activation of AVP and CRH neurons in the hypothalamus. These findings suggest that AVP and CRH cooperatively contribute to exercise-induced ACTH response, reflecting the stress response to moderate-intensity exercise in humans.
NEUROENDOCRINOLOGY
(2022)
Article
Biology
Alessandra Caruso, Alessandra Gaetano, Sergio Scaccianoce
Summary: CRH plays a role in regulating multiple biological systems, and is also associated with reproduction, neuropsychiatric, gastrointestinal, immune disorders, and tumor development. Further research on the physiological functions of CRH will help determine its role in human diseases and may serve as novel therapeutic targets.
Article
Agriculture, Dairy & Animal Science
Yuanli Cai, Zhigang Song
Summary: This study investigated the effects of corticotropin-releasing factor (CRF) on the feed intake of broiler chickens. The results showed that CRF at a dose of 10 μg suppressed feed intake and increased the expression of ghrelin in the hypothalamus and CRFR1 in the small intestine.
Article
Medicine, General & Internal
Lei Guo, Yang-Jian Qi, Hong Tan, Dan Dai, Rawien Balesar, Arja Sluiter, Joop van Heerikhuize, Shao-Hua Hu, Dick F. Swaab, Ai -Min Bao
Summary: Increased expression of OXT in PVN and OXTR in DLPFC are characteristic for male BD patients. Stimulation of PVN-OXT neurons induced mood changes in mice, in a pattern different from BD.
Review
Cell Biology
Mirmohammadali Mirramezani Alizamini, Mojdeh Fattahi, Fatemeh Sayehmiri, Abbas Haghparast, Jing Liang
Summary: Stress plays a significant role in psychiatric disorders, particularly depression. Impairment of the prefrontal cortex (PFC) is associated with cognitive and executive deficits caused by stress. This review examines the potential use of the corticotropin-releasing factor (CRF) system within the PFC as a treatment for stress-induced depression. The results suggest that modulating CRF receptors within the PFC can regulate depression caused by stress, but further research is needed to determine the most effective treatment.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Review
Biology
Mark W. Bohler, Vishwajit S. Chowdhury, Mark A. Cline, Elizabeth R. Gilbert
Summary: Heat stress is a major environmental condition causing significant losses in the poultry industry and impacting the world's food economy negatively. Exposure to heat leads to various physiological impairments in birds, affecting productivity and leading to mortality. Mitigation techniques include changes in airflow, dietary composition, building insulation, air cooling systems, and genetic alterations. The hypothalamus plays a central role in mediating responses to heat stress, food intake, and stress, with little research exploring the interaction of these systems.
Article
Biochemistry & Molecular Biology
Yukiomi Nakade, Rena Kitano, Taeko Yamauchi, Satoshi Kimoto, Kazumasa Sakamoto, Tadahisa Inoue, Yuji Kobayashi, Tomohiko Ohashi, Yoshio Sumida, Kiyoaki Ito, Masashi Yoneda
Summary: The study showed that central corticotropin-releasing factor (CRF) affects hepatic de novo lipogenesis and inflammation-related gene expression in rats through the sympathetic-noradrenergic nervous system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Hua Zhang, Jing-Jing Zhou, Jian-Ying Shao, Zhao-Fu Sheng, Jingxiong Wang, Peiru Zheng, Xunlei Kang, Zhenguo Liu, Zixi Jack Cheng, David D. Kline, De -Pei Li
Summary: Elevated levels of CRH and CRHR1 in the PVN are associated with increased sympathetic outflow in primary hypertension, potentially contributing to the hyperactivity of PVN presympathetic neurons.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Mirmohammadali Mirramezani Alizamini, Xing Chen, Lina Nie, Zhonghua Dai, Ying Liu, Abbas Haghparast, Ning Wu, Jianjun Zhang, Fang Shen, Nan Sui, Jing Liang
Summary: Chronic stress can lead to a bias towards habitual behavioral strategies, and it is still unclear which neuronal system modulates stress-induced behavioral abnormalities during decision making. This study found that the corticotropin-releasing factor (CRF) system in the medial prefrontal cortex (mPFC) plays a critical role in governing strategy choice and stress response. Antagonists of CRF receptor 1 (CRFR1) can alleviate stress-induced behavioral abnormalities, suggesting that CRFR1 may be a potential target for treating chronic stress-altered behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Veterinary Sciences
Ginevra Brocca, Angela Rebesco, Massimo Castagnaro, Emanuele Ricci
Summary: The study aims to find a suitable immunohistochemical marker for the assessment of suffering in Veterinary Forensic Pathology by analyzing the expression of CRF in dogs' brains. CRF is identified as a promising marker of stress in abused patients, demonstrating its significance in Veterinary Medicine.
RESEARCH IN VETERINARY SCIENCE
(2021)