Article
Biochemistry & Molecular Biology
Rocio Salsoso, Alfonso Mate, Fernando Toledo, Carmen M. Vazquez, Luis Sobrevia
Summary: Late-onset preeclampsia is associated with altered endothelial function in the fetoplacental vasculature, causing an imbalance in the L-arginine/NO signaling pathway and reducing umbilical vein dilation to insulin, which requires A(2B)AR activation in HUVECs.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Physiology
Farjana Akther, Md Rahatullah Razan, Sonali Shaligram, James L. Graham, Kimber L. Stanhope, Kaitlin N. Allen, Jose Pablo Vazquez-Medina, Peter J. Havel, Roshanak Rahimian
Summary: This study found sexual differences in aortic function in UCD-T2DM rats, with females showing impaired contraction response and males exhibiting potentiated relaxation response. Diabetes led to reduced nitric oxide generation and insulin sensitivity, contributing to enhanced contractile responses in both sexes' aortas.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Guang Ren, Patrick Tae Joon Hwang, Reid Millican, Juhee Shin, Brigitta C. Brott, Thomas van Groen, Craig M. Powell, Sushant Bhatnagar, Martin E. Young, Ho-Wook Jun, Jeong-A Kim
Summary: This study demonstrates the effects of using PANO gel to inject exogenous NO on high-fat diet-induced obesity, insulin resistance, and cognitive functions. The use of PANO gel reduces body weight gain, improves glucose tolerance, decreases insulin and leptin levels, and enhances insulin signaling. Additionally, the PANO gel reduces inflammation, increases lipolysis, decreases serum lipids and liver triglycerides, stimulates the development of brown and beige fat tissues, increases cerebral blood flow, and improves learning and memory abilities.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Medicine, General & Internal
Daniel Alberto Maldonado-Ortega, Gabriel Martinez-Castanon, Gabriela Palestino, Gabriela Navarro-Tovar, Carmen Gonzalez
Summary: This study evaluated the biological effects of AuNPs with different capping agents in an artery model and found that AuNPsCA exhibited contractile effects while AuNPsGA showed dilator effects. Moreover, the presence or absence of glycocalyx had different effects on the nitric oxide levels induced by AuNPsCA and AuNPsGA.
FRONTIERS IN MEDICINE
(2022)
Article
Nutrition & Dietetics
Patrycja Bielawiec, Ewa Harasim-Symbor, Klaudia Sztolsztener, Karolina Konstantynowicz-Nowicka, Adrian Chabowski
Summary: Excessive intake of fatty acids leads to oxidative stress and inflammation, while CBD has potential therapeutic properties by improving the n-6/n-3 PUFA ratio, preventing lipid peroxidation, and attenuating inflammatory response in skeletal muscles.
Article
Biochemistry & Molecular Biology
Cher-Rin Chong, Saifei Liu, Hasan Imam, Tamila Heresztyn, Benedetta C. Sallustio, Yuliy Y. Chirkov, John D. Horowitz
Summary: Perhexiline (Px) can inhibit platelet aggregation and improve insulin sensitivity in patients with Type 2 diabetes (T2D) and cardiovascular disease. However, approximately 30% of Px-treated patients with T2D lack the NO-sensitizing effect and show increased insulin resistance.
Article
Food Science & Technology
Francineide Fernandes-Costa, Rayanelle Tissiane Gomes da Silva, Atalia Ferreira de Lima Flor, Maria Claudia R. Brandao, Petronio F. Athayde-Filho, Maria do Socorro Franca-Falcao, Valdir de Andrade Braga, Gustavo Jorge dos Santos, Mattias Carlstrom, Josiane de Campos Cruz
Summary: Our study investigated the cardiometabolic effect of NDBP treatment in a mouse model of type 1 diabetes (T1DM). The results showed that NDBP treatment reduced hyperglycemia, improved glucose tolerance, and decreased oxidative stress in the liver and pancreas. Additionally, NDBP treatment improved vascular function but had no effect on hypertension.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Bianca Maria Rotoli, Rossana Visigalli, Francesca Ferrari, Marianna Ranieri, Grazia Tamma, Valeria Dall'Asta, Amelia Barilli
Summary: This study evaluated the effects of desmopressin on human pulmonary microvascular endothelial cells and found that it had no cytotoxic effect on the endothelium, but significantly stimulated the production of nitric oxide.
Article
Biochemistry & Molecular Biology
Natasha de Alwis, Natalie K. Binder, Yeukai T. M. Mangwiro, Sally Beard, Natasha Pritchard, Elif Kadife, Bianca R. Fato, Emerson Keenan, Fiona C. Brownfoot, Tu'uhevaha J. Kaitu'u-Lino, Natalie J. Hannan
Summary: Esomeprazole, a proton pump inhibitor, shows potential therapeutic effects in the treatment of pregnancy-induced hypertension, and may work via the nitric oxide pathway. Further research is needed to fully understand its mechanism of action.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Samantha L. Saunders, Dana S. Hutchinson, Fiona C. Britton, Lu Liu, Irit Markus, Shaun L. Sandow, Timothy V. Murphy
Summary: The study demonstrated the presence of all three beta-adrenoceptor subtypes in the endothelium of rat cremaster muscle artery, with beta(3)-adrenoceptor mediated vasodilation only evident after blockade of beta(1/2)-adrenoceptors. Constitutive beta(1/2)-adrenoceptor activity inhibits beta(3)-adrenoceptor function in the endothelium of skeletal muscle resistance arteries.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yuting Meng, Huaikang Jing, Jing Huang, Renfang Shen, Xiaofang Zhu
Summary: Nitric oxide (NO) is a crucial signaling molecule in plants, playing roles in regulating plant growth and development, and responding to stress. Cadmium (Cd) pollution is a widespread environmental hazard that inhibits plant growth and threatens human health. Plants have evolved mechanisms to cope with Cd stress, and NO is known to be involved in these responses. However, the mechanisms by which Cd stress affects the accumulation of endogenous NO in plants and the role of exogenous NO in plant responses to Cd stress remain unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Ignatios Ikonomidis, George Pavlidis, Maria Tsoumani, Foteini Kousathana, Konstantinos Katogiannis, Damianos Tsilivarakis, John Thymis, Aikaterini Kountouri, Emmanouil Korakas, Loukia Pliouta, Athanasios Raptis, John Parissis, Ioanna Andreadou, Vaia Lambadiari
Summary: Oxidative stress plays a significant role in the pathogenesis of diabetes. This study found that nitrite/nitrate levels decreased, perfused boundary region increased, and coronary flow reserve and left ventricular global longitudinal strain decreased in subjects with high blood sugar, indicating a correlation with insulin resistance.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Albino Carrizzo, Concetta Iside, Angela Nebbioso, Vincenzo Carafa, Antonio Damato, Sebastiano Sciarretta, Giacomo Frati, Flavio Di Nonno, Valentina Valenti, Michele Ciccarelli, Eleonora Venturini, Mariarosaria Scioli, Paola Di Pietro, Tommaso Bucci, Valentina Giudice, Marianna Storto, Bianca Serio, Annibale Alessandro Puca, Giuseppe Giugliano, Valentina Trimarco, Raffaele Izzo, Bruno Trimarco, Carmine Selleri, Lucia Altucci, Carmine Vecchione
Summary: In addition to well-known risk factors, cardiovascular events may also be associated with epigenetic and genetic alterations. This study found that the MTHFR C677T gene variant is related to increased cardiovascular risk. Interestingly, even with normal homocysteine levels, heterozygous carriers of this gene variant have an augmented risk of cardiovascular accidents, suggesting the presence of additional deregulated processes. The study suggests that targeting SIRT1 activation could be a new therapeutic strategy to control cardiovascular risk in MTHFR carriers.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Katie E. Cohen, Boran Katunaric, Mary E. Schulz, Gopika SenthilKumar, Micaela S. Young, James E. Mace, Julie K. Freed
Summary: This study found that chronic administration of exogenous adiponectin can restore nitric oxide as the mediator of flow-induced dilation in arterioles from patients with coronary artery disease. The Adiponectin Receptor 1 (AdipoR1) plays a critical role in adiponectin-induced NO signaling during shear. Additionally, osmotin, a plant-derived protein, showed similar effects to adiponectin.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Xiuwen Geng, Jiajun Ji, Yuanhua Liu, Xueyan Li, Yunan Chen, Lei Su, Lina Zhao
Summary: The anthocyanin cyanidin-3-O-glucoside (Cy3G) has the potential to prevent diabetes and its vascular complications by restoring impaired nitric oxide-mediated endothelial insulin transport and improving metabolic insulin resistance. This finding offers a novel explanation for the anti-diabetic effects of Cy3G.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Education, Scientific Disciplines
Fernanda Klein Marcondes, Lais Tono Cardozo, Kelly Cristina Gaviao Luchi, Muhammad Irfannuddin, Christina Karatzaferi, Maria Jose Rocha, Robert G. Carroll
ADVANCES IN PHYSIOLOGY EDUCATION
(2018)
Article
Dentistry, Oral Surgery & Medicine
Patricia Oliveira de Lima, Bruno Dias Nani, Barbara Almeida, Fernanda Klein Marcondes, Francisco Carlos Groppo, Antonio Bento Alves de Moraes, Michelle Franz-Montan, Karina Cogo-Mueller
Article
Biochemistry & Molecular Biology
Vinicius Guzzoni, Tatiana Sousa Cunha, Vander Jose das Neves, Larissa Briet, Rafaela Costa, Maria Jose Costa Sampaio Moura, Vanessa Oliveira, Maria do Carmo Pinho Franco, Pedro Duarte Novaes, Fernanda Klein Marcondes
Article
Behavioral Sciences
Lilia Taddeo Firoozmand, Andrea Sanches, Nilsa Regina Damaceno-Rodrigues, Juliana Dineia Perez, Danielle Sanches Aragao, Rodolfo Mattar Rosa, Fernanda Klein Marcondes, Dulce Elena Casarini, Elia Garcia Caldini, Tatiana Sousa Cunha
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2018)
Article
Multidisciplinary Sciences
Bruno Dias Nani, Patricia Oliveira de Lima, Fernanda Klein Marcondes, Francisco Carlos Groppo, Gustavo Sattolo Rolim, Antonio Bento Alves de Moraes, Karina Cogo-Mueller, Michelle Franz-Montan
Article
Behavioral Sciences
Vinicius Guzzoni, Larissa Briet, Rafaela Costa, Rodrigo W. A. Souza, Fernanda R. Carani, Maeli Dal-Pai-Silva, Kleiton A. S. Silva, Tatiana S. Cunha, Fernanda K. Marcondes
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2019)
Article
Education, Scientific Disciplines
Kelly Cristina Gaviao Luchi, Lais Tono Cardozo, Fernanda Klein Marcondes
ADVANCES IN PHYSIOLOGY EDUCATION
(2019)
Article
Behavioral Sciences
Rafaela Costa, Mariana Leite Tamascia, Andrea Sanches, Roseli Peres Moreira, Tatiana Sousa Cunha, Marie Doki Nogueira, Dulce Elena Casarini, Fernanda Klein Marcondes
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Behavioral Sciences
Rafaela Costa, Maeline Santos Morais Carvalho, Juliana Dineia Perez Brandao, Roseli Peres Moreira, Tatiana Sousa Cunha, Dulce Elena Casarini, Fernanda Klein Marcondes
Summary: The study evaluated the effects of environmental enrichment on hormonal and behavioral responses induced by chronic stress in rats. The results showed that environmental enrichment improved stress hormone secretion, depression-like behaviors, and memory impairment, while reducing anxiety-like behavior and norepinephrine secretion.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Fernanda R. Roque, Tiago Fernandes, Henrique Cho, Vander J. das Neves, Gloria de Fatima A. Mota, Luciana Rossoni, Edilamar M. Oliveira
Article
Education, Scientific Disciplines
Pamela B. Mello-Carpes, Barbekka Hurtt, Fernanda K. Marcondes, Colleen J. Thomas, Kathleen Marie Bartlow, Maria Jose Alves Rocha
ADVANCES IN PHYSIOLOGY EDUCATION
(2017)
Article
Education, Scientific Disciplines
Kelly Cristina Gaviao Luchi, Luis Henrique Montrezor, Fernanda K. Marcondes
ADVANCES IN PHYSIOLOGY EDUCATION
(2017)